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12401. Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study

Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study (DAIR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02087020 Recruitment Status : Completed First Posted

2014 Clinical Trials

12402. Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients

Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02305940 Recruitment Status : Completed First Posted : December 3, 2014 Last Update Posted : July 26, 2017 Sponsor: Imperial College London Information

2014 Clinical Trials

12403. Sensitivity of Antibiotics for Urinary Tract Infections Patients Attending Family Physicians

Sensitivity of Antibiotics for Urinary Tract Infections Patients Attending Family Physicians Sensitivity of Antibiotics for Urinary Tract Infections Patients Attending Family Physicians - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Sensitivity of Antibiotics for Urinary Tract Infections Patients Attending Family Physicians The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02305342 Recruitment Status : Completed First Posted : December 2, 2014 Last Update Posted : March 6, 2015 Sponsor: Abbott Information

2014 Clinical Trials

12404. Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance?

Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance? Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02292160 Recruitment Status : Completed First Posted : November 17, 2014 Last Update Posted : June 14, 2017 Sponsor: University Hospital, Rouen Information

2014 Clinical Trials

12405. World-wide Randomized Antibiotic Envelope Infection Prevention Trial

Infection Device: TYRX Absorbable Antibacterial Envelope Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 7075 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Prevention Official Title: Cardiovascular Implantable Electronic Device (CIED) Antibiotic Envelope Infection Prevention Trial Actual Study Start Date : January 2015 Actual Primary Completion Date (...) for the antimicrobial agents. Device: TYRX Absorbable Antibacterial Envelope No Intervention: Control No TYRX envelope, bare CIED Outcome Measures Go to Primary Outcome Measures : The first occurrence of a major CIED infection. [ Time Frame: Implant to 12 months ] CIED infections are defined as (1) superficial cellulitis in the region of the CIED pocket with wound dehiscence, erosion, or purulent drainage, (2) deep incisional or organ/space (generator pocket) surgical site infection that meets the Centers

2014 Clinical Trials

12406. Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy

Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy (Abx) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02247960 Recruitment Status : Terminated (Interim analysis determined that the study should be concluded for futility.) First Posted : September 25, 2014 Results First

2014 Clinical Trials

12407. Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone (AntibioCor) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02281929 Recruitment Status : Recruiting First Posted

2014 Clinical Trials

12408. Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients

in critically ill patients with suspected infection is of utmost importance with significant effect on survival. Procalcitonin is a reliable sepsis marker but results about its usefulness in initiating antimicrobials are conflicting. Our aim is to investigate the predictive value of 24 hours procalcitonin kinetics before starting empirical antibiotic therapy in intensive care patients as an indicator of the presence of bacterial infection. Study Design Go to Layout table for study information Study Type (...) Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2014 Clinical Trials

12409. Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections

Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections (PIVVOT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02311452 Recruitment Status : Completed First Posted : December 8, 2014 Last Update Posted

2014 Clinical Trials

12410. Antibacterial Dental Composites with Chlorhexidine and Mesoporous Silica. Full Text available with Trip Pro

Antibacterial Dental Composites with Chlorhexidine and Mesoporous Silica. One of the leading causes for the failure of dental composite restorations is secondary caries. Effectively inhibiting cariogenic biofilms and reducing secondary caries could extend the service life of composite restorations. Dental composites releasing antibacterial agents such as chlorhexidine (CHX) have shown biofilm-inhibitory efficacy, but they usually have poor physical and mechanical properties. Herein, we present (...) particle = 70 wt%). The monomer mixture consisted of bisphenol A glycidyl methacrylate (BisGMA), hexanediol dimethacrylate (HDDMA), ethoxylated bisphenol A dimethacrylate (EBPADMA), and urethane dimethacrylates (UEDMA) at a weight ratio of 40:30:20:10. The composites were tested for CHX release and recharge, flexural strength and modulus (at 24 hr and 1 mo), surface roughness, in vitro wear, and antibacterial activity against Streptococcus mutans and Lactobacillus casei (in both planktonic growth

2014 Journal of Dental Research

12411. Hospitalized AECOPD Patients Not Treated With Antibiotic Have Higher Rates of 1-Year Pneumonia Related Hospitalization. (Abstract)

Hospitalized AECOPD Patients Not Treated With Antibiotic Have Higher Rates of 1-Year Pneumonia Related Hospitalization.

