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1. COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital

issues about data collected in England and Wales. Both of these suggest potential areas of concern in non-hospital settings. First, many more individuals, compared to a baseline of the weekly five-year average, appear to be dying at home. Second, a large discrepancy is apparent in COVID-19 deaths according to whether these are measured using a death certificate-based method or a positive test-based method. Explaining these issues has implications for public policy regarding COVID-19 mitigation (...) COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-19 deaths in England and Wales: resolving discrepancies in deaths outside of hospital July 28, 2020 Daniel Howdon, Carl Heneghan We note two potentially important

2020 Oxford COVID-19 Evidence Service

2. Death audits and reviews for reducing maternal, perinatal and child mortality. Full Text available with Trip Pro

Death audits and reviews for reducing maternal, perinatal and child mortality. The United Nations' Sustainable Development Goals (SDGs) include reducing the global maternal mortality rate to less than 70 per 100,000 live births and ending preventable deaths of newborns and children under five years of age, in every country, by 2030. Maternal and perinatal death audit and review is widely recommended as an intervention to reduce maternal and perinatal mortality, and to improve quality of care (...) -certainty evidence). The effect of the intervention on stillbirth rate, neonatal mortality, mortality rate in children under five years of age, maternal mortality or adverse effects was not reported. The QUARITE intervention in West Africa focused on training leaders of hospital obstetric teams using the ALARM (Advances in Labour And Risk Management) course, which included one day of training about conducting maternal death reviews. The leaders returned to their hospitals, established

2020 Cochrane

3. What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? How have rates of overdoses and substance-related deaths been affected during the COVID-19 pandemic? What strategies have been used to mitigate substanc

What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? How have rates of overdoses and substance-related deaths been affected during the COVID-19 pandemic? What strategies have been used to mitigate substanc Version 1: June 19, 2020 Rapid Review: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms? Prepared by: The National Collaborating Centre for Methods and Tools Date: June 19, 2020 Suggested Citation (...) up to June 16, 2020. In this rapid review, we provide the most recent research evidence to answer the question: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms? Key Points There has been no scientific assessment to date of the effects of the COVID-19 pandemic on opioid and substance use. Minimal surveillance evidence is available to identify effects on overdoses and deaths, and these findings do not show a consistent trend during the COVID-19 pandemic

2020 COVID-19 Rapid Evidence Service

4. Ebola vaccine rVSV-Zebov (Ervebo) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection

Ebola vaccine rVSV-Zebov (Ervebo) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection Prescrire IN ENGLISH - Spotlight ''Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection'', 1 February 2021 {1} {1} {1} | | > > > Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those (...) at risk for this often-fatal infection Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection FEATURED REVIEW Ebola virus disease is a contagious and often fatal infection for which there was no vaccine

2021 Prescrire

5. COVID-19 and risk factors for hospital admission, severe disease and death 3rd update

COVID-19 and risk factors for hospital admission, severe disease and death 3rd update COVID-19 and risk factors for hospital admission, severe disease and death 3rd update - NIPH Search for: Søk Menu To top level Close Infectious diseases & Vaccines Mental & Physical health Environment & Lifestyle Health in Norway Quality & Knowledge Research & Access to data About NIPH Close COVID-19 and risk factors for hospital admission, severe disease and death 3rd update Subscribe me! You have subscribed (...) to alerts about: COVID-19 and risk factors for hospital admission, severe disease and death 3rd update Oops, something went wrong... ... contact nettredaksjon@fhi.no. ... reload the page and try again- Note COVID-19 and risk factors for hospital admission, severe disease and death – a rapid review, 3rd update Published 15.11.2020 This rapid review is an update of a version published on May 12th, 2020. In this review, only peer-reviewed population-based studies with more than 5000 laboratory test

