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fluoroquinolones

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181. Fluoroquinolone antimicrobial drugs Full Text available with Trip Pro

Fluoroquinolone antimicrobial drugs 28461376 2017 10 30 2018 11 13 1488-2329 189 17 2017 05 01 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Fluoroquinolone antimicrobial drugs. E638 10.1503/cmaj.160938 Chan Tiffany T Department of Medicine (Chan, Bunce), University of Toronto; Division of Infectious Diseases (Bunce), University Health Network, Toronto, Ont. Bunce Paul E PE Department of Medicine (Chan, Bunce), University of Toronto; Division (...) of Infectious Diseases (Bunce), University Health Network, Toronto, Ont. Paul.Bunce@uhn.ca. eng Journal Article Canada CMAJ 9711805 0820-3946 0 Anti-Bacterial Agents 0 Fluoroquinolones AIM IM Anti-Bacterial Agents pharmacology Fluoroquinolones pharmacology Humans Competing interests: None declared. 2017 5 3 6 0 2017 5 4 6 0 2017 10 31 6 0 ppublish 28461376 189/17/E638 10.1503/cmaj.160938 PMC5415392 Clin Infect Dis. 1999 Feb;28(2):352-64 10064255 Clin Infect Dis. 2000 Feb;30(2):243-54 10671323 Antimicrob

2017 CMAJ : Canadian Medical Association Journal

182. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool Full Text available with Trip Pro

Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool Around 70-90% of peptic ulcer disease (PUD) is due to Helicobacter pylori and requires treatment with antimicrobials to which these bacteria are susceptible. Common H. pylori diagnostic tests do not provide drug susceptibility data. Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous (...) detection of H. pylori and its resistance to clarithromycin (CLA)/fluoroquinolones (FLQ), we present evidence for stool as an optional test specimen and also provide data on prevalence of H. pylori resistance to CLA and FLQ in Uganda.Stool from 142 symptomatic PUD patients at three hospitals in Kampala was screened for H. pylori using a rapid antigen test. The GenoType HelicoDR test was run on all H. pylori antigen positives to determine PCR positivity and resistance to CLA/FLQ.Thirty-one samples (22

2017 BioMed research international

183. Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets Full Text available with Trip Pro

Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets Fluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in clinical settings. Over the last decade, several families of qnr genes have been discovered and characterized, but their true

2017 BMC genomics

184. Septic Shock with Multi Organ Failure Due to Fluoroquinolones Resistant Campylobacter Jejuni Full Text available with Trip Pro

Septic Shock with Multi Organ Failure Due to Fluoroquinolones Resistant Campylobacter Jejuni BACKGROUND Campylobacter jejuni infections are typically self-limited, and severe extra-intestinal complications are uncommon. CASE REPORT We report a case of a man with septic shock due to fluoroquinolones resistant Campylobacter jejuni. CONCLUSIONS This manuscript emphasizes the potential lethality of fluorquinolones resistant Campylobacter jejuni bacteremia.

2017 The American journal of case reports

185. Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China Full Text available with Trip Pro

Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China To determine the prevalence, antimicrobial susceptibility patterns and related presence of mutations in quinolone resistance-determining region (QRDR) genes and plasmid-mediated quinolone resistance (PMQR) among Shigella flexneri isolates obtained from Jiangsu Province, China.A total of 400 Shigella flexneri clinical isolates collected during 2012-2015 were identified by biochemical (...) and His211Tyr), while 84.3% had parC mutations (Ser80Ile, Ala81Pho, Gln91His and Ser129Pro). The most prevalent point mutations in gyrA and parC were Ser83Leu (75.5%, 302/400) and Ser80Ile (74.5%, 298/400), relatively. Besides, the Gln517Arg alternation in gyrB was detected in 13 S. flexneri isolates and no mutations were identified in parE. PMQR determinations of qnrB, qnrS and aac(6')-Ib-cr were detected among 16 strains (4.0%).The results presented here show that fluoroquinolone resistance

2017 Antimicrobial resistance and infection control

186. Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications Full Text available with Trip Pro

Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells

2017 Oxidative medicine and cellular longevity

187. Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas Aeruginosa Full Text available with Trip Pro

Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas Aeruginosa Carbapenems, fluoroquinolones (FQs), and aminoglycosides (AGs) are key drugs for treating Pseudomonas aeruginosa infections, and accumulation of drug resistances make antibiotic therapy difficult.We evaluated 169 patients with imipenem (IPM)-resistant P. aeruginosa and compared patient background and microbiological characteristics between groups

2017 The open microbiology journal

188. Fluoroquinolone-resistant Escherichia coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy – possible shift in biopsy prophylaxis Full Text available with Trip Pro