2014 Chest

12412. Effect of Budesonide/Formoterol or Formoterol on Exacerbation Rates (Including and Excluding Antibiotics) and Responder Analysis: Pooled Analysis of Chronic Obstructive Pulmonary Disease Patients With Moderate vs Severe/Very Severe Airflow Limitation. (Abstract)

Effect of Budesonide/Formoterol or Formoterol on Exacerbation Rates (Including and Excluding Antibiotics) and Responder Analysis: Pooled Analysis of Chronic Obstructive Pulmonary Disease Patients With Moderate vs Severe/Very Severe Airflow Limitation.

2014 Chest

12413. What are the Patterns of Prophylactic Postoperative Oral Antibiotic Use After Foot and Ankle Surgery? Full Text available with Trip Pro

What are the Patterns of Prophylactic Postoperative Oral Antibiotic Use After Foot and Ankle Surgery? The CDC estimates 23% of healthcare-associated infections to be surgical site infections, with alarming prevalence of antibiotic-resistant organisms. While there is consensus regarding preoperative prophylaxis, orthopaedic surgeons' use of prophylactic postoperative oral antibiotics is less defined.We investigated surgeons' use of prophylactic postoperative oral antibiotics after elective (...) participants. After nonresponses and exclusions, 312 (28%) responses were analyzed. Statistical analysis used Pearson's chi-square test, Fisher's exact test, and multivariate regression.The majority (75%) of respondents reported use of prophylactic postoperative oral antibiotics. Most users (69%) prescribed to fewer than 25% of patients, although 16% prescribed for all elective cases. The most frequent regimen was cephalexin 500 mg four times a day (63%) and the most common duration was 5 to 7 days (50

2014 Clinical Orthopaedics and Related Research

12414. Surgical Site Infection After Arthroplasty: Comparative Effectiveness of Prophylactic Antibiotics: Do Surgical Care Improvement Project Guidelines Need to Be Updated? (Abstract)

Surgical Site Infection After Arthroplasty: Comparative Effectiveness of Prophylactic Antibiotics: Do Surgical Care Improvement Project Guidelines Need to Be Updated? Prophylactic antibiotics decrease surgical site infection (SSI) rates, and their timing, choice, and discontinuation are measured and reported as part of the Surgical Care Improvement Project (SCIP). The aim of this study was to assess the comparative effectiveness of the SCIP-approved antibiotics for SSI prevention.This (...) retrospective cohort study utilized national Veterans Affairs (VA) data on patients undergoing elective hip or knee arthroplasty from 2005 to 2009. Data on prophylactic antibiotics were merged with VA Surgical Quality Improvement Program data to identify patient and procedure-related risk factors for SSI. Patients were stratified by documented penicillin allergy. Chi-square and Wilcoxon rank-sum tests were used to compare SSI rates among patients receiving SCIP-approved prophylactic antibiotics.A total

2014 The Journal of Bone and Joint Surgery. American Volume

12415. Antibacterial and Anti-biofilm Activity of AH Plus with Chlorhexidine and Cetrimide. (Abstract)

Antibacterial and Anti-biofilm Activity of AH Plus with Chlorhexidine and Cetrimide. The use of root canal filling materials with antibacterial activity can be considered beneficial to reduce the remaining microorganisms in the root canal system, where Enterococcus faecalis is often found, and prevent recurrent infection. The aim of this study was to evaluate the antimicrobial activity and capacity for inhibiting E. faecalis biofilm formation of AH Plus, alone and mixed with chlorhexidine (CHX (...) ), cetrimide (CTR), and combinations of the two.AH Plus alone and mixed with 1% and 2% CHX, 0.1%-0.5% CTR, and combinations of both were tested to assess antimicrobial activity by a modified direct contact test and determine inhibition of E. faecalis biofilm formation at 24 hours. The results were expressed as log10 viable counts. Eradication and inhibition of biofilm formation were understood as no bacterial growth or log10 reduction = 5 with respect to the control (AH Plus alone).AH Plus + CHX showed

2014 Journal of Endodontics

12416. Acute rhinosinusitis: no tangible benefit with antibiotic therapy. (Abstract)

Acute rhinosinusitis: no tangible benefit with antibiotic therapy. In a new randomised placebo-placebo-controlled trial in adults with uncomplicated acute rhinosinusitis, amoxicillin was not shown to speed clinical improvement.

