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61. Mycoplasma genitalium in Singapore is associated with Chlamydia trachomatis infection and displays high macrolide and Fluoroquinolone resistance rates. (Full text)

Mycoplasma genitalium in Singapore is associated with Chlamydia trachomatis infection and displays high macrolide and Fluoroquinolone resistance rates. Mycoplasma genitalium is an emerging sexually transmitted infection, with increasing rates of resistance to fluroquinolones and macrolides, the recommended treatments. Despite this, M. genitalium is not part of routine screening for Sexually Transmitted Infections (STIs) in many countries and the prevalence of infection and patterns of disease (...) with macrolide and fluroquinolone resistance.We report the results of a study into M. genitalium prevalence at the national sexual health clinic in Singapore. M. genitalium was heavily associated with CT infection (8.1% of cases), but present in only of 2.4% in CT negative cases and not independently linked to NG infection. Furthermore, we found high rates of resistance mutations to both macrolides (25%) and fluoroquinolones (37.5%) with a majority of resistant strains being dual-resistant. Resistance

2020 BMC Infectious Diseases PubMed abstract

62. Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014. (Full text)

Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014. The purpose of the study is to discuss the correlation between the resistance rate of gram negative bacteria to fluoroquinolones (FQ) and antibiotic consumption intensity of 145 China tertiary hospitals in 2014.This retrospective study adopted national monitoring data from 2014. Each participating hospital required to report annual (...) consumption of each antibiotic, and the resistance rate of gram negative bacteria to FQ. Then the correlation between antibiotic usage and fluoroquinolones -resistant (FQR) rate was consequently investigated.One hundred forty-five hospitals were included in the study, and the median antibiotic consumption intensity was 46.30 (23.93-115.39) defined daily dosages (DDDs) per 100 patient-days. Cephalosporins ranks first in the antibiotics consumption, followed by fluoroquinolones, penicillins, and carbapenems

2020 BMC Infectious Diseases PubMed abstract

63. The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan. (Full text)

The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan. To evaluate the safety of using fluoroquinolones in pediatric population in Taiwan.Patients aged 0~18 years old with fluoroquinolones prescriptions ≥5 consecutive days during year 2000 to 2013 were selected from the National Health Insurance Research Database, 4-time case number were selected as controls. We evaluated the patient's outcome after (...) the use of fluoroquinolones by reviewing a newly diagnosis of the following collagen-associated adverse events by International Classification of Diseases, Ninth Revision, Clinical Modification codes, covering tendons rupture, retinal detachments, gastrointestinal tract perforation, aortic aneurysm or dissection.Of the enrolled patients (n = 167,105), collagen-associated adverse effects developed in 85 cases (0.051%) in 6-month tracking, including 0.051% in the fluoroquinolones study cohort (17

2020 BMC Pediatrics PubMed abstract

64. Tigecycline in the treatment of fulminant Mycoplasma pneumoniae pneumonia non-responsive to azithromycin and fluoroquinolone: A case report. (Full text)

Tigecycline in the treatment of fulminant Mycoplasma pneumoniae pneumonia non-responsive to azithromycin and fluoroquinolone: A case report. Fulminant macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) has seldom been reported, and cases of MPP usually show rapid improvement after fluoroquinolones or tetracyclines addition. The purpose of this case report is to highlight the importance of proper selection of antibiotics for treatment of severe MPP and increase awareness concerning (...) the emergence of fluoroquinolone-resistant MPP.A case of severe life-threatening pneumonia in a 26-year-old man with high fever and cough was non-responsive to azithromycin and fluoroquinolones.The patient was diagnosed with MPP based on the test results of bronchoalveolar lavage using real-time quantitative PCR method.Tigecycline was given to the patient after azithromycin and fluoroquinolones failed.The patients fever subsided within the first day of tigecycline therapy. He showed rapid symptom resolution

2020 Medicine PubMed abstract

65. Are Fluoroquinolones or Macrolides Better for Treating Legionella Pneumonia? A Systematic Review and Meta-analysis. (Abstract)

Are Fluoroquinolones or Macrolides Better for Treating Legionella Pneumonia? A Systematic Review and Meta-analysis. The Infectious Diseases Society of America recommends either a fluoroquinolone or a macrolide as a first line antibiotic treatment for Legionella pneumonia, but it is unclear which antibiotic leads to optimal clinical outcomes. We compare the effectiveness of fluoroquinolone versus macrolide monotherapy in Legionella pneumonia using a systematic review and meta-analysis.We (...) conducted a systematic search of literature in PubMed, Cochrane, Scopus and Web of Science from inception to June 1, 2019. Randomized controlled trials and observational studies comparing macrolide vs. fluoroquinolone monotherapy using clinical outcomes in patients with Legionella pneumonia were included. Twenty-one publications out of an initial 2,073 unique records met the selection criteria. Following PRISMA guidelines, two reviewers participated in data extraction. The primary outcome was mortality

