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brain injury or concussion or head injury

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61. In Reply to the Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial". (Abstract)

In Reply to the Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial". 28847125 2017 09 14 2018 12 02 1878-8769 105 2017 09 World neurosurgery World Neurosurg In Reply to the Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate (...) Department, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Heydari Seyed Taghi ST Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. eng Letter Comment United States World Neurosurg 101528275 1878-8750 SX6K58TVWC Glyburide IM World Neurosurg. 2017 Sep;105:1020 28847124 Brain Contusion Brain Injuries Brain Injuries, Traumatic Contusions Double-Blind Method Glyburide Humans Treatment

2017 World neurosurgery Controlled trial quality: uncertain

62. Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial". (Abstract)

Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial". 28847124 2017 09 14 2018 12 02 1878-8769 105 2017 09 World neurosurgery World Neurosurg Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries (...) 28185976 World Neurosurg. 2017 Sep;105:1021 28847125 Brain Contusion Brain Injuries Brain Injuries, Traumatic Contusions Double-Blind Method Glyburide Humans Treatment Outcome 2017 06 03 2017 06 05 2017 8 30 6 0 2017 8 30 6 0 2017 9 15 6 0 ppublish 28847124 S1878-8750(17)30926-9 10.1016/j.wneu.2017.06.034

2017 World neurosurgery Controlled trial quality: predicted high

63. RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients Full Text available with Trip Pro

RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients Traumatic brain injury (TBI) causes activation of several neurochemical and physiological cascades, leading to neurological impairment. We aimed to investigate the level of novel chemokine RANTES in plasma, cerebrospinal fluid (CSF) and contused brain tissue in traumatic brain injury patients and to correlate the expression of this chemokine with the severity of head (...) injury and neurological outcome.This longitudinal case control study was performed on 70 TBI patients over a period of 30 months. Glasgow coma scale (GCS) and Glasgow outcome score were used to assess the severity of head injury and clinical outcome. Level of RANTES was quantified in plasma (n = 60), CSF (N = 10) and contused brain tissue (n = 5). Alterations in the plasma levels on 1st and 5th day following TBI were assessed. Patients were categorized as severe (GCS < 8) (SHI), moderate and mild

2017 BMC research notes

64. Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injury; A Randomized Double-Blind Placebo-Controlled Clinical Trial. (Abstract)

difference between the 2 groups regarding functional outcome measured by Glasgow Outcome Scale, modified Rankin Scale, and Disability Rating Scale.Oral glibenclamide is associated with decreased contusion expansion rate in patients with moderate and severe traumatic brain injuries sustaining cerebral contusions.Copyright © 2017 Elsevier Inc. All rights reserved. (...) Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injury; A Randomized Double-Blind Placebo-Controlled Clinical Trial. This study investigated effects of oral glibenclamide on brain contusion volume and functional outcome of patients with moderate and severe traumatic brain injuries.A randomized clinical trial including 66 patients with moderate (Glasgow Coma Scale score 9-12) to severe (Glasgow Coma Scale score 5

2017 World neurosurgery Controlled trial quality: predicted high

65. Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study. (Abstract)

Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study. The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) study, sponsored by the Department of Defense and held under an investigational new drug application by the Office of the Army Surgeon General, is one of the largest (...) and most complex clinical trials of hyperbaric oxygen (HBO₂) for post-concussive symptoms (PCS) in U.S. military service members.Copyright© Undersea and Hyperbaric Medical Society.

2017 Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc Controlled trial quality: uncertain

66. Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients

Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

67. Therapeutic hypothermia for intacranial hypertension following traumatic brain injury

cerebral perfusion pressure, the fundamental therapeutic goals after TBI. 2 Traumatic brain injury may be caused by a variety of mechanisms. Aetiology of TBI includes traffic accidents, falls, gunshot wounds, sports, combat events and other violence-related Hypothermia for intracranial hypertension: December 2016 2 incidents. 3, 4 TBI ranges in severity from mild to severe, and in addition to short-term impairment, those who sustain TBI often suffer from persistent symptoms. Symptoms may be lifelong (...) degrees C hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury'. J Trauma, 66 (1), 166-73. 18. NSW Ministry of Health (2011). Initial Management of Closed Head Injury in Adults: Adult Trauma Clinical Practice Guidelines, NSW Ministry of Health, Sydney, NSW 19. Colorado Division of Workers' Compensation (2012). Traumatic brain injury medical treatment guidelines, Colorado Division of Workers' Compensation, Denver, CO

