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101. Reducing brain injury after cardiopulmonary resuscitation

Reducing brain injury after cardiopulmonary resuscitation Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share May 30, 2017 ; 88 (22) Special Article Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation Report of the Guideline Development (...) , Kansas City; and Department of Neurology (J.L.), University of Toronto, Canada. Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation Romergryko G. Geocadin , Eelco Wijdicks , Melissa J. Armstrong , Maxwell Damian , Stephan A. Mayer , Joseph P. Ornato , Alejandro Rabinstein , José I. Suarez , Michel T. Torbey , Richard M. Dubinsky , Jason Lazarou Neurology May 2017, 88 (22) 2141-2149; DOI: 10.1212/WNL.0000000000003966 Citation Manager Formats Make Comment See

2017 American Academy of Neurology

102. Randomised controlled trial: Decompressive craniectomy for severe traumatic brain injury reduces mortality but increases survival with severe disability

disability Article Text Therapeutics/Prevention Randomised controlled trial Decompressive craniectomy for severe traumatic brain injury reduces mortality but increases survival with severe disability Stephen Honeybul Statistics from Altmetric.com Commentary on: Hutchinson PJ , Kolias AG , Timofeev IS , et al. , RESCUEicp Trial Collaborators . Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension . Context There is little doubt that decompressive craniectomy can reduce mortality (...) Randomised controlled trial: Decompressive craniectomy for severe traumatic brain injury reduces mortality but increases survival with severe disability Decompressive craniectomy for severe traumatic brain injury reduces mortality but increases survival with severe disability | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies

2017 Evidence-Based Medicine

103. Portable neuromodulation stimulator for traumatic brain injury

Portable neuromodulation stimulator for traumatic brain injury Portable neuromodulation stimulator for traumatic brain injury | Innovation Observatory toggle menu Menu Search View All Filter by Speciality Filter by Year Filter by Category This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced (...) as required for our stakeholders. > > > Portable neuromodulation stimulator for traumatic brain injury Portable neuromodulation stimulator for traumatic brain injury March 2017 The Portable Neuromodulation Stimulator or PoNS™, developed by Helius Medical Technologies, is a non-invasive device that is designed to deliver neurostimulation through the tongue to treat balance disorders caused by mild to moderate Traumatic Brain Injury (mTBI). The device is intended to be used as part of targeted functional

2017 NIHR Innovation Observatory

104. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury

Stuttering Disruption in the fluency of speech (e.g., repetition of sounds, words, phrases or prolongation of sounds) Swallowing disorder Difficulty eating or drinking during any of the core oral-pharyngeal phases of swallowing (i.e., oral preparatory, oral, and pharyngeal) Syntax Structure of sentences Tracheostomy Surgical opening into the trachea (windpipe) that allows for the insertion of a tube to assist with breathing Traumatic brain injury Injury to the brain caused by trauma to the head (...) data is limited to guide speech, language and swallowing disorders. The following variables may be considered by speech-language pathologists and medical specialists when determining prognosis: • Extent and severity of brain damage (including size and site of lesion(s)) and other proxy measures e.g., Glasgow Coma Scale score, length of ventilation and intubation, loss of consciousness and length of post traumatic amnesia, brain surgery required post-injury, raised intracranial pressure • Cause

2017 Clinical Practice Guidelines Portal

105. Rehabilitation of adults with moderate to severe traumatic brain injury

Rehabilitation of adults with moderate to severe traumatic brain injury Home // Ontario Neurotrauma Foundation Toggle navigation NAVIGATION > > > > > > > > > > > > > > > > > > > > > > > > Clinical Practice Guideline For the rehabilitation of Adults with Moderate to Severe TBI WHAT'S NEW February 3, 2020 : The patient version of the guideline is now available for download in PDF format. This 15-page handbook describes the rehabilitation of adults with moderate to severe traumatic brain injury (...) in each section of the guidelines. The ''Key indicators'' tab proposes examples of indicators that can be used to monitor the implementation of specific recommendations in each section of the guidelines. Downloadable PDF document with all and are also available.-- SECTION 1: Components of the Optimal TBI Rehabilitation System SECTION 2: Assessment and Rehabilitation of Brain Injury Sequelae Search By Keyword: and / or SEARCH BY TAG: Assessment Management Acute Inpatient Outpatient/ Community Coping

