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aspirin and Reye syndrome

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21. Acute Coronary Syndrome (Follow-up)

strategy for the treatment of acute coronary syndromes. J Thromb Thrombolysis . 2000 Aug. 10(1):77-82. . Januzzi JL, Chae CU, Sabatine MS, Jang IK. Elevation in serum troponin I predicts the benefit of tirofiban. J Thromb Thrombolysis . 2001 May. 11(3):211-5. . Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA . 1996 Sep 11. 276(10):811-5. . Steg PG, Jolly SS, Mehta SR, Afzal R (...) Acute Coronary Syndrome (Follow-up) Acute Coronary Syndrome Treatment & Management: Approach Considerations, Pharmacologic Anti-ischemic Therapy, Pharmacologic Antithrombotic Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Emergency Medicine

22. Sturge-Weber Syndrome (Treatment)

and migraine headaches self-reported treatment patterns through a questionnaire. [ ] Previous Next: Strokelike Events Aspirin has been used for headaches and to prevent vascular disease, although it typically is used in patients who have had neurologic progression or recurrent vascular events. [ ] Aspirin needs to be used with extreme caution in children because of the risk that Reye syndrome could develop, and the risks and benefits need to be carefully weighed. Thomas-Sohl, Vaslow, and Maria have (...) recommended 3-5 mg/kg/day of aspirin for stroke-like events. They also recommended varicella and yearly influenza immunizations because of the association of varicella and influenza infections with Reye syndrome. [ ] Maria et al reported a decreased incidence of strokelike events in 20 patients with SWS who received aspirin. Of 119 strokelike events, 31 occurred in patients treated with aspirin, whereas 88 of these events occurred in those not treated with aspirin. The authors suggested further

2014 eMedicine.com

23. Antiphospholipid Antibody Syndrome (Follow-up)

inpatient care is indicated if a catastrophic antiphospholipid antibody syndrome (CAPS) occurs. Previous Next: Inpatient & Outpatient Medications See the list below: Antiplatelet therapy, such as administration of aspirin, dipyridamole, hydroxychloroquine, ticlopidine, clopidogrel, or combinations of these agents Vasodilator and/or antiplatelet therapy, such as pentoxifylline or cilostazol Vasodilators, such as niacin or topical nitroglycerin (nitropaste) Anticoagulation therapy, such as warfarin (...) Antiphospholipid Antibody Syndrome (Follow-up) Pediatric Antiphospholipid Antibody Syndrome Follow-up: Further Outpatient Care, Further Inpatient Care, Inpatient & Outpatient Medications Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Pediatrics

24. Acute Coronary Syndrome (Diagnosis)

strategy for the treatment of acute coronary syndromes. J Thromb Thrombolysis . 2000 Aug. 10(1):77-82. . Januzzi JL, Chae CU, Sabatine MS, Jang IK. Elevation in serum troponin I predicts the benefit of tirofiban. J Thromb Thrombolysis . 2001 May. 11(3):211-5. . Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA . 1996 Sep 11. 276(10):811-5. . Steg PG, Jolly SS, Mehta SR, Afzal R (...) clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet . 2010 Oct 9. 376(9748):1233-43. . Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, et al. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA . 2007 Apr 25. 297(16):1775-83

2014 eMedicine Emergency Medicine

25. Acute Coronary Syndrome (Overview)

strategy for the treatment of acute coronary syndromes. J Thromb Thrombolysis . 2000 Aug. 10(1):77-82. . Januzzi JL, Chae CU, Sabatine MS, Jang IK. Elevation in serum troponin I predicts the benefit of tirofiban. J Thromb Thrombolysis . 2001 May. 11(3):211-5. . Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA . 1996 Sep 11. 276(10):811-5. . Steg PG, Jolly SS, Mehta SR, Afzal R (...) clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet . 2010 Oct 9. 376(9748):1233-43. . Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, et al. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA . 2007 Apr 25. 297(16):1775-83

