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aspirin and Reye syndrome

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61. Pruritus and Systemic Disease (Follow-up)

and is effective but may only be available in intravenous form. [ ] To prevent opioid withdrawal syndrome, low starting doses should be used. These drugs should not be used in patients in need of palliative opioid treatment. Butorphanol, which antagonizes the mu receptor but agonizes the kappa receptor, has been shown to be effective in suppressing cholestatic pruritus. [ ] Ursodeoxycholic acid and S-adenosyl-L-methionine have both been reported to decrease pruritus in women with cholestasis of pregnancy (...) vera may benefit from aspirin, which is considered the first-line therapy. Cimetidine, danazol, cholestyramine, UV-B light therapy, and psoralen with UV-A therapy have all been shown to help. [ , ] Interferon-alfa may provide relief, but its adverse effects may decrease compliance. [ ] Treatment with paroxetine at 20 mg/d has been shown to be effective, but further clinical trials are needed. One patient with severe pruritus due to Hodgkin disease responded dramatically to thalidomide at 200 mg

2014 eMedicine.com

62. Kawasaki Disease (Follow-up)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine.com

63. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Follow-up)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

64. Disorders of Carbohydrate Metabolism (Follow-up)

with the lactate-producing bacterium Enterobacter cloacae, Reye syndrome); poisoning by salicylates; seizures (seizures lead to increase in CNS lactic acid that results in increase in systemic lactic acid as in patients with bacterial meningitis); liver failure; and short gut syndrome. After all of these have been ruled out, the inherited disorders need to be excluded, including organic acidemia (especially glutaric acid), disorders of metabolism of branched chain amino acids (especially the biotin-dependent (...) and thoroughly treat other associated medical problems. The patient with acidosis benefits very little if the ketosis is corrected but an underlying cause is missed, for example, by a delayed spinal tap if meningitis or encephalitis happens to be the illness that has tipped the metabolic balance. Some of the inherited disorders of carbohydrate metabolism are fatal. For some of these conditions, the more profoundly the mutation interferes with enzyme activity, the more likely the disorder will be fatal. Other

2014 eMedicine.com

65. Pediatrics, Kawasaki Disease (Treatment)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine Emergency Medicine

66. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Diagnosis)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

67. Disorders of Carbohydrate Metabolism (Diagnosis)

with the lactate-producing bacterium Enterobacter cloacae, Reye syndrome); poisoning by salicylates; seizures (seizures lead to increase in CNS lactic acid that results in increase in systemic lactic acid as in patients with bacterial meningitis); liver failure; and short gut syndrome. After all of these have been ruled out, the inherited disorders need to be excluded, including organic acidemia (especially glutaric acid), disorders of metabolism of branched chain amino acids (especially the biotin-dependent (...) and thoroughly treat other associated medical problems. The patient with acidosis benefits very little if the ketosis is corrected but an underlying cause is missed, for example, by a delayed spinal tap if meningitis or encephalitis happens to be the illness that has tipped the metabolic balance. Some of the inherited disorders of carbohydrate metabolism are fatal. For some of these conditions, the more profoundly the mutation interferes with enzyme activity, the more likely the disorder will be fatal. Other

2014 eMedicine.com

68. Kawasaki Disease (Follow-up)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine Pediatrics

69. Kawasaki Disease (Treatment)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine Pediatrics

70. Antiphospholipid Antibody Syndrome (Follow-up)

would you like to print? What would you like to print? Sections Pediatric Antiphospholipid Antibody Syndrome Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Pediatric Antiphospholipid Antibody Syndrome) and Pediatric Antiphospholipid Antibody Syndrome What to Read Next on Medscape Related Conditions and Diseases (...) testing, and, in the case of secondary antiphospholipid syndrome, underlying disease activity Imaging and Doppler studies for follow-up of previous thrombotic process Dietary and lifestyle counseling Next: Further Inpatient Care Further inpatient care in patients with antiphospholipid (aPL) antibody syndrome (APS) is only on an as-needed basis for management of thrombotic events but may include the following: Imaging studies Medical therapy Invasive procedures for thrombolytic therapy Further

