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81. Case-control study: Height of head centre of gravity predicts paediatric head injury severity in short-distance falls

Case-control study: Height of head centre of gravity predicts paediatric head injury severity in short-distance falls Height of head centre of gravity predicts paediatric head injury severity in short-distance falls | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Height of head centre of gravity predicts paediatric head injury severity in short-distance falls Article Text Prognosis Case-control study Height of head centre of gravity

2017 Evidence-Based Medicine

82. Normobaric hyperoxia does not improve derangements in diffusion tensor imaging found distant from visible contusions following acute traumatic brain injury Full Text available with Trip Pro

Normobaric hyperoxia does not improve derangements in diffusion tensor imaging found distant from visible contusions following acute traumatic brain injury We have previously shown that normobaric hyperoxia may benefit peri-lesional brain and white matter following traumatic brain injury (TBI). This study examined the impact of brief exposure to hyperoxia using diffusion tensor imaging (DTI) to identify axonal injury distant from contusions. Fourteen patients with acute moderate/severe TBI

2017 Scientific reports

83. Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury. Full Text available with Trip Pro

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury. Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have had limited success and muscle-related pathology remains a clinical priority. mTOR signaling is known to play a critical role in skeletal muscle

2018 PLoS ONE

84. [Clinical practice guidelines for the rehabilitation of adults having sustained a moderate to severe traumatic brain injury: development process and recommendations]

[Clinical practice guidelines for the rehabilitation of adults having sustained a moderate to severe traumatic brain injury: development process and recommendations] Guide de pratique clinique pour la réadaptation des adultes ayant subi un traumatisme craniocérébral modéré-grave [Clinical practice guidelines for the rehabilitation of adults having sustained a moderate to severe traumatic brain injury: development process and recommendations] Guide de pratique clinique pour la réadaptation des (...) adultes ayant subi un traumatisme craniocérébral modéré-grave [Clinical practice guidelines for the rehabilitation of adults having sustained a moderate to severe traumatic brain injury: development process and recommendations] Truchon C Citation Truchon C. Guide de pratique clinique pour la réadaptation des adultes ayant subi un traumatisme craniocérébral modéré-grave. [Clinical practice guidelines for the rehabilitation of adults having sustained a moderate to severe traumatic brain injury

2017 Health Technology Assessment (HTA) Database.

85. Head Injury and patients on Anticoagulation/Antiplatelet Therapies

have their anticoagulant therapy reversed. A summary of recommendations for reversal of antithrombotic agents in patients with intracranial haemorrhage were identified and reported. 1 Objective B: What is the optimal timing and frequency of CT brain scans in the period following the minor head trauma (eg fall) to ensure that intracranial bleeding has not occurred? Identified evidence suggests that an initial head CT scan should be performed on all head injury patients when they present. 2, 3, 5-9 (...) in patients with intracranial haemorrhage: Vitamin K Antagonists, Direct Thrombin Inhibitor, Unfractionated Heparin, Low Molecular Weight Heparin, Pentasccharide, Thrombolytic agents, Antiplatelet agents. Head Injury and patients on anticoagulant or antiplatelet therapy 4 Decision B: What is the optimal timing and frequency of CT brain scans in the period following the minor head trauma (e.g. fall) to ensure that intracranial bleeding has not occurred? Identified evidence suggests that an initial head CT

2017 Monash Health Evidence Reviews

86. Sirens to Scrubs: Minor Head Injury

-hospital management of isolated minor head injury Introduce the Canadian CT Head Rule as a guide for decision-making in minor head injury Discuss return-to-activity guidelines for patients with concussions What pre-hospital treatments may be considered for Judy? Spinal motion restriction Although spinal cord injury is always considered in patients who have fallen and/or struck their head, Judy is an otherwise healthy patient who suffered a simple mechanical fall from standing and has no obvious (...) that she is at low risk for significant brain injury, and a CT scan would not be beneficial for Judy. She is diagnosed with a mild traumatic brain injury, or a concussion, and discharged home. What advice will the physician give Judy about post-concussion recovery? Regardless of the patient’s daily vocation, they should be advised to avoid participating in any activities that put them at risk for another concussion while recovering, especially in the first 7 to 10d after injury. Return-to-work

2018 CandiEM

87. Head Injury: minor, minimal or trivial. The difference matters!

J. Validation of the Scandinavian guidelines for initial management of minimal, mild and moderate traumatic brain injury in adults. BMC Med . 2015;13:292. [ ] 7. Sharp A, Huang B, Tang T, et al. Implementation of the Canadian CT Head Rule and Its Association With Use of Computed Tomography Among Patients With Head Injury. Ann Emerg Med . 2018;71(1):54-63.e2. [ ] 8. Easter J, Haukoos J, Claud J, et al. Traumatic intracranial injury in intoxicated patients with minor head trauma. Acad Emerg Med (...) , and this likely is secondary to a lack of appreciation regarding decision making. Here, we seek to dissect some of the nuances. The vast majority of literature examining the utilization of imaging in patients with head injury is focused on patients with minor head injury 1 . Minor head injury is defined as a loss of consciousness, definite amnesia or witnessed disorientation in patients with a GCS 13-15. In all cases of head trauma, it is the role of the ED physician to rule out intracranial pathology

