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aspirin and gastrointestinal bleeding

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7681. Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin? (Full text)

adults taking lower doses of aspirin for long periods. No clinical benefits in terms of reduction of gastrointestinal bleeding or ulceration with enteric coating have, therefore, been successfully demonstrated, although the endoscopic studies show that potentially these benefits could exist. (...) Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin? A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether enteric-coated aspirin results in a lower incidence of gastrointestinal complications compared to normal aspirin in CABG surgery. Using the reported search, 340 papers were identified. Nine papers represented the best evidence on the subject. The author

2007 Interactive cardiovascular and thoracic surgery PubMed abstract

7682. What is the evidence for Aspirin as a preventer of bowel cancer and for which patient group?

longer periods may be associated with a reduction in the incidence of colorectal cancer. There is poor-quality evidence that aspirin and NSAID use leads to a reduction in colorectal cancer–associated mortality. Harms of aspirin and NSAID use: There is good evidence that aspirin increases the incidence of gastrointestinal bleeding in a dose-related manner and fair evidence that aspirin increases the incidence of hemorrhagic stroke. There is good evidence that NSAIDs increase the incidence (...) ) and aspirin for preventing colorectal adenomas and carcinomas (2003)(1). The summary states: “Colorectal (bowel) cancer is common worldwide but is especially prevalent in industrialised countries. Genes, diet and lifestyle all seem to be important in the development of bowel cancer. Experimental animals studies and observational studies have suggested that nonsteroidal anti-inflammatory drugs and aspirin may reduce the development of colorectal cancer and recurrence of adenomas in patients with familial

2007 TRIP Answers

7683. A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients. (Abstract)

reviewed the literature on SSRI-associated bleeding.We performed a MEDLINE search of literature from 1966 to the present using hemorrhage, SSRI, and antidepressants as search terms and followed up on relevant citations. We reviewed 6 retrospective studies, 5 of which were case-control studies, and 18 case reports of bleeding in 37 people. Our review is supplemented with a case report of a possible connection between SSRI treatment and a fatal gastrointestinal bleed in an HCV-infected man.Bleeding (...) events in 12/18 reports (67%) describing 19/24 people (79%) were closely associated with the use of SSRIs.Combining aspirin or nonsteroidal anti-inflammatory drugs with SSRIs for the treatment of interferon-associated neuropsychiatric side effects increases the risks of hemorrhage in patients with HCV who have developed cirrhosis and either portal hypertension or hepatic failure or both. We recommend that clinicians exercise caution when prescribing medications that can promote spontaneous bleeding

2003 Journal of Clinical Psychiatry

7684. Anti-inflammatory drugs and variceal bleeding: a case-control study (Full text)

Anti-inflammatory drugs and variceal bleeding: a case-control study Non-steroidal anti-inflammatory drugs (NSAIDs) can have severe gastrointestinal effects and cause peptic ulcers to bleed. Acute bleeding from oesophageal varices is a major complication of cirrhosis of the liver.To investigate the role, using a case-control study, of NSAIDs in first bleeding episodes associated with oesophageal or cardial varices in cirrhotic patients.A structured interview was conducted of 125 cirrhotic (...) patients with bleeding mainly related to oesophageal varices and 75 cirrhotic controls with oesophageal varices who had never bled.Cirrhotic patients who were admitted for bleeding related to portal hypertension were more likely to have used NSAIDs during the week before the index day (31 of 125 (25%)) than the cirrhotic controls (eight of 75 (11%); odds ratio = 2.8, p = 0.016). Use of aspirin alone or combined with other NSAIDs was also more prevalent in the cases (21 of 125 (17%)) than

1999 Gut PubMed abstract

7685. Risk of ulcer bleeding in patients infected with Helicobacter pylori taking non-steroidal anti-inflammatory drugs (Full text)

Risk of ulcer bleeding in patients infected with Helicobacter pylori taking non-steroidal anti-inflammatory drugs To determine whether Helicobacter pylori is an independent risk factor for bleeding peptic ulcer in users of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin.A prospective matched case-control study.Odense University Hospital, Denmark.132 patients with a bleeding peptic ulcer (n=124) or haemorrhagic gastritis (n=8) at endoscopy who had taken an NSAID in the previous (...) week and 136 controls who had taken NSAIDs without gastrointestinal complications. The controls were recruited from rheumatology and geriatric outpatient clinics.H pylori status assessed by serology and 13C-urea breath test and regarded as positive if either test was positive. Data on potential confounding factors including smoking and alcohol were collected by interview.H pylori was present in 57% of cases and 43% of controls. The adjusted odds ratio of bleeding from a peptic ulcer owing to H

2000 Gut PubMed abstract

7686. In patients on warfarin + aspirin, would adding a PPI for gastroprotection reduce risk of gastric bleeding if no previous history of PUD ?

