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cephalosporin

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161. IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins. (Abstract)

IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins. Studies regarding the cross-reactivity and tolerability of alternative cephalosporins in large samples of subjects with an IgE-mediated hypersensitivity to cephalosporins are lacking.We sought to evaluate the possibility of using alternative cephalosporins in subjects with cephalosporin allergy who especially require them.One hundred two subjects with immediate reactions (...) to cephalosporins and positive skin test results to the responsible drugs underwent serum specific IgE assays with cefaclor and skin tests with different cephalosporins. Subjects were classified in 4 groups: group A, positive responses to 1 or more of ceftriaxone, cefuroxime, cefotaxime, cefepime, cefodizime, and ceftazidime; group B, positive responses to aminocephalosporins; group C, positive responses to cephalosporins other than those belonging to the aforementioned groups; and group D, positive responses

2015 Journal of Allergy and Clinical Immunology

162. A protocol for a systematic review and meta-analysis of the health and healthcare system burden due to human Escherichia coli infections resistant to third/fourth/fifth generation cephalosporins or quinolones, or with multidrug resistance

A protocol for a systematic review and meta-analysis of the health and healthcare system burden due to human Escherichia coli infections resistant to third/fourth/fifth generation cephalosporins or quinolones, or with multidrug resistance Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration

2018 PROSPERO

163. Third Generation Anti-Pseudomonal Cephalosporins

Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Aka: Third Generation Anti-Pseudomonal Cephalosporins , Ceftazidime From Related Chapters II. Coverage Pseudomonas (Main indication) poorly covered No coverage III. Preparations: Ceftazidime (Fortaz) Adult: 1-2 grams IM or IV every 8 to 12 hours Child: 30-50 mg/kg IV every 8 hours IV. Disadvantages Most expensive Limited spectrum Images: Related links to external sites (from Bing) These images

2018 FP Notebook

164. Third Generation Broad-Spectrum Cephalosporins

Third Generation Broad-Spectrum Cephalosporins Third Generation Broad-Spectrum Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Third Generation Broad-Spectrum Cephalosporins Third Generation Broad-Spectrum Cephalosporins Aka: Third Generation Broad-Spectrum Cephalosporins , Third Generation Cephalosporins , Ceftriaxone , Ceftizoxime , Cefotaxime , Cefpodoxime , Cefixime , Claforan , Rocephin , Vantin From Related Chapters II. Mechanism: Spectrum of Activity Less activity than Better activity than Better activity than No Pseudomonas activity III. Preparations: Oral agents Cefixime (Suprax) Adult Standard: 400 mg PO

2018 FP Notebook

165. Second Generation Broad-spectrum Cephalosporins

Second Generation Broad-spectrum Cephalosporins Second Generation Broad-spectrum Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Second Generation Broad-spectrum Cephalosporins Second Generation Broad-spectrum Cephalosporins Aka: Second Generation Broad-spectrum Cephalosporins , Second Generation Cephalosporins , Cefuroxime , Loracarbef , Cefprozil , Lorabid , Cefzil , Ceftin From Related Chapters II. Coverage III. Indications Respiratory tract infections IV. Preparations Loracarbef (Lorabid) Adult: 200 to 400 mg po bid Child : 30 mg/kg/day divided bid Other infections: 15 mg/kg/day divided bid Directions Take more

2018 FP Notebook

166. Second Generation Anti-anaerobe Cephalosporins

Second Generation Anti-anaerobe Cephalosporins Second Generation Anti-anaerobe Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Second Generation Anti-anaerobe Cephalosporins Second Generation Anti-anaerobe Cephalosporins Aka: Second Generation Anti-anaerobe Cephalosporins , Cefoxitin , Cefotetan , Cefamandole From Related Chapters II. Coverage III. Indications Abdominal Surgery prophylaxis Colorectal surgery prophylaxis IV. Coverage Cefoxitin (Mefoxin) 1-2 grams IM or IV every 6-8 hours Cefotetan (Cefotan) 1-2 grams IM or IV every 12 hours Cefamandole V. Downsides Poor overall activity Expensive Images: Related

2018 FP Notebook

167. First Generation Cephalosporins

First Generation Cephalosporins First Generation Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 First Generation (...) Cephalosporins First Generation Cephalosporins Aka: First Generation Cephalosporins , Cephalexin , Cefazolin , Cefadroxil , Keflex , Duricef , Ancef From Related Chapters II. Indications Effective alternative to s Covers Clinical Conditions Not indicated for III. Mechanism: Activity Spectrum Good Coverage Modest covered IV. Preparations: Oral Directions May take with or without food Cephalexin (Keflex) Adult: 250 to 500 mg PO qid Child : 75 to 100 mg/kg/day divided qid Standard Dose: 25 to 50 mg/kg/day