2018 CandiEM

88. Association of Statewide Implementation of the Prehospital Traumatic Brain Injury Treatment Guidelines With Patient Survival Following Traumatic Brain Injury: The Excellence in Prehospital Injury Care (EPIC) Study. Full Text available with Trip Pro

Association of Statewide Implementation of the Prehospital Traumatic Brain Injury Treatment Guidelines With Patient Survival Following Traumatic Brain Injury: The Excellence in Prehospital Injury Care (EPIC) Study. Traumatic brain injury (TBI) is a massive public health problem. While evidence-based guidelines directing the prehospital treatment of TBI have been promulgated, to our knowledge, no studies have assessed their association with survival.To evaluate the association of implementing (...) ; P < .001) for survival to hospital admission. Among the severe injury cohorts (but not moderate or critical), guideline implementation was significantly associated with survival to discharge (Regional Severity Score-Head 3-4: aOR, 2.03; 95% CI, 1.52-2.72; P < .001; Injury Severity Score 16-24: aOR, 1.61; 95% CI, 1.07-2.48; P = .02). This was also true for survival to discharge among the severe, intubated subgroups (Regional Severity Score-Head 3-4: aOR, 3.14; 95% CI, 1.65-5.98; P < .001; Injury

2019 JAMA surgery

89. rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head

rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head (TOPiCS-rTMS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03691272 Recruitment Status : Active

2018 Clinical Trials

90. Bilateral medial rectus palsy due to midbrain infarction following concussion head injury Full Text available with Trip Pro

Bilateral medial rectus palsy due to midbrain infarction following concussion head injury Here, we report a rare case of bilateral medial rectus palsy following closed head injury. An adult male had an accidental fall which rendered him unconscious. This was followed by diplopia and restricted ocular motility. He received supportive medical therapy. He was examined for systemic medical and ophthalmic findings. Routine laboratory tests and imaging techniques were employed as per the symptoms

2018 Indian journal of ophthalmology

91. Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type Full Text available with Trip Pro

Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type Microglial activation is a pathological hallmark of traumatic brain injury (TBI). Following brain injury, activated microglia/macrophages adopt different phenotypes, generally categorized as M-1, or classically activated, and M-2, or alternatively activated. While the M-1, or pro-inflammatory phenotype is detrimental to recovery, M-2, or the anti-inflammatory phenotype, aids in brain (...) repair. Recent findings also suggest the existence of mixed phenotype following brain injury, where activated microglia simultaneously express both M-1 and M-2 markers. The present study sought to determine microglial activation states at early time points (6-72 h) following single or repeated concussive injury in rats. Closed-head concussive injury was modeled in rats using projectile concussive impact injury, with either single or repeated impacts (4 impacts, 1 h apart). Brain samples were examined

2018 Frontiers in neurology

92. Adapting the Canadian CT head rule age criteria for mild traumatic brain injury. (Abstract)

Adapting the Canadian CT head rule age criteria for mild traumatic brain injury. With the ageing population, the prevalence of mild traumatic brain injury (mTBI) among older patients is increasing, and the age criteria of the Canadian CT head rule (CCHR) is challenged by many emergency physicians. We modified the age criteria of the CCHR to evaluate its predictive capacity.We conducted a retrospective cohort study at a level 1 trauma centre ED of all mTBI patients 65 years old and over (...) with an mTBI between 2010 and 2014. Main outcome was a clinically important brain injury (CIBI) reported on CT. The clinical and radiological data collection was standardised. Univariate analyses were performed to measure the predictive capacities of different age cut-offs at 70, 75 and 80 years old.104 confirmed mTBI were included; CT scan identified 32 (30.8%) CIBI. Sensitivity and specificity (95% CI) of the CCHR were 100% (89.1 to 100) and 4.2% (0.9 to 11.7) for a modified criteria of 70 years old; 100

2019 Emergency Medicine Journal

93. Trauma Bay Disposition of Infants and Young Children With Mild Traumatic Brain Injury and Positive Head Imaging. Full Text available with Trip Pro

Trauma Bay Disposition of Infants and Young Children With Mild Traumatic Brain Injury and Positive Head Imaging. To describe the disposition of infants and young children with isolated mild traumatic brain injury and neuroimaging findings evaluated at a level 1 pediatric trauma center, and identify factors associated with their need for ICU admission.Retrospective cohort.Single center.Children less than or equal to 4 years old with mild traumatic brain injury (Glasgow Coma Scale 13-15 (...) ) and neuroimaging findings evaluated between January 1, 2013, and December 31, 2015. Polytrauma victims and patients requiring intubation or vasoactive infusions preadmission were excluded.None.Two-hundred ten children (median age/weight/Glasgow Coma Scale: 6 mo/7.5 kg/15) met inclusion criteria. Most neuroimaging showed skull fractures with extra-axial hemorrhage/no midline shift (30%), nondisplaced skull fractures (28%), and intracranial hemorrhage without fractures/midline shift (19%). Trauma bay disposition

