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101. Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines

Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Published on: March 3, 2017 Project Number: RC0852-000 Product (...) Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of topical antibiotics for patients with infected dermatitis? What are the evidence-based guidelines regarding the use of topical antibiotics for the treatment of infected dermatitis? Key Message Evidence to date suggests that topical antibiotics provide no additional benefits when added to other topical treatments in both children and adults with clinically

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

102. Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines

Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines Published on: February 21, 2017 Project Number: RC0851-000 Product Line: Research Type: Drug Report Type (...) : Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of topical antibiotics for patients with impetigo? What are the evidence-based guidelines regarding the use of topical antibiotics for the treatment of impetigo? Key Message The evidence identified in this report supports the clinical efficacy of topical antibiotics, specifically mupirocin and fusidic acid, for the treatment of impetigo. Insufficient evidence was identified to support the clinical efficacy

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

103. Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Published on: March 23, 2017 Project Number (...) : RB1076-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of antibiotics for acute asthma exacerbations without clear signs of bacterial infection? What is the cost-effectiveness of antibiotics for acute asthma exacerbations without clear signs of bacterial infection? What are the evidence-based guidelines regarding the use of antibiotics for acute asthma exacerbations? Key Message Three randomized-control trials

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

104. Antimicrobial prescribing: ceftolozane with tazobactam for treating hospital-acquired pneumonia, including ventilator-associated pneumonia

for Antimicrobial Utilisation and Resistance (ESPAUR) Report 2018 to 2019 states that monitoring the use of new antibiotics and detecting emerging resistance to these medicines is a crucial component of antimicrobial usage surveillance to inform antimicrobial stewardship activities and preserve treatment effectiveness. Although susceptibility testing for ceftolozane with tazobactam is currently uncommon and selective (following resistance to first- and second-line antibiotics), resistance has nonetheless been (...) ) is Antimicrobial prescribing: ceftolozane with tazobactam for treating hospital-acquired pneumonia, including ventilator-associated pneumonia (ES22) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 6£402.18 (BNF, November 2019). The acquisition costs (excluding VAT) of many other IV antibiotics that are used for HAP and VAP (caused or suspected to be caused by Gram-negative pathogens) are lower than that of ceftolozane

2020 National Institute for Health and Clinical Excellence - Advice

105. Reduced user fees for antibiotics under age 5 in Hungary: Effect on antibiotic use and imbalances in the implementation. Full Text available with Trip Pro

Reduced user fees for antibiotics under age 5 in Hungary: Effect on antibiotic use and imbalances in the implementation. In August 2016, new prescription guidelines were introduced in Hungary to reduce the co-payments for antibiotics among children aged 0-4. This study aims at analysing the implementation of this policy and its effect on the use of antibiotics.The analysis is based on administrative prescription records between January 2010-February 2018, covering the entire population (...) of Hungary aged 0-7. Spatial autocorrelation indices are calculated and settlement level regression models are estimated to analyse the spatial variation in the application of the new guidelines. The effect of reduced co-payments on antibiotic use is estimated with a difference-in-differences type model: the treatment and control groups are children aged 0-4 and 5-7, respectively; the treatment and control periods are August 2016-February 2018 and January 2010-July 2016, respectively.The new prescription

2019 PLoS ONE

106. "Without antibiotics, I cannot treat": A qualitative study of antibiotic use in Paschim Bardhaman district of West Bengal, India. Full Text available with Trip Pro

"Without antibiotics, I cannot treat": A qualitative study of antibiotic use in Paschim Bardhaman district of West Bengal, India. Misuse of antibiotics is a well-known driver of antibiotic resistance. Given the decentralized model of the Indian health system and the shortage of allopathic doctors in rural areas, a wide variety of healthcare providers cater to the needs of patients in urban and rural settings. This qualitative study explores the drivers of antibiotic use among formal (...) and deductive manner.Our results indicate that patients demand antibiotics from healthcare providers and seek the fastest cure possible, which influences the prescription choices of healthcare providers, particularly informal health providers. Many allopathic doctors provide antibiotics without any clinical indication due to inconsistent follow up, lack of testing facilities, risk of secondary infections, and unhygienic living conditions. Pharmaceutical company representatives actively network with informal

2019 PLoS ONE

107. Selection and co-selection of antibiotic resistances among Escherichia coli by antibiotic use in primary care: An ecological analysis. Full Text available with Trip Pro

Selection and co-selection of antibiotic resistances among Escherichia coli by antibiotic use in primary care: An ecological analysis. The majority of studies that link antibiotic usage and resistance focus on simple associations between the resistance against a specific antibiotic and the use of that specific antibiotic. However, the relationship between antibiotic use and resistance is more complex. Here we evaluate selection and co-selection by assessing which antibiotics, including those (...) mainly prescribed for respiratory tract infections, are associated with increased resistance to various antibiotics among Escherichia coli isolated from urinary samples.Monthly primary care prescribing data were obtained from National Health Service (NHS) Digital. Positive E. coli records from urine samples in English primary care (n = 888,207) between April 2014 and January 2016 were obtained from the Second Generation Surveillance System. Elastic net regularization was used to evaluate associations

