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1. What is the evidence for use of macrolide antibiotics for treatment of COVID-19?

What is the evidence for use of macrolide antibiotics for treatment of COVID-19? What is the evidence for use of macrolide antibiotics for treatment of COVID-19? - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website What is the evidence for use of macrolide antibiotics for treatment of COVID-19? April 28, 2020 Kome Gbinigie and Kerstin Frie On behalf of the Oxford COVID-19 Evidence Service Team Centre (...) for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford Correspondence to VERDICT We identified three studies, two in vitro and one in vivo , assessing the use of macrolide antibiotics for the treatment of COVID-19. Each of these studies assessed treatment with azithromycin. The evidence from the in vivo study and one in vitro study suggest a possible synergy between azithromycin and hydroxychloroquine. However, the in vivo study had a small number

2020 Oxford COVID-19 Evidence Service

2. BTS Guideline for Long Term Macrolide Use

BTS Guideline for Long Term Macrolide Use British Thoracic Society guideline for the use of long- term macrolides in adults with respiratory disease David Smith, 1 Ingrid Du Rand, 2 Charlotte Louise Addy, 3 Timothy Collyns, 4 Simon Paul Hart , 5 Philip J Mitchelmore , 6,7 Najib M Rahman, 8 Ravijyot Saggu 9 BTS Guideline To cite: Smith D, Du Rand I, Addy CL, et al. Thorax Epub ahead of print: [please include Day Month Year]. doi:10.1136/ thoraxjnl-2019-213929 ? Additional material is published (...) . smith@ nbt. nhs . uk ? http:// dx. doi . org/ 10. 1136/ thor axjnl- 2019- 214039 © Author(s) (or their employer(s)) 2020. No commercial re- use. See rights and permissions. Published by BMJ. SUMMARY OF RECOMMENDATIONS AND GOOD PRACTICE POINTS Asthma Recommendations ? Oral macrolide therapy could be considered to reduce exacerbation frequency in adults (50–70 years), with ongoing symptoms despite >80% adherence to high- dose inhaled steroids (>800 µg/day) and at least one exacerbation requiring oral

2020 British Thoracic Society

3. Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial. Full Text available with Trip Pro

Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial. Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). However, which of these antibiotics is more effective for treating non-aspiration CAP remains unclear.This (...) study was a prospective, single-center, open-label, quasi-randomized controlled trial. Patients with adult CAP without risk for aspiration were allocated to either a CTRX or ABPC/SBT group based on the date of hospital admission. Macrolide was added to patients in each group. The primary outcome was the clinical response in the validated per-protocol (VPP) population at end of treatment (EOT). The secondary outcomes were clinical response during treatment and at end of study (EOS) in the VPP

2020 BMC pulmonary medicine

4. Use Of Macrolides In Pregnancy

Use Of Macrolides In Pregnancy USE OF MACROLIDES IN PREGNANCY 0344 892 0909 USE OF MACROLIDES IN PREGNANCY (Date of issue: May 2020 , Version: 3.1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary The macrolide antibiotics include azithromycin (...) , clarithromycin, erythromycin, spiramycin and telithromycin. Macrolides have an antibacterial spectrum similar to that of penicillin and are thus considered an alternative in penicillin-allergic patients. Indications include sinusitis, otitis media, pharyngitis, tonsillitis, bronchitis, skin and soft tissue infection. Azithromycin is also used in the treatment of chlamydia, and clarithromycin in the eradication of Helicobacter pylori. The majority of studies investigating malformation risk following maternal

2020 UK Teratology Information Service

5. Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis Full Text available with Trip Pro

Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal (...) . Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Systematic Review Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis Sitaram Khadka, Pravash Budhathoki, Dhan Bahadur

