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1. Search strategies to identify observational studies in MEDLINE and Embase. (PubMed)

of articles.Studies using a relative recall approach, i.e. comparing sensitivity or precision of a search strategy containing a methodological filter to identify observational studies in MEDLINE and Embase against a reference standard, or studies that compared two or more methodological filters.Two review authors independently screened articles, extracted relevant information and assessed the quality of the search strategies using the InterTASC Information Specialists' Sub-Group (ISSG) Search Filter Appraisal (...) specificity while maximum sensitivity was maintained), both of which were adapted for MEDLINE, for Embase, and for combined MEDLINE/Embase searches. The study reported one reference standard consisting of 217 articles from one systematic review of which 83.9% of the included studies were case seriesThe second study reported on 12 filters for retrieving comparative non-randomised studies (cNRSs) including cohort, case-control, and cross-sectional studies. This study reported on 12 filters using four

2019 Cochrane

2. Pruning Emtree: Does Focusing Embase Subject Headings Impact Search Strategy Precision and Sensitivity?

1 Impact Search Strategy Precision and Sensitivity? 1. BACKGROUND Embase is a key database to be searched when undertaking health technology assessments (HTAs). Despite its overlap of coverage with MEDLINE, much empirical research demonstrates that it contains unique content; 1 which has meant that it should be searched to inform HTAs. Recent developments within The Cochrane Collaboration to incorporate Embase records reporting randomized controlled trials (RCTs) have illustrated (...) to ensure that the researchers employed a consistent approach. 3.3 Identifying the relevant records in Embase The relevant studies that contributed to the identification of the efficacy/safety records of each SR/HTA were sought in Embase (OvidSP) and MEDLINE (OvidSP) using a known author and/or title search approach and the Find Citations tab in Ovid. Typical examples are shown below: A prospective randomized comparison of vertical banded gastroplasty.ti. agren g.au. and vertical.ti. prospective

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

3. Comparing the coverage, recall, and precision of searches for 120 systematic reviews in Embase, MEDLINE, and Google Scholar: a prospective study. (PubMed)

Comparing the coverage, recall, and precision of searches for 120 systematic reviews in Embase, MEDLINE, and Google Scholar: a prospective study. Previously, we reported on the low recall of Google Scholar (GS) for systematic review (SR) searching. Here, we test our conclusions further in a prospective study by comparing the coverage, recall, and precision of SR search strategies previously performed in Embase, MEDLINE, and GS.The original search results from Embase and MEDLINE and the first (...) and MEDLINE combined (97.5 %). MEDLINE on its own achieved 92.3 % coverage. Total recall of Embase/MEDLINE combined was 81.6 % for all included references, compared to GS at 72.8 % and MEDLINE alone at 72.6 %. However, only 46.4 % of the included references were among the downloadable first 1000 references in GS. When examining data for each SR, the traditional databases' recall was better than GS, even when taking into account included references listed beyond the first 1000 search results. Finally

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2016 Systematic reviews

4. Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE. (PubMed)

Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE. A systematic and extensive search for as many eligible studies as possible is essential in any systematic review. When searching for diagnostic test accuracy (DTA) studies in bibliographic databases, it is recommended that terms for disease (target condition) are combined with terms for the diagnostic test (index test). Researchers have developed methodological filters to try to increase the precision (...) 2012); EMBASE (1980 to 2012 Week 48); the Cochrane Methodology Register (Issue 3, 2012); ISI Web of Science (11 January 2013); PsycINFO (13 March 2013); Library and Information Science Abstracts (LISA) (31 May 2010); and Library, Information Science & Technology Abstracts (LISTA) (13 March 2013). We undertook citation searches on Web of Science, checked the reference lists of relevant studies, and searched the Search Filters Resource website of the InterTASC Information Specialists' Sub-Group (ISSG

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2013 Cochrane

5. Assignment of adverse event indexing terms in randomized clinical trials involving spinal manipulative therapy: an audit of records in MEDLINE and EMBASE databases. (PubMed)

manipulative therapy (SMT). During a previous investigation, it became apparent that comprehensive search strategies combining text words with indexing terms was not sufficiently sensitive for retrieving records that were known to contain reports on adverse events. The aim of this analysis was to compare the proportion of articles containing data on adverse events associated with SMT that were indexed in MEDLINE and/or EMBASE and the proportion of those that included adverse event-related words (...) Assignment of adverse event indexing terms in randomized clinical trials involving spinal manipulative therapy: an audit of records in MEDLINE and EMBASE databases. Reporting of adverse events in randomized clinical trials (RCTs) is encouraged by the authors of The Consolidated Standards of Reporting Trials (CONSORT) statement. With robust methodological design and adequate reporting, RCTs have the potential to provide useful evidence on the incidence of adverse events associated with spinal

