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aspirin and gastrointestinal bleeding

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161. Efficacy and Safety of Proton Pump Inhibitors in the Long-Term Aspirin Users: A Meta-Analysis of Randomized Controlled Trials. (Abstract)

Efficacy and Safety of Proton Pump Inhibitors in the Long-Term Aspirin Users: A Meta-Analysis of Randomized Controlled Trials. Long-term aspirin use in cardiovascular disease prevention may result in gastrointestinal bleeding. Although proton pump inhibitors (PPI) have been shown to reduce the risks of peptic ulcers and dyspeptic symptoms in long-term aspirin users in the randomized controlled trials, there are safety concerns about the long-term use of PPI.What is the safety and efficacy (...) of PPI in patients using aspirin in long term for prevention of cardiovascular diseases and stroke?We searched MEDLINE, EMBASE, CENTRAL, CINAHL, ProQuest, and relevant references from inception through February 2015, and used random-effects model for meta-analysis.A total of 10 publications from 9 studies (n = 6382) were included in the meta-analysis. Compared with control, PPI reduced the risks of peptic ulcers [risk ratio (RR): 0.19; 95% confidence interval: 0.13-0.26; P < 0.00001], gastric ulcers

2017 American journal of therapeutics

162. Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours

of anticoagulants. Current or longterm use of oral corticosteroids. The treating physician should make the clinical decision whether a patient has been exposed to longterm therapy. Active or previous peptic ulceration Previous gastrointestinal bleeding except where the cause of the bleeding has been surgically removed. Active or previous history of inflammatory bowel disease. History of moderate or severe renal impairment, with eGFR<45ml/min/1.73m2. Previous invasive or noninvasive malignancy except: - DCIS (...) Number ) 120104 ( Registry Identifier: R&D ) First Posted: June 17, 2016 Last Update Posted: November 22, 2017 Last Verified: November 2017 Keywords provided by University College, London: Aspirin prostate colorectal breast gastro-oesophageal recurrence Additional relevant MeSH terms: Layout table for MeSH terms Colorectal Neoplasms Recurrence Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site Neoplasms Digestive System Diseases Gastrointestinal Diseases

2016 Clinical Trials

163. Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding

Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01998776 Recruitment Status : Completed First

2013 Clinical Trials

164. Upper Gastrointestinal Bleeding (Overview)

of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124(5):426-33. . . American College of Surgeons Committee on Trauma. Advanced Trauma Life Support Course Manual . Chicago, Ill: American College of Surgeons; 1997. Bornman PC, Theodorou NA, Shuttleworth RD, Essel HP, Marks IN. Importance of hypovolaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation. Br Med J (Clin Res Ed) . 1985 Jul 27. 291(6490):245-7 (...) Upper Gastrointestinal Bleeding (Overview) Upper Gastrointestinal Bleeding: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LW92ZXJ2aWV3 processing > Upper

2014 eMedicine.com

165. Lower Gastrointestinal Bleeding (Overview)

. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei GN, Popa B, Gulie L, et al. Highlighted steps of the management algorithm in acute lower gastrointestinal bleeding - case reports and literature review. Chirurgia (Bucur) . 2016 Jan-Feb. 111 (1):74 (...) Lower Gastrointestinal Bleeding (Overview) Lower Gastrointestinal Bleeding: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg4NDc4LW92ZXJ2aWV3 processing > Lower

2014 eMedicine.com

166. Lower Gastrointestinal Bleeding (Diagnosis)

. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei GN, Popa B, Gulie L, et al. Highlighted steps of the management algorithm in acute lower gastrointestinal bleeding - case reports and literature review. Chirurgia (Bucur) . 2016 Jan-Feb. 111 (1):74 (...) Lower Gastrointestinal Bleeding (Diagnosis) Lower Gastrointestinal Bleeding: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg4NDc4LW92ZXJ2aWV3 processing > Lower

2014 eMedicine.com

167. Upper Gastrointestinal Bleeding (Diagnosis)

of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124(5):426-33. . . American College of Surgeons Committee on Trauma. Advanced Trauma Life Support Course Manual . Chicago, Ill: American College of Surgeons; 1997. Bornman PC, Theodorou NA, Shuttleworth RD, Essel HP, Marks IN. Importance of hypovolaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation. Br Med J (Clin Res Ed) . 1985 Jul 27. 291(6490):245-7 (...) Upper Gastrointestinal Bleeding (Diagnosis) Upper Gastrointestinal Bleeding: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LW92ZXJ2aWV3 processing > Upper

