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brain injury or concussion or head injury

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181. Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Full Text available with Trip Pro

Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients following head trauma that have previously been considered a marker of axonal injury. The linear appearance and location of some traumatic microbleeds suggests a vascular origin. The aims of this study were to: (i) identify and characterize traumatic microbleeds in patients with acute traumatic brain injury (...) ; (ii) determine whether appearance of traumatic microbleeds predict clinical outcome; and (iii) describe the pathology underlying traumatic microbleeds in an index patient. Patients presenting to the emergency department following acute head trauma who received a head CT were enrolled within 48 h of injury and received a research MRI. Disability was defined using Glasgow Outcome Scale-Extended ≤6 at follow-up. All magnetic resonance images were interpreted prospectively and were used for subsequent

2019 Brain

182. Prospective evaluation of the Quality of Life after Brain Injury (QOLIBRI) score: minor differences in patients with major versus no or mild traumatic brain injury at one-year follow up Full Text available with Trip Pro

of the severity of head injury (AIS head) on total QOLIBRI was weaker than that of injured extremities (R2 = 0.02; p < 0.05 vs. R2 = 0.04; p = 0.001) and equal to the QOLIBRI cognitive subscore (R2 = 0.03, p < 0.01 each).Given the unexpected result of similar mean QOLIBRI total score values and only minor differences in cognitive deficits following major trauma independently of whether patients sustained major brain injury or not, further studies should investigate whether the QOLIBRI actually has (...) Prospective evaluation of the Quality of Life after Brain Injury (QOLIBRI) score: minor differences in patients with major versus no or mild traumatic brain injury at one-year follow up The Quality of Life after Brain Injury (QOLIBRI) score was developed to assess disease-specific health-related quality of life (HRQoL) after traumatic brain injury (TBI). So far, validation studies on the QOLIBRI were only conducted in cohorts with traumatic brain injury. This study investigated the longer-term

2018 Health and quality of life outcomes

183. Predicting Long-Term Global Outcome after Traumatic Brain Injury: Development of a Practical Prognostic Tool Using the Traumatic Brain Injury Model Systems National Database Full Text available with Trip Pro

Predicting Long-Term Global Outcome after Traumatic Brain Injury: Development of a Practical Prognostic Tool Using the Traumatic Brain Injury Model Systems National Database For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Outcome (...) ), and 6,165 (year-5) after cross-sectional exclusions (death, vegetative state, insufficient post-injury time, and unavailable outcome). In our final models, post-traumatic amnesia (PTA) duration consistently dominated branching hierarchy and was the lone injury characteristic significantly contributing to GOS predictability. Lower-order variables that added predictability were age, pre-morbid education, productivity, and occupational category. Generally, patient outcomes improved with shorter PTA

2018 Journal of neurotrauma

184. Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) st Full Text available with Trip Pro

Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) st General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation (...) in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers.We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. We analyzed 23 questions focused on: 1) circulatory and respiratory management; 2) fever control; 3) use of corticosteroids; 4) nutrition and glucose management; and 5) seizure prophylaxis and treatment.The survey was completed predominantly by intensivists (n

2018 Critical Care

185. Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling Full Text available with Trip Pro

Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling Neuroinflammation plays an important role in secondary injury after traumatic brain injury (TBI). Andrographolide (Andro), a diterpenoid lactone isolated from Andrographis paniculata, has been demonstrated to exhibit anti-inflammatory activity in neurodegenerative disorders. This study therefore aimed to investigate the potential neuroprotective effects of Andro (...) were conducted to detect the expression levels of pro-inflammatory cytokines, Western blot was used to examine the expression level of proteins of relative signaling pathway. Our results showed that after Andro administration, the neurological deficit was attenuated, and the cerebral edema and apoptosis in brain tissues were also decreased following TBI. Both microglial activation and the expression of pro-inflammatory cytokines were significantly inhibited by Andro after TBI. Moreover, Andro