2017 Ontario Neurotrauma Foundation

106. Disorder of Executive Function of the Brain after Head Injury and Mild Traumatic Brain Injury – Neuroimaging and Diagnostic Criteria for Implementation of Administrative Support in Japan Full Text available with Trip Pro

of minute organic lesions and metabolic dysfunction in the brain where organic lesions may be absent or cannot be detected on conventional CT or MRI. In this review, we discuss diagnostic criteria for mild TBI and ad-DEFB, the relationship between the two disorders, characteristic neuroimaging [(MRI and 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET)] of diffuse brain injury including cerebral concussion, which is the principal cause of mild TBI, and suggested pathological mechanisms of ad (...) Disorder of Executive Function of the Brain after Head Injury and Mild Traumatic Brain Injury – Neuroimaging and Diagnostic Criteria for Implementation of Administrative Support in Japan The diagnotic criteria for disorder of the executive function of the brain (DEFB) as a syndrome of sequela were administratively established (ad-DEFB) in Japan in 2006 to support disabled patients whose impairment, limited to cognition (memory, attention, execution, and behavior), emerges after organic brain

2017 Neurologia medico-chirurgica

107. Mouthguards for the Prevention of Dental Injuries and Concussions: Clinical Effectiveness

regarding the clinical effectiveness of mouthguards for the prevention of dental injuries or concussions during contact sports. Tags athletic injuries, brain injuries, football, hockey, mouth protectors, nervous system, soccer, sports, tooth injuries, wounds and injuries, dental, medical devices, athlete, brain injury, dental trauma, mouthguard, mouthguards, orofacial injuries, orofacial injury, orofacial trauma, player, protective mouth piece, protective mouthpiece Files Rapid Response Summary (...) Mouthguards for the Prevention of Dental Injuries and Concussions: Clinical Effectiveness Mouthguards for the Prevention of Dental Injuries and Concussions: Clinical Effectiveness | CADTH.ca Find the information you need Mouthguards for the Prevention of Dental Injuries and Concussions: Clinical Effectiveness Mouthguards for the Prevention of Dental Injuries and Concussions: Clinical Effectiveness Published on: February 12, 2016 Project Number: RB0961-000 Product Line: Research Type: Devices

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

108. Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury. Full Text available with Trip Pro

Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury. Mild traumatic brain injury in the form of concussion is extremely common, and the potential effects on pulmonary priming have been underestimated. The aim of this study was to characterize the pulmonary response following mild traumatic brain injury and assess the pulmonary susceptibility to lung injury after a subsequent innocuous pulmonary insult.Experimental in vivo study.University research laboratory.Male CD1 (...) mice.We developed a model of concussive traumatic brain injury in mice followed by pulmonary acid microaspiration. To assess the dependent role of neutrophils in mediating pulmonary injury, we specifically depleted neutrophils.Lateral fluid percussion to the brain resulted in neuronal damage and neutrophil infiltration as well as extensive pulmonary interstitial neutrophil accumulation but no alveolar injury. Following subsequent innocuous acid microaspiration, augmented alveolar neutrophil influx led

2018 Critical Care Medicine

109. Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury. (Abstract)

Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury. Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysfunction for 6 weeks. At 6 weeks, we tested (...) ganglion neurons to noxious heat stimulation in Pirt-GCaMP6s mice after SCI. Western blot analysis showed upregulation of MOR in the lumbar spinal cord and sciatic nerves at 6 weeks after SCI. Our findings suggest that peripherally acting MOR agonist may inhibit heat hypersensitivity below the injury level with minimal adverse effects.

2019 Pain

110. Increased lateral meniscal slope is associated with greater incidence of lateral bone contusions in noncontact ACL injury. (Abstract)

Increased lateral meniscal slope is associated with greater incidence of lateral bone contusions in noncontact ACL injury. (1) To investigate whether an increased lateral meniscal slope measured on magnetic resonance image (MRI) would be associated with greater risk of bone contusions in noncontact anterior cruciate ligament injury, and (2) to measure the relationship between the occurrence of bone contusions and associated findings observed in ACL deficient knees such as cartilage damage (...) , anterolateral complex injury and concomitant meniscal tears.Patients who underwent ACL reconstruction surgery between 2013 and 2018 were retrospectively reviewed. Sixty-three patients were included in the study group (ACL + bone contusions group), 56 participants were in the control group (isolated ACL group). The presence and severity of bone contusions were determined from preoperative MRIs. The lateral meniscal slope and lateral posterior tibial slope were measured on the MRIs in a blinded fashion