2014 eMedicine.com

168. Upper Gastrointestinal Bleeding (Follow-up)

Upper Gastrointestinal Bleeding (Follow-up) Upper Gastrointestinal Bleeding Treatment & Management: Approach Considerations, PPIs, Therapeutic Endoscopy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LXRyZWF0bWVudA== processing > Upper Gastrointestinal Bleeding Treatment & Management Updated: Mar 21, 2016 Author: Maurice A Cerulli, MD, FACP, FACG, FASGE, AGAF; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Upper Gastrointestinal Bleeding Treatment Approach Considerations The goal of medical therapy in upper gastrointestinal bleeding (UGIB) is to correct shock and coagulation abnormalities and to stabilize the patient so that further evaluation and treatment can proceed

2014 eMedicine.com

169. Lower Gastrointestinal Bleeding (Follow-up)

(9):979-82. . Saperas E, Videla S, Dot J, et al. Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. Eur J Gastroenterol Hepatol . 2009 Dec. 21 (12):1333-9. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei (...) Lower Gastrointestinal Bleeding (Follow-up) Lower Gastrointestinal Bleeding Treatment & Management: Approach Considerations, Resuscitation and Initial Assessment, Localization of the Bleeding Site Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

170. Lower Gastrointestinal Bleeding (Treatment)

(9):979-82. . Saperas E, Videla S, Dot J, et al. Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. Eur J Gastroenterol Hepatol . 2009 Dec. 21 (12):1333-9. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei (...) Lower Gastrointestinal Bleeding (Treatment) Lower Gastrointestinal Bleeding Treatment & Management: Approach Considerations, Resuscitation and Initial Assessment, Localization of the Bleeding Site Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

171. Upper Gastrointestinal Bleeding (Treatment)

Upper Gastrointestinal Bleeding (Treatment) Upper Gastrointestinal Bleeding Treatment & Management: Approach Considerations, PPIs, Therapeutic Endoscopy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LXRyZWF0bWVudA== processing > Upper Gastrointestinal Bleeding Treatment & Management Updated: Mar 21, 2016 Author: Maurice A Cerulli, MD, FACP, FACG, FASGE, AGAF; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Upper Gastrointestinal Bleeding Treatment Approach Considerations The goal of medical therapy in upper gastrointestinal bleeding (UGIB) is to correct shock and coagulation abnormalities and to stabilize the patient so that further evaluation and treatment can proceed

2014 eMedicine.com

172. Upper Gastrointestinal Bleeding: Surgical Perspective (Treatment)

Upper Gastrointestinal Bleeding: Surgical Perspective (Treatment) Upper Gastrointestinal Bleeding Treatment & Management: Approach Considerations, PPIs, Therapeutic Endoscopy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LXRyZWF0bWVudA== processing > Upper Gastrointestinal Bleeding Treatment & Management Updated: Mar 21, 2016 Author: Maurice A Cerulli, MD, FACP, FACG, FASGE, AGAF; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Upper Gastrointestinal Bleeding Treatment Approach Considerations The goal of medical therapy in upper gastrointestinal bleeding (UGIB) is to correct shock and coagulation abnormalities and to stabilize the patient so that further evaluation and treatment can proceed

2014 eMedicine Surgery

173. Upper Gastrointestinal Bleeding: Surgical Perspective (Overview)

of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124(5):426-33. . . American College of Surgeons Committee on Trauma. Advanced Trauma Life Support Course Manual . Chicago, Ill: American College of Surgeons; 1997. Bornman PC, Theodorou NA, Shuttleworth RD, Essel HP, Marks IN. Importance of hypovolaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation. Br Med J (Clin Res Ed) . 1985 Jul 27. 291(6490):245-7 (...) Upper Gastrointestinal Bleeding: Surgical Perspective (Overview) Upper Gastrointestinal Bleeding: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LW92ZXJ2aWV3

2014 eMedicine Surgery

174. Lower Gastrointestinal Bleeding: Surgical Perspective (Treatment)

(9):979-82. . Saperas E, Videla S, Dot J, et al. Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. Eur J Gastroenterol Hepatol . 2009 Dec. 21 (12):1333-9. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei (...) Lower Gastrointestinal Bleeding: Surgical Perspective (Treatment) Lower Gastrointestinal Bleeding Treatment & Management: Approach Considerations, Resuscitation and Initial Assessment, Localization of the Bleeding Site Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Surgery