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2017 BMC medical research methodology

6. A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo

A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo A network meta-analysis to compare glycaemic control in patients (...) with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo Scott DA, Boye KS, Timlin L, Clark JF, Best JH CRD summary This network meta-analysis concluded that exenatide once weekly and liraglutide (1.2mg or 1.8mg) had similar effects in improving the control of blood glucose in people with type 2 diabetes. The quality of the included trials and the applicability of the results to UK practice are uncertain

2014 DARE.

7. Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison

Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison Gagne JJ, Bykov K, Choudhry NK, Toomey TJ, Connolly JG, Avorn J CRD summary This review concluded that the efficacy (...) was used to make indirect comparisons in a network meta-analysis. A sensitivity analysis was conducted, using the primary outcome from one trial that reported the composite of cardiovascular death, MI, and stroke as a secondary outcome. Publication bias was investigated using a funnel plot. Results of the review Nine trials met the inclusion criteria (109,793 patients; range 2,080 to 25,074; 33,650 smokers). Six trials evaluated clopidogrel compared with aspirin, placebo or a different dose

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2013 DARE.

8. Comparative Efficacy and Safety of Nine Anti-Platelet Therapies for Patients with Ischemic Stroke or Transient Ischemic Attack: a Mixed Treatment Comparisons.

Comparative Efficacy and Safety of Nine Anti-Platelet Therapies for Patients with Ischemic Stroke or Transient Ischemic Attack: a Mixed Treatment Comparisons. Anti-platelet treatments, an effective anti-thrombotic therapy, are widely used in non-cardioembolic ischemic stroke or transient ischemic attack (TIA), including aspirin, cilostazol, clopidogrel, and other mono or dual therapies, while the optimal choice remains uncertain. All the literatures of 38 eligible randomized control trials were (...) searched in PubMed, Embase, and China National Knowledge Internet (CNKI) without language limitation. And, nine anti-platelet therapies were assessed, including aspirin, clopidogrel, cilostazol, ticlopidine, triflusal, terutroban, sarpogrelate, dipyridamole plus aspirin, and clopidogrel plus aspirin. Additionally, we extract data of composite vascular events, major bleeding, ischemic stroke, intracranial hemorrhage, and all-cause death, as indicators of efficacy and safety. And among them, composite

2018 Molecular neurobiology

9. Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease: A meta-analysis of comparative studies. (PubMed)

Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease: A meta-analysis of comparative studies. The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD (...) patients.A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed.Altogether, 22 studies with 1,244 IBS

2018 Journal of Affective Disorders

10. Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa). (PubMed)

0.63; 95% CI 0.00 to 106.95; 86 women; one study; very low-certainty evidence) between the comparison groups.Nerve-sparing radical hysterectomy may lessen the risk of postoperative bladder dysfunction compared to the standard technique, but the certainty of this evidence is low. The very low-certainty evidence for disease-free survival and lack of information for overall survival indicate that the oncological safety of nerve-sparing radical hysterectomy for women with early stage cervical cancer (...) Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa). Radical hysterectomy is one of the standard treatments for stage Ia2 to IIa cervical cancer. Bladder dysfunction caused by disruption of the pelvic autonomic nerves is a common complication following standard radical hysterectomy and can affect quality of life significantly. Nerve-sparing radical hysterectomy is a modified radical hysterectomy, developed

2019 Cochrane

11. Aripiprazole Lauroxil Compared with Paliperidone Palmitate in Patients with Schizophrenia: An Indirect Treatment Comparison. (PubMed)

indirectly compare efficacy and safety of the pivotal AL study with all PP studies meeting indirect comparison criteria.Systematic searches of MEDLINE, Embase, Cochrane CENTRAL, PsycINFO, ClinicalTrials.gov, International Clinical Trials Registry Platform, and gray literature were performed to identify randomized controlled trials of PP with similar designs to the AL trial. Bayesian network meta-analysis compared treatments with respect to symptom response and tolerability issues including weight gain (...) Aripiprazole Lauroxil Compared with Paliperidone Palmitate in Patients with Schizophrenia: An Indirect Treatment Comparison. Aripiprazole lauroxil (AL) is a long-acting injectable atypical antipsychotic recently approved for treatment of schizophrenia on the basis of a large-scale trial of two doses of AL versus placebo. There are no direct-comparison studies with paliperidone palmitate (PP; long-acting antipsychotic used most often in acute settings) for the acute psychotic episode.To