In patients on warfarin + aspirin, would adding a PPI for gastroprotection reduce risk of gastric bleeding if no previous history of PUD ? In patients on warfarin + aspirin, would adding a PPI for gastroprotection reduce risk of gastric bleeding if no previous history of PUD ? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere (...) search. As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com In patients on warfarin + aspirin, would adding a PPI for gastroprotection reduce risk of gastric bleeding if no previous history

2007 TRIP Answers

7687. Etodolac, aspirin, and gastrointestinal microbleeding. (Abstract)

in 41 subjects. Subjects in both studies received a single-blind placebo on days 1 through 7, either etodolac or aspirin on days 8 through 14, and a single-blind placebo on days 15 through 19. GI blood loss (milliliters per day) was estimated by the radiolabeled (51Cr) erythrocyte method and was based on daily radioactivity counts of stool specimens and regression-estimated daily blood radioactivity. Etodolac, 600 mg/day, induced no significant GI blood loss at any time during the experiments, nor (...) Etodolac, aspirin, and gastrointestinal microbleeding. The effects of etodolac, a new nonsteroidal anti-inflammatory drug, on gastrointestinal (GI) microbleeding were quantitatively assessed in two studies in healthy adult men. The first was a two-group, open-label, parallel comparison of etodolac, 600 mg/day, aspirin, 2600 mg/day, and placebo in 20 subjects; the second was a four-group, double-blind, parallel comparison of etodolac, 600, 800, and 1200 mg/day, aspirin, 2600 mg/day, and placebo

1984 Clinical pharmacology and therapeutics Controlled trial quality: uncertain

7688. Comparative study of gastrointestinal microbleeding caused by aspirin, fenbufen, and placebo. (Abstract)

Comparative study of gastrointestinal microbleeding caused by aspirin, fenbufen, and placebo. Fifty volunteers, randomly divided into five groups, received placebo, fenbufen, or aspirin at dosages used in treating osteoarthritis and rheumatoid arthritis (fenbufen, 600 or 900 mg daily; aspirin, 3.6 g daily) for 28 days. Following radioactive chromium labeling of red cells in each subject, stool specimens were collected weekly for determination of blood loss by radioisotope procedure. Statistical (...) analyses demonstrated no significant differences in gastrointestinal microbleeding between subjects who received fenbufen (600 or 900 mg daily) and those who received placebo. Conversely, there were significant (p less than 0.01) differences in microbleeding between subjects given aspirin and those given either dosage of fenbufen or placebo.

1983 The American journal of medicine Controlled trial quality: uncertain

7689. The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)

The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2005 Clinical Trials

7690. Analysis of trials evaluating combinations of acetylsalicylic acid and dipyridamole in the secondary prevention of stroke

Analysis of trials evaluating combinations of acetylsalicylic acid and dipyridamole in the secondary prevention of stroke Analysis of trials evaluating combinations of acetylsalicylic acid and dipyridamole in the secondary prevention of stroke Analysis of trials evaluating combinations of acetylsalicylic acid and dipyridamole in the secondary prevention of stroke Redman A R, Ryan G J Authors' objectives To investigate whether the addition of dipyridamole to aspirin further reduces the risk (...) of stroke recurrence. Searching MEDLINE, International Pharmaceutical Abstracts, EMBASE and BIOSIS Previews were searched from 1966 to May 2001 for articles in the English language. The search terms used were 'dipyridamole', 'aspirin', 'acetylsalicylic acid', 'ischaemic stroke' and 'cerebrovascular disorders'. Study selection Study designs of evaluations included in the review The authors aimed to identify clinical trials. Four of the identified studies were reported to be randomised double-blind trials