175. Upper Gastrointestinal Bleeding: Surgical Perspective (Diagnosis)

of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124(5):426-33. . . American College of Surgeons Committee on Trauma. Advanced Trauma Life Support Course Manual . Chicago, Ill: American College of Surgeons; 1997. Bornman PC, Theodorou NA, Shuttleworth RD, Essel HP, Marks IN. Importance of hypovolaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation. Br Med J (Clin Res Ed) . 1985 Jul 27. 291(6490):245-7 (...) Upper Gastrointestinal Bleeding: Surgical Perspective (Diagnosis) Upper Gastrointestinal Bleeding: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LW92ZXJ2aWV3

2014 eMedicine Surgery

176. Upper Gastrointestinal Bleeding: Surgical Perspective (Follow-up)

Upper Gastrointestinal Bleeding: Surgical Perspective (Follow-up) Upper Gastrointestinal Bleeding Treatment & Management: Approach Considerations, PPIs, Therapeutic Endoscopy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg3ODU3LXRyZWF0bWVudA== processing > Upper Gastrointestinal Bleeding Treatment & Management Updated: Mar 21, 2016 Author: Maurice A Cerulli, MD, FACP, FACG, FASGE, AGAF; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Upper Gastrointestinal Bleeding Treatment Approach Considerations The goal of medical therapy in upper gastrointestinal bleeding (UGIB) is to correct shock and coagulation abnormalities and to stabilize the patient so that further evaluation and treatment can proceed

2014 eMedicine Surgery

177. Lower Gastrointestinal Bleeding: Surgical Perspective (Overview)

. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei GN, Popa B, Gulie L, et al. Highlighted steps of the management algorithm in acute lower gastrointestinal bleeding - case reports and literature review. Chirurgia (Bucur) . 2016 Jan-Feb. 111 (1):74 (...) Lower Gastrointestinal Bleeding: Surgical Perspective (Overview) Lower Gastrointestinal Bleeding: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg4NDc4LW92ZXJ2aWV3

2014 eMedicine Surgery

178. Lower Gastrointestinal Bleeding: Surgical Perspective (Follow-up)

(9):979-82. . Saperas E, Videla S, Dot J, et al. Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. Eur J Gastroenterol Hepatol . 2009 Dec. 21 (12):1333-9. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei (...) Lower Gastrointestinal Bleeding: Surgical Perspective (Follow-up) Lower Gastrointestinal Bleeding Treatment & Management: Approach Considerations, Resuscitation and Initial Assessment, Localization of the Bleeding Site Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Surgery

179. Lower Gastrointestinal Bleeding: Surgical Perspective (Diagnosis)

. . Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. Am J Gastroenterol . 1998 Feb. 93 (2):175-8. . Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med . 2011 May. 124 (5):426-33. . . Andrei GN, Popa B, Gulie L, et al. Highlighted steps of the management algorithm in acute lower gastrointestinal bleeding - case reports and literature review. Chirurgia (Bucur) . 2016 Jan-Feb. 111 (1):74 (...) Lower Gastrointestinal Bleeding: Surgical Perspective (Diagnosis) Lower Gastrointestinal Bleeding: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg4NDc4LW92ZXJ2aWV3

2014 eMedicine Surgery

180. Gastrointestinal adverse effects of short-term aspirin use: a meta-analysis of published randomized controlled trials. Full Text available with Trip Pro

that contained gastrointestinal adverse event data from clinical trials of aspirin versus placebo or an active comparator. Odds ratios (ORs) computed using a Mantel-Haenszel estimator were used to summarize the comparative effects on dyspepsia, nausea/vomiting, and abdominal pain, considered separately and also aggregated as 'minor gastrointestinal events'. Gastrointestinal bleeds, ulcers, and perforations were also investigated.Data were obtained regarding 19,829 subjects (34 % treated with aspirin, 17 (...) % placebo, and 49 % an active comparator). About half of the aspirin subjects took a single dose. Aspirin was associated with a higher risk of minor gastrointestinal events than placebo or active comparators: the summary ORs were 1.46 (95 % confidence interval [CI] 1.15-1.86) and 1.81 (95 % CI 1.61-2.04), respectively. Ulcers, perforation, and serious bleeding were not seen after use of aspirin or any of the other interventions.During short-term use, aspirin is associated with a higher frequency

2013 Drugs in R&D

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