2020 Research Square

6. Macrolides as Adjunctive Treatment in Sepsis: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Macrolides as Adjunctive Treatment in Sepsis: A Systematic Review and Meta-Analysis Macrolides as Adjunctive Treatment in Sepsis: A Systematic Review and Meta-Analysis | B45. CRITICAL CARE: SEPSIS IDENTIFICATION AND MANAGEMENT Cookies Notification This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Search Menu Connect With Us Search in: B45. CRITICAL CARE: SEPSIS IDENTIFICATION AND MANAGEMENT > > > Macrolides as Adjunctive Treatment in Sepsis (...) : A Systematic Review and Meta-Analysis Abstract American Journal of Respiratory and Critical Care Medicine 2020;201:A3490 Macrolides as Adjunctive Treatment in Sepsis: A Systematic Review and Meta-Analysis x C.A.G. Villanueva , x J.R. Luzano , x V.L.A. Roque , x M.B.R. Siasoco , 25 Broadway New York, NY 10004 (212) 315-8600 ATS Journals Services General Information Copyright © 1987-2020 American Thoracic Society, All Rights Reserved.

2020 B45. CRITICAL CARE: SEPSIS IDENTIFICATION AND MANAGEMENT

7. Hydroxychloroquine with or without macrolide and standard of care versus standard of care alone for COVID-19 cases: a systematic review and meta-analysis Full Text available with Trip Pro

Hydroxychloroquine with or without macrolide and standard of care versus standard of care alone for COVID-19 cases: a systematic review and meta-analysis Hydroxychloroquine with or without macrolide and standard of care versus standard of care alone for COVID-19 cases: a systematic review and meta-analysis | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct (...) peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Systematic Review Hydroxychloroquine with or without macrolide and standard of care versus standard of care alone for COVID-19 cases: a systematic review and meta-analysis Dhan Bahadur Shrestha , Pravash Budhathoki, Sitaram Khadka, Era Rawal Dhan Bahadur Shrestha

2020 Research Square

8. British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease Full Text available with Trip Pro

British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease British Thoracic Society Guideline for the Use of Long-Term Macrolides in Adults With Respiratory Disease - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National (...) Actions . 2020 May;75(5):370-404. doi: 10.1136/thoraxjnl-2019-213929. Epub 2020 Apr 17. British Thoracic Society Guideline for the Use of Long-Term Macrolides in Adults With Respiratory Disease , , , , , , , Affiliations Expand Affiliations 1 North Bristol Lung Centre, Southmead Hospital, Bristol, UK david.smith@nbt.nhs.uk. 2 Respiratory, Wye Valley NHS Trust, Hereford, UK. 3 Centre for Medical Education, Queens University Belfast, Regional Respiratory Centre, Belfast City Hospital, Belfast, UK. 4

2020 EvidenceUpdates

9. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. Full Text available with Trip Pro

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) whose mothers were prescribed one macrolide monotherapy (erythromycin, clarithromycin, or azithromycin) or one penicillin monotherapy from the fourth gestational week to delivery. Two negative control cohorts consisted of 82 314 children whose mothers were prescribed macrolides or penicillins before conception, and 53 735 children who were siblings of the children in the study cohort.Risks of any major malformations and system specific major malformations (nervous, cardiovascular, gastrointestinal

2020 BMJ

10. Prescription of macrolides vs penicillin during pregnancy was linked to major malformations in offspring. (Abstract)

Prescription of macrolides vs penicillin during pregnancy was linked to major malformations in offspring. Fan H, Gilbert R, O'Callaghan F, Li L. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. BMJ. 2020;368:m331. 32075790.

2020 Annals of Internal Medicine

11. RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Full Text available with Trip Pro

RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated (...) in COVID-19.We did a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19. The registry comprised data from 671 hospitals in six continents. We included patients hospitalised between Dec 20, 2019, and April 14, 2020, with a positive laboratory finding for SARS-CoV-2. Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine

2020 Lancet

12. Tailored Helicobacter pylori eradication based on prior intake of macrolide antibiotics allows the use of triple therapy with optimal results in an area with high clarithromycin resistance. Full Text available with Trip Pro

Tailored Helicobacter pylori eradication based on prior intake of macrolide antibiotics allows the use of triple therapy with optimal results in an area with high clarithromycin resistance. the previous intake of macrolide antibiotics is associated with a failure to eradicate Helicobacter pylori (H. pylori) with clarithromycin-containing regimens. However, the standard triple therapy achieves eradication rates of over 90% in patients without a previous use of macrolides in our health area (...) . The aim of this study was to evaluate the efficacy of an H. pylori eradication strategy based on the intake of macrolides by the patient during the previous years.one hundred and sixty-nine patients with H. pylori infection were prospectively included in the study. The electronic medical record of each patient was reviewed at the time of inclusion. Depending on their previous intake of macrolides, patients were assigned to one of two eradication regimens: group A) patients without a previous intake