2019 PLoS ONE

108. Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria. Full Text available with Trip Pro

Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria. Inappropriate and excessive use of surgical antibiotic prophylaxis are associated with the emergence of antibiotic resistance. Antibiotic prophylaxis malpractices are common in obstetrics and gynecology settings and antibiotic stewardship is used to correct such malpractice.To evaluate the impact of antibiotic stewardship (...) interventions on compliance with surgical antibiotic prophylaxis practice in obstetrics and gynecology surgeries.A prospective pre- and post-intervention study was conducted in two tertiary hospitals between May and December 2016. The duration of the each period was 3 months. Antibiotic stewardship interventions including development of a protocol, educational meeting and audit and feedback were implemented. Data were collected using the patient records and analyzed with SPSS version 23.A total of 226

2019 PLoS ONE

109. Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship. Full Text available with Trip Pro

Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship. Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover (...) infections, in which pneumonia is the most common. Cephalosporins were the most widely prescribed class of drugs in all the wards. Initial antibiotics were empiric in almost all of the cases. About 28% of the ward and 59% of the ICU patients died during the in-hospital stay. The mean length of stay (LoS) was 18.5+12.2 in the wards and 8.9+4.9 days in the ICU. Whilst digestive disease (AOR = 6.94, 95% CI: 2.24, 21.49), different signs and symptoms of disease (AOR = 2.43, 95% CI: 1.30, 4.56), sepsis (AOR

2019 PLoS ONE

110. Emergence of antibiotic resistance in immunocompromised host populations: A case study of emerging antibiotic resistant tuberculosis in AIDS patients. Full Text available with Trip Pro

Emergence of antibiotic resistance in immunocompromised host populations: A case study of emerging antibiotic resistant tuberculosis in AIDS patients. The evolution of antibiotic resistance is far outpacing the development of new antibiotics, causing global public health concern about infections that will increasingly be unresponsive to antimicrobials. This risk of emerging antibiotic resistance may be meaningfully altered in highly AIDS-immunocompromised populations. Such populations (...) fundamentally alter the bacterial evolutionary landscape in two ways, which we seek to model and analyze. First, widespread, population-level immunoincompetence creates a novel host environment with disrupted selective pressures. Second, within AIDS-prevalent populations, the recommendation that antibiotics be taken to treat and prevent opportunistic infection raises the risk of selection for drug-resistant pathogens.To determine the impact of HIV/AIDS on the emergence of antibiotic resistance-specifically

2019 PLoS ONE

111. Integrated one-day surveillance of antimicrobial use, antimicrobial consumption, antimicrobial resistance, healthcare-associated infection, and antimicrobial resistance burden among hospitalized patients in Thailand. (Abstract)

Integrated one-day surveillance of antimicrobial use, antimicrobial consumption, antimicrobial resistance, healthcare-associated infection, and antimicrobial resistance burden among hospitalized patients in Thailand. Surveillance of antimicrobial use (AMU), antimicrobial consumption (AMC), antimicrobial resistance (AMR), healthcare-associated infection (HAI), and AMR burden are usually measured by time-consuming and expensive multiple separate longitudinal surveys. This study aimed (...) to investigate feasibility and benefit of integrated one-day surveillance to estimate and monitor these parameters.Integrated one-day surveillance of AMU, AMC, AMR, HAI, and AMR burden among hospitalized patients in 183 hospitals in Thailand was conducted. Parameter data was collected for each patient who received antibiotic on a survey day.AMU prevalence was 51.5% among 23,686 hospitalized patients. The most commonly used antibiotic for infection prophylaxis and treatment was cefazolin and ceftriaxone

2020 Journal of Infection

112. Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use

(including antibiotics) in children, young people and adults. It aims to change prescribing practice to help slow the emergence of antimicrobial resistance and ensure that antimicrobials remain an effective treatment for infection. Who is it for? Health and social care practitioners Organisations commissioning, providing or supporting the provision of care People who are taking antimicrobials and their families and carers. Antimicrobial stewardship: systems and processes for effective antimicrobial (...) Antimicrobial stewardship Antimicrobial stewardship The term 'antimicrobial stewardship' is defined as 'an organisational or healthcare-system-wide approach to promoting and monitoring judicious use of antimicrobials to preserve their future effectiveness' . Antimicrobial resistance Antimicrobial resistance The term 'antimicrobial resistance' is defined as the 'loss of effectiveness of any anti-infective medicine, including antiviral, antifungal, antibacterial and antiparasitic medicines' . Antimicrobials