2019 Knee Surgery, Sports Traumatology, Arthroscopy

111. The Effect of Hyperbaric Oxygen Treatment on Myoblasts and Muscles After Contusion Injury. (Abstract)

The Effect of Hyperbaric Oxygen Treatment on Myoblasts and Muscles After Contusion Injury. The recommended treatment varies depending on the severity of muscle injuries. The aim of this study was to evaluate the in vitro myoblast proliferation and the in vivo histologic and physiologic effects of hyperbaric oxygen treatment on muscle healing after contusion. Cells from the C2C12 myoblast cell line were exposed to 100% O2 for 25 min then to air for 5 min at 2.5 atmospheres absolute (...) in a hyperbaric chamber for a total treatment duration of 90 min per 48 h at intervals of 2, 4, 6 and 8 days. Cell growth measurements and western blot analysis of myogenin and actin were performed. Then, 18 mice aged 8-10 weeks were used in the muscle contusion model. The histologic and physiologic effects and muscle regeneration after hyperbaric oxygen treatment were evaluated. The myoblast growth rate was significantly higher (p < 0.05) after hyperbaric oxygen treatment. Densitometric evaluation

2019 Journal of Orthopaedic Research

112. Comparison of Effects of Manual and Mechanical Airway Clearance Techniques on Intracranial Pressure in Patients With Severe Traumatic Brain Injury on a Ventilator: Randomized, Crossover Trial (Abstract)

Comparison of Effects of Manual and Mechanical Airway Clearance Techniques on Intracranial Pressure in Patients With Severe Traumatic Brain Injury on a Ventilator: Randomized, Crossover Trial Physical therapist intervention can play a significant role in the prevention of mechanical and infectious complications in patients with traumatic brain injury (TBI) who are mechanically ventilated.The objective of this study was to observe and compare the effects of manual and mechanical airway clearance (...) techniques on intracranial pressure (ICP) and hemodynamics in patients with severe TBI.The design was a prospective, randomized, crossover trial.The setting was a neurointensive care unit at a level 1 trauma center.Forty-six adult patients aged 18 to 75 years, of either sex, with severe TBI, receiving mechanical ventilatory support with continuous ICP monitoring, and undergoing regular airway clearance techniques participated in this study.Two techniques were performed by a single trained physical

2019 EvidenceUpdates

113. Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. (Abstract)

orthopedic traumatic injury in the first 12 months postinjury using data from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study, and, using clinical computed tomographic (CT) scans, examine whether the presence (CT+) or absence (CT-) of acute intracranial findings in the mTBI group was associated with outcomes.TRACK-TBI, a cohort study of patients with mTBI presenting to US level I trauma centers, enrolled patients from February 26, 2014, to August 8, 2018 (...) Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence of persistent functional limitations for these patients is unclear.To characterize the natural history of recovery of daily function following mTBI vs peripheral

2019 JAMA neurology

114. Post-traumatic stress disorder in UK civilians with traumatic brain injury: an observational study of TBI clinic attendees to estimate PTSD prevalence and its relationship with radiological markers of brain injury severity. Full Text available with Trip Pro

Post-traumatic stress disorder in UK civilians with traumatic brain injury: an observational study of TBI clinic attendees to estimate PTSD prevalence and its relationship with radiological markers of brain injury severity. To estimate the prevalence of post-traumatic stress disorder (PTSD) in a large civilian population with traumatic brain injury (TBI), and to assess whether brain injury severity is correlated with PTSD symptoms.Observational, cross-sectional study.Outpatient clinic (...) this, the prevalence of PTSD was estimated in our cohort. Postresuscitation Glasgow Coma Score and Marshall grade on CT brain scan were recorded as indicators of brain injury severity. A hierarchical regression explored whether TBI severity may predict PTSD scores.A high prevalence of PTSD was estimated (21% with PCL-C score >50). Higher Marshall grading displayed a slight negative correlation with PTSD symptoms. This statistically significant relationship persisted after confounding factors such as depression

2019 BMJ open

115. The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury, Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial. (Abstract)

The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury, Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial. To estimate the impact of goal-directed therapy on outcome after traumatic brain injury, our team applied goal-directed therapy to standardize care in patients with moderate to severe traumatic brain injury, who were enrolled in a large multicenter clinical trial.Planned secondary analysis of data from (...) Progesterone for the Treatment of Traumatic Brain Injury III, a large, prospective, multicenter clinical trial.Forty-two trauma centers within the Neurologic Emergencies Treatment Trials network.Eight-hundred eighty-two patients were enrolled within 4 hours of injury after nonpenetrating traumatic brain injury characterized by Glasgow Coma Scale score of 4-12.Physiologic goals were defined a priori in order to standardize care across 42 sites participating in Progesterone for the Treatment of Traumatic

2019 Critical Care Medicine

116. Head injury on Warfarin: likelihood of delayed intracranial bleeding in patients with negative initial head CT Full Text available with Trip Pro

