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41. Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease Full Text available with Trip Pro

−1 ·d −1 . Maximum 81–325 mg·d −1 . , None studied There are no studies that link outcome to measuring aspirin effect. Bruising, confusion, vertigo, nausea, vomiting, tinnitus, abdominal pain, cramping, burning, fatigue, bleeding Kawasaki disease 80–100 mg·kg −1 ·d −1 during acute phase of illness, then 3-5 mg·kg −1 ·d −1 for additional 6–8 wk Clopidogrel , Inhibition of ADP-induced platelet aggregation. No effects on arachidonic acid metabolism. t½=7 h.Renal clearance.Hepatic metabolism. Failure (...) . (3) low-dose tPA combined with abciximab (Kawasaki disease section in the text).In stroke, see text. Reassess thrombus with imaging at the completion of the infusion. Retreatment may be indicated once hematologic parameters are acceptable. Hemorrhage requiring transfusion 20-30%Minor bleeding 54-68%. ACT indicates activated clotting time; ADP, Adenosine diphosphate; ASA, acetylsalicylic acid; cAMP, cyclic adenosine monophosphate; CHD, congestive heart disease; COX, cyclooxygenase; CPB

2013 American Heart Association

42. Low Dose Aspirin for the Prevention of Preeclampsia

the incidence of preeclampsia. Condition or disease Intervention/treatment Phase Preeclampsia Drug: Aspirin Drug: Placebo Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 476 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Prevention Official Title: Low Dose Aspirin Between 13 and 16 Weeks of Pregnancy (...) Mass Index > 32 Multiple pregnancy Lupus or other autoimmune disorder Chronic Renal Disease. Exclusion Criteria: Blood coagulation disorders of any kind Peptic ulcers Allergy to aspirin Chronic use of anti-inflammatory drugs Fetus with mayor anomalies Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study

2013 Clinical Trials

43. The Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease

- RHDAustralia • Expanded discussion around Surveillance • Proposed minimum dataset (Table 3.12 in 2006 version) replaced with Recommended dataset for ARF /RHD Registers (presented as an Appendix 2) • Removal of criteria for Communicable Disease Network of Australia (CDNA) national notification (of a condition) • Revised section on Screening for RHD • Proposed indicators for evaluating ARF/RHD programs (Table 3.13 in 2006 version) replaced with Key Performance Indicators for ARF/RHD (presented in Appendix 3 (...) in individuals with RHD to reduce symptoms and disability, and prevent premature death. Primordial and primary prevention of acute rheumatic fever Primordial prevention aims to stop the development of risk factors for a disease in a population. In the case of ARF and RHD, primordial prevention means preventing GAS infections through implementing actions and measures that target environmental, economic, social and behavioural conditions, and cultural patterns of living that are known to increase the risk

2012 Clinical Practice Guidelines Portal

44. Reye's syndrome

in . A retrospective study of 49 survivors of cases diagnosed as "Reye's Syndrome" showed that the majority of the surviving patients had various metabolic disorders, particularly a fatty-acid oxidation disorder . Aspirin [ ] There is an association between taking for viral illnesses and the development of Reye syndrome, but no animal model of Reye syndrome has been developed in which aspirin causes the condition. The serious symptoms of Reye syndrome appear to result from damage to cellular , at least (...) been no cases of Reye syndrome following its use, and the measure is a precaution. Other medications containing salicylates are often similarly labeled as a precaution. The (CDC), the U.S. Surgeon General, the (AAP) and the (FDA) recommend that aspirin and combination products containing aspirin not be given to children under 19 years of age during episodes of fever-causing illnesses. Hence, in the , it is advised that the opinion of a doctor or pharmacist should be obtained before anyone under 19