2021 Norwegian Institute of Public Health

6. Covid-19 by country of birth: Persons tested, confirmed infected and associated hospitalizations and deaths

Covid-19 by country of birth: Persons tested, confirmed infected and associated hospitalizations and deaths Covid-19 by country of birth: Persons tested, confirmed infected and associated hospitalizations and deaths - NIPH Search for: Søk Menu To top level Close Infectious diseases & Vaccines Mental & Physical health Environment & Lifestyle Health in Norway Quality & Knowledge Research & Access to data About NIPH Close Covid-19 by country of birth: Persons tested, confirmed infected (...) and associated hospitalizations and deaths Subscribe me! You have subscribed to alerts about: Covid-19 by country of birth: Persons tested, confirmed infected and associated hospitalizations and deaths Oops, something went wrong... ... contact nettredaksjon@fhi.no. ... reload the page and try again- Report Covid-19 by country of birth: Persons tested, confirmed infected and associated hospitalizations and deaths Published 03.12.2020 In this report we present statistics that provide an overview on Covid-19

2021 Norwegian Institute of Public Health

7. The role of service factors on variations in place of death: an observational study Full Text available with Trip Pro

The role of service factors on variations in place of death: an observational study The role of service factors on variations in place of death: an observational study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit (...) 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Almost all service categories were associated with some of the variation in place of death, with service type and capacity having the strongest link. {{author}} {{($index , , , , & . Wei Gao 1, * , Emeka Chukwusa 1 , Julia Verne 2 , Peihan Yu 1 , Giovanna Polato 3 , Irene J Higginson 1 1 Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King’s College London, London, UK 2 Knowledge and Intelligence (South West

2019 NIHR HTA programme

8. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). (Abstract)

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). This is an updated version of the original Cochrane Review, published in 2016, Issue 7. Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in whom postmortem examination does not reveal a structural or toxicological cause (...) for death. SUDEP has a reported incidence of 1 to 2 per 1000 patient-years and represents the most common epilepsy-related cause of death. The presence and frequency of generalised tonic-clonic seizures (GTCS), male sex, early age of seizure onset, duration of epilepsy, and polytherapy are all predictors of risk of SUDEP. The exact pathophysiology of SUDEP is currently unknown, although GTCS-induced cardiac, respiratory, and brainstem dysfunction appears likely. Appropriately chosen antiepileptic drug

2020 Cochrane

9. Subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death

in the transvenous ICD group (3 from non-cardiac causes, 2 from cardiac causes and 1 for an unknown reason) in a retrospective propensity-matched cohort study of 280 patients with a 5-year follow-up. Death from congestive heart failure was reported in 1 patient in the subcutaneous ICD group in a matched-controlled study of 138 patients comparing 69 patients with subcutaneous ICDs and 69 matched patients with transvenous ICDs (average follow-up 217 days). All-cause mortality rate was 3% (26/882) in a case series (...) Subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death Subcutaneous implantable cardio Subcutaneous implantable cardiov verter erter defibrillator insertion for pre defibrillator insertion for prev venting sudden enting sudden cardiac death cardiac death Interventional procedures guidance Published: 20 December 2017 nice.org.uk/guidance/ipg603 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

10. Fatal and non-fatal events within 14 days after early, intensive mobilization post stroke

Ratio of 1.76 (95% CI 1.06-2.92, p = 0.029). Stroke progression was more common in VEM. Exploratory subgroup analyses showed higher odds of death in intracerebral haemorrhage and >80 years subgroups, but there was no significant treatment by subgroup interaction. No difference in non-fatal SAEs found. Conclusion: While the overall case fatality at 14 days post-stroke was only 3.8%, mortality adjusted for age and stroke severity was increased with high dose, intensive training compared to usual care (...) . The primary early safety outcome was fatal SAEs within 14 days. Secondary outcomes were non-fatal SAEs classified as neurologic, immobility-related, and other. Mortality influences were assessed using binary logistic regression adjusted for baseline stroke severity (NIHSS) and age. Results: 2,104 participants were randomized to VEM (n = 1,054) or UC (n = 1,050) with a median age of 72 years (IQR 63-80) and NIHSS 7 (IQR 4-12). By 14 days, 48 had died in VEM, 32 in UC, age and stroke severity adjusted Odds

2021 EvidenceUpdates

11. Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease

Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Febuxostat (Adenuric): increased risk (...) of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease Avoid treatment with febuxostat in patients with pre-existing major cardiovascular disease (for example, myocardial infarction, stroke, or unstable angina), unless no other therapy options are appropriate. Findings from a phase 4 clinical study (the CARES study) in patients with gout and a history of major cardiovascular disease show a higher risk for cardiovascular-related death