2019 Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva Controlled trial quality: uncertain

13. Long term macrolide antibiotics for the treatment of bronchiectasis in adults - individual participant data meta-analysis Full Text available with Trip Pro

Long term macrolide antibiotics for the treatment of bronchiectasis in adults - individual participant data meta-analysis Long term macrolide antibiotics for the treatment of bronchiectasis in adults - individual participant data meta-analysis | European Respiratory Society Main menu User menu Search Search for this keyword Search for this keyword Long term macrolide antibiotics for the treatment of bronchiectasis in adults - individual participant data meta-analysis Josje Altenburg , James (...) Health Services, Brisbane, Australia Steven Taylor 6 South Australian Health and Medical Research Institute, Adelaide, Australia Conroy Wong 7 Counties Manukau District Health Board, Dept of Respiratory Medicine, Middlemore Hospital, Auckland, New Zealand Wim Boersma 8 Department of Pulmonary Diseases, Northwest Hospital Group, Alkmaar, Netherlands Abstract Background: Bronchiectasis (BE) guidelines recommend long term macrolide treatment for patients with ≥3 exacerbations/year without P aeruginosa

2019 Respiratory infections

14. P601 Macrolide and fluoroquinolone resistance-associated mutations inmycoplasma genitalium:a systematic review and meta-analysis Full Text available with Trip Pro

P601 Macrolide and fluoroquinolone resistance-associated mutations inmycoplasma genitalium:a systematic review and meta-analysis P601 Macrolide and fluoroquinolone resistance-associated mutations in mycoplasma genitalium: a systematic review and meta-analysis | Sexually Transmitted Infections Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main (...) menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here P601 Macrolide and fluoroquinolone resistance-associated mutations in mycoplasma genitalium: a systematic review and meta-analysis Article Text Poster Presentations PS02 – POSTER VIEWING SESSION – TUESDAY Tuesday, July 16, 2019 5:45 PM – 7:00 PM P601 Macrolide and fluoroquinolone resistance-associated mutations in mycoplasma

2019 Poster Presentations

15. F1000Prime recommendation of Prophylactic use of macrolide antibiotics for the prevention of chronic obstructive pulmonary disease exacerbation: a meta-analysis. Full Text available with Trip Pro

F1000Prime recommendation of Prophylactic use of macrolide antibiotics for the prevention of chronic obstructive pulmonary disease exacerbation: a meta-analysis. Prophylactic use of macrolide antibiotics for the... | Faculty Opinions On April 12th, 2020, F1000Prime became Faculty Opinions. See our to learn more. Welcome Guest 1 Recommendations info_outline Systematic Review / Meta-analysis New Finding close Classified As New Finding 1 Article Type Systematic Review / Meta-analysis More (...) more_vert close Download article Export article Sciwheel Download citation BibTeX RIS Share Email Prophylactic use of macrolide antibiotics for the prevention of chronic obstructive pulmonary disease exacerbation: a meta-analysis. ARTICLE PUBLISHED: 2015 CITE AS: PLoS ONE. 2015 ; 10 ( 3 ): e0121257 Recommendations Abstract Comments You have reached your article limit. Register for 30-day free trial Registration is free and only takes a moment, or subscribe for unlimited access. Already registered

2019 Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

16. Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption. Full Text available with Trip Pro

Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption. We hypothesized that the large global variations in the prevalence of macrolide resistance in Treponema pallidum are related to differences in population-level macrolide consumption. The hypothesis was tested by, at a country-level, regressing the peak prevalence of macrolide resistance against the national macrolide consumption in the year prior to this, controlling for the year of the resistance (...) prevalence estimate. A strong association was found between the per capita consumption of macrolides and macrolide resistance (coefficient 0.7, 95 % confidence interval 0.2-0.12, P=0.009).