2018 Frontiers in neuroscience

186. A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection Full Text available with Trip Pro

A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection The gut microbiome and its role in health and disease have recently been major focus areas of research. In this review, we summarize the different ways in which the gut microbiome interacts with the rest of the body, with focus areas on its relationships with immunity, the brain, and injury. The gut⁻brain axis, a communication network (...) linking together the central and enteric nervous systems, represents a key bidirectional pathway with feed-forward and feedback mechanisms. The gut microbiota has a central role in this pathway and is significantly altered following injury, leading to a pro-inflammatory state within the central nervous system (CNS). Herein, we examine traumatic brain injury (TBI) in relation to this axis and explore potential interventions, which may serve as targets for improving clinical outcomes and preventing

2018 Brain sciences

187. LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats Full Text available with Trip Pro

LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats Leucine-rich repeat kinase 2 (LRRK2) is widely expressed in the brain and exerts neurotoxicity in Parkinson's disease. The p38/Drosha signaling activation has been reported to increase cell death under stress. This study was designed to investigate the potential role and mechanism of LRRK2 in secondary brain injury after traumatic brain injury (TBI). A total of 130 male (...) Sprague-Dawley rats were examined using a weight-drop model of TBI. The rats received the specific LRRK2 inhibitor PF-06447475 or LRRK2 pDNA alone or in combination with Drosha pDNA. Real-time PCR, western blot, immunofluorescence, neuronal apoptosis, brain water content, and neurological score analyses were conducted. Our results showed that after TBI, endogenous LRRK2 expression and p38 phosphorylation were increased, whereas Drosha expression was inhibited. Administration of the LRRK2 inhibitor PF

2018 Frontiers in cellular neuroscience

188. Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury Full Text available with Trip Pro

Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a variety of tumors. However, few studies of ANXA7 in TBI have been performed. We here observed how (...) ANXA7 changes after TBI and discuss whether brain injury is associated with the use of ANXA7 antagonist intervention. Experimental Results: 1. After TBI, ANXA7 levels were higher than in the sham group, peaking 24 h after TBI. 2. The use of siA7 was found to reduce the expression of A7 in the injured brain tissue, and also brain edema, BBB damage, cell death, and apoptosis relative to the sham group. Conclusion: ANXA7 promotes the development of secondary brain injury (SBI) after TBI.

2018 Frontiers in neuroscience

189. A Proposed Mechanism for Development of CTE Following Concussive Events: Head Impact, Water Hammer Injury, Neurofilament Release, and Autoimmune Processes Full Text available with Trip Pro

A Proposed Mechanism for Development of CTE Following Concussive Events: Head Impact, Water Hammer Injury, Neurofilament Release, and Autoimmune Processes During the past decade, there has been an increasing interest in early diagnosis and treatment of traumatic brain injuries (TBI) that lead to chronic traumatic encephalopathy (CTE). The subjects involved range from soldiers exposed to concussive injuries from improvised explosive devices (IEDs) to a significant number of athletes involved (...) (Immediate Post-Concussion Assessment and Cognitive Testing), and C3 Logix behavioral and physiological assessment measures. The MRI Studies show several significant findings: first, a marked increase in the width of sulci in the frontal to occipital cortices; second, an appearance of subtle hemorrhagic changes at the base of the sulci; third was a sustained reduction in total brain volume in several soccer players at a developmental time when brain growth is generally seen. Although all of the athletes

2017 Brain sciences

190. A Mechanistic End-to-End Concussion Model That Translates Head Kinematics to Neurologic Injury Full Text available with Trip Pro

A Mechanistic End-to-End Concussion Model That Translates Head Kinematics to Neurologic Injury Past concussion studies have focused on understanding the injury processes occurring on discrete length scales (e.g., tissue-level stresses and strains, cell-level stresses and strains, or injury-induced cellular pathology). A comprehensive approach that connects all length scales and relates measurable macroscopic parameters to neurological outcomes is the first step toward rationally unraveling (...) correlate is obtained by calculating a neurological injury measure (the average reduction in the axonal signal amplitude) over the corpus callosum. By using a neurologically based quantity rather than externally measured head kinematics, the E2E model is able to unify concussion data across a range of exposure conditions and species with greater sensitivity and specificity than correlates based on external measures. In addition, this model quantitatively links injury of the corpus callosum to observed