2017 Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

12. Comparative Efficacy and Acceptability of Anti-TNF-Alpha Therapy in Ankylosing Spondylitis: A Mixed-Treatments Comparison.

anti-TNFα therapies were searched electronically through PubMed, Embase and Cochrane until April 1, 2015. Odds ratios (ORs) were estimated and compared for efficacy (ASAS20, ASAS40, ASAS5/6 responses and ASAS partial remission) and acceptability (serious adverse effects (SAE)) among the anti-TNFα reagents.Totally, 25 trials with 2989 participants were incorporated in this mixed treatment comparison. All the 5 TNFα blockers achieved better ASAS20, ASAS40, ASAS5/6 and ASAS-PR responses than (...) Comparative Efficacy and Acceptability of Anti-TNF-Alpha Therapy in Ankylosing Spondylitis: A Mixed-Treatments Comparison. Tumor necrosis factor α (TNFα) antagonists, namely, golimumab, adalimumab, infliximab, etanercept and certolizumab have been prescribed to alleviate and treat ankylosing spondylitis (AS). However, the lack of comparative evidence does not enable us to make constructive recommendations particularly for AS patient populations.Eligible controlled trials regarding the above 5

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2017 Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

13. Provision of respiratory support compared to no respiratory support before cord clamping for preterm infants. (PubMed)

Provision of respiratory support compared to no respiratory support before cord clamping for preterm infants. Placental transfusion (by means of delayed cord clamping (DCC), cord milking, or cord stripping) confers benefits for preterm infants. It is not known if providing respiratory support to preterm infants before cord clamping improves outcomes.To assess the efficacy and safety of respiratory support provided during DCC compared with no respiratory support during placental transfusion (...) (in the form of DCC, milking, or stripping) in preterm infants immediately after delivery.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL, 2017, Issue 5), MEDLINE via PubMed (1966 to 19 June 2017), Embase (1980 to 19 June 2017), and CINAHL (1982 to 19 June 2017). We also searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles for randomized controlled trials and quasi-randomized

2018 Cochrane

14. Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients. (PubMed)

Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients. Sepsis is a life-threatening condition that is usually diagnosed when a patient has a suspected or documented infection, and meets two or more criteria for systemic inflammatory response syndrome (SIRS). The incidence of sepsis is higher among people admitted to critical care settings such as the intensive care unit (ICU) than among people in other settings. If left untreated sepsis can (...) it shouldn't be), or healthcare staff may not respond to alerts quickly enough, or get 'alarm fatigue' especially if the alarms go off frequently or give too many false alarms.To evaluate whether automated systems for the early detection of sepsis can reduce the time to appropriate treatment (such as initiation of antibiotics, fluids, inotropes, and vasopressors) and improve clinical outcomes in critically ill patients in the ICU.We searched CENTRAL; MEDLINE; Embase; CINAHL; ISI Web of science; and LILACS

2018 Cochrane

15. Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2 cervical cancer. (PubMed)

(type II or type III radical hysterectomy with lymphadenectomy) improves survival compared to primary chemoradiotherapy.To determine if primary surgery combined with postoperative adjuvant chemoradiotherapy, for stage IB2 cervical cancer increases patient morbidity in the management of stage IB2 cervical cancer compared to primary chemoradiotherapy.We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 3), MEDLINE via Ovid (1946 to April week 2, 2018) and Embase via (...) Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2 cervical cancer. Cervical cancer is the fourth most common cancer in women, with 528,000 estimated new cases globally in 2012. A large majority (around 85%) of the disease burden occurs in low- and middle-income countries (LMICs), where it accounts for almost 12% of all female cancers. Treatment of stage IB2 cervical cancers, which sit between early and advanced disease

2018 Cochrane

16. What is the clinical and cost-effectiveness evidence comparing robot assisted laparoscopic partial nephrectomy with open partial nephrectomy or conventional laparoscopic partial nephrectomy in patients with T1a or T1b renal cancer?

was systematically searched on the 27 June 2017 using the following databases: Medline, Medline in process, Cochrane, Embase and Web of Science. Results were limited to randomised controlled trials and volume and outcome studies. An additional search to identify literature comparing the learning curve for robotic partial nephrectomy and laparoscopic partial nephrectomy was carried out on the 19 July 2017. Key websites were searched for guidelines, policy documents, clinical summaries, economic studies (...) and use of critical care. RALPN versus OPN No randomised controlled trials were identified. The evidence base comparing RALPN with OPN consists of non-randomised observational studies. These include single centre and multi-centre comparisons. Many are retrospective and most focus on short-term peri-operative outcomes rather than longer term outcomes such as survival or cancer recurrence. Where such oncological outcomes were reported, variation in length of follow-up period prevented meta-analysis 10

2018 Evidence Notes from Healthcare Improvement Scotland

17. Is the Risk of Bleeding Among Older Adults With Atrial Fibrillation Lower With Antiplatelet Compared With Oral Anticoagulants?