Fluoroquinolone-resistant Escherichia coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy – possible shift in biopsy prophylaxis Infection of prostate gland following biopsy is common complication. Most common pathogen is E.coli. Since fluorochinolones are commonly prescribed as prophylaxis, infection caused by E.coli leads to complicated infections, especially due to fluoroquinolone-resistant species. The aim of this study was to evaluate (...) the incidence of fluoroquinolone-resistant E.coli species in rectal swabs of patients undergoing prostate biopsy and to define appropriate antimicrobial agent as prostate biopsy prophylaxis.Rectal swabs were collected in 159 patients undergoing prostate biopsy. The identification of E.coli was performed using the BBL Crystal E/NF identification (ID) System.In the rectal swab of 112/159 patients E.coli was found. In 47/159 cases after incubation, the microbiological evaluation showed no E.coli in these swabs

2017 Central European journal of urology

189. Simultaneous Determination of Fluoroquinolones and Sulfonamides Originating from Sewage Sludge Compost Full Text available with Trip Pro

Simultaneous Determination of Fluoroquinolones and Sulfonamides Originating from Sewage Sludge Compost A simultaneous method for quantitative determination of traces of fluoroquinolones (FQs) and sulfonamides (SAs) in edible plants fertilized with sewage sludge was developed. The compounds were extracted from the plants by rapid and simple liquid extraction followed by extracts clean-up using solid phase extraction. The eluent additive 1,1,1,3,3,3-hexafluoro-2-propanol was used for liquid

2017 The Scientific World Journal

190. DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties Full Text available with Trip Pro

DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2-10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited blue shifts by 5 nm and 10 nm, respectively, in the presence of DOM. The presence

2017 Scientific reports

191. Preparation of polydopamine-coated graphene oxide/Fe3O4 imprinted nanoparticles for selective removal of fluoroquinolone antibiotics in water Full Text available with Trip Pro

Preparation of polydopamine-coated graphene oxide/Fe3O4 imprinted nanoparticles for selective removal of fluoroquinolone antibiotics in water Antibiotics in water have recently caused increasing concerns for public health and ecological environments. In this work, we demonstrated polydopamine-coated graphene oxide/Fe3O4 (PDA@GO/Fe3O4) imprinted nanoparticles coupled with magnetic separation for fast and selective removal of fluoroquinolone antibiotics in water. The nanoparticles were prepared (...) . The nanoparticles were successfully used for the removal of fluoroquinolone antibiotics in seawater, with removal efficiencies of more than 95%. The proposed strategy has potentials for efficient removal of antibiotics in environmental water.

2017 Scientific reports

192. Emergence of fluoroquinolone resistance among drug resistant tuberculosis patients at a tertiary care facility in Karachi, Pakistan Full Text available with Trip Pro

Emergence of fluoroquinolone resistance among drug resistant tuberculosis patients at a tertiary care facility in Karachi, Pakistan Pakistan is classified as one of the high multi-drug resistant tuberculosis (MDR-TB) burden countries. A poorly regulated private sector, over-prescription of antibiotics and self-medication has led to augmented rates of drug-resistance in the country. Pakistan's first national anti-tuberculosis drug resistance survey identified high prevalence of fluoroquinolone (...) resistance among MDR-TB patients. Further institutional evidence of fluoroquinolone drug-resistance can support re-evaluation of treatment regimens as well as invigorate efforts to control antibiotic resistance in the country.In this study, data for drug-susceptibility testing (DST) was retrospectively analyzed for a total of 133 patients receiving MDR-TB treatment at the Chest Department of Jinnah Postgraduate Medical Center, Karachi, Pakistan. Frequency analyses for resistance patterns was carried out

2017 BMC research notes

193. Triceps Ruptures After Fluoroquinolone Antibiotics: A Report of 2 Cases Full Text available with Trip Pro

Triceps Ruptures After Fluoroquinolone Antibiotics: A Report of 2 Cases Rupture of the triceps brachii tendon is exceedingly rare, and surgical repair is generally indicated. Fluoroquinolone antibiotics have been implicated in tendon pathology, including tendon ruptures. Triceps rupture has not been previously reported in the setting of fluoroquinolone antibiotic therapy. We present 2 cases of triceps tendon rupture after treatment with fluoroquinolones. In both cases, triceps repair (...) was performed with good outcomes. These cases highlight a risk of fluoroquinolone-induced tendinopathy to athletes. The sports medicine team should be aware of this risk and consider it when choosing antibiotics to treat athletes.