2017 Frontiers in neurology

191. Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury Full Text available with Trip Pro

Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury 29451222 2018 11 13 1673-5374 13 1 2018 Jan Neural regeneration research Neural Regen Res Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury. 161-162 10.4103/1673-5374.224384 Jang Sung Ho SH Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu (...) Lett. 2010 Aug 30;481(1):51-3 20599587 Brain Inj. 2001 Feb;15(2):99-106 11260760 Am J Phys Med Rehabil. 2016 Mar;95(3):e34-8 26544855 Am J Phys Med Rehabil. 1988 Oct;67(5):211-6 3179011 J Neuropsychiatry Clin Neurosci. 1995 Winter;7(1):103-12 7711480 Arch Phys Med Rehabil. 2008 Dec;89(12 Suppl):S85-91 19081446 Brain Inj. 2014;28(11):1485-8 24960471 Neuroradiology. 2006 Sep;48(9):661-9 16786351 Brain. 2008 Dec;131(Pt 12):3209-21 18952679 AJNR Am J Neuroradiol. 2005 Oct;26(9):2267-74 16219832 Philos

2018 Neural Regeneration Research

192. A case of real spinal cord injury without radiologic abnormality in a pediatric patient with spinal cord concussion Full Text available with Trip Pro

A case of real spinal cord injury without radiologic abnormality in a pediatric patient with spinal cord concussion Real spinal cord injury without radiologic abnormality (SCIWORA) is a rare clinical entity.The patient was a 13-year-old girl whose body was overturned anteriorly after crashing her bicycle into a curb. Following the accident, in which her neck and upper back hit the ground, she could not move due to paralysis. On arrival, she had paresis of the bilateral upper extremities (...) dysesthesia in both forearms. Roentgenography revealed no instability. Her motor weakness completely recovered on the third day after accident and she was diagnosed with spinal cord concussion.The present case study, in which MRI was performed, showed that an immediate improvement was obtained in a patient who experienced real SCIWORA. The importance of not only spinal cord lesions, but also perispinal soft tissue injury on MRI has been emphasized for predicting patient outcomes. Accordingly, immediate

2017 Spinal cord series and cases

193. Impact of the SIGN head injury guidelines and NHS 4-hour emergency target on hospital admissions for head injury in Scotland: an interrupted times series. Full Text available with Trip Pro

intracranial lesions yet safely reducing hospital admissions.This study aims to assess the impact of these guidelines and any effect the national 4-hour ED performance target had on hospital admissions for head injury.All Scottish hospitals between April 1998 and March 2016.Patients admitted to hospital for head injury or traumatic brain injury (TBI) diagnosed by CT imaging identified using administrative Scottish Information Services Division data. There are 275 hospitals in Scotland. In 2015/2016 (...) , there were 571 221 emergency hospital admissions in Scotland.The SIGN head injury guidelines introduced in 2000 and 2009. The 4-hour ED target introduced in 2004.The monthly rate of hospital admissions for head injury and traumatic brain injury.An interrupted time series analysis.The first guideline was associated with a reduction in monthly admissions of 0.14 (95% CI 0.09 to 4.83) per 100 000 population. The 4-hour target was associated with a monthly increase in admissions of 0.13 (95% CI 0.06 to 0.20

2018 BMJ open

194. Magnitude of Severe Head Injury and Its Associated Factors among Head Injury Patients in Gedeo Zone, Southern Ethiopia: A Two-Year Retrospective Study Full Text available with Trip Pro

Magnitude of Severe Head Injury and Its Associated Factors among Head Injury Patients in Gedeo Zone, Southern Ethiopia: A Two-Year Retrospective Study Severe head injury is a major public health threat that is the main cause of morbidity and mortality in all age groups of the world's populations including Ethiopia. In view of this, this study was assessed the severity of head injury and its contributing factors.A Two-year retrospective study was conducted at Dilla University Referral Hospital (...) , from December 2014 to November 2016. All head injury patients admitted to the surgical ward were included. Bivariate and multivariate regression analyses were used to identify factors associated with severity of head injury.A total of 106 eligible head injury patient charts were reviewed. The magnitude of severe head injury was 32.1%. Young populations, mainly males, were the highest risk groups, and road traffic accident was the main cause of severe head injury. In adjusted analysis, age interval