2018 FP Notebook

168. Cephalosporin

Cephalosporin Cephalosporin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cephalosporin Cephalosporin Aka: Cephalosporin From (...) Related Chapters II. General Spectrum changes from first to third generation First ration: Better coverage Third ration: Better coverage III. Contraindications Drug allergy to other Cephalosporin Type I to a Less than 10% of those who report actually have a Cross reactivity was originally over-estimated as high as 10% in the 1960s Attributed to cross contamination from co-production of Cephalosporins and s in the same factory has only an overall 1-2% risk of cross-reactivity with Cephalosporins

2018 FP Notebook

169. Comparable Effectiveness of First Week Treatment with Anti-Staphylococcal Penicillin versus Cephalosporin in Methicillin-Sensitive Staphylococcus aureus Bacteremia: A Propensity-Score Adjusted Retrospective Study. Full Text available with Trip Pro

Comparable Effectiveness of First Week Treatment with Anti-Staphylococcal Penicillin versus Cephalosporin in Methicillin-Sensitive Staphylococcus aureus Bacteremia: A Propensity-Score Adjusted Retrospective Study. The objective was to compare the prognostic impact of first week treatment with anti-staphylococcal penicillin (ASP) versus cephalosporin in methicillin-sensitive Staphylococcus aureus bacteremia (MS-SAB). Altogether 580 patients were retrospectively followed and categorized according (...) to first week treatment; 84% (488) received ASP (cloxacillin) and 16% (92) cephalosporin (cefuroxime or ceftriaxone). SAB management was optimized with formal bedside infectious disease specialist consultation in 88%, deep infection foci diagnosed in 77% and adjunctive rifampicin therapy given to 61% of patients. The total case fatality in 580 patients was 12% at 28 days and 18% at 90 days. When comparing effectiveness of first week ASP versus cephalosporin treatment there were no significant

2016 PLoS ONE

170. Adverse events in patients taking cephalosporins versus placebo for any indication [Cochrane protocol]

Adverse events in patients taking cephalosporins versus placebo for any indication [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO

171. Adverse events in patients taking cephalosporins versus placebo for any indication [Cochrane Protocol]

Adverse events in patients taking cephalosporins versus placebo for any indication [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO

172. A systematic review on the clinical significance of quinolone-resistant and third-generation cephalosporin- resistant non-typhoidal Salmonella in humans of any age

A systematic review on the clinical significance of quinolone-resistant and third-generation cephalosporin- resistant non-typhoidal Salmonella in humans of any age Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2017 PROSPERO

173. Anaphylactic Cross-Reactivity Between Penicillin and Cephalosporin

Anaphylactic Cross-Reactivity Between Penicillin and Cephalosporin UTCAT848, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Minimal Risk Of Severe Type 1 Hypersensitivity Reaction To Third Generation Cephalosporin In Patients Who Experience Type 1 Hypersensitivity Reaction And Allergy To Penicillin Clinical Question Do patients who experience a severe type 1 hypersensitivity reaction to penicillin and demonstrate (...) an allergy to cephalosporin experience a severe type 1 hypersensitivity reaction to the cephalosporin? Clinical Bottom Line It appears that patients who have a severe type 1 hypersensitivity reaction to penicillin do not have an increased risk of anaphylaxis to cephalosporins. This evidence may be skewed however by adherence to the recommendation not to give cephalosporins to individuals with a history of penicillin anaphylaxis. (See Comments on the CAT below) Best Evidence (you may view more info

2011 UTHSCSA Dental School CAT Library

174. Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance Full Text available with Trip Pro

Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance Fifth-generation cephalosporins, ceftobiprole and ceftaroline, are promising drugs for treatment of bacterial infections from methicillin-resistant Staphylococcus aureus (MRSA). These antibiotics are able to bind native PBP2a, the penicillin-binding protein encoded by the mecA resistance determinant that mediates broad class (...) to ceftaroline or ceftobiprole, were detected in multiple selections. These genomic findings suggest that non-mecA mechanisms, while yet to be encountered in the clinical setting, may also be important in mediating resistance to 5th-generation cephalosporins.

2016 PloS one

175. Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo †Electronic supplementary information (ESI) available: General experimental procedures and supplementary figures. See DOI: 10.1039/c6cc00529b Click here f Full Text available with Trip Pro

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo †Electronic supplementary information (ESI) available: General experimental procedures and supplementary figures. See DOI: 10.1039/c6cc00529b Click here f Bacterial metallo-β-lactamases (MBLs) are involved in resistance to β-lactam antibiotics including cephalosporins. Human SNM1A and SNM1B are MBL superfamily exonucleases that play a key role in the repair of DNA interstrand cross-links, which (...) are induced by antitumour chemotherapeutics, and are therefore targets for cancer chemosensitization. We report that cephalosporins are competitive inhibitors of SNM1A and SNM1B exonuclease activity; both the intact β-lactam and their hydrolysed products are active. This discovery provides a lead for the development of potent and selective SNM1A and SNM1B inhibitors.