2017 Sports health

194. Evaluation of automated systems for aminoglycosides and fluoroquinolones susceptibility testing for Carbapenem-resistant Enterobacteriaceae Full Text available with Trip Pro

Evaluation of automated systems for aminoglycosides and fluoroquinolones susceptibility testing for Carbapenem-resistant Enterobacteriaceae Automated systems (MicroScan WalkAway 96 Plus, Phoenix 100, and Vitek 2 Compact) are widely used in clinical laboratories nowadays. The aim of this study is to evaluate the performance of these three systems for susceptibility testing of aminoglycosides and fluoroquinolones against Carbapenem-resistant Enterobacteriaceae (CRE).A total of 75 CRE isolates (...) were used in this study. Quinolone resistance determinants (QRDs) (qnrA, qnrB, qnrC, qnrD, qnrS, aac(6')-Ib-cr, oqxAB and qepA) and aminoglycoside resistance determinants (ARDs) (aac(6')-Ib, armA, npmA, rmtA, rmtB, rmtC, rmtD and rmtE) of these CRE were screened by PCR. The MICs of aminoglycosides (gentamicin and amikacin) and fluoroquinolones (ciprofloxacin and levofloxacin) to CRE obtained with the automated systems were compared with the reference method (agar dilution method).Totally, 97.3% (73

2017 Antimicrobial resistance and infection control

195. Absence of tmRNA Has a Protective Effect against Fluoroquinolones in Streptococcus pneumoniae Full Text available with Trip Pro

Absence of tmRNA Has a Protective Effect against Fluoroquinolones in Streptococcus pneumoniae The transfer messenger RNA (tmRNA), encoded by the ssrA gene, is a small non-coding RNA involved in trans-translation that contributes to the recycling of ribosomes stalled on aberrant mRNAs. In most bacteria, its inactivation has been related to a decreased ability to respond to and recover from a variety of stress conditions. In this report, we investigated the role of tmRNA in stress adaptation (...) to fluoroquinolones, showing twofold higher MIC values and up to 1000-fold higher survival rates than the wild type. Deletion of SmpB, the other partner in trans-translation, also reduced survival to levofloxacin in a similar extent. Accumulation of intracellular reactive oxygen species associated to moxifloxacin and levofloxacin treatment was also highly reduced (∼100-fold). Nevertheless, the ΔssrA strain showed higher intracellular accumulation of ethidium bromide and levofloxacin than the wild type, suggesting

2017 Frontiers in microbiology

196. High Fluoroquinolone Resistant Strains of Helicobacter pylori in the Golden triangle Full Text available with Trip Pro

High Fluoroquinolone Resistant Strains of Helicobacter pylori in the Golden triangle Background and aims: Helicobacter pylori (H. pylori) infections, associated with fatal GI diseases such as gastric cancer and MALT lymphoma, remain a major health problem in ASEAN countries. The Golden triangle has long been known as one of Asia’s main opium-producing areas. There have been no prior studies of H. pylori infection in this area. The major objectives of this project were therefore to establish (...) ). Results: Total of 148 patients was included. H. pylori infection was present in 36.3%(37/102) of Chiang khong and 34.8 % (16/46) of Chiang saen subjects and the overall H. pylori infection rate was 35.8% (53/148). Antibiotic resistance was demonstrated in 44%, including 2% for CLR and 26% for MNZ, whereas fluoroquinolone resistance was demonstrated to be as high as 25% in Chiang khong. Multi-drug resistant H. pylori was detected in 4%. There was no AMX and TET resistance in this study. The prevalence

2017 Asian Pacific journal of cancer prevention : APJCP

197. Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis Full Text available with Trip Pro

Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis Routine fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies is still controversial, because of antibiotic resistance concerns. The recovery of the fecal microbiota to the initial composition in patients receiving multiple courses of quinolone prophylaxis and repeated chemotherapy has not been evaluated.We prospectively examined the changes

2017 Infection and drug resistance

198. Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli Full Text available with Trip Pro

Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli Objectives: Sequence type 1193 is emerging as a new, virulent and resistant lineage among fluoroquinolone resistant Escherichia coli (FQrE. coli). In this study, we investigated the prevalence and molecular characteristics of this clone isolated from a Chinese university hospital. Methods: 73 phylogenetic group B2-FQr-non-ST131 isolates were collected from August 2014

2017 Frontiers in microbiology

199. A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure. Full Text available with Trip Pro

A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure. The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S. Typhi isolates were genome sequenced and clinical observations, treatment (...) failures and fever clearance times (FCTs) were stratified by lineage. Most fluoroquinolone-resistant S. Typhi belonged to a specific H58 subclade. Treatment failure with S. Typhi-H58 was significantly less frequent with ceftriaxone (3/31; 9.7%) than gatifloxacin (15/34; 44.1%)(Hazard Ratio 0.19, p=0.002). Further, for gatifloxacin-treated patients, those infected with fluoroquinolone-resistant organisms had significantly higher median FCTs (8.2 days) than those infected with susceptible (2.96

2017 eLife Controlled trial quality: uncertain

200. Fluoroquinolone antibiotic-induced joint and cartilage damage in children: a meta-analysis

Fluoroquinolone antibiotic-induced joint and cartilage damage in children: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

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