2001 DARE.

7691. Risk factors for early postoperative small-bowel obstruction after colectomy in colorectal cancer. (Abstract)

events (bleeding, bowel perforation), diversion stoma, repair of mesenteric defect, intra-abdominal drainage, local remnant tumor, status of bowel preparation, status of American Society of Anesthesiologists (ASA) grade, obesity, and history of previous abdominal surgery. The influence of these factors on the development of EPSBO after colectomies for colorectal cancer was analyzed. Cases were classified according to anastomotic level and extent of pelvic dissection into pelvic surgery group (PSG (...) patients who underwent a colectomy for colorectal cancer were prospectively monitored and entered into the study. Patients were assessed to have an EPSBO if, within the first 30 days, they presented with symptoms, such as nausea, vomiting, and abdominal distention, lasting for at least 2 days, with radiologic findings of small-bowel obstruction after evidence of small-bowel motility return. In this study, the following parameters were monitored prospectively: anti-adhesive, intraoperative adverse

2008 World Journal of Surgery

7692. Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis

perforation; small or large bowel hemorrhage; clinically significant anemia of defined GI origin; acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage; clinically significant anemia of presumed occult GI origin including possible small bowel blood loss. Subjects were assessed by an independent GI Events Adjudication Committee, who were blinded to study treatment assignments. Number of Subjects With Moderate to Severe Abdominal Symptoms [ Time Frame: 6 month treatment duration (...) outlet obstruction; GD, small or large bowel perforation; small or large bowel hemorrhage; clinically significant anemia of defined GI origin; acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage; clinically significant anemia of presumed occult GI origin including possible small bowel blood loss. Subjects were assessed by an independent GI Events Adjudication Committee, who were blinded to study treatment assignments. Secondary Outcome Measures : Number of Subjects

2005 Clinical Trials

7693. Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers

provided by Research Associates of New York, LLP: NSAID ulcer gastroduodenal ulcer naproxen aspirin ASA celecoxib clopidogrel healing Cyclooxygenase 2 Inhibitors Anti-Inflammatory Agents, Non-Steroidal Platelet Aggregation Inhibitors Wound Healing Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Peptic Ulcer Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Aspirin Celecoxib Naproxen Anti-Inflammatory Agents (...) Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2008 Clinical Trials

7694. Aspirin/Folate Prevention of Large Bowel Polyps

Study I); and brief participation in the “VA Cooperative Study” with no continuing involvement. Exclusion Criteria: Invasive carcinoma in any colonic polyp removed. Familial colonic polyposis syndromes. Ulcerative colitis or Crohn's disease. Malabsorption syndrome (e.g. pancreatic insufficiency). Large bowel resection for any reason. Diagnosed narcotic or alcohol dependence Contraindication to aspirin use, including: documented peptic ulcer disease in the past 20 years aspirin sensitivity bleeding (...) Last Update Posted: January 5, 2006 Last Verified: November 2005 Keywords provided by Dartmouth-Hitchcock Medical Center: Colorectal neoplasms Adenomatous polyps Additional relevant MeSH terms: Layout table for MeSH terms Colorectal Neoplasms Polyps Adenoma Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site Neoplasms Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases Rectal Diseases Pathological Conditions, Anatomical

2006 Clinical Trials

7695. The pharmacokinetics and effects of intravenously administered carprofen and salicylate on gastrointestinal mucosa and selected biochemical measurements in healthy cats. (Abstract)

The pharmacokinetics and effects of intravenously administered carprofen and salicylate on gastrointestinal mucosa and selected biochemical measurements in healthy cats. The pharmacokinetics of carprofen, a propionic acid-derived nonsteroidal anti-inflammatory (NSAID), and its effect on gastrointestinal mucosa, complete blood counts (CBC) and biochemical indicators of liver and renal function were investigated in healthy cats using a randomized crossover design. A single dose of 4 mg/kg (...) of carprofen (Zenecarp(R) Injection), normal saline, or 20 mg/kg of DL-lysine acetyl salicylate (Vetalgine(R)) was given intravenously (i.v.) to each of five cats with a washout period of 2 weeks between treatments. Endoscopy of the stomach and duodenum 8 h postinjection revealed one acetyl salicylate-(aspirin)-treated cat with minor pinpoint erosions. None of the other cats in the three treatment groups had evidence of bleeding or ulceration. Serum biochemistry measurements of blood urea nitrogen (BUN

