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1. Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

2. Integrated Care Models for Acquired Brain Injury: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Integrated Care Models for Acquired Brain Injury: Clinical Effectiveness, Cost-Effectiveness and Guidelines Integrated Care Models for Acquired Brain Injury: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Integrated Care Models for Acquired Brain Injury: Clinical Effectiveness, Cost-Effectiveness and Guidelines Integrated Care Models for Acquired Brain Injury: Clinical Effectiveness, Cost-Effectiveness and Guidelines Last updated: May 21, 2019 (...) Project Number: RB1327-000 Product Line: Research Type: Non-Pharma Mental Health Intervention Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of integrated care models for patients with acquired brain injury with mental health and/or substance use disorders compared to patients who do not have access to patient-centered care? What is the cost-effectiveness of integrated care models for patients with acquired brain injury with mental health

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

3. Care for Acquired Brain Injury and Concurrent Mental Health and Substance Use Issues

Care for Acquired Brain Injury and Concurrent Mental Health and Substance Use Issues Care for Acquired Brain Injury and Concurrent Mental Health and Substance Use Issues | CADTH.ca Find the information you need Care for Acquired Brain Injury and Concurrent Mental Health and Substance Use Issues Care for Acquired Brain Injury and Concurrent Mental Health and Substance Use Issues Last updated: October 11, 2019 Project Number: ES0339-000 Product Line: Result type: Report Expected Completion Date (...) : February 21, 2020 CADTH is undertaking an Environmental Scan of systems and services that are in place in Canada for caring for individuals affected by acquired brain injury (ABI) and concurrent mental health and/or substance use issues. This project is being conducted to help inform decision-making and support practice change to improve the health and well-being of people living with ABI and concurrent mental health and/or substance use issues. The key objectives of this Environmental Scan

2019 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

4. Neuroprotection from acute brain injury in preterm infants

Neuroprotection from acute brain injury in preterm infants Infants born at ≤32 +6 weeks gestation are at higher risk for intracranial ischemic and hemorrhagic injuries, which often occur in the first 72 hours postbirth. Antenatal strategies to reduce the incidence of acute brain injuries include administering maternal corticosteroids and prompt antibiotic treatment for chorioamnionitis. Perinatal strategies include delivery within a tertiary centre, delayed cord clamping, and preventing (...) hypothermia. Postnatal strategies include empiric treatment with antibiotics when chorioamnionitis is suspected, the cautious use of inotropes, the avoidance of blood PCO2 fluctuation, and neutral head positioning. Clinicians should be aware of the policies and procedures that, especially when combined, can provide neuroprotection for preterm infants. Keywords: Acute brain injury; Infant; Intraventricular hemorrhage; Neuroprotection; Neuroprotective strategies; Premature

2019 Canadian Paediatric Society

5. Can S100B Serum Biomarker Testing Reduce Head Computed Tomography Scanning in Children With Mild Traumatic Brain Injury? Full Text available with Trip Pro

Message S100B serum biomarker has high sensitivity and negative predictive value for detecting traumatic intracranial lesions in children with mild traumatic brain injury. However, how to incorporate this into existing risk-stratification tools is unclear, and reduced availability of the test currently limits its practical application in the emergency department (ED). Methods Data Sources The authors searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Scopus (...) . The 8 included studies comprised 601 children with mild traumatic brain injury who underwent serum S100B biomarker testing compared with head CT or clinical follow-up as the references standard. S100B levels for detecting traumatic intracranial lesions in children with mild traumatic brain injury had a pooled sensitivity of 100% (95% CI 98% to 100%) and negative predictive value of 100% (95% CI 99% to 100%), whereas the pooled specificity was 41% (95% CI 26% to 57%), with significant heterogeneity

2019 Annals of Emergency Medicine Systematic Review Snapshots

6. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders 4 March 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Mark Helfand, MD, MPH, MS, Director (...) Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review Authors: Principal Investigator: Nancy Greer, PhD Timothy J. Wilt, MD, MPH Co-Investigators: Princess Ackland, PhD, MSPH Roderick MacDonald, MS Nina Sayer, PhD Michele Spoont, PhD Brent Taylor, PhD Research Assistants: Lauren McKenzie, MPH Christina Rosebush, MPH Evidence Synthesis Program 4 Relationship

2019 Veterans Affairs Evidence-based Synthesis Program Reports

7. Traumatic Brain Injury and Dementia

Traumatic Brain Injury and Dementia 4 February 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Coordinating Center Portland VA Health Care System Portland, OR Mark Helfand, MD, MPH, MS, Director Evidence Brief: Traumatic Brain Injury and Dementia Authors: Kim Peterson, MS Stephanie Veazie, MPH Donald Bourne, MPH Johanna Anderson, MPH Evidence (...) , Veazie S, Bourne D, Anderson J. Evidence Brief: Traumatic Brain Injury and Dementia. VA ESP Project #09-199; 2019. Posted final reports are located on the ESP search page. This report is based on research conducted by the Evidence Synthesis Program (ESP) Center located at the Portland VA Health Care System, Portland, OR, funded by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development. The findings and conclusions in this document are those