2014 eMedicine Emergency Medicine

26. Acute Coronary Syndrome (Treatment)

strategy for the treatment of acute coronary syndromes. J Thromb Thrombolysis . 2000 Aug. 10(1):77-82. . Januzzi JL, Chae CU, Sabatine MS, Jang IK. Elevation in serum troponin I predicts the benefit of tirofiban. J Thromb Thrombolysis . 2001 May. 11(3):211-5. . Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA . 1996 Sep 11. 276(10):811-5. . Steg PG, Jolly SS, Mehta SR, Afzal R (...) Acute Coronary Syndrome (Treatment) Acute Coronary Syndrome Treatment & Management: Approach Considerations, Pharmacologic Anti-ischemic Therapy, Pharmacologic Antithrombotic Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Emergency Medicine

27. Aspirin Full Text available with Trip Pro

, many medical societies and regulatory agencies, including the , the , and the , strongly advise against using aspirin for treatment of fever in children because of the risk of , a rare but often fatal illness associated with the use of aspirin or other salicylates in children during episodes of viral or bacterial infection. Because of the risk of Reye's syndrome in children, in 1986, the FDA required labeling on all aspirin-containing medications advising against its use in children and teenagers (...) of aspirin, cause temporary (ringing in the ears) based on experiments in rats, via the action on and cascade. Reye's syndrome [ ] Main article: Reye's syndrome, a rare but severe illness characterized by acute and , can occur when children or adolescents are given aspirin for a fever or other illness or infection. From 1981 through 1997, 1207 cases of Reye's syndrome in people younger than 18 were reported to the U.S. . Of these, 93% reported being ill in the three weeks preceding the onset of Reye's

2012 Wikipedia

28. Laboratory diagnosis of G6PD deficiency Full Text available with Trip Pro

) and permanent neurological damage or death. Haemolysis does not seem to contribute as much as impaired bilirubin conjugation and clearance by the liver (Kaplan et al. , ). G6PD‐deficient newborn babies who also inherit a mutation of the uridine‐diphosphate‐glucuronosyltransferase 1 ( UGT1A1 ) gene promoter, responsible for Gilbert syndrome, are particularly at risk for neonatal jaundice (Kaplan et al. , ). Neonatal screening for G6PD deficiency is routinely performed in many countries, mainly on dried blood (...) haemolysis in G6PD‐deficient subjects. Category of drug Predictable haemolysis Possible haemolysis Antimalarials Dapsone Chloroquine Primaquine Quinine Pamaquin * Not on UK market. Tafenoquine Methylene blue Analgesics/antipyretic Phenazopyridine Aspirin (high doses) † Acceptable up to a dose of at least 1 g daily in most G6PD‐deficient individuals. Paracetamol (Acetaminophen) Antibacterials Cotrimoxazole Sulfasalazine Sulfadiazine Quinolones ‡ Including ciprofloxacin, moxifloxacin, nalidixic acid

2020 British Committee for Standards in Haematology

29. Pharmacological management of migraine

combined. 21 Associated symptoms of nausea, vomiting, photophobia (NNT=7.7) and phonophobia (NNT=6.6) were reduced by aspirin when compared to placebo. The addition of metoclopramide further reduced nausea (NNT=2.6) and vomiting. 21 Aspirin is a potential gastrointestinal irritant and may cause ulcers or gastrointestinal bleeding, however adverse effects from short-term use are mostly mild and transient. 21 Aspirin should not be used in patients under 16 years of age due to the risk of Reye’s syndrome (...) for the purpose of implementation in NHSScotland. Pharmacological management of migraineContents 1 Introduction 1 1.1 The need for a guideline 1 1.2 Remit of the guideline 2 1.3 Statement of intent 3 2 Key recommendations 5 2.1 Acute treatment 5 2.2 Prevention of migraine 6 2.3 Medication-overuse headache 6 3 Treatment for patients with acute migraine 7 3.1 Introduction 7 3.2 Aspirin 7 3.3 Non-steroidal anti-inflammatory drugs 8 3.4 Paracetamol 8 3.5 Antiemetics 9 3.6 Triptans 9 3.7 Combined therapies 11 3.8

