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41. Literature meta-analysis about the efficacy of anti-programmed death protein 1 and anti-programmed death ligand 1 re-challenge in cancer patients Full Text available with Trip Pro

Literature meta-analysis about the efficacy of anti-programmed death protein 1 and anti-programmed death ligand 1 re-challenge in cancer patients Literature meta-analysis about the efficacy of anti-programmed death protein 1 and anti-programmed death ligand 1 re-challenge in cancer patients | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review (...) prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Literature meta-analysis about the efficacy of anti-programmed death protein 1 and anti-programmed death ligand 1 re-challenge in cancer patients Elisa Gobbini, Julie Charles, Anne-Claire Toffart, Marie-Thérèse Leccia, Denis Moro-Sibilot, Matteo Giaj Levra Elisa

2020 Research Square

42. Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged >/= 80 YEARs OLD Full Text available with Trip Pro

Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged >/= 80 YEARs OLD Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 Information Show account info Close Account Logged (...) Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arch Gerontol Geriatr Actions . 2021 Feb 25;95:104383. doi: 10.1016/j.archger.2021.104383. Online ahead of print. Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD , , , , , , , , , , Affiliations Expand Affiliations 1 Emergency Department - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore

2021 EvidenceUpdates

43. Tofacitinib (Xeljanz): new measures to minimise risk of venous thromboembolism and of serious and fatal infections

data). The risk of serious infections and fatal infections was further increased in older patients aged 65 years or older, as compared to younger patients (aged 50–64 years) – see for data. Healthcare professionals are advised only to use tofacitinib in patients older than age 65 years if there is no alternative treatment. Mortality in rheumatoid arthritis In the interim analysis of study A3921133 in patients with rheumatoid arthritis, mortality within 28 days of last treatment was increased (...) Tofacitinib (Xeljanz): new measures to minimise risk of venous thromboembolism and of serious and fatal infections Tofacitinib (Xeljanz▼): new measures to minimise risk of venous thromboembolism and of serious and fatal infections - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Stay

2020 MHRA Drug Safety Update

44. Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression

Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Stay at home Only go outside for food, health reasons (...) or work (but only if you cannot work from home) If you go out, stay 2 metres (6ft) away from other people at all times Wash your hands as soon as you get home Do not meet others, even friends or family. You can spread the virus even if you don’t have symptoms. Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression Benzodiazepines and opioids can both cause respiratory depression, which can be fatal if not recognised in time. Only prescribe together

2020 MHRA Drug Safety Update

45. What is the effect of the COVID-19 pandemic on alcohol use, poisonings, and alcohol-related deaths? What strategies have been used to mitigate alcohol abuse during the COVID-19 pandemic?

What is the effect of the COVID-19 pandemic on alcohol use, poisonings, and alcohol-related deaths? What strategies have been used to mitigate alcohol abuse during the COVID-19 pandemic? Version 1: June 23, 2020 Rapid Review: What is the effect of the COVID-19 pandemic on alcohol use and alcohol-related harms? Prepared by: The National Collaborating Centre for Methods and Tools Date: June 23, 2020 Suggested Citation: National Collaborating Centre for Methods and Tools. (2020). What (...) Comparisons Pre-pandemic Outcomes Alcohol-related overdoses and death; any data on increased or new usage, if available Inclusion Criteria Exclusion Criteria Population People who use alcohol Intervention Any intervention implemented during COVID-19 pandemic Comparisons Pre-pandemic interventions Outcomes Alcohol-related overdoses and death; any data on increased or new usage, if available; adherence to interventions Data Extraction and Synthesis Data relevant to the research question, such as study

2020 COVID-19 Rapid Evidence Service

46. Emollients and risk of severe and fatal burns: new resources available

Emollients and risk of severe and fatal burns: new resources available Emollients and risk of severe and fatal burns: new resources available - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance and support Emollients and risk of severe and fatal burns: new resources available We (...) inform healthcare professionals of the recent campaign to promote awareness of the risk and new resources available to support safe use following previous advice to health and care professionals. Published 26 August 2020 From: Therapeutic area: , There is a risk of severe and fatal burns with all emollients – see the . Emollients can transfer from the skin onto clothing, bedding, dressings, and other fabric. Once there, they can dry onto the fabric and build up over time. In the presence of a naked