2018 Ethiopian journal of health sciences

195. Head injury patterns in helmeted and non-helmeted cyclists admitted to a London Major Trauma Centre with serious head injury. Full Text available with Trip Pro

injury.Helmet use was shown to be protective against intracranial injury in general (OR 0.2, CI 0.07-0.55, p = 0.002). A protective effect against subdural haematoma was demonstrated (OR 0.14, CI 0.03-0.72, p = 0.02). Wearing a helmet was also protective against skull fractures (OR 0.12, CI 0.04-0.39, p<0.0001) but not any other specific extracranial injuries. This suggests that bicycle helmets are protective against those injuries caused by direct impact to the head. Further research is required to clarify (...) Head injury patterns in helmeted and non-helmeted cyclists admitted to a London Major Trauma Centre with serious head injury. Cycle use across London and the UK has increased considerably over the last 10 years. With this there has been an increased interest in cycle safety and injury prevention. Head injuries are an important cause of mortality and morbidity in cyclists. This study aimed to ascertain the frequency of different head injury types in cyclists and whether wearing a bicycle helmet

2017 PLoS ONE

196. Hypothermia for Traumatic Brain Injury in Children-A Phase II Randomized Controlled Trial

Hypothermia for Traumatic Brain Injury in Children-A Phase II Randomized Controlled Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2015 PedsCCM Evidence-Based Journal Club

197. Telerehabilitation for Pediatric Patients with Traumatic Brain Injury: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

of telerehabilitation in pediatric patients with traumatic brain injury? Key Message No relevant literature was identified regarding telerehabilitation for pediatric patients with traumatic brain injury. Tags brain injuries, head injuries, pediatrics, remote consultation, telecommunications, telehealth, telemedicine, traumatic brain injury, videoconference, Telecare, brain injury, head injury, virtual therapy Files Rapid Response Summary of Abstracts Published : July 17, 2015 Related Content Follow us: © 2019 (...) Telerehabilitation for Pediatric Patients with Traumatic Brain Injury: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Telerehabilitation for Pediatric Patients with Traumatic Brain Injury: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Telerehabilitation for Pediatric Patients with Traumatic Brain Injury: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Telerehabilitation for Pediatric Patients with Traumatic Brain

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

198. Upper and Lower Extremity Robotic Therapy and Assistive Devices for Pediatric Patients with Complex Developmental Disabilities, Brain Injury, or Complex Pain Disorders

Developmental Disabilities, Brain Injury, or Complex Pain Disorders 3 OVERALL SUMMARY OF FINDINGS One systematic review 1 of mainly case studies reported that overall, robotic therapy had positive effects on upper limb function and clinical assessment scores in children with cerebral palsy (CP). However, the authors noted a paucity of rigorously designed studies and called for further research. Two randomized controlled trials (RCTs) evaluated the impact of robot-assisted therapy on upper limb function 2 (...) , Brain Injury, or Complex Pain Disorders 4 REFERENCES SUMMARIZED Health Technology Assessments No literature identified. Systematic Reviews and Meta-analyses 1. Chen YP, Howard AM. Effects of robotic therapy on upper-extremity function in children with cerebral palsy: a systematic review. Dev Neurorehabil. 2014 Apr 11. PubMed: PM24724587 Randomized Controlled Trials 2. Gilliaux M, Renders A, Dispa D, Holvoet D, Sapin J, Dehez B, et al. Upper limb robot- assisted therapy in cerebral palsy: a single

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

199. Very Early Administration of Progesterone for Acute Traumatic Brain Injury

Very Early Administration of Progesterone for Acute Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2015 PedsCCM Evidence-Based Journal Club

200. A Clinical Trial of Progesterone for Severe Traumatic Brain Injury

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2015 PedsCCM Evidence-Based Journal Club

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