2019 Veterans Affairs Evidence-based Synthesis Program Reports

8. Assessment of traumatic brain injury, acute

include the following: Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008 Aug;7(8):728-41. http://www.ncbi.nlm.nih.gov/pubmed/18635021?tool=bestpractice.com Cerebral oedema Increased intracranial pressure (ICP) Haemorrhage Seizures Ischaemia Infection. Epidemiology of TBI TBI is a substantial cause of morbidity and mortality, leading to more than 2 million accident and emergency department visits annually in the US, Coronado VG, McGuire LC (...) /pubmed/11356436?tool=bestpractice.com After traumatic brain injury, there is an inverse relationship between the GCS score and the incidence of positive findings on CT; in fact, the rate of intracranial injury (ICI) and need for neurosurgical intervention doubles when the GCS drops from 15 to 14. Smits M, Dippel DW, Steyerberg EW, et al. Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: the CHIP prediction rule. Ann Intern Med. 2007;146(6):397-405

2018 BMJ Best Practice

9. Assessment of traumatic brain injury, acute

include the following: Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008 Aug;7(8):728-41. http://www.ncbi.nlm.nih.gov/pubmed/18635021?tool=bestpractice.com Cerebral oedema Increased intracranial pressure (ICP) Haemorrhage Seizures Ischaemia Infection. Epidemiology of TBI TBI is a substantial cause of morbidity and mortality, leading to more than 2 million accident and emergency department visits annually in the US, Coronado VG, McGuire LC (...) /pubmed/11356436?tool=bestpractice.com After traumatic brain injury, there is an inverse relationship between the GCS score and the incidence of positive findings on CT; in fact, the rate of intracranial injury (ICI) and need for neurosurgical intervention doubles when the GCS drops from 15 to 14. Smits M, Dippel DW, Steyerberg EW, et al. Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: the CHIP prediction rule. Ann Intern Med. 2007;146(6):397-405

2018 BMJ Best Practice

10. Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants. Full Text available with Trip Pro

Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants. Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants. Cerebral near-infrared spectroscopy (NIRS) enables continuous estimation of cerebral oxygenation. This diagnostic method coupled with appropriate interventions if NIRS is out of normal range (that is cerebral oxygenation within the 55% to 85% range) may offer benefits without causing more harms (...) . Therefore, NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of randomised clinical trials and quasi-randomised studies.To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury, improve neurological outcome, and increase survival in preterm infants born more than 8 weeks preterm.We used the standard search strategy of the Cochrane

2017 Cochrane

11. Long-Term Psychosocial Support Interventions for Individuals with Moderate to Severe Acquired Brain Injury: Clinical and Cost Effectiveness

Long-Term Psychosocial Support Interventions for Individuals with Moderate to Severe Acquired Brain Injury: Clinical and Cost Effectiveness Long-Term Psychosocial Support Interventions for Individuals with Moderate to Severe Acquired Brain Injury: Clinical and Cost Effectiveness | CADTH.ca Find the information you need Long-Term Psychosocial Support Interventions for Individuals with Moderate to Severe Acquired Brain Injury: Clinical and Cost Effectiveness Long-Term Psychosocial Support (...) Interventions for Individuals with Moderate to Severe Acquired Brain Injury: Clinical and Cost Effectiveness Last updated: April 27, 2018 Project Number: RB1214-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of professionally-administered, long-term psychosocial support for individuals with moderate to severe traumatic or acquired brain injuries? What is the cost effectiveness of community-based acquired

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

12. Falls Prevention Strategies for Acquired Brain Injury Patients with Impulsivity Issues: Clinical Effectiveness and Guidelines

Falls Prevention Strategies for Acquired Brain Injury Patients with Impulsivity Issues: Clinical Effectiveness and Guidelines Falls Prevention Strategies for Acquired Brain Injury Patients with Impulsivity Issues: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Falls Prevention Strategies for Acquired Brain Injury Patients with Impulsivity Issues: Clinical Effectiveness and Guidelines Falls Prevention Strategies for Acquired Brain Injury Patients with Impulsivity (...) Issues: Clinical Effectiveness and Guidelines Last updated: October 18, 2018 Project Number: RA0974-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the comparative clinical effectiveness of falls prevention strategies compared with usual care for the prevention of falls in patients with acquired brain injury or stroke? What are the evidence-based guidelines regarding falls prevention strategies for the prevention of falls