2018 Journal of Medical Microbiology

17. Therapeutic Efficacy and Safety of Prolonged Macrolide, Corticosteroid, Doxycycline, and Levofloxacin against Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children Full Text available with Trip Pro

Therapeutic Efficacy and Safety of Prolonged Macrolide, Corticosteroid, Doxycycline, and Levofloxacin against Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children We aimed to compare the therapeutic efficacy of prolonged macrolide (PMC), corticosteroids (CST), doxycycline (DXC), and levofloxacin (LFX) against macrolide-unresponsive Mycoplasma pneumoniae (MP) pneumonia in children and to evaluate the safety of the secondary treatment agents.We retrospectively analyzed the data (...) of patients with MP pneumonia hospitalized between January 2015 and April 2017. Macrolide-unresponsiveness was clinically defined with a persistent fever of ≥ 38.0°C at ≥ 72 hours after macrolide treatment. The cases were divided into four groups: PMC, CST, DXC, and LFX. We compared the time to defervescence (TTD) after secondary treatment and the TTD after initial macrolide treatment in each group with adjustment using propensity score-matching analysis.Among 1,165 cases of MP pneumonia, 190 (16.3%) were

2018 Journal of Korean medical science

18. Evaluation of the Lightmix<sup>®</sup>Mycoplasma macrolide assay for the detection of macrolide resistant Mycoplasma pneumoniae in pneumonia patients. Full Text available with Trip Pro

Evaluation of the Lightmix®Mycoplasma macrolide assay for the detection of macrolide resistant Mycoplasma pneumoniae in pneumonia patients. Rapid detection of macrolide resistance-associated mutations in Mycoplasma pneumoniae is crucial for effective antimicrobial treatment. We evaluated the Lightmix Mycoplasma macrolide assay for the detection of point mutations at nucleotide positions 2063 and 2064 in the 23S ribosomal RNA (rRNA) gene of M. pneumoniae that confer macrolide (...) ) and a specificity of 100% (95% confidence interval, 97.5-100) as the detected M. pneumoniae genotype (148 wild type and 15 non-wild type) was confirmed by 23S rRNA sequencing in all samples.The Lightmix assay is an easy-to-use and accurate molecular test that allows rapid determination of macrolide resistance in M. pneumoniae.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

2018 Clinical Microbiology and Infection

19. Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant <i>Streptococcus pneumoniae</i>. Full Text available with Trip Pro

Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae. Streptococcus pneumoniae is a leading cause of community-acquired pneumonia. Over the past 2 decades, macrolide resistance among S. pneumoniae organisms has been increasing steadily and has escalated at an alarming rate worldwide. However, the use of macrolides in the treatment of community-acquired pneumonia has been reported (...) to be effective regardless of the antibiotic susceptibility of the causative pneumococci. Although previous studies suggested that sub-MICs of macrolides inhibit the production of the pneumococcal pore-forming toxin pneumolysin by macrolide-resistant S. pneumoniae (MRSP), the underlying mechanisms of the inhibitory effect have not been fully elucidated. Here, we show that the release of pneumococcal autolysin, which promotes cell lysis and the release of pneumolysin, was inhibited by treatment

2018 Antimicrobial Agents and Chemotherapy

20. Macrolides for diffuse panbronchiolitis. Full Text available with Trip Pro

Macrolides for diffuse panbronchiolitis. Diffuse panbronchiolitis (DPB) is a chronic airways disease predominantly affecting East Asians. Macrolides, a class of antibiotics, have been used as the main treatment for DPB, based on evidence from retrospective and non-randomised studies.To assess the efficacy and safety of macrolides for DPB.We searched CENTRAL (2014, Issue 6), MEDLINE (1966 to July week 1, 2014), EMBASE (1974 to July 2014), Chinese Biomedical Literature Database (CBM) (1978 (...) to July 2014), China National Knowledge Infrastructure (CNKI) (1974 to July 2014), KoreaMed (1997 to July 2014) and Database of Japana Centra Revuo Medicina (1983 to July 2014).Randomised controlled trials (RCTs) or quasi-RCTs assessing the effect of macrolides for DPB.Two review authors independently assessed study quality and subsequent risk of bias according to The Cochrane Collaboration's tool for assessing risk of bias. The primary outcomes were five-year survival rate, lung function and clinical

2015 Cochrane

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