How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

7,686 results for

aspirin and gastrointestinal bleeding

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Clinical, clinicopathologic, and gastrointestinal changes from aspirin, prednisone, or combination treatment in healthy research dogs: A double-blind randomized trial. Full Text available with Trip Pro

trial of dogs administered placebo, aspirin (2 mg/kg q24h), prednisone (2 mg/kg q24h), or combination treatment PO for 28 days. Clinical signs were recorded daily, with laboratory work performed at baseline and day 28. Gastrointestinal mucosal hemorrhages, erosions, and ulcers were numerated for endoscopic studies performed on days 0, 14, and 28; endoscopic mucosal lesion scores were calculated. Results were compared using mixed model repeated-measures analyses of variance and generalized estimating (...) -73.6) and 31.5 times (95% CI, 3.5-288.0) higher odds, respectively, of having endoscopic mucosal lesion scores ≥4 than dogs receiving placebo (P ≤ .01).Gastrointestinal bleeding occurs commonly in dogs administered aspirin, prednisone, or prednisone/aspirin treatment, with higher lesion scores for dogs receiving combination treatment. Even severe lesions are not accompanied by clinical signs.© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf

2019 Journal of Veterinary Internal Medicine Controlled trial quality: predicted high

142. Appropriate Use Criteria: Imaging of the Abdomen and Pelvis

Lymphadenopathy 29 Pelvic floor disorders associated with urinary or bowel incontinence 29 Prostate cancer 29 Retroperitoneal conditions 30 Splenic hematoma 30 Splenomegaly 30 Sports hernia (athletic pubalgia) 30 Undescended testicle (cryptorchidism) 31 Imaging of the Abdomen and Pelvis Copyright © 2019. AIM Specialty Health. All Rights Reserved. 4 Nonspecific Signs and Symptoms 31 Abdominal pain 31 Azotemia 32 Lower extremity edema 32 Fever of unknown origin 32 Pelvic pain 32 Weight loss 33 Exclusions 33 (...) Tumor or neoplasm – not otherwise referenced 12 Female Reproductive System and Obstetrics 12 Adenomyosis 12 Adnexal mass 12 Endometriosis 13 Obstetric indications 13 Uterine artery embolization procedures 13 Gastrointestinal Conditions 14 Appendicitis 14 Bowel obstruction 14 Constipation (Pediatric only) 15 Diverticulitis 15 Enteritis and colitis 15 Foreign body (Pediatric only) 16 Gastrointestinal bleeding (Pediatric only) 16 Henoch-Schonlein purpura (Pediatric only) 16 Inflammatory bowel disease

2019 AIM Specialty Health

143. Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. (Abstract)

Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. The feasibility of determining the exact site and amount of drug-induced gastric bleeding was tested. Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2.4 gm/day, in randomized order for seven days. Acetaminophen (...) was given for 14 days just prior to each of these periods. By fiberoptic gastroscopy, antral ulceration and acute mucosal lesions were found in seven patients following aspirin ingestion, in one taking fenoprofen, and in none taking acetaminophen. Fecal blood loss in four-day stool collections, quantitated by autologous chromium 51-labeled erythrocytes shed into the stool averaged 5.0 ml/day while taking aspirin, 2.2 ml/day while taking fenoprofen calcium, and 0.8 ml/day while taking acetaminophen

1977 JAMA Controlled trial quality: uncertain

144. Delayed bleeding of the Transplant Duodenum After Simultaneous Kidney Pancreas Transplantation: Case Series. Full Text available with Trip Pro

, and the resection specimen showed enlarged and congestive submucosal veins in both patients. There was no recurrence of bleeding after re intervention. In the third patient, enteric derivation was not possible because of the extremely fragile intestinal tissue perioperatively and a conservative approach was taken. As possible precipitating factors are concerned, all three of our patients were taking low dose aspirin and/or clopidogrel as secondary cardiovascular prevention.Bleeding of the transplanted donor (...) Delayed bleeding of the Transplant Duodenum After Simultaneous Kidney Pancreas Transplantation: Case Series. In simultaneous pancreas kidney (SPK) transplant recipients, the majority of complications described in the literature, are early postoperative complications. However, there is growing attention for late complications associated with SPK transplantation.In this case series, we present three cases, two enteric and one bladder derived SPK transplant patients, with anastomotic hemorrhage