2012 Wikipedia

45. Thoughts on a 23-year-old athlete dying from the Lemierre Syndrome

must do better. Share this: Like this: Like Loading... Comments (2) said on 04-11-2018 In another era we had Reyes Syndrome where children with a trivial illness would get aspirin for their fever, develop hepatic encephalopathy and die at the pedicatric hospital with supportive care. At the time tylenol was a relatively new and costly alternative for a fever and most parents opted for aspirin. Today we physicians get a lot of public flack for antibiotic use for things that usually are self-limited (...) the antibiotics. The Danish data suggest that in the 15-25 age group 1/70,000 will develop the Lemierre Syndrome. Even when patients survive the infection is likely equivalent to endocarditis (or perhaps even worse). We must develop a better strategy for adolescent sore throats. Reading about another death or even another patient who spends a month in the hospital including a week in the ICU for a disease that we might be able to prevent is tragic. She died and everyone around here is suffering her loss. We

2018 db's Medical Rants blog

46. Guideline on the management of patients with extracranial carotid and vertebral artery disease

Guideline on the management of patients with extracranial carotid and vertebral artery disease ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/ SCAI/SIR/SNIS/SVM/SVS Guideline 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/ SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American Stroke Association, American (...) WS, Panagos PD, Riles TS, Rosenwasser RH, Taylor AJ. 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, andtheAmericanStrokeAssociation,AmericanAssociationofNeuroscienceNurses,AmericanAssociationofNeurologicalSurgeons,AmericanCollege of Radiology, American Society

2011 American Academy of Neurology

47. Guideline on the Management of Patients with Extracranial Carotid and Vertebral Artery Disease

Guideline on the Management of Patients with Extracranial Carotid and Vertebral Artery Disease ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/ SCAI/SIR/SNIS/SVM/SVS Guideline 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/ SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American Stroke Association, American (...) WS, Panagos PD, Riles TS, Rosenwasser RH, Taylor AJ. 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, andtheAmericanStrokeAssociation,AmericanAssociationofNeuroscienceNurses,AmericanAssociationofNeurologicalSurgeons,AmericanCollege of Radiology, American Society

2011 Congress of Neurological Surgeons

48. Extracranial Carotid and Vertebral Artery Disease: Guideline on the Management of Patients With

, carotid artery stenting (CAS), extracranial carotid artery stenosis, stroke, transient ischemic attack (TIA), and vertebral artery disease. Additional searches cross-referenced these topics with the following subtopics: acetylsalicylic acid, antiplatelet therapy, carotid artery dissection, cerebral embolism, cerebral protection, cerebrovascular disorders, complications, comorbidi- ties, extracranial atherosclerosis, intima-media thickness (IMT), medical therapy, neurological examination, noninva- sive (...) of each syndrome, enhance prevention, and decrease rates of stroke and related long-term disability and death. The ultimate goal of the guideline statement is to improve the duration and quality of life for people with ECVD. 1.2. Organization of the Writing Committee The writing committee to develop the 2011 ASA/ACCF/ AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/ SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease was composed of experts in the areas

2011 American College of Cardiology

49. Fatal case of Reye's syndrome associated with H3N2 influenza virus infection and salicylates intake in a 12 year-old patient. Full Text available with Trip Pro

Fatal case of Reye's syndrome associated with H3N2 influenza virus infection and salicylates intake in a 12 year-old patient. We describe a fatal case of Reye's syndrome in a 12-year-old male patient during an influenza A (H3N2) infection for which he received salicylates. In the current situation of the novel A/H1N1 virus pandemic, we believe that it is of high importance to emphasize the risks associated with salicylate intake to avoid the reappearance of Reye's syndrome.© 2010 The Authors (...) . Journal Compilation © 2010 European Society of Clinical Microbiology and Infectious Diseases.

2010 Clinical Microbiology and Infection

50. von Willebrand Disease (Follow-up)

, Rand ML, Bouskill V, Reyes JT, et al. Idiopathic pulmonary arterial hypertension - a unrecognized cause of high-shear high-flow haemostatic defects (otherwise referred to as acquired von Willebrand syndrome) in children. Br J Haematol . 2018 Aug 23. . Byams VR, Kouides PA, Kulkarni R, et al. Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres. Haemophilia . 2011 Jul. 17 Suppl 1:6-13. . Sanders YV, Giezenaar MA, Laros-van Gorkom BA, Meijer (...) functional von Willebrand factor (vWF) but should be avoided if at all possible because of the potential transmission of viral disease. An additional drawback of fresh frozen plasma is the large infusion volume most often required. [ , ] For prophylaxis in major surgery or for treatment of serious bleeding episodes, rVWF (with or without FVIII) or vWF-containing factor VIII (FVIII) concentrates are the treatment of choice. However, a hematologist experienced in the management of bleeding disorders should