2016 Chemical communications (Cambridge, England)

176. Plasmid and Host Strain Characteristics of Escherichia coli Resistant to Extended-Spectrum Cephalosporins in the Norwegian Broiler Production Full Text available with Trip Pro

Plasmid and Host Strain Characteristics of Escherichia coli Resistant to Extended-Spectrum Cephalosporins in the Norwegian Broiler Production Escherichia coli resistant to extended-spectrum cephalosporins have been detected in the Norwegian broiler production, despite the fact that antimicrobial agents are rarely used. The genetic mechanism responsible for cephalosporin resistance is mainly attributed to the presence of the blaCMY-2 gene encoding a plasmid-mediated AmpC-beta-lactamase (pAmpC (...) relationship within the two most prevalent STs. The IncK plasmids within these two STs also shared a high degree of similarity. Cephalosporin-resistant E. coli with the same genetic characteristics have been identified in the broiler production in other European countries, and the IncK plasmid characterized in this study showed close homology to a plasmid isolated from retail chicken meat in the Netherlands. The results indicate that both clonal expansion and horizontal transfer of blaCMY-2 containing

2016 PloS one

177. Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers Full Text available with Trip Pro

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers Radiation therapy remains a significant therapeutic modality in the treatment of cancer. An attractive strategy would be to enhance the benefits of ionizing radiation (IR)with radiosensitizers. A high-content drug repurposing screen of approved and investigational agents, natural products and other small molecules has identified multiple candidates that blocked repair of IR damage in vitro. Here, we validated a subset (...) of these hits in vitro and then examined effects on tumor growth after IR in a murine tumor model. Based on robust radiosensitization in vivo and other favorable properties of cephalexin, we conducted additional studies with other beta-lactam antibiotics. When combined with IR, each cephalosporin tested increased DNA damage and slowed tumor growth without affecting normal tissue toxicity. Our data implicate reactive oxygen species in the mechanism by which cephalosporins augment the effects of IR. This work

2016 Oncotarget

178. Nonconvulsive status epilepticus cases arising in connection with cephalosporins Full Text available with Trip Pro

Nonconvulsive status epilepticus cases arising in connection with cephalosporins Cephalosporins, particularly cefepime, exert neurotoxic side effects that can lead to status epilepticus. These neurotoxic side effects include myoclonus, dystonic movements, tremor, asterixis, seizure, status epilepticus, encephalopathy, and sometimes coma. Status epilepticus, particularly nonconvulsive status epilepticus (NCSE), is a well-known but unusual complication in patients with altered renal function who (...) were receiving treatment with intravenous cephalosporins, especially cefepime. We reviewed the clinical and electroencephalographic (EEG) characteristics of 7 patients with renal failure who developed consciousness alterations with changes in EEG activity while being treated with cephalosporins. All patients developed renal failure: six patients had chronic renal failure, one patient had acute renal failure, and two patients were administered hemodialysis. Nonconvulsive status epilepticus

2016 Epilepsy & behavior case reports

179. Polyclonal Intestinal Colonization with Extended-Spectrum Cephalosporin-Resistant Enterobacteriaceae upon Traveling to India Full Text available with Trip Pro

Polyclonal Intestinal Colonization with Extended-Spectrum Cephalosporin-Resistant Enterobacteriaceae upon Traveling to India We aimed to assess the intestinal colonization dynamics by multiple extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) clones in Swiss travelers to India, a country with high prevalence of these multidrug-resistant pathogens. Fifteen healthy volunteers (HVs) colonized with ESC-R-Ent after traveling to India who provided stools before, after, and at 3

2016 Frontiers in microbiology

180. Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study Full Text available with Trip Pro

Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study Existing data regarding the risk of hemorrhagic events associated with exposure to hypoprothrombinemia-inducing cephalosporins are limited by the small sample size. This population-based study aimed to examine the association between exposure to hypoprothrombinemia-inducing cephalosporins and hemorrhagic events using National Health Insurance Research Database (...) in Taiwan.A nationwide nested case-control study.National Health Insurance Research database.We conducted a nested case-control study within a cohort of 6191 patients who received hypoprothrombinemia-inducing cephalosporins and other antibiotics for more than 48 hours. Multivariable conditional logistic regressions were used to calculate the adjusted odds ratio (aOR) and 95% confidence interval (CI) for hemorrhagic events associated with exposure to hypoprothrombinemia-inducing cephalosporins (overall

2016 PloS one

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