2019 Transplantation

145. Effects (MACE and bleeding events) of ticagrelor combined with omeprazole on patients with acute myocardial infarction undergoing primary PCI. Full Text available with Trip Pro

and control group by the draw, with 43 patients in each group. All patients were routinely treated with dual antiplatelet therapy with aspirin plus ticagrelor. Omeprazole was used in the observation group and placebo was used in the control group. Baseline data of patients, platelet response index (PRI) ADP-induced platelet aggregation (ADP-Ag), major adverse cardiac events (MACE), and incidence of bleeding events were recorded and compared.PRI and ADP-Ag at 7 days, 1 month, and 6 months after operation (...) patients undergoing primary PCI, omeprazole can reduce the incidence of gastrointestinal bleeding without reducing the antiplatelet aggregation effect of ticagrelor or increasing the risk of MACE, which is worthy of clinical promotion.Copyright © 2019 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved.

2019 Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese Controlled trial quality: uncertain

146. Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication

aspirin use is an individual one. Grade: C No recommendation. Grade: I (insufficient evidence) No recommendation. Grade: I (insufficient evidence) Risk Assessment Primary risk factors for CVD are older age, male sex, race/ethnicity, abnormal lipid levels, high blood pressure, diabetes, and smoking. Risk factors for GI bleeding with aspirin use include higher aspirin dose and longer duration of use, history of GI ulcers or upper GI pain, bleeding disorders, renal failure, severe liver disease (...) artery stenosis, coronary heart disease, high blood pressure, lipid disorders, obesity, diabetes, peripheral artery disease, and colorectal cancer. These recommendations are available on the USPSTF Web site ( ) Abbreviations: ACC/AHA=American College of Cardiology/American Heart Association; CVD=cardiovascular disease; GI=gastrointestinal. For a summary of the evidence systematically reviewed in making this recommendation, the full recommendation statement, and supporting documents, please go

2016 U.S. Preventive Services Task Force

147. The Effect of a Probiotic Strain on Aspirin-induced GI Damage.

within endurance sports) Willing to abstain from any other probiotic products and/or medication known to alter gastrointestinal function throughout the participation of the trial Exclusion Criteria: Abdominal surgery which, as judged by the investigator, might affect the GI function (except appendectomy and cholecystectomy) History of peptic ulcer disease Any known bleeding disorder Allergy to Aspirin History of H. pylori disease Resting diastolic blood pressure ≥ 90 mmHg Resting systolic blood (...) or disease Intervention/treatment Phase Side Effects of Acetylsalicylic Acid Use Dietary Supplement: probiotic strain Dietary Supplement: Placebo Phase 2 Detailed Description: The trial includes a run-in period of two weeks duration followed by a six weeks intervention period where a probiotic strain/placebo and Aspirin is co-administered. After the 6 weeks, probiotic strain/placebo is given for two additional weeks to investigate the potential effects of the probiotic strain on intestinal healing after

2017 Clinical Trials

148. Gastrointestinal hemorrhage and aspirin. Full Text available with Trip Pro

Gastrointestinal hemorrhage and aspirin. 5305535 1969 06 29 2013 11 21 0007-1447 1 5646 1969 Mar 22 British medical journal Br Med J Gastrointestinal hemorrhage and aspirin. 781 Saperia J J eng Journal Article England Br Med J 0372673 0007-1447 R16CO5Y76E Aspirin AIM IM Aspirin adverse effects Child, Preschool Gastrointestinal Hemorrhage chemically induced Humans Male 1969 3 22 1969 3 22 0 1 1969 3 22 0 0 ppublish 5305535 PMC1982758

1969 British medical journal

149. Upper Gastrointestinal Complications and Cardiovascular/Gastrointestinal Risk Calculator in Patients with Myocardial Infarction Treated with Aspirin Full Text available with Trip Pro

Upper Gastrointestinal Complications and Cardiovascular/Gastrointestinal Risk Calculator in Patients with Myocardial Infarction Treated with Aspirin Aspirin is widely used for the prevention of cardiovascular and cerebrovascular diseases for the past few years. However, much attention has been paid to the adverse effects associated with aspirin such as gastrointestinal bleeding. How to weigh the benefits and hazards? The current study aimed to assess the feasibility of a cardiovascular (...) diagnostic cutoff point of predicted gastrointestinal events was 68.0‰, yielding sensitivity and specificity of 60.6% and 93.1%, respectively, for predicting gastrointestinal events in Chinese patients with MI.AsaRiskCalculator had a predictive value for gastrointestinal events in Chinese patients with MI. HP infection seemed to be an independent risk factor for gastrointestinal events caused by long-term aspirin treatment in Chinese patients with MI, and it should be included in the risk calculator