2018 COAG Health Council - Horizon Scanning Technology Briefs

68. Hyperbaric Oxygen Therapy for Traumatic Brain Injury and/or PTSD

Hyperbaric Oxygen Therapy for Traumatic Brain Injury and/or PTSD Management Briefs eBrief-no143 -- Hyperbaric Oxygen Therapy for TBI and PTSD Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs eBrief-no143 -- Hyperbaric Oxygen Therapy for TBI and PTSD Health Services Research & Development Management eBrief no. 143 » Issue 143 April 2018 The report is a product of the VA/HSR&D Evidence (...) Synthesis Program. Evidence Brief: Hyperbaric Oxygen Therapy for Traumatic Brain Injury and/or PTSD Following certain types of injuries, our bodies may demand more oxygen than is available in the normal air we breathe to supply our cells with the fuel necessary for healing processes (i.e., metabolism, cellular growth and repair). Hyperbaric oxygen therapy (HBOT) is designed to increase the supply of oxygen to our blood and tissues. In normal air, the oxygen level is only around 21%; HBOT delivers 100

2018 Veterans Affairs - R&D

69. Management of Perceived Devastating Brain Injury After Hospital Admission

of DBI is not dependent on the underlying diagnosis. It can be used in patients with any primarily neurological diagnosis, most commonly traumatic brain injury, subarachnoid haemorrhage, intra-cerebral haemorrhage, stroke and hypoxic brain injury from a range of causes. The early limitation or WLST is usually considered in DBI because the presenting neurological insult is not thought to be compatible with survival and not amenable to active intervention. In practice this usually means that a short (...) therapies in patients with devastating brain injuries. Journal of the Intensive Care Society 2016;:1–7. 2. Chamoun RB, Robertson CS, Gopinath SP . Outcome in patients with blunt head trauma and a Glasgow Coma Scale score of 3 at presentation. Journal of Neurosurgery 2009;111(4):683–7. 3. Souter MJ, Blissitt PA, Blosser S, et al. Recommendations for the Critical Care Management of Devastating Brain Injury: Prognostication, Psychosocial, and Ethical Management. Neurocrit Care 2015;23(1):4–13. 4. Manara AR

2018 Faculty of Intensive Care Medicine

70. Intensive care for pediatric traumatic brain injury

Intensive care for pediatric traumatic brain injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

71. Functional Status Scale in Children With Traumatic Brain Injury: A Prospective Cohort Study

Functional Status Scale in Children With Traumatic Brain Injury: A Prospective Cohort Study PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

72. Derivation of a Predictive Score for Hemorrhagic Progression of Cerebral Contusions in Moderate and Severe Traumatic Brain Injury Full Text available with Trip Pro

Derivation of a Predictive Score for Hemorrhagic Progression of Cerebral Contusions in Moderate and Severe Traumatic Brain Injury After traumatic brain injury (TBI), hemorrhagic progression of contusions (HPCs) occurs frequently. However, there is no established predictive score to identify high-risk patients for HPC.Consecutive patients who were hospitalized (2008-2013) with non-penetrating moderate or severe TBI were studied. The primary outcome was HPC, defined by both a relative increase (...) contusion, larger contusion volume, and shorter interval from injury to initial CT. In the final model, SAH (OR 6.33, 95 % CI, 1.80-22.23), SDH (OR 3.46, 95 % CI, 1.39-8.63), and skull fracture (OR 2.67, 95 % CI, 1.28-5.58) were associated with HPC. Based on these factors, the HPC Score was derived (SAH = 2 points, SDH = 1 point, and skull fracture = 1 point). This score had an area under the receiver operating curve of 0.77. Patients with a score of 0-2 had a 4.0 % incidence of HPC, while patients

2017 Neurocritical care

73. Integration of Biomarkers Into a Signature Profile of Persistent Traumatic Brain Injury Involving Autoimmune Processes Following Water Hammer Injury From Repetitive Head Impacts Full Text available with Trip Pro

Integration of Biomarkers Into a Signature Profile of Persistent Traumatic Brain Injury Involving Autoimmune Processes Following Water Hammer Injury From Repetitive Head Impacts To assemble an algorithm that will describe a "Signature" predictive of an individual's vulnerability to persistent traumatic brain injury (TBI).Studies of athletes and warriors who are subjected to repeated head impacts with rapid acceleration/deceleration forces are used to assist in the diagnosis and management (...) of the sulci via a "water hammer effect" is consistent with the localization of microvascular and inflammatory responses in the affected brain region.An assessment of an individuals' predisposition to persistent TBI with delayed cognitive deficits and behavioral changes requires an understanding of host vulnerability (genetic factors and brain structure) and external stressors (force and torque of impact as well as repetitive head injury and time interval between impacts). An algorithm that has utility

2018 Biomarker insights

74. Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls. (Abstract)

Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls. In this exploratory, double-blind, longitudinal sham-controlled trial of hyperbaric oxygen (HBO2) for military personnel with post concussive mild traumatic brain injury (mTBI), self-reports and objective measures of sleep-wake disturbances were assessed and compared to normals.Self-reports consisting of Pittsburg Sleep Quality Index (...) was defined as consisting of head injury associated loss of consciousness (<24 h), post-traumatic amnesia, and neurological deficits.Sleep quality by self-reports was markedly degraded in the mTBI group at baseline compared to a normative cohort; insomnia 87.3 versus 2.8%, OSA risk 70% versus 1.3%, RLS 32.4% versus and 2.7%. (all p-values <0.001), but actigraphy measures did not differentiate between groups. HBO2 compared to sham treatment improved self-reports of PSQI sleep measures, reports (five out