2000 Journal of veterinary pharmacology and therapeutics Controlled trial quality: uncertain

7696. Role of Doppler Ultrasound in Severe Peptic Ulcer Hemorrhage

: Other Study ID Numbers: DOP-US study First Posted: September 14, 2005 Last Update Posted: August 28, 2012 Last Verified: August 2012 Keywords provided by James Yun-wong Lau, Chinese University of Hong Kong: Peptic ulcer hemorrhage Doppler ultrasound Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases (...) Center Information provided by (Responsible Party): James Yun-wong Lau, Chinese University of Hong Kong Study Details Study Description Go to Brief Summary: The aim of study is to evaluate whether Doppler ultrasound can accurately identify patients who are at risk of recurrent bleeding, who will require endoscopic therapy, and who will fail endoscopic therapy. Condition or disease Intervention/treatment Phase Peptic Ulcer Hemorrhage Device: Doppler ultrasound probe Not Applicable Detailed Description

2005 Clinical Trials

7697. Application of 10 percent formalin for the treatment of radiation-induced hemorrhagic proctitis. (Abstract)

-tolerated method of controlling hemorrhagic radiation proctitis. It is performed by using materials readily available in the office of a colon and rectal surgeon, eliminating the need for bowel preparation, anesthesia, or a surgical suite. (...) Application of 10 percent formalin for the treatment of radiation-induced hemorrhagic proctitis. Rectal instillation of 4 percent formalin solution has been described as a successful treatment for hemorrhagic radiation proctitis recalcitrant to medical treatment. We present our experience with a new method of treatment involving the topical application of 10 percent buffered formalin, which is well tolerated and suitable for office use.Patients with marked or refractory rectal bleeding

2007 Diseases of the Colon & Rectum

7698. Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease

provided by (Responsible Party): Fook-Hong Ng, Ruttonjee Hospital Study Details Study Description Go to Brief Summary: Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and effective treatment for unstable cardiac patients. However, the major complication was gastrointestinal bleeding (GIB) due to peptic ulcer. In the prevention of GIB, anti-ulcer drug either H2-receptor antagonist (H2RA) and proton pump inhibitor (PPI) were commonly prescribed. There has been (...) or gastrointestinal within 8 wk known iron deficiency anemia with Hb < 10 gm/dl mechanical ventilation active cancer, liver cirrhosis, end-stage renal failure life expectancy < 1 yr known allergic to aspirin, clopidogrel, enoxaparin famotidine or esomeprazole pregnancy, lactation, child-bearing potential in the absence of contraception, co-prescription of NSAID, corticosteroid, or warfarin non-oral feeding or impaired GI absorption e.g. vomiting already on proton pump inhibitor for > 1 day or another clinical

2008 Clinical Trials

7699. Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy

Kong: Peptic ulcer IVPPI prior endoscopy Additional relevant MeSH terms: Layout table for MeSH terms Peptic Ulcer Gastrointestinal Hemorrhage Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Hemorrhage Pathologic Processes Omeprazole Proton Pump Inhibitors Anti-Ulcer Agents Gastrointestinal Agents Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action (...) Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2005 Clinical Trials

7700. Endoscopic Evaluation of Lower Gastrointestinal Bleeding (GIB) in Patients Presenting With Melena

bleeding, it can also be a manifestation of lower gastrointestinal (GI) bleeding. Examples include colonic cancer, small bowel tumors, and small or large bowel ulcers induced by aspirin or painkillers (NSAIDs). However, clinicians are often misled by the finding of peptic ulcers as the source of GI bleeding. It is not uncommon to detect peptic ulcers incidentally but the source of bleeding is actually in the lower GI tract (e.g. NSAID- or aspirin-induced small or large bowel bleeding ulcers, small (...) Sponsor: Chinese University of Hong Kong Information provided by (Responsible Party): Francis KL Chan, Chinese University of Hong Kong Study Details Study Description Go to Brief Summary: To evaluate the incidence and etiology of small bowel or large bowel bleeding in patients presenting with melena. Condition or disease Intervention/treatment Phase Gastrointestinal Hemorrhage Procedure: Capsule endoscopy Not Applicable Detailed Description: Although tarry stool is a common feature of peptic ulcer

2005 Clinical Trials

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