2017 Chinese medical journal

150. Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer Full Text available with Trip Pro

Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer A growing body of research suggests daily low-dose aspirin (ASA) reduces heart diseases and colorectal cancers. However, the major limitation to the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract. Preclinical studies have shown that ginger constituents ameliorate ASA-induced gastric ulceration. We here report the design and synthesis (...) of a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS). Our data show that GAS exerts enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol. We further present that GAS inactivates both COX-1 and COX-2 equally. Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS

2017 Scientific reports

151. Cohort study: In people with atrial fibrillation receiving antithrombotics, short-term non-steroidal anti-inflammatory drug exposure increases risk of serious bleeding

Since the discovery of salicylic acid from willow bark in the mid-19th century, a multitude of NSAIDs have been developed. They are widely used for their anti-inflammatory and analgesic properties, good tolerability and speed of action. Conversely their use can increase the risk of gastrointestinal bleeding, kidney injury, … Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You (...) Cohort study: In people with atrial fibrillation receiving antithrombotics, short-term non-steroidal anti-inflammatory drug exposure increases risk of serious bleeding In people with atrial fibrillation receiving antithrombotics, short-term non-steroidal anti-inflammatory drug exposure increases risk of serious bleeding | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time

2016 Evidence-Based Nursing

152. Coping with Common GI Symptoms in the Community: A Global Perspective on Heartburn, Constipation, Bloating, and Abdominal Pain/Discomfort

countries, due to H. pylori infection and use of acetylsalicylic acid (ASA) and NSAIDs. • Unrecognized constipation. • Celiac disease. • Hepatic congestion/swelling of any cause—e.g., right-sided heart failure, steatosis, hepatitis. • IBD, especially Crohn’s disease. • Chronic mesenteric ischemia (older patients): pain is exacerbated by eating (intestinal angina) and is out of proportion to the physical examination; new onset in older patients, history of vascular disease, symptoms of nausea, vomiting (...) entrapment syndrome 4.5 Alarm features • Abnormal findings on physical examination • Unintentional progressive weight loss • Age at onset • GI bleeding • Family history of abdominal cancer • Laboratory abnormalities: anemia, hypoalbuminemia, abnormal liver function tests, elevated ESR or CRP, positive fecal occult blood test • New onset of symptoms without obvious trigger(s) 4.6 Abdominal pain/discomfort—management cascade • The community prevalence, severity, health-care seeking, and medication use

2013 World Gastroenterology Organisation

153. Primary non-variceal upper gastrointestinal bleeding in NSAID and low-dose aspirin users: development and validation of risk scores for either medication in two large Dutch cohorts. (Abstract)

Primary non-variceal upper gastrointestinal bleeding in NSAID and low-dose aspirin users: development and validation of risk scores for either medication in two large Dutch cohorts. Non-steroidal anti-inflammatory drugs (NSAIDs) and low-dose acetylsalicylic acid (ASA) have several adverse gastrointestinal (GI) effects, including upper GI bleeding. We aimed to develop a simple risk score to identify high risk NSAID and ASA users for primary upper GI bleeding.Using data from two large anonymized (...) or NSAID and ASA users, respectively.Risk factors for primary upper GI bleeding are to a large extent similar for NSAID and ASA users. Using a risk score based on these risk factors, patients at the highest risk can be identified with moderate accuracy.

2014 Journal of gastroenterology

154. Low-dose aspirin and upper gastrointestinal bleeding in primary versus secondary cardiovascular prevention: a population-based, nested case-control study. Full Text available with Trip Pro

Low-dose aspirin and upper gastrointestinal bleeding in primary versus secondary cardiovascular prevention: a population-based, nested case-control study. The benefit-risk profile of low-dose aspirin in primary prevention of cardiovascular disease is unclear. We sought to quantify upper gastrointestinal bleeding (UGIB) risk associated with low-dose aspirin in secondary versus primary prevention patients.We performed a population-based nested case-control study using The Health Improvement (...) Network (THIN) Database between 2000 and 2007. We identified 2049 cases of UGIB and 20,000 controls, frequency-matched to the cases on age, sex, and calendar year, who were subdivided into primary (without previous cardiovascular disease) and secondary (with previous cardiovascular disease) prevention populations. We estimated the relative risk of UGIB associated with the use of low-dose aspirin by multivariate logistic regression. The UGIB risk in patients taking low-dose aspirin relative to nonusers

2014 Circulation. Cardiovascular quality and outcomes

155. Aspirin for primary prevention: USPSTF recommendations for CVD and colorectal cancer. (Abstract)

Aspirin for primary prevention: USPSTF recommendations for CVD and colorectal cancer. Patient age, baseline cardiovascular disease risk, bleeding risk, and personal preference regarding aspirin use are key to decision making. A clinical decision tool can help.