2014 eMedicine.com

51. Pruritus and Systemic Disease (Diagnosis)

, cholestasis of pregnancy, and end-stage liver disease of any cause. Drug-induced cholestasis may be caused by chlorpropamide, tolbutamide, phenothiazines, erythromycin, anabolic steroids, and oral contraceptives. Hematologic pruritus may be seen in association with the following conditions: Iron deficiency Polycythemia rubra vera Hypereosinophilic syndrome Essential thrombocythemia Myelodysplastic syndrome Endocrine pruritus may be seen in association with the following disorders: Hyperthyroidism (...) on the basis of the underlying causative disease: renal pruritus, cholestatic pruritus, hematologic pruritus, endocrine pruritus, pruritus related to malignancy, and idiopathic generalized pruritus. Pruritus, or itch, is most commonly associated with a primary skin disorder such as xerosis, atopic dermatitis, urticaria, psoriasis, arthropod assault, mastocytosis, dermatitis herpetiformis, or pemphigoid. However, when a primary skin condition cannot be identified as the cause of pruritus, then a systemic

2014 eMedicine.com

52. Pruritus and Systemic Disease (Overview)

, cholestasis of pregnancy, and end-stage liver disease of any cause. Drug-induced cholestasis may be caused by chlorpropamide, tolbutamide, phenothiazines, erythromycin, anabolic steroids, and oral contraceptives. Hematologic pruritus may be seen in association with the following conditions: Iron deficiency Polycythemia rubra vera Hypereosinophilic syndrome Essential thrombocythemia Myelodysplastic syndrome Endocrine pruritus may be seen in association with the following disorders: Hyperthyroidism (...) on the basis of the underlying causative disease: renal pruritus, cholestatic pruritus, hematologic pruritus, endocrine pruritus, pruritus related to malignancy, and idiopathic generalized pruritus. Pruritus, or itch, is most commonly associated with a primary skin disorder such as xerosis, atopic dermatitis, urticaria, psoriasis, arthropod assault, mastocytosis, dermatitis herpetiformis, or pemphigoid. However, when a primary skin condition cannot be identified as the cause of pruritus, then a systemic

2014 eMedicine.com

53. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Treatment)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

54. Disorders of Carbohydrate Metabolism (Treatment)

with the lactate-producing bacterium Enterobacter cloacae, Reye syndrome); poisoning by salicylates; seizures (seizures lead to increase in CNS lactic acid that results in increase in systemic lactic acid as in patients with bacterial meningitis); liver failure; and short gut syndrome. After all of these have been ruled out, the inherited disorders need to be excluded, including organic acidemia (especially glutaric acid), disorders of metabolism of branched chain amino acids (especially the biotin-dependent (...) and thoroughly treat other associated medical problems. The patient with acidosis benefits very little if the ketosis is corrected but an underlying cause is missed, for example, by a delayed spinal tap if meningitis or encephalitis happens to be the illness that has tipped the metabolic balance. Some of the inherited disorders of carbohydrate metabolism are fatal. For some of these conditions, the more profoundly the mutation interferes with enzyme activity, the more likely the disorder will be fatal. Other

2014 eMedicine.com

55. Pruritus and Systemic Disease (Treatment)

and is effective but may only be available in intravenous form. [ ] To prevent opioid withdrawal syndrome, low starting doses should be used. These drugs should not be used in patients in need of palliative opioid treatment. Butorphanol, which antagonizes the mu receptor but agonizes the kappa receptor, has been shown to be effective in suppressing cholestatic pruritus. [ ] Ursodeoxycholic acid and S-adenosyl-L-methionine have both been reported to decrease pruritus in women with cholestasis of pregnancy (...) vera may benefit from aspirin, which is considered the first-line therapy. Cimetidine, danazol, cholestyramine, UV-B light therapy, and psoralen with UV-A therapy have all been shown to help. [ , ] Interferon-alfa may provide relief, but its adverse effects may decrease compliance. [ ] Treatment with paroxetine at 20 mg/d has been shown to be effective, but further clinical trials are needed. One patient with severe pruritus due to Hodgkin disease responded dramatically to thalidomide at 200 mg