2020 MHRA Drug Safety Update

47. Rapid Review Update 1: What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths?

Rapid Review Update 1: What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? Update 1: September 21, 2020 1 Rapid Review Update 1: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms? Prepared by: The National Collaborating Centre for Methods and Tools Date: September 21, 2020 Suggested Citation: National Collaborating Centre for Methods and Tools. (2020, September 21). What is the effect of the COVID-19 (...) pandemic on supply, safety, overdoses and deaths associated with opioid and other substance use, although the relevance of other events to the COVID-19 pandemic is not known. • More Canadian surveillance evidence is available to address effect of the COVID-19 pandemic on overdoses and deaths associated with opioid and other substance use, although making appropriate comparisons to pre-pandemic rates continues to be challenging. • Expert opinion sources, apart from descriptions of models, were excluded

2020 COVID-19 Rapid Evidence Service

48. Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing

Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve (...) accepted all cookies. You can at any time. Hide Show or hide search Search on GOV.UK Search National restrictions in England from 5 November Take action now for new rules in 2021 Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing In autoimmune conditions and some cancer therapies, methotrexate should be taken once a week; however, we continue to receive reports of inadvertent overdose due to more frequent

2020 MHRA Drug Safety Update

49. APHRS/HRS Expert Consensus Statement on the Investigation of Decedents with Sudden Unexplained Death and Patients with Sudden Cardiac Arrest, and of Their Families

APHRS/HRS Expert Consensus Statement on the Investigation of Decedents with Sudden Unexplained Death and Patients with Sudden Cardiac Arrest, and of Their Families 2020 APHRS/HRS Expert Consensus Statement on the Investigation of Decedents with Sudden Unexplained Death and Patients with Sudden Cardiac Arrest, and of Their Families | Heart Rhythm Society Utility Menu Main navigation Search Leave this field blank Main Menu Breadcrumb on Heart Rhythm TV. Sudden Cardiac Arrest Downloads (...) The document provides a framework for the investigation of patients with sudden cardiac arrest (SCA), decedents with sudden unexplained death (SUD), and families of both SCA survivors and SUD victims, as many conditions responsible for the cardiac arrest or unexplained death may be familial. The disciplines of cardiology, pediatrics, radiology, pathology, counseling, psychology, and genetics are all involved in this process. The formation of multidisciplinary teams is central to thorough investigation, so

2020 Heart Rhythm Society

50. 5-fluorouracil (intravenous), capecitabine, tegafur: DPD testing recommended before initiation to identify patients at increased risk of severe and fatal toxicity

5-fluorouracil (intravenous), capecitabine, tegafur: DPD testing recommended before initiation to identify patients at increased risk of severe and fatal toxicity 5-fluorouracil (intravenous), capecitabine, tegafur: DPD testing recommended before initiation to identify patients at increased risk of severe and fatal toxicity - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government (...) services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Show or hide search Search on GOV.UK Search National restrictions in England from 5 November Take action now for new rules in 2021 5-fluorouracil (intravenous), capecitabine, tegafur: DPD testing recommended before initiation to identify patients at increased risk of severe and fatal toxicity Patients with complete or partial dihydropyrimidine dehydrogenase (DPD) deficiency are at increased risk of severe and fatal

2020 MHRA Drug Safety Update

51. 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 2. Environment for cardiac arrest survival and the chain of survival Full Text available with Trip Pro

2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 2. Environment for cardiac arrest survival and the chain of survival 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 2. Environment for cardiac arrest survival and the chain of survival - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 Information (...) of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Guideline Clin Exp Emerg Med Actions . 2021 May;8(S):S8-S14. doi: 10.15441/ceem.21.022. Epub 2021 May 21. 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 2. Environment for cardiac arrest survival and the chain of survival , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Yonsei University Wonju College