2019 MHRA Drug Safety Update

12. Portable Normothermic Cardiac Perfusion System in Donation After Cardiocirculatory Death

Analyses 80 Appendix 6: Letter of Information 82 Appendix 7: Interview Guide 83 REFERENCES 84 March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 3, pp. 1–90, March 2020 8 LIST OF TABLES Table 1: Characteristics of Included Studies 18 Table 2: Survival and Deaths Following Cardiac Transplants With Donation After Cardiocirculatory Death Hearts Versus Donation After Neurological Determination of Death Hearts 20 Table 3: Survival of Donation After Cardiocirculatory Death Heart Transplant (...) There is a chronic shortage of donor hearts to meet the need. 11-13 Over the past decade, the number of people listed for cardiac transplant has increased by approximately 25%, while the supply of donor hearts has remained steady. 8 An estimated 50% of Canadians on the active waitlist for a heart transplant will never receive one; with 20% to 30% dying while waiting and the rest deteriorating until they become ineligible for transplant. 8 Organ Donation Neurological Determination of Death Organ donation occurs

2020 Health Quality Ontario

13. Assessment of the Global Covid-19 Case Fatality Rates?

Assessment of the Global Covid-19 Case Fatality Rates? Global Covid-19 Case Fatality Rates - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Global Covid-19 Case Fatality Rates Jason Oke, Carl Heneghan The total number of cases and the total number of deaths from COVID-19 outbreak data was drawn down (scraped) from . The proportion of deaths to the total numbers of cases was meta-analysed using the R (...) function metaprop , using fixed-effect inverse-variance weighting. Estimates from the cruise ship ‘Diamond Princess’ as well as countries with three or fewer deaths to date recorded were excluded from the analysis. Country-level case fatality is presented as a percentage along with 95% confidence intervals in a forest plot. Estimates of heterogeneity and a 95% prediction interval are presented, but a pooled overall estimate is suppressed due to heterogeneity. *case fatality rate is the number

2020 Oxford COVID-19 Evidence Service

14. COVID-19 – Florence Nightingale Diagrams of UK Deaths

COVID-19 – Florence Nightingale Diagrams of UK Deaths COVID-19 - Florence Nightingale Diagram's of UK Deaths - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-19 – Florence Nightingale Diagram’s of UK Deaths April 24, 2020 Irene Stratton When time-series data is plotted as a normal x-y plot with the time variable along the x axis it is difficult to identify seasonality or other factors that may (...) influence the data. Florence Nightingale used a form of and to demonstrate that better hygiene would reduce the death rate amongst soldiers could be reduced by better hygiene. Plotting the weekly numbers of deaths using this radial form demonstrates the variability during the first months of the year – deaths from “Aussie flu” in the first weeks of 2018. The increase in the number of deaths from the first week in April 2020 can clearly be seen. Radial plots are available in all the main stats packages

2020 Oxford COVID-19 Evidence Service

15. Six Countries: Three Quarters of the COVID-19 Deaths

Six Countries: Three Quarters of the COVID-19 Deaths Six Countries: Three-quarters of the COVID Deaths - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Six Countries: Three-quarters of the COVID Deaths April 27, 2020 Carl Heneghan, Marcy C McCall, Tom Jefferson As of the 26th April, six countries accounted for 155,457 out of 206,008 (75.5%) COVID-19 deaths. These countries are Belgium, France, Italy (...) , Spain, the UK and the US, which make up 7.5% of the global population (approx 569 million people). It is possible that some deaths occurring during the reported period are still unaccounted for, and that deaths in other countries might rise. In addition, the definition of “COVID deaths” may be different from country to country and during the reporting period. These six countries, however, have been disproportionately affected: their combined death rate is 27.3 per 100,000, which is 39 times higher