2014 eMedicine.com

56. von Willebrand Disease (Treatment)

, Rand ML, Bouskill V, Reyes JT, et al. Idiopathic pulmonary arterial hypertension - a unrecognized cause of high-shear high-flow haemostatic defects (otherwise referred to as acquired von Willebrand syndrome) in children. Br J Haematol . 2018 Aug 23. . Byams VR, Kouides PA, Kulkarni R, et al. Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres. Haemophilia . 2011 Jul. 17 Suppl 1:6-13. . Sanders YV, Giezenaar MA, Laros-van Gorkom BA, Meijer (...) functional von Willebrand factor (vWF) but should be avoided if at all possible because of the potential transmission of viral disease. An additional drawback of fresh frozen plasma is the large infusion volume most often required. [ , ] For prophylaxis in major surgery or for treatment of serious bleeding episodes, rVWF (with or without FVIII) or vWF-containing factor VIII (FVIII) concentrates are the treatment of choice. However, a hematologist experienced in the management of bleeding disorders should

2014 eMedicine.com

57. Kawasaki Disease (Treatment)

the use of aspirin in children with KD as part of their treatment regimen. [ ] Patients who remain on long-term, low-dose aspirin should receive an annual influenza vaccine and be vaccinated against varicella. Additionally, the risks of developing Reye syndrome during an active infection with influenza or varicella should be addressed. Clopidogrel (Plavix) may be briefly substituted for aspirin in patients who develop influenza or varicella. This agent can also be used in patients allergic to aspirin (...) , and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation . 2017 Apr 25. 135 (17):e927-e999. . Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited. Pediatrics . 2004 Dec. 114(6):e689-93. . Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst

2014 eMedicine.com

58. Sturge-Weber Syndrome (Treatment)

and migraine headaches self-reported treatment patterns through a questionnaire. [ ] Previous Next: Strokelike Events Aspirin has been used for headaches and to prevent vascular disease, although it typically is used in patients who have had neurologic progression or recurrent vascular events. [ ] Aspirin needs to be used with extreme caution in children because of the risk that Reye syndrome could develop, and the risks and benefits need to be carefully weighed. Thomas-Sohl, Vaslow, and Maria have (...) recommended 3-5 mg/kg/day of aspirin for stroke-like events. They also recommended varicella and yearly influenza immunizations because of the association of varicella and influenza infections with Reye syndrome. [ ] Maria et al reported a decreased incidence of strokelike events in 20 patients with SWS who received aspirin. Of 119 strokelike events, 31 occurred in patients treated with aspirin, whereas 88 of these events occurred in those not treated with aspirin. The authors suggested further

2014 eMedicine.com

59. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Overview)

=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen by urologists. For most (...) of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made to include the most recent

2014 eMedicine.com

60. Disorders of Carbohydrate Metabolism (Overview)

with the lactate-producing bacterium Enterobacter cloacae, Reye syndrome); poisoning by salicylates; seizures (seizures lead to increase in CNS lactic acid that results in increase in systemic lactic acid as in patients with bacterial meningitis); liver failure; and short gut syndrome. After all of these have been ruled out, the inherited disorders need to be excluded, including organic acidemia (especially glutaric acid), disorders of metabolism of branched chain amino acids (especially the biotin-dependent (...) and thoroughly treat other associated medical problems. The patient with acidosis benefits very little if the ketosis is corrected but an underlying cause is missed, for example, by a delayed spinal tap if meningitis or encephalitis happens to be the illness that has tipped the metabolic balance. Some of the inherited disorders of carbohydrate metabolism are fatal. For some of these conditions, the more profoundly the mutation interferes with enzyme activity, the more likely the disorder will be fatal. Other

2014 eMedicine.com

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