2021 Korean Clinical Guidelines

52. Sudden infant death syndrome

that onset of the fatal event seems to be associated with sleep, Krous HF, Beckwith JB, Byard RW, et al. Sudden infant death syndrome (SIDS) and unclassified sudden infant death (USID): a definitional and diagnostic approach. Pediatrics. 2004 Jul;114(1):234-8. http://www.ncbi.nlm.nih.gov/pubmed/15231934?tool=bestpractice.com Bajanowski T, Vege A, Byard RW, et al. Sudden infant death syndrome (SIDS) - standardised investigations and classification: recommendations. Forensic Sci Int. 2007 Jan 17;165(2-3 (...) Sudden infant death syndrome Sudden infant death syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sudden infant death syndrome Last reviewed: February 2019 Last updated: November 2018 Summary Leading cause of infant death beyond the neonatal period. Incidence roughly 1 in 2000 infants. Peak incidence between 1 and 3 months of age, although events may occur up to 12 months of age. Risk factors include exposure

2018 BMJ Best Practice

53. Epinephrine in Out-of-Hospital Cardiac Arrest: Saving Lives or Prolonging Death? Full Text available with Trip Pro

. A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med. 2018; 379 : 711-721 This 0.8% absolute difference in survival remained consistent at 3 months (3% versus 2.2%) and translated to a number needed to treat of 112 patients to prevent 1 death at 30 days. The authors also reported an increase in the number of patients who were transported to the hospital (50.8% versus 30.7%) and survived to ICU admission (14.1% versus 6.8%). Despite a small increase in overall survival (...) survival, it did not increase the number of patients who survived neurologically intact, leading to a higher number of survivors with severe neurologic disability. Perkins G.D. Ji C. Deakin C.D. et al. A randomized trial of epinephrine in out-of-hospital cardiac arrest. N Engl J Med. 2018; 379 : 711-721 Discussion Points 1. The authors noted a statistically significant increase in 30-day survival, citing a 0.8% absolute difference in mortality, with a corresponding P value of .02. Although

2019 Annals of Emergency Medicine Journal Club

54. Liver Chemistries in COVID-19 Patients with Survival or Death: A Meta-Analysis Full Text available with Trip Pro

Liver Chemistries in COVID-19 Patients with Survival or Death: A Meta-Analysis Liver Chemistries in COVID-19 Patients with Survival or Death: A Meta-Analysis | medRxiv Search for this keyword Liver Chemistries in COVID-19 Patients with Survival or Death: A Meta-Analysis Qing-Qing Xing , Xuan Dong , Yan-Dan Ren , Wei-Ming Chen , Dan-Yi Zeng , Yan-Yan Cai , Mei-Zhu Hong , Jin-Shui Pan doi: https://doi.org/10.1101/2020.04.26.20080580 Qing-Qing Xing 1 Liver Research Center, the First Affiliated (...) disease (COVID-19), liver manifestations may be diverse and even confused. Thus, we performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19 patients with death or survival. Methods We searched PubMed, Google Scholar, medRxiv, bioRxiv, Cochrane Library, Embase, and three Chinese electronic databases through April 22, 2020. We analyzed pooled data on liver chemistries stratified by the main clinical outcome of COVID-19 using a fixed or random-effects model

2020 Cold Spring Harbor Laboratory

55. Context and Implications Document for: Death and Dying: A Systematic Review into Approaches Used to Support Bereaved Children Full Text available with Trip Pro

Context and Implications Document for: Death and Dying: A Systematic Review into Approaches Used to Support Bereaved Children Context and Implications Document for: Death and Dying: A Systematic Review into Approaches Used to Support Bereaved Children - Duncan - 2020 - Review of Education - Wiley Online Library Working off-campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term Context & Implications (...) Context and Implications Document for: Death and Dying: A Systematic Review into Approaches Used to Support Bereaved Children University of Strathclyde, Glasgow, UK University of Strathclyde, Glasgow, UK First published: 17 February 2020 Give access Share full-text access Please review our and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use Shareable Link Use the link below to share a full-text version of this article