2018 Sleep medicine Controlled trial quality: uncertain

75. Single cell molecular alterations reveal target cells and pathways of concussive brain injury Full Text available with Trip Pro

Single cell molecular alterations reveal target cells and pathways of concussive brain injury The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the convoluted cytoarchitecture of affected brain regions such as the hippocampus. Hippocampal dysfunction during TBI results in cognitive decline that may escalate to other neurological disorders, the molecular basis of which is hidden in the genomic programs of individual cells. Using the unbiased single cell (...) sequencing method Drop-seq, we report that concussive TBI affects previously undefined cell populations, in addition to classical hippocampal cell types. TBI also impacts cell type-specific genes and pathways and alters gene co-expression across cell types, suggesting hidden pathogenic mechanisms and therapeutic target pathways. Modulating the thyroid hormone pathway as informed by the T4 transporter transthyretin Ttr mitigates TBI-associated genomic and behavioral abnormalities. Thus, single cell

2018 Nature communications

76. Emotional reserve and prolonged post-concussive symptoms and disability: a Swedish prospective 1-year mild traumatic brain injury cohort study. Full Text available with Trip Pro

Emotional reserve and prolonged post-concussive symptoms and disability: a Swedish prospective 1-year mild traumatic brain injury cohort study. Prolonged post-concussive symptoms (PCS) affect a significant minority of patients withmild traumatic brain injury (mTBI). The aetiology is multifactorial depending on preinjury as well as peri-injury and postinjury factors. In this study, we examine outcome from an emotional reserve perspective.Prospective cohort study.Patients were recruited from (...) previous significant head injury.Recruitment in three emergency departments. Initial assessments were made within 1 week after the injury. Patients were mailed the follow-up questionnaires 1 year postinjury.A psychiatric assessment was performed at 1 week post injury. The participants also completed a personality inventory, measures of psychological resilience, depression, anxiety and post-traumatic symptoms. One-year outcome was measured by the Rivermead Post Concussion Symptoms and the Rivermead Head

2018 BMJ open

77. Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion. Full Text available with Trip Pro

Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion. Growth hormone deficiency (GHD) is a potential consequence of traumatic brain injury (TBI), including sport-related concussion (SRC). GH stimulation testing is required for definitive diagnosis; however, this is resource intensive and can be associated with adverse symptoms or risks. Measurement of serum IGF-1 is more practical and accessible, and pituitary tumour (...) stimulation results. IGF-1 values were used to calculate z-scores per age and gender specific reference ranges. Receiver operator curve analysis was performed to evaluate diagnostic threshold of IGF-1 z-score for determining GHD by GST or ITT.Sixty four patient charts were reviewed. 48 patients had mild, six had moderate, eight had severe TBI, and two had non-traumatic brain injuries. 47 patients underwent ITT or GST. 27 were confirmed to have GHD (peak hGH < 5 μg/L). IGF-1 level was within the age

2018 BMC Endocrine Disorders

78. The association between post-concussion symptoms and health-related quality of life in patients with mild traumatic brain injury. (Abstract)

The association between post-concussion symptoms and health-related quality of life in patients with mild traumatic brain injury. A subset of mild traumatic brain injury (mTBI) patients experience post-concussion symptoms. When a cluster of post-concussion symptoms persists for over three months, it is referred to as post-concussion syndrome (PCS). Little is known about the association between PCS and Health-Related Quality of Life (HRQoL) after mTBI. The aims of this study were to assess (...) the implications of PCS on HRQoL six months after mTBI and the relationship between PCS and HRQoL domains. A prospective observational cohort study was conducted among a sample of mTBI patients. Follow-up postal questionnaires at six months after emergency department (ED) admission included socio-demographic information, the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), and HRQoL measured with the 36-item Short-Form Health Survey (SF-36) and the Perceived Quality of Life Scale (PQoL). In total, 731

2018 Injury

79. Is eye tracking useful in the evaluation of concussion/mild traumatic brain injury?

Is eye tracking useful in the evaluation of concussion/mild traumatic brain injury? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2020 PROSPERO

80. Scientific Rigor and Efficacy in Randomized Controlled Trials of Therapeutic Interventions for Concussive Traumatic Brain Injury Symptoms: A Protocol for a Systematic Review

Scientific Rigor and Efficacy in Randomized Controlled Trials of Therapeutic Interventions for Concussive Traumatic Brain Injury Symptoms: A Protocol for a Systematic Review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2020 PROSPERO

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