2020 Oxford COVID-19 Evidence Service

16. Case fatality rate for serious Covid-19

across countries The overview of the case fatality rate in Italy compared to China shows that case fatality rate is higher in Italy than that observed in other countries and may be related to three factors: population age, definition of COVID-19 related death and testing strategies. In addition, the delay between testing and mortality in the numbers of early epidemic is a crucial bias. In a pandemic like COVID-19, even advanced health-care systems be overwhelmed by the increased hospitalisation (...) to find estimates of age-stratified case fatality ratio (China, Italy and South Korea). The age-stratified case fatality range is very similar for the younger age groups. For some additional countries we found the case fatality rate for the whole population. These numbers differ across sites, mainly because of the denominator populations in these datasets. Dividing the cumulative number of death by the cumulative reported case will underestimate the true fatality ratio, especially early in the growing

2020 Norwegian Institute of Public Health

17. Is the UK Coronavirus death toll 70-80% higher?

Is the UK Coronavirus death toll 70-80% higher? Is the UK Coronavirus death toll 70-80% higher? - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Is the UK Coronavirus death toll 70-80% higher? April 10, 2020 Jason Oke, Carl Heneghan A recent article in the Daily Mail suggested that the death toll from COVID-19 is This was based on a comparison of the 1,649 deaths reported by ONS for March 27th (...) with the figure of 926 deaths reported on that day by the Department of Health and Social Care (DHSC). Because the number of new deaths reported daily adds to the totals of previous days there is a lag effect. Cumulative totals do not necessarily represent all of the deaths that have occurred up to that date. The percentage difference was large (80%) at the beginning of the pandemic (late March) but is reducing mainly: because the number of new deaths announced each day is smaller as a proportion

2020 Oxford COVID-19 Evidence Service

18. COVID-19 deaths compared with 'Swine Flu'

, this H1N1 pandemic caused most of its severe or fatal disease in younger people, both those with chronic conditions as well as healthy persons, and caused many more cases of viral pneumonia than is normally seen with seasonal influenza. In a pandemic, the proportion of deaths among the young should increase (See and ), and have further demonstrated this age shift in deaths to younger populations. In a 1918 scenario, the major prevention strategies are to target to minimize the loss to expected years (...) of life. An analysis of three other pandemics over the last century also suggests pandemic viruses cause excess mortality in ‘ .’ COVID-19 with at least 250 COVID-19 deaths as of 4th April reports that individuals aged <65 accounts for less than 10% of all COVID-19 deaths. People <65 years old had 34- to 73-fold lower risk than those ≥65 years old in the European countries People aged < 65 had 13- to 15-fold lower risk in New York City, Louisiana and Michigan. that older people are at highest risk

2020 Oxford COVID-19 Evidence Service

19. COVID-19 Death Data in England

COVID-19 Death Data in England COVID-19 death data in England - Update 9th April - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-19 death data in England – Update 9th April April 9, 2020 Jason Oke, Carl Heneghan NHS England releases data at 2 pm each day and reports daily counts up to the previous day as well as a total figure. We wrote about the problems with reconciling the different data (...) : Today’s figure is 765 deaths in hospitals in England These deaths are distributed across the following days: Figure 2 shows the updated counts by date of death in England Summary Daily reports generally add more to the previous two days (up to a maximum 300 deaths), and can add back to the previous week’s counts (the grey shaded area in figure 2). We consider the data is now flatlining consistent with hitting the peak.* *Inaccuracies in the data can give rise to considerable uncertainties. See also

2020 Oxford COVID-19 Evidence Service

20. Reconciling COVID-19 death rate in the UK

at 2 pm every day; Deaths outside NHS services are not included. Reporting The Public Health England dashboard ( ) extracts data at 5 pm each day and reports the following day, so numbers visible on the 8 th April are current for the 7 th of April. NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. The ONS mortality statistics are compiled from information supplied when deaths are certified and registered as part of civil (...) Reconciling COVID-19 death rate in the UK Reconciling COVID-19 death data in the UK - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Reconciling COVID-19 death data in the UK April 8, 2020 Jason Oke, Carl Heneghan How many people have died from COVID-19 in the UK? You’d think this was an easy question to answer, but you would be wrong. There are numerous places in which you can find this data

2020 Oxford COVID-19 Evidence Service

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