2014 eMedicine Pediatrics

71. Pediatrics, Kawasaki Disease (Follow-up)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine Emergency Medicine

72. Acute Coronary Syndrome (Diagnosis)

of an atherosclerotic plaque and partial or complete thrombosis of the infarct-related artery. The image below illustrates an algorithm for triaging patients with chest pain. Suggested algorithm for triaging patients with chest pain. ACS = ACS; ASA = aspirin; EKG = ECG; MI = myocardial infarction; Rx = treat; STEMI = ST-elevation myocardial infarction. Courtesy of Wu et al (1999). See , a Critical Images slideshow, to help identify a variety of electrocardiographic abnormalities. Signs and symptoms Atherosclerosis (...) in patients with coronary disease and has a significant negative impact on mortality. Further study is needed to assess the effect of treatment on survival. [ ] A study by Sanchis et al suggests renal dysfunction, dementia, peripheral artery disease, previous heart failure, and previous myocardial infarction are the comorbid conditions that predict mortality in NSTEMI ACS. [ ] In patients with comorbid conditions, the highest risk period was in the first weeks after NSTEMI ACS. In-hospital management

2014 eMedicine Emergency Medicine

73. Antiphospholipid Antibody Syndrome (Treatment)

. 15(2):255-259. . Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med . 2001 Mar 12. 161(5):695-700. . Erkan D, Lockshin MD. New approaches for managing antiphospholipid syndrome. Nat Clin Pract Rheumatol . 2009 Mar. 5(3):160-70. . Lockshin M, Tenedios F, Petri M, McCarty G, Forastiero R, Krilis S. Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus report. Lupus . 2003. 12 (...) by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Pediatric Antiphospholipid Antibody Syndrome) and Pediatric Antiphospholipid Antibody Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles According to Pediatricians Recommended 2002 2500032-overview Diseases & Conditions Diseases & Conditions 2001 /viewarticle/896448 News News

2014 eMedicine Pediatrics

74. Acute Coronary Syndrome (Overview)

of an atherosclerotic plaque and partial or complete thrombosis of the infarct-related artery. The image below illustrates an algorithm for triaging patients with chest pain. Suggested algorithm for triaging patients with chest pain. ACS = ACS; ASA = aspirin; EKG = ECG; MI = myocardial infarction; Rx = treat; STEMI = ST-elevation myocardial infarction. Courtesy of Wu et al (1999). See , a Critical Images slideshow, to help identify a variety of electrocardiographic abnormalities. Signs and symptoms Atherosclerosis (...) in patients with coronary disease and has a significant negative impact on mortality. Further study is needed to assess the effect of treatment on survival. [ ] A study by Sanchis et al suggests renal dysfunction, dementia, peripheral artery disease, previous heart failure, and previous myocardial infarction are the comorbid conditions that predict mortality in NSTEMI ACS. [ ] In patients with comorbid conditions, the highest risk period was in the first weeks after NSTEMI ACS. In-hospital management

2014 eMedicine Emergency Medicine

75. Acute Coronary Syndrome (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTkxMDczNS10cmVhdG1lbnQ= processing > Acute Coronary Syndrome Treatment & Management Updated: Sep 05, 2018 Author: David L Coven, MD, PhD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Acute Coronary Syndrome Treatment Approach Considerations Initial therapy for ACS should focus on stabilizing the patient's condition, relieving ischemic pain, and providing antithrombotic therapy to reduce myocardial damage and prevent further ischemia. Morphine (or fentanyl) for pain control, oxygen (...) with ACS who require urgent CABG, proceeding despite the continuation of clopidogrel is likely safe. [ ] Clopidogrel can be considered an alternative to aspirin in patients with aspirin intolerance or who are allergic to aspirin. Patients with chronic kidney disease who have low platelet response to clopidogrel tend to have worse outcomes after PCI. [ ] Evidence has shown that dexlansoprazole and lansoprazole do not significantly reduce the conversion of clopidogrel to its active metabolite (reduced

2014 eMedicine Emergency Medicine

76. Acute Coronary Syndrome (Follow-up)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTkxMDczNS10cmVhdG1lbnQ= processing > Acute Coronary Syndrome Treatment & Management Updated: Sep 05, 2018 Author: David L Coven, MD, PhD; Chief Editor: Eric H Yang, MD Share Email Print Feedback Close Sections Sections Acute Coronary Syndrome Treatment Approach Considerations Initial therapy for ACS should focus on stabilizing the patient's condition, relieving ischemic pain, and providing antithrombotic therapy to reduce myocardial damage and prevent further ischemia. Morphine (or fentanyl) for pain control, oxygen (...) with ACS who require urgent CABG, proceeding despite the continuation of clopidogrel is likely safe. [ ] Clopidogrel can be considered an alternative to aspirin in patients with aspirin intolerance or who are allergic to aspirin. Patients with chronic kidney disease who have low platelet response to clopidogrel tend to have worse outcomes after PCI. [ ] Evidence has shown that dexlansoprazole and lansoprazole do not significantly reduce the conversion of clopidogrel to its active metabolite (reduced