2014 Prescrire international

12417. Antibiotic prophylaxis in the management of vesicoureteric reflux: a randomized double-blind placebo-controlled trial. (Abstract)

Antibiotic prophylaxis in the management of vesicoureteric reflux: a randomized double-blind placebo-controlled trial. The benefits of long-term low-dose antibiotics in preventing urinary tract infection (UTI) and renal damage in children with primary vesicoureteric reflux (VUR) are unclear.Children aged between 1 and 12 years with VUR grade I-IV and a microbiologically proven UTI were randomized into two groups to receive either antibiotic prophylaxis [2 mg/kg trimethoprim + sulfamethoxazole (...) (TMP-SMX)] daily or placebo, respectively, for 12 months. Primary outcome was microbiologically confirmed symptomatic UTI. Intention-to-treat analysis using time-to-event data was performed.A total of 93 children (66.7 % boys) with a median age of 4.6 years were enrolled in this study; VUR grade III-IV was present in 73.1 % of these children. At least one symptomatic UTI occurred in ten (21.3 %) patients receiving antibiotic prophylaxis and in three (6.5 %) patients receiving placebo [hazard ratio

2014 Pediatric nephrology (Berlin, Germany) Controlled trial quality: predicted high

12418. Electronic Health Records for Intervention Research: A Cluster Randomized Trial to Reduce Antibiotic Prescribing in Primary Care (eCRT Study). Full Text available with Trip Pro

Electronic Health Records for Intervention Research: A Cluster Randomized Trial to Reduce Antibiotic Prescribing in Primary Care (eCRT Study). This study aimed to implement a point-of-care cluster randomized trial using electronic health records. We evaluated the effectiveness of electronically delivered decision support tools at reducing antibiotic prescribing for respiratory tract infections in primary care.Family practices from England and Scotland participating in the Clinical Practice (...) with an antibiotic prescribed based on electronic health records. Family practice-specific proportions were included in a cluster-level analysis.Data were analyzed for 603,409 patients: 317,717 at intervention practices and 285,692 at control practices. Use of the intervention was less than anticipated, varying among practices. There was a reduction in proportion of consultations with antibiotics prescribed of 1.85% (95% CI, 0.10%-3.59%, P=.038) and in the rate of antibiotic prescribing for respiratory tract

2014 Annals of family medicine Controlled trial quality: uncertain

12419. Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study. Full Text available with Trip Pro

Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study. To describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given to age-group-specific distributions of antibiotic subgroups, since comparison in this regard between countries is lacking so far.Outpatient paediatric prescriptions of systemic antibiotics during (...) the years 2005-2008 were analysed using health care databases from the UK, the Netherlands, Denmark, Italy and Germany. Annual antibiotic prescription rates per 1,000 person years were estimated for each database and stratified by age (≤4, 5-9, 10-14, 15-18 years). Age-group-specific distributions of antibiotic subgroups were calculated for 2008.With 957 prescriptions per 1000 person years, the highest annual prescription rate in the year 2008 was found in the Italian region Emilia Romagna followed

2014 BMC Pediatrics

12420. Synergism of antimalarial antibiotics with hydrogen peroxide in inhibiting Plasmodium falciparum growth in culture. (Abstract)

Synergism of antimalarial antibiotics with hydrogen peroxide in inhibiting Plasmodium falciparum growth in culture. Although morbidity and mortality from malaria have steadily decreased worldwide, the ever present menace of the appearance of Plasmodium falciparum resistant to all antimalarials in current use, including most recently to artemisinin and its analogs, is of utmost concern, especially when development of new and affordable antimalarials has not kept abreast of this phenomenon (...) . An alternative approach is to identify synergistic drug combinations, which would allow employment of otherwise non-efficacious antimalarial drugs. This study demonstrates that combinations of the chemical oxidant hydrogen hydroxide with antimalarial antibiotics targeting parasite mitochondrial and apicoplast ribosomes, which normally produce 'delayed-death' of parasites, act synergistically to inhibit P. falciparum growth in culture.

2014 Southeast Asian Journal of Tropical Medicine and Public Health

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