2020 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

66. Photosensitivity induced by lomefloxacin versus other fluoroquinolones: A meta-analysis. (Abstract)

Photosensitivity induced by lomefloxacin versus other fluoroquinolones: A meta-analysis. Lomefloxacin may be more likely than other fluoroquinolones to cause photosensitivity. However, the rate of photosensitivity is variable and a meta-analysis has yet to be performed. The aim of this meta-analysis is to compare the rate of photosensitivity between outpatients who received lomefloxacin and those who received other fluoroquinolones. PubMed, EMBASE, Cochrane Library databases and trial (...) with lomefloxacin than with other fluoroquinolones (RD, 3.4%; 95% CI, 0.7%-6.2%; P-value = 0.013; I2 = 10.9%). The odds of photosensitivity was also significantly higher with lomefloxacin (Peto OR, 5.81; 95% CI, 3.34 to 10.11; P-value <0.001; I2 = 0%). This meta-analysis of RCTs found significantly higher photosensitivity with lomefloxacin compared to other fluoroquinolones. Considering this finding and given its lack of additional efficacy compared to other fluoroquinolones, lomefloxacin as a fluoroquinolone

2020 Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

67. The safety of quinolones and fluoroquinolones in pregnancy: a meta-analysis (Full text)

The safety of quinolones and fluoroquinolones in pregnancy: a meta-analysis Quinolones were contraindicated during pregnancy because of concerns regarding fetal malformations and carcinogenesis in animals. The literature is conflicting regarding their safety in humans.To conduct a meta-analysis evaluating the risk for fetal malformations and pregnancy complications following exposure to quinolones during pregnancy.We searched Embase, PubMed, Medline, the Cochrane database, clinicaltrials.gov (...) , and Dart Databases. We added articles found through the references of included articles.Relevant English citations using the terms quinolone/s, fluoroquinolone/s, and pregnancy in humans. Exclusion criteria were case reports, reviews, and articles without data regarding the study outcomes.Two authors performed the database search, assessment of eligibility, and abstraction of data from included studies. Disagreement was settled by consensus among all authors. The pooled odds ratios (with 95% CIs) were

2018 EvidenceUpdates PubMed abstract

68. Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis. (Full text)

Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis. Wide-ranging evidence on the occurrence of fluoroquinolone (FQ) resistance genetic determinants in African Salmonella strains is not available. The main objectives of this study were to assess the heterogeneity, estimate pooled proportions and describe the preponderance of FQ-resistance determinants in typhoidal and non-typhoidal Salmonella (NTS) isolates of Africa.Genetic

2018 PLoS ONE PubMed abstract

69. Practice Advisory: FDA Issues Updated Fluoroquinolone Warning

Practice Advisory: FDA Issues Updated Fluoroquinolone Warning Page Not Found | ACOG Clinical Information Practice Management Career Support Education & Events Advocacy Topics Education Events Clinical Topics Hi, Education Events Clinical Topics Page Not Found The page you're trying to access is currently unavailable. It may have moved during our website redesign. Try searching below or visiting our to find the resource you need. ACOG Sites ACOG Sites American College of Obstetricians

2016 American College of Obstetricians and Gynecologists

70. Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea. (Full text)

Administration of oral fluoroquinolone and the risk of rhegmatogenous retinal detachment: A nationwide population-based study in Korea. To investigate the association between oral fluoroquinolones (FQ) and the risk of rhegmatogenous retinal detachment (RRD) using a nationwide population-based study in Korea, designed to control for time-related bias.As a nested case-control study within a cohort, the KNHIS-NSC 2002-2013 (Korean National Health Insurance Service National Sample Cohort) data used

2018 PLoS ONE PubMed abstract

71. Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. (Full text)

Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial. To evaluate whether stopping the effective antibiotic treatment following clinical improvement at Day 7 (Truncated treatment) would be non-inferior to continued treatment until Day 14 (Continued treatment) in patients with acute pyelonephritis (APN) requiring hospitalization treated with non-fluoroquinolone

2018 PLoS ONE PubMed abstract

72. Fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli from poultry and human samples assessed by PCR-restriction fragment length polymorphism assay. (Full text)

Fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli from poultry and human samples assessed by PCR-restriction fragment length polymorphism assay. The objective of this study was to determine fluoroquinolone resistance in Campylobacter spp from poultry and human isolates. Forty-one Campylobacter jejuni isolates (30 of poultry origin and 11 of human origin) and 11 Campylobacter coli isolates (10 of human origin and 1 of poultry origin) were examined for ciprofloxacin (...) poultry and moderate resistance for C. jejuni (9.1%) and C. coli (40%) samples of human origin. A mutation in codon 86 of the gyrA gene with a Thr-to-Ile substitution is reported to be the main cause of high resistance to quinolones. This mutation can be analyzed by PCR-RFLP assay, which has been proven to be a simple and fast method for the detection of fluoroquinolone resistance in Campylobacter spp.