2014 eMedicine Emergency Medicine

77. Aspirin Full Text available with Trip Pro

(=O)O InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) Y Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N Y Aspirin , also known as acetylsalicylic acid ( ASA ), is a used to treat , , or . Specific inflammatory conditions which aspirin is used to treat include , , and . Aspirin given shortly after a decreases the risk of death. Aspirin is also used long-term to help prevent further heart attacks, , and in people at high risk. It may also decrease the risk of certain types of , particularly (...) , many medical societies and regulatory agencies, including the , the , and the , strongly advise against using aspirin for treatment of fever in children because of the risk of , a rare but often fatal illness associated with the use of aspirin or other salicylates in children during episodes of viral or bacterial infection. Because of the risk of Reye's syndrome in children, in 1986, the FDA required labeling on all aspirin-containing medications advising against its use in children and teenagers

2012 Wikipedia

78. Transcatheter Aortic Valve Implantation in Patients With Severe, Symptomatic Aortic Valve Stenosis at Intermediate Surgical Risk

BACKGROUND 10 Health Condition 10 Clinical Need and Target Population 10 Current Treatment Options 10 Health Technology Under Review 11 Regulatory Information 12 Ontario Context 12 PROSPERO Registration 12 CLINICAL EVIDENCE 13 Research Question 13 Methods 13 Clinical Literature Search 13 Literature Screening 14 Inclusion Criteria 14 Exclusion Criteria 14 Outcomes of Interest 15 Data Extraction 15 Evidence Synthesis and Statistical Analysis 15 Critical Appraisal of Evidence 16 Expert Consultation 16 (...) valve replacement (SAVR) in patients with severe, symptomatic aortic valve stenosis at intermediate surgical risk. BACKGROUND Health Condition The aortic valve is located between the aorta and the left ventricle of the heart. 1 It opens to allow blood to flow from the left ventricle into the aorta when the heart contracts, and closes to prevent blood from flowing backward into the heart when the heart relaxes. 1 Aortic valve stenosis occurs when the valve partially narrows, obstructing blood flow

2020 Health Quality Ontario

79. Clinical care of severe acute respiratory infections – Tool kit

in Wuhan, China, in December 2019. While most people with COVID-19 develop only mild or uncomplicated illness, approximately 14% develop severe disease that requires hospitalization and oxygen support, and 5% require admission to an intensive care unit. In severe cases, COVID-19 can be complicated by acute respiratory distress syndrome (ARDS), sepsis and septic shock, multi-organ failure, including acute kidney injury, and cardiac injury. Tools 1.1 COVID-19 fact sheet 1.2 Other viruses with pandemic (...) fatality ratios (CFR) of 1–6% have been reported from some countries. • According to data from China, approximately 80% of people will have mild (40%) to moderate (40%) disease and recover. Moderate disease will include a mild form of pneumonia. • More severe disease and higher CFRs have been seen in the elderly (over 60 years old) and those with chronic medical conditions, with clinical deterioration occurring at around day 7 of illness. Children appear to mainly have mild disease. • The most common

2020 WHO Coronavirus disease (COVID-19) Pandemic

80. Five Don'ts to Prevent Novel Coronavirus Infection (COVID-19) and Death - part 1

/ Vol.6 No.16 · Page 5 Figure 2: NSAIDs such as aspirin or diclofenac increase death from Reye’s syndrome/influenza encephalitis by 20-folds (meta-analysis of case-control studies in the U.S. and Japan) Japan: A case-control study of influenza associated encephalopathy comparing use of NSAIDs including diclofenac and mefenamate. Others: all are case-control studies for Reye’s syndrome conducted in US. . and liver damage, was reported in 1960’s. This condition was named after a doctor who found (...) , when it was used to lower fever to the normal temperature in serious infection such as sepsis, risk for death was increased by seven-fold in human. Aspirin is considered to have relatively mild effect among NSAIDs. However, it is epidemiologically and medically established that it causes Reye syndrome, in which mainly children experienced encephalitis and liver damage after infection, which became an international issue in 1970’s (risk is about 20 times higher). Ibuprofen is generally believed

2020 Med Check - The Informed Prescriber

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