2020 Review of Education

56. Forms for the Diagnosis of Death using neurological criteria

Forms for the Diagnosis of Death using neurological criteria November 2019 1 Form for the Diagnosis of Death using Neurological Criteria {long version} HOSPITAL ADDRESSOGRAPH or Surname First Name Date of Birth NHS / CHI Number This form is consistent with and should be used in conjunction with, the AoMRC (2008) A Code of Practice for the Diagnosis and Confirmation of Death and has been endorsed for use by the following institutions: Intensive Care Society and the Faculty of Intensive Care (...) Medicine. Objective of Care • To diagnose and confirm the death of a mechanically ventilated, severely brain injured patient in coma, using neurological criteria. Academy of the Medical Royal Colleges Definition of Human Death (2008).1 “Death entails the irreversible loss of those essential characteristics which are necessary to the existence of a living human person and, thus, the definition of death should be regarded as the irreversible loss of the capacity for consciousness, combined

2019 Faculty of Intensive Care Medicine

57. Emollients: new information about risk of severe and fatal burns with paraffin-containing and paraffin-free emollients

50% paraffins have been associated with fatal burns and paraffin-free products also have a fire accelerant effect in tests when emollient residue builds up on fabric and the fabric is ignited. It is difficult to estimate the true size of the risk based on case reports because of the likely under reporting of such events. We are currently aware of 11 cases (5 Coroner’s Regulation 28 reports to Prevent Future Deaths and 6 others) in which paraffin-based emollients are suspected to have contributed (...) to the speed and intensity of a fire, resulting in fatal burns injury. There are also 50 fire incidents (49 fatal) reported by Fire and Rescue Services across the UK between 2000 and November 2018, in which emollients were known to have been used by the victim or were present at the fire premises. However, in most of these it is not clear what the attributable role of paraffin creams in the deaths would have been, in the presence of multiple risk factors for a fire incident. Mechanism of the risk

2019 MHRA Drug Safety Update

58. Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events

Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events Onivyde has been associated with reports of serious thromboembolic events, such as pulmonary embolism, venous thrombosis, and arterial (...) thromboembolism. Published 21 March 2019 From: Therapeutic area: , , Contents Advice for healthcare professionals: be aware of reports of serious and fatal cases of thromboembolic events in patients receiving Onivyde for metastatic adenocarcinoma of the pancreas a thorough medical history should be obtained in order to identify patients with multiple risk factors in addition to the underlying neoplasm advise patients to seek medical advice immediately if signs or symptoms of thromboembolism occur (for example

2019 MHRA Drug Safety Update

59. Maternal and child health: Mothers who give birth to offspring with low birth weight may have increased risk for cardiovascular death

Maternal and child health: Mothers who give birth to offspring with low birth weight may have increased risk for cardiovascular death Mothers who give birth to offspring with low birth weight may have increased risk for cardiovascular death | BMJ Evidence-Based Medicine Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Mothers who give birth to offspring with low birth weight may have increased risk for cardiovascular death Article Text Commentary Maternal and child health Mothers who give birth to offspring with low birth weight may have increased risk for cardiovascular death Anne Eskild 1 , 2 Statistics from Altmetric.com Commentary on : Morken NH, Halland F, DeRoo LA, et

2019 Evidence-Based Medicine

60. Spread the Word: Widespread Distribution of Naloxone to Decrease Opioid-Related Deaths

Spread the Word: Widespread Distribution of Naloxone to Decrease Opioid-Related Deaths September 16, 2019 (en français) Love Tools for Practice? Want to see it in conference format? You're in luck! Visit the ACFP website for more information. Spread the Word: Widespread Distribution of Naloxone to Decrease Opioid-Related Deaths Clinical Question: Does population-based or programmatic provision of naloxone kits decrease the risk of opioid- related deaths in people who use opioids? Bottom Line (...) : Offering naloxone kits and overdose related education for people who use opioids and their community may decrease opioid related deaths by ~7 per 100,000 population over one year. Effectiveness is likely influenced by magnitude of opioid problem in a given community and other confounders (like co-ingestions, co- morbidities, type and dose of opioid used). Evidence: • Randomized controlled trial: o 1676 inmates being released from prison were randomized to kit with single dose naloxone versus

2019 Tools for Practice

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