2018 SIGN

30. Management of Cardiovascular Diseases during Pregnancy

3.10.4 In vitro fertilization 3181 3.11 Recommendations 3182 4. Congenital heart disease and pulmonary hypertension 3182 4.1 Introduction 3182 4.2 Pulmonary hypertension and Eisenmenger’s syndrome 3183 4.2.1 Pulmonary hypertension 3183 4.2.2 Eisenmenger’s syndrome 3183 4.2.3 Cyanotic heart disease without pulmonary hypertension 3184 4.3 Specific congenital heart defects 3184 4.3.1 Left ventricular outflow tract obstruction 3184 4.3.2 Atrial septal defect 3184 4.3.3 Ventricular septal defect 3184 (...) syndromes 3187 5.2.1 Marfan syndrome 3187 5.2.2 Bicuspid aortic valve 3187 5.2.3 Vascular Ehlers–Danlos syndrome 3187 5.2.4 Turner syndrome 3187 5.2.5 Other autosomal dominant aortopathies 3187 5.3 Management 3187 5.3.1 Follow-up and medical therapy 3187 5.3.2 Interventions 3188 5.3.3 Delivery 3188 5.4 Recommendations 3189 6. Valvular heart disease 3190 6.1 Stenotic valve lesions 3190 6.1.1 Mitral stenosis 3190 6.1.2 Valvular aortic stenosis 3190 6.2 Regurgitant lesions 3191 6.2.1 Mitral and aortic

2018 European Society of Cardiology

32. BSG consensus guidelines on the management of inflammatory bowel disease in adults

, cognitive behavioural therapy, CBT, smoking Abbreviations 5-ASA: 5-aminosalicylate; AIDS: acquired immunodeficiency syndrome; ASUC: acute severe ulcerative colitis; AXR: abdominal x-ray; BCG: Bacillus Calmette-Guérin (TB vaccination); BMI: Body Mass Index; BSG: British Society of Gastroenterology; CBD: cannabinoid; CDAI: Crohn’s Disease Activity Index; CAMs: complementary and alternative medicines; CDEIS: Crohn’s Disease Endoscopic Index of Severity; CDI: Clostridium difficile infection; CI: Confidence (...) Assessment Tool; FBC: full blood count; HBI: Harvey Bradshaw Index; Hb: haemoglobin; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; HPV: human papilloma virus; HR: hazard ratio; HSTC: haematopoietic stem cell transplantation; HSV: herpes simplex virus; IBD: inflammatory bowel disease; IBD-U: inflammatory bowel disease unclassified; IBS: irritable bowel syndrome; IGRA: interferon gamma release assays; IL: interleukin; i.m.: intramuscular; IPAA: ileoanal pouch

2019 British Society of Gastroenterology

34. Pruritus

that it is frequently refractory to therapy, it causes a high burden and impairs quality of life. This guideline addresses all causes and types of CP including chronic prurigo. In its early stage, CP is considered a symptom of the underlying disease. However, with time, CP may develop its own dynamics that are no longer linked to the course of the underlying disease. In this stage, and much like chronic pain, this can be considered a distinct syndrome (CP syndrome) or even a disease in its own right (...) to be most pronounced in patients showing the JAK2 617V mutation (Siegel, Tauschert et al. 2013, Tefferi, Vannucchi et al. 2018). Pruritus in Hodgkin’s disease often starts on the legs and is most severe at night, but generalised pruritus soon ensues. Several factors such as secretion of leukopeptidases and bradykinin, histamine release and high IgE levels with cutaneous depositions may contribute to pruritus in lymphoma (Krajnik and Zylicz 2001). Patients with carcinoid syndrome may experience pruritus

2019 European Dermatology Forum

36. WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents

infiltration or destruction of brachial plexus Central Injury to central nervous system Spinal cord compression by tumour Mixed Peripheral and central injury Central sensitization due to unrelieved peripheral neuropathic pain Sympathetically maintained Dysfunction of sympathetic system Chronic regional pain syndrome following fracture or other trauma16 WHO GUIDELINES FOR THE PHARMACOLOGICAL AND RADIOTHERAPEUTIC MANAGEMENT OF CANCER PAIN IN ADULTS AND ADOLESCENTS WHO GUIDELINES FOR THE PHARMACOLOGICAL