2019 Pediatric Critical Care Medicine

94. Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial. Full Text available with Trip Pro

Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial. Reconfiguration of trauma services, with direct transport of patients with traumatic brain injury (TBI) to specialist neuroscience centres (SNCs)-bypassing non-specialist acute hospitals (NSAHs), could improve outcomes. However, delays in stabilisation of airway (...) , breathing and circulation (ABC) may worsen outcomes when compared with selective secondary transfer from nearest NSAH to SNC. We conducted a pilot cluster randomised controlled trial to determine the feasibility and plausibility of bypassing suspected patients with TBI -directly into SNCs-producing a measurable effect.Two English Ambulance Services.74 clusters (ambulance stations) were randomised within pairs after matching for important characteristics. Clusters enrolled head-injured adults-injured

2017 BMJ open Controlled trial quality: predicted high

95. Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial Full Text available with Trip Pro

Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S (...) Permalink Copy Page navigation World J Surg Actions . 2020 Jan 30. doi: 10.1007/s00268-020-05391-8. Online ahead of print. Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial , , , , , , , , , Affiliations Expand Affiliations 1 Department of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Department of Surgery, Karolinska University Hospital, Stockholm, Sweden. 3 School

2020 EvidenceUpdates

96. Tranexamic acid is safe to use following mild-to-moderate traumatic brain injury. (Abstract)

Tranexamic acid is safe to use following mild-to-moderate traumatic brain injury. The studyThe CRASH-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.Lancet 2019;394:1713-23.This trial was funded by NIHR Health Technology Assessment Programme (project number 14/190/01), JP Moulton Charitable Trust, Department of Health and Social (...) Care, Department for International Development, Global Challenges Research Fund, Medical Research Council, and the Wellcome Trust (Joint Global Health Trials scheme).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000870/tranexamic-acid-following-mild-to-moderate-traumatic-brain-injury-is-safe-and-reduces-deaths.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group

2020 BMJ

97. Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity Full Text available with Trip Pro

Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity Bone contusions are frequently encountered in magnetic resonance imaging (MRI) evaluation of knee anterior cruciate ligament (ACL) injuries. Their role as indicators of injury severity remains unclear, primarily due to indeterminate levels of joint injury forces and to a lack of preinjury imaging.The purpose of this study was to 1) quantify bone contusion pathogenesis (...) following traumatic joint injuries using fixed imaging follow-ups, and 2) assess the feasibility of using longitudinal bone contusion volumes as an indicator of knee injury severity.Prospective sequential MRI follow-ups of a goat cohort exposed to controlled stifle trauma in vivo were compared to parallel clinical MRI follow-ups of a human ACL tear patient series.Reproducible cartilage impact damage of various energy magnitudes was applied in a survival goat model, coupled with partial resection

2017 Open access journal of sports medicine

98. Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury. Full Text available with Trip Pro

Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury. Brain activation in response to spoken motor commands can be detected by electroencephalography (EEG) in clinically unresponsive patients. The prevalence and prognostic importance of a dissociation between commanded motor behavior and brain activation in the first few days after brain injury are not well understood.We studied a prospective, consecutive series of patients in a single intensive care unit who had acute (...) brain injury from a variety of causes and who were unresponsive to spoken commands, including some patients with the ability to localize painful stimuli or to fixate on or track visual stimuli. Machine learning was applied to EEG recordings to detect brain activation in response to commands that patients move their hands. The functional outcome at 12 months was determined with the Glasgow Outcome Scale-Extended (GOS-E; levels range from 1 to 8, with higher levels indicating better outcomes).A total

2019 NEJM

99. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury

Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury | Murdoch Children's Research Institute Search form Search Search You are here Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury for the management (...) of communication and swallowing disorders following paediatric traumatic brain injury. Traumatic brain injury (TBI) is a leading cause of disability, affecting approximately 765 to 2008 per 100 000 Australian children each year. Its effects are vast and include speech, language and swallowing disorders. To ensure a standard, best-evidence approach to the clinical care of children with communication and swallowing disorders following moderate or severe TBI, a multidisciplinary guideline committee has developed

2017 Clinical Practice Guidelines Portal

100. Beta Blockers After Traumatic Brain Injury

Beta Blockers After Traumatic Brain Injury Beta-blockers and Traumatic Brain Injury: A Systematic Revie... : Annals of Surgery You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account Registered users can save articles, searches, and manage email alerts. All (...) and Traumatic Brain Injury: A Systematic Revie... If you're not a subscriber, you can: You can read the full text of this article if you: Institutional members Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Annals of Surgery. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your

2017 Eastern Association for the Surgery of Trauma

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