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

113. A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation Full Text available with Trip Pro

A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation

2020 NIHR HTA programme

114. Pneumonia (hospital-acquired): antimicrobial prescribing

of 23Contents Contents Overview 4 Who is it for? 4 Recommendations 5 1.1 Managing hospital-acquired pneumonia 5 1.2 Choice of antibiotic 6 T erms used in the guideline 13 Hospital-acquired pneumonia 13 Summary of the evidence 14 Antibiotic prescribing strategies 14 Choice of antibiotics 15 Antibiotic course length, dosage and route of administration 22 Other considerations 23 Medicines adherence 23 Resource implications 23 Pneumonia (hospital-acquired): antimicrobial prescribing (NG139) © NICE 2019. All (...) rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 23Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for adults, young people, children and babies aged 72 hours and over with a confirmed diagnosis of hospital-acquired pneumonia. It does not cover ventilator-associated pneumonia. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 3-page visual summary of the recommendations

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

115. Pneumonia (community-acquired): antimicrobial prescribing

37 Resource implications 37 Pneumonia (community-acquired): antimicrobial prescribing (NG138) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 37Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for adults, young people, children and babies aged 72 hours and over with a confirmed diagnosis of community-acquired pneumonia. It aims to optimise antibiotic use and reduce antibiotic (...) disease or immunosuppression local antimicrobial resistance and surveillance data (such as flu and Mycoplasma pneumoniae infection rates) recent antibiotic use recent microbiological results, including colonisation with multidrug-resistant bacteria. 1.1.2 Start antibiotic treatment as soon as possible after establishing a diagnosis of community-acquired pneumonia, and certainly within 4 hours (within 1 hour if the person has suspected sepsis and meets any of the high risk criteria for this – see

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

116. Cellulitis and erysipelas: antimicrobial prescribing

. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 3-page visual summary of the recommendations, including tables to support prescribing decisions. For managing other skin conditions, see our web page on skin conditions. NICE has also produced a guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. Who is it for? Healthcare professionals People with cellulitis and erysipelas, their families and carers Cellulitis and erysipelas (...) Staphylococcus aureus (MRSA) status if known. 1.1.5 Give oral antibiotics first line if the person can take oral medicines, and the severity of their condition does not require intravenous antibiotics. Cellulitis and erysipelas: antimicrobial prescribing (NG141) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 361.1.6 If intravenous antibiotics are given, review by 48 hours and consider switching to oral antibiotics

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

117. Cough (acute): antimicrobial prescribing

1.1 Managing acute cough 5 1.2 Self-care 8 1.3 Choice of antibiotic 9 T erms used in the guideline 11 Acute cough 11 Acute bronchitis 11 Self-care treatments 11 Summary of the evidence 12 Self-care 12 Bronchodilators 22 Corticosteroids 23 Mucolytics 24 No antibiotic 25 Back-up antibiotics 29 Choice of antibiotic 33 Antibiotic course length 35 Other considerations 36 Medicines adherence 36 Resource implications 36 Cough (acute): antimicrobial prescribing (NG120) © NICE 2019. All rights reserved (...) . Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 36Ov Overview erview This guideline sets out an antimicrobial prescribing strategy for acute cough associated with an upper respiratory tract infection or acute bronchitis in adults, young people and children. It aims to limit antibiotic use and reduce antibiotic resistance. See a 2-page visual summary of the recommendations, including tables to support prescribing decisions. For treating coughs

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

118. Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing

Reassessment 14 Referral and seeking specialist advice 14 Choice of antibiotic for treating an acute exacerbation of bronchiectasis 15 Preventing acute exacerbations of bronchiectasis (non-cystic fibrosis) and choice of antibiotic 17 Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing (NG117) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 19Ov Overview erview This guideline sets out (...) an antimicrobial prescribing strategy for managing and preventing acute exacerbations of bronchiectasis (non-cystic fibrosis). It aims to optimise antibiotic use and reduce antibiotic resistance. See a 3-page visual summary of the recommendations, including tables to support prescribing decisions. NICE has also produced a guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. Who is it for? Health professionals People with bronchiectasis, their families

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

119. Antibiotic prophylaxis in TURP: a prospective analysis concerning antibiotic stewardship and a potential reduction of antibiotic use in TURP. (Abstract)

Antibiotic prophylaxis in TURP: a prospective analysis concerning antibiotic stewardship and a potential reduction of antibiotic use in TURP. Antibiotic prophylaxis is standard procedure in transurethral resection of the prostate (TURP). We evaluated the necessity of antibiotic (AB) prophylaxis in TURP due to increasing microbial antibiotic resistance.This is a prospective cohort study of 506 patients. Only patients with a pre-operative catheter/pyuria received AB-prophylaxis. Urine analysis (...) (pre-operative, at discharge, and 3 week post-operative) was performed next to an analysis of the blood culture/irrigation fluid and of the resected prostatic tissue. Statistical analysis was performed using Fisher's exact test.67/506 