2019 World Health Organisation Guidelines

37. Prostate Cancer

. 29. Esposito, K., et al. Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis. J Endocrinol Invest, 2013. 36: 132. 30. Blanc-Lapierre, A., et al. Metabolic syndrome and prostate cancer risk in a population-based case-control study in Montreal, Canada. BMC Public Health, 2015. 15: 913. 31. Preston, M.A., et al. Metformin use and prostate cancer risk. Eur Urol, 2014. 66: 1012. 32. Freedland, S.J., et al. Statin use and risk of prostate cancer and high-grade (...) : A Systematic Review and Meta-analysis. JAMA Intern Med, 2017. 177: 1273. 66. Cremers, R.G., et al. Self-reported acne is not associated with prostate cancer. Urol Oncol, 2014. 32: 941. 67. Huang, T.B., et al. Aspirin use and the risk of prostate cancer: a meta-analysis of 24 epidemiologic studies. Int Urol Nephrol, 2014. 46: 1715. 68. Bhindi, B., et al. The impact of the use of aspirin and other nonsteroidal anti-inflammatory drugs on the risk of prostate cancer detection on biopsy. Urology, 2014. 84: 1073

2019 European Association of Urology

38. Treatment of Diabetes in Older Adults Full Text available with Trip Pro

heart failure, the following oral hypoglycemic agents should be prescribed with caution to prevent worsening of heart failure: glinides, rosiglitazone, pioglitazone, and dipeptidyl peptidase-4 inhibitors. (Ungraded Good Practice Statement) Management of atherosclerosis in older adults with diabetes 5.9 In patients aged 65 years and older with diabetes and a history of atherosclerotic cardiovascular disease, we recommend low-dosage aspirin (75 to 162 mg/d) for secondary prevention of cardiovascular

2019 The Endocrine Society

39. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada

, Doreen Rabi MD, MSc, FRCPC, Robyn L. Houlden MD, FRCPC S10 Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome Zubin Punthakee MD, MSc, FRCPC, Ronald Goldenberg MD, FRCPC, FACE, Pamela Katz MD, FRCPC S16 Screening for Diabetes in Adults Jean-Marie Ekoe MD, CSPQ, PD, Ronald Goldenberg MD, FRCPC, FACE, Pamela Katz MD, FRCPC S20 Reducing the Risk of Developing Diabetes Ally P.H. Prebtani MD, BScPhm, FRCPC, Harpreet S. Bajaj MD, MPH, ECNU, FACE, Ronald Goldenberg MD (...) . Prebtani MD, FRCPC, Vincent Woo MD, FRCPC S190 Management of Acute Coronary Syndromes Jean-Claude Tardif MD, FRCPC, FACC, FCAHS, Phillipe L. L'Allier MD, David H. Fitchett MD, FRCPCCONTENTS (continued): April 2018 Volume 42 Supplement 1 S196 Treatment of Diabetes in People With Heart Failure Kim A. Connelly MBBS, PhD, FCCS, Richard E. Gilbert MBBS, PhD, Peter Liu MD, FRCPC, FACC S201 Chronic Kidney Disease in Diabetes Philip McFarlane MD, PhD, FRCPC, David Cherney MD, PhD, FRCPC, Richard E. Gilbert

2018 Diabetes Canada

40. Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease Full Text available with Trip Pro

; hyperthermia; hypothermia; hypoplastic left heart syndrome; infant, newborn; infusions, intraosseous; intensive care units, neonatal; intensive care units, pediatrics; ischemia; isoproterenol; kidney injury; kidney; lidocaine; medi- cal response team; mitral valve insufficiency/surgery; natriuretic peptide, brain; neonatology; nitric oxide; Norwood procedures; out-of-hospital cardiac arrest; patient transfer; pediatric early warning system; pe- diatrics; pericardial effusion; pericardial tamponade (...) ; pericardiocentesis; pericardiectomy; pharmaceutical preparations; phenylephrine; pneumothorax; post- pericardiotomy syndrome; pulsus paradoxus; qual- ity; quality improvement; quality of life; radiography, thoracic; resuscitation; resuscitation orders; scimitar syndrome/surgery; signs and symptoms; sodium bi- carbonate; spectroscopy, near-infrared; sudden death; therapy; transportation of patients; treatment; treat- ment outcome; vasopressin; ventricular dysfunction, left; ventricular dysfunction, right

2018 American Heart Association

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