2018 PLoS ONE PubMed abstract

73. Tavanic (levofloxacin), fluoroquinolone - the treatment of complicated skin and soft tissue infections

Tavanic (levofloxacin), fluoroquinolone - the treatment of complicated skin and soft tissue infections TAVANIC SUMMARY CT12590

2015 Haute Autorite de sante

74. Randomised controlled trial: Four-month fluoroquinolone-containing regimens are inferior to standard 6-month tuberculosis treatment

Randomised controlled trial: Four-month fluoroquinolone-containing regimens are inferior to standard 6-month tuberculosis treatment Four-month fluoroquinolone-containing regimens are inferior to standard 6-month tuberculosis treatment | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Four-month fluoroquinolone-containing regimens are inferior to standard 6-month tuberculosis treatment Article Text Therapeutics/Prevention Randomised

2015 Evidence-Based Medicine

75. Limited Scope of Shorter Drug Regimen for MDR TB Caused by High Resistance to Fluoroquinolone. (Full text)

Limited Scope of Shorter Drug Regimen for MDR TB Caused by High Resistance to Fluoroquinolone. Resistance to second-line tuberculosis drugs for patients with multidrug-resistant tuberculosis has emerged globally and is a potential risk factor for unfavorable outcomes of shorter duration drug regimens. We assessed the proportion of patients eligible for a shorter drug regimen in Uttar Pradesh, India, which had the highest rate of multidrug-resistant tuberculosis in India.

2019 Emerging Infectious Diseases PubMed abstract

76. BET 1: What is the incidence of cardiac arrhythmia in adult patients with acute infection prescribed fluoroquinolones? (Abstract)

BET 1: What is the incidence of cardiac arrhythmia in adult patients with acute infection prescribed fluoroquinolones? A shortcut review was carried out to establish the incidence of arrhythmia after prescription of a fluoroquinolone antibiotic. 332 papers were found using the reported searches, of which 14 presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses (...) of these papers are tabulated. It is concluded that the incidence of arrhythmia after prescription of a fluoroquinolone antibiotic is low (<3%), but estimates are imprecise.© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

2019 Emergency Medicine Journal

77. Pandemic uropathogenic fluoroquinolone-resistant Escherichia coli have enhanced ability to persist in the gut and cause bacteriuria in healthy women. (Abstract)

Pandemic uropathogenic fluoroquinolone-resistant Escherichia coli have enhanced ability to persist in the gut and cause bacteriuria in healthy women. We report that fluoroquinolone resistant Escherichia coli are found in feces of 8.8% healthy adult women, with most bacteria belonging to pandemic multi-drug resistant ST131-H30R or ST1193 clonal groups. Moreover, these highly uropathogenic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria without

2019 Clinical Infectious Diseases

78. Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals. (Full text)

Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals. We analyzed antibiotic use data from 29 southeastern US hospitals over a 5-year period to determine changes in antibiotic use after the fluoroquinolone US Food and Drug Administration (FDA) advisory update in 2016. Fluoroquinolone use declined both before and after the FDA announcement, and the use of select, alternative antibiotics increased after the announcement.Fluoroquinolones (...) are among the 4 most commonly prescribed antibiotic classes.1,2 Postmarketing reports of serious adverse events linked to fluoroquinolones include tendonitis, neuropathy, hypoglycemia, psychiatric side effects, and possible aortic vessel rupture, leading to safety label changes in July 2008 and August 2013.3 In July 2016, the US Food and Drug Administration (FDA) strengthened the "black box" warning following an initial safety announcement in May 2016, recommending avoidance of fluoroquinolones

2019 Infection control and hospital epidemiology PubMed abstract

79. Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis. (Abstract)

Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis. 30412944 2019 03 21 2019 03 21 1527-3792 200 3 2018 09 The Journal of urology J. Urol. Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis. 478-479 S0022-5347(18)43266-1 10.1016/j.juro.2018.05.090 Schaeffer Edward M EM eng Journal Article Comment 2018 05 26 United (...) States J Urol 0376374 0022-5347 0 Fluoroquinolones 2N81MY12TE Fosfomycin AIM IM World J Urol. 2018 Mar;36(3):323-330 29288398 Antibiotic Prophylaxis Biopsy Fluoroquinolones Fosfomycin Humans Male Prostate 2018 11 11 6 0 2018 11 11 6 0 2019 3 22 6 0 ppublish 30412944 S0022-5347(18)43266-1 10.1016/j.juro.2018.05.090

2019 The Journal of urology

80. Adverse events of fluoroquinolones vs. other antimicrobials prescribed in primary care: A systematic review and meta-analysis of randomized controlled trials. (Full text)

Adverse events of fluoroquinolones vs. other antimicrobials prescribed in primary care: A systematic review and meta-analysis of randomized controlled trials. Fluoroquinolones (FQs) are second-line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, the choice of antimicrobial should be based on both the benefits and adverse effects. This systematic review quantifies the occurrence of common adverse events (AEs) related to FQs in relation to any other antimicrobial

2019 International journal of antimicrobial agents PubMed abstract

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