Head injury on Warfarin: likelihood of delayed intracranial bleeding in patients with negative initial head CT To determine the likelihood that head injured patients on Warfarin with a negative initial head CT will have a positive repeat head CT. A retrospective chart review of our institution's trauma registry was performed for all patients admitted for blunt head trauma and on Warfarin anti-coagulation from January 2009 to April 2014. Inclusion criteria included patients over 18 years of age (...) with initial GCS ≥ 13, INR greater than 1.5 and negative initial head CT. Initial CT findings, repeat CT findings and INR were recorded. Interventions performed on patients with a delayed bleed were also investigated.394 patients met the study inclusion criteria. 121 (31%) of these patients did not receive a second CT while 273 patients (69%) underwent a second CT. The mean INR was 2.74. Six patients developed a delayed bleed, of which two were clinically significant. No patients had any neurosurgical

2018 BMC research notes

117. Head and Neck Injuries from Rock Climbing: A Query of the National Electronic Injury Surveillance System. (Abstract)

(OR 6.6), intracranial hemorrhage (OR 951.8), skull fracture (OR 81.2), and hospitalization (OR 3.8). Injuries associated with hospitalization included facial fracture (OR 23.7), cervical spine fracture (OR 24.6), intracranial hemorrhage (OR 2210.2), and skull fracture (OR 9.8).Concussions and facial lacerations are the most common head and neck injuries from rock climbing. Males more commonly suffer severe injuries. Falls over 20 ft are associated with more severe injuries and an increased likelihood (...) the years 2009 to 2018. Demographics, injury characteristics, and disposition data were reviewed. Data were evaluated using chi-square analysis with Cochran-Mantel-Haenszal odds ratios (ORs).An estimated 5067 patients (from 129 raw NEISS case numbers) suffered head and neck injuries from rock climbing nationally from 2009 to 2018. Concussion/closed head injury was the most common injury (44%), followed by laceration (23%), soft tissue injury (15%), neck strain/sprain (6%), skull fracture (3%), facial

2020 Rhinology and Laryngology

118. Association of cause of injury and traumatic axonal injury: a clinical MRI study of moderate and severe traumatic brain injury. Full Text available with Trip Pro

Association of cause of injury and traumatic axonal injury: a clinical MRI study of moderate and severe traumatic brain injury. The authors investigated the association between the cause of injury and the occurrence and grade of traumatic axonal injury (TAI) on clinical MRI in patients with moderate or severe traumatic brain injury (TBI).Data for a total of 396 consecutive patients, aged 7-70 years, with moderate or severe TBI admitted to a level 1 trauma center were prospectively registered (...) , hemispheric/cerebellar white matter (grade 1), corpus callosum (grade 2), and brainstem (grade 3). The absence of TAI was analyzed as grade 0. Contusions and mass lesions on CT were also registered.Cause of injury did not differ between included and nonincluded patients. TAI was found in 83% of patients in the included group after RTAs and 62% after falls (p < 0.001). Observed TAI grades differed between the subcategories of both RTAs (p = 0.004) and falls (p = 0.006). Pedestrians in RTAs, car drivers

2019 Journal of Neurosurgery

119. Lack of Health Insurance Associated With Lower Probability of Head Computed Tomography Among United States Traumatic Brain Injury Patients. (Abstract)

Lack of Health Insurance Associated With Lower Probability of Head Computed Tomography Among United States Traumatic Brain Injury Patients. Uninsured traumatic brain injury (TBI) patients have higher mortality than their insured counterparts. One possible reason is disparities in receipt of appropriate diagnostic imaging.Examine the association between lack of insurance and use of diagnostic imaging.This is a retrospective cohort study.All adult patients admitted with severe (AIS>4 and GCS<15 (...) ) TBI, in the National Trauma Data Bank 2010-2015.Primary outcome was receipt of head computed tomography (CT) and number of CT scans received. Secondary outcomes included head x-ray, angiography, or magnetic resonance imaging. Patients were classified as uninsured if their payment method was self-pay or not billed.Of 59,540 patients meeting inclusion criteria, 18.9% were uninsured. After adjusting for demographic, clinical, and facility characteristics, compared with patients with any insurance

2018 Medical Care

120. modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury Full Text available with Trip Pro

modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation. We report a tunable, monitored model of murine non-surgical, diffuse closed-head injury-modCHIMERA-characterized by impact as well as linear and rotational acceleration. modCHIMERA is based on the Closed-Head Impact Model of Engineered Rotational Acceleration (...) (CHIMERA) platform. We tested this model at 2 energy levels: 1.7 and 2.1 Joules-substantially higher than previously reported for this system. Kinematic analysis demonstrated linear acceleration exceeding injury thresholds in humans, although outcome metrics tracked impact energy more closely than kinematic parameters. Acute severity metrics were consistent with a complicated-mild or moderate TBI, a clinical population characterized by high morbidity but potentially reversible pathology. Axonal injury

2018 Scientific reports

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