RCTs, 1 NRS) 7,831 0.99 (0.82–1.21) Major bleeding severity for aspirin or clopidogrel compared with warfarin Subgroup >80 y 5 (4 RCTs, 1 NRS) 7,723 0.80 (0.69–0.90) 65–80 y 4 (2 RCTs, 2 NRSs) 11,016 0.87 (0.64–1.19) Aspirin 100 mg/day 3 (3 RCTs) 799 0.71 (0.38–1.33) RCT, Randomized controlled trial; NRS, nonrandomized controlled study. *Lower risk ratio favors antiplatelet agents in comparison with warfarin (less risk of outcome with lower risk ratio). METHODS DATA SOURCES Two reviewers (...) hospital admission or causing death were comparable. With warfarin as a reference, the hazard ratio for nonfatal bleeding from aspirin alone was 0.84 (95% CI 0.80 to 0.89) and from clopidogrel alone was 0.94 (95% CI 0.76 to 1.16). Additionally, in comparison with warfarin, the hazard ratio for fatal bleeding from aspirin alone was 1.37 (95% CI 1.13 to 1.65) and from clopidogrel alone was 2.22 (95% CI 1.30 to 3.77), suggesting an increase in the risk of fatal bleeding with antiplatelet agents

2018 Annals of Emergency Medicine Systematic Review Snapshots

18. What Is the Utility of Coronary Computed Tomography Angiography Compared With Standard of Care for the Evaluation of Acute Chest Pain? (SRS diagnosis)

mortality, major adverse cardiac events, or myocardial infarction (Table). However, coronary CT angiography was associated with an increased risk of invasive coronary angiography and revascularization compared with standard of care. Coronary CT angiography was also associated with a decreased length of stay in Comparison of outcomes between coronary CT angiography and standard-of-care approaches. Outcome Number of Studies (Number of Participants) RR Favoring CCTA (95% CI) Heterogeneity (I 2 (...) What Is the Utility of Coronary Computed Tomography Angiography Compared With Standard of Care for the Evaluation of Acute Chest Pain? (SRS diagnosis) TAKE-HOME MESSAGE Compared with existing standards of care for the evaluation of acute chest pain, coronary computed tomography (CT) angiography is associated with similar rates of major adverse events, but higher rates of revascularization. What Is the Utility of Coronary Computed Tomography Angiography Compared With Standard of Care

2018 Annals of Emergency Medicine Systematic Review Snapshots

19. Clear Aligner Therapy provides lower caries risk compared to Fixed Orthodontic Treatment

with fixed appliance therapy when compared to those using removable aligners. A significantly greater (P Evidence Search plaque AND clear aligners Comments on The Evidence Validity: This was a meta-analysis in which the investigators searched for qualifying papers using PubMed, Web of Science, Cochrane Library, and Embase. They included RCT and cohort studies of healthy human subjects that used clear aligners and fixed appliances as intervention and control. Any studies that contained patients (...) Clear Aligner Therapy provides lower caries risk compared to Fixed Orthodontic Treatment UTCAT3365, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Clear Aligner Therapy provides lower caries risk compared to Fixed Orthodontic Treatment Clinical Question Do clear aligners increase patient’s risk for dental caries when compared to traditional attached braces? Clinical Bottom Line The removable nature of clear aligners

2019 UTHSCSA Dental School CAT Library

20. Pre-emptive compared with empirical antifungal strategies for invasive Aspergillus infection

as a serious threat which could lead to untreatable infections and make routine surgery or chemotherapy much more hazardous 19, 20 . Cost effectiveness Three potentially relevant studies were excluded from this review owing to irrelevant clinical context or lack of appropriate comparisons 18, 21, 22 . Three economic evaluations were identified that compared various forms of pre-emptive diagnostic-driven antifungal treatment strategies with an empirical treatment strategy 1, 23, 24 . Two utilised decision (...) Pre-emptive compared with empirical antifungal strategies for invasive Aspergillus infection SHTG Evidence Synthesis | 1 Evidence Synthesis Number 01 March 2019 Pre-emptive antifungal strategies incorporating galactomannan (GM) testing and/or polymerase chain reaction (PCR) assays compared with empirical antifungal strategies for invasive Aspergillus infection in patients with haematological malignancies What were we asked to look at? The Scottish Antimicrobial Prescribing Group (SAPG) asked us

2019 SHTG Advice Statements

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