2019 Journal of Family Practice

156. Aspirin for primary prevention: USPSTF recommendations for CVD and colorectal cancer. (Abstract)

Aspirin for primary prevention: USPSTF recommendations for CVD and colorectal cancer. Patient age, baseline cardiovascular disease risk, bleeding risk, and personal preference regarding aspirin use are key to decision making. A clinical decision tool can help.

2019 Journal of Family Practice

157. Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. (Abstract)

with no history of dementia, cardiovascular disease or physical disability. Interim analysis indicated no significant treatment effect and the trial was terminated slightly early after a median of 4.7 years' follow-up. There was no evidence of a difference in incidence of dementia between aspirin and placebo groups (risk ratio (RR) 0.98, 95% CI 0.83 to 1.15; high-certainty evidence). Participants allocated aspirin had higher rates of major bleeding (RR 1.37, 95% CI 1.17 to 1.60, high-certainty evidence (...) Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. Dementia is a worldwide concern. Its global prevalence is increasing. At present, there is no medication licensed to prevent or delay the onset of dementia. Inflammation has been suggested as a key factor in dementia pathogenesis. Therefore, medications with anti-inflammatory properties could be beneficial for dementia prevention.To evaluate the effectiveness and adverse effects of aspirin and other non

2020 Cochrane

158. Bowel preparation before colonoscopy

with acute lower GI bleeding. 65 A disadvantage of 4-L PEG-ELS is the relatively large volume of ?uid consumption required, which can cause abdominal fullness and cramping. There is a sulfate- associated taste that is often perceived as unpleasant and is only partially masked by the addition of ?avorings. Taking the solution after it is chilled may make it more palatable. These preparations work most effectively when ingested quickly (eg, 240 mL every 10 minutes). Adverse events in patients receiving PEG (...) ,butdidnotimprovecoloniccleansing. 59 However, a second study revealed no advantage with either patient tolerance or colonic cleansing. 60 Metoclopramide is notrecommendedasanadjuncttooralbowelpreparation. Simethicone Simethicone promotes the clearance of excessive gas in the GI tract that reduces bloating, abdominal discomfort, and abdominal pain and improves visualization in the GI tract. There have been several studies investigating the addition of simethicone to bowel preparation regimens. 122 Overall, simethicone does

2015 American Society for Gastrointestinal Endoscopy

159. Inflammatory Bowel Disease (IBD)

radiography: — Not typically recommended in severe cases. — Can be useful for identifying fistulas that arise from or bridge to the colon. — Barium small-bowel radiography is still widely used to assess the gastrointestinal tract as far as the distal small bowel. — Can provide an anatomic “road-map” prior to surgery. ? Sigmoidoscopy, colonoscopy: — Examine for ulcers, inflammation, bleeding, stenoses. — Multiple biopsies from the colon and terminal ileum. — Colonoscopy in severe or fulminant cases may (...) be considered for a first presentation or a single inflammatory exacerbation in a 12-month period [37]. — Do not offer 5-ASA for moderate to severe CD or exacerbations or for extensive small-bowel disease or disease with penetrating or fibrostenosing complications [37]. ? In CD, sulfasalazine and mesalazine/mesalamine are presumed to be mainly effective in disease affecting the colon. However, this has not been specifically studied. ? Patients receiving sulfasalazine should take folic acid

2015 World Gastroenterology Organisation

160. Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

that low-dose Aspirin prevents diseases of heart and blood vessels as well as cancer of the colon and rectum and it is also associated with risk of bleeding. In this study, they want to learn how patients regard the benefits and risks of low-dose Aspirin for the prevention of these diseases. The researchers also want to learn how patients balance these risks and benefits. Condition or disease Intervention/treatment Cardiovascular Disease, Colorectal Cancer Drug: Acetylsalicylic acid (Aspirin, BAYE4465 (...) Neoplasms by Site Neoplasms Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases Rectal Diseases Aspirin Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Platelet Aggregation Inhibitors Cyclooxygenase Inhibitors Enzyme

2018 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>