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Duration of Physiotherapy Rehabilitation after Acquired Brain Injury: A Review of Guidelines

Duration of Physiotherapy Rehabilitation after Acquired Brain Injury: A Review of Guidelines Duration of Physiotherapy Rehabilitation after Acquired Brain Injury: A Review of Guidelines | CADTH.ca Find the information you need Duration of Physiotherapy Rehabilitation after Acquired Brain Injury: A Review of Guidelines Duration of Physiotherapy Rehabilitation after Acquired Brain Injury: A Review of Guidelines Last updated: November 16, 2018 Project Number: RC1044-000 Product Line: Research Type (...) : Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What are the evidence-based guidelines regarding the duration and frequency of physiotherapy treatment/rehabilitation for adults with acquired brain injury? Key Message The review found eight guidelines that offered recommendations on the duration and/or frequency/intensity of rehabilitation for acquired brain injury (from stroke or other means). Wherever possible, recommendations on physiotherapy or elements

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. Traumatic brain injury

intracranial pressure (ICP)] are [hypertonic sodium solutions better than mannitol] at [reducing morbidity and mortality]? Clinical Scenario A 54 year old female pedestrian has been hit by a bus. She is brought into the ED by ambulance. Her GCS is 13 on arrival and examination reveals an isolated head injury with a haematoma over the left occiput. CT confirms a right 2011 13. Elevation of the head during intensive care management in people with severe traumatic brain injury . BACKGROUND: Traumatic brain (...) injury (TBI) is a major public health problem and a fundamental cause of morbidity and mortality worldwide. The burden of TBI disproportionately affects low- and middle-income countries. Intracranial hypertension is the most frequent cause of death and disability in brain -injured people. Special interventions in the intensive care unit are required to minimise factors (...) contributing to secondary brain injury after trauma. Therapeutic positioning of the head (different degrees of head-of-bed

2018 Trip Latest and Greatest

17. Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post-traumatic Stress Disorder

Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post-traumatic Stress Disorder Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post-traumatic Stress Disorder Health Services Research & Development Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post (...) on the use of hyperbaric oxygen therapy (HBOT) for the treatment of traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), or their cooccurrence. Findings from this evidence brief will be used to inform considerations of clinical use of HBOT in Veterans with TBI and/or PTSD. Key Questions KQ1: What are the potential benefits of HBOT for the treatment of TBI and/or PTSD? KQ2: What are the potential risks of using HBOT for the treatment of TBI and/or PTSD? KQ3: Do the benefits or risks of HBOT

2018 Veterans Affairs Evidence-based Synthesis Program Reports

18. Functional Outcome After Intracranial Pressure Monitoring for Children With Severe Traumatic Brain Injury

Functional Outcome After Intracranial Pressure Monitoring for Children With Severe Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

19. Is traumatic brain injury preventable in amateur boxing competition?

. 1996;6(2):97-101. Ryan AJ. Intracranial injuries resulting from boxing. Clin Sports Med. 1998;17(1):155-168. doi:10.1016/S0278-5919(05)70070-3. Blennow K, Hardy J, Zetterberg H. The neuropathology and neurobiology of traumatic brain injury. Neuron. 2012;76(5):886-899. doi:10.1016/j.neuron.2012.11.021. McCrory P, Feddermann-Demont N, Dvorak J, et al. What is the definition of sports-related concussion: a systematic review. Br J Sports Med. 2017;51(11):877–887. doi:10.1136/bjsports-2016-097393. Baugh (...) Is traumatic brain injury preventable in amateur boxing competition? Is Traumatic Brain Injury Preventable in Amateur Boxing Competition? – Clinical Correlations Search Is Traumatic Brain Injury Preventable in Amateur Boxing Competition? January 18, 2019 5 min read By Kevin Rezzadeh Peer Reviewed Injuries associated with amateur . 1 While many of the superficial wounds and bone fractures can completely heal, brain damage secondary to boxing has also been well 2 Boxers are at risk for sequelae

2019 Clinical Correlations

20. Evidence Brief: Traumatic Brain Injury and Dementia

Evidence Brief: Traumatic Brain Injury and Dementia Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Health Services Research & Development Management eBrief no. 150 » Issue 150 March 2019 The report is a product of the VA/HSR&D Evidence Synthesis Program. Evidence (...) Brief: Traumatic Brain Injury and Dementia Traumatic brain injury (TBI) is a common condition among both civilian and military populations. While some TBIs cause acute symptoms that resolve over several weeks or months, evidence accumulated over nearly three decades suggests that TBI may lead to chronic neurodegenerative diseases such as dementia. More public awareness about TBI in active-duty service members as a risk factor for earlier onset of dementia and/or of Chronic Traumatic Encephalopathy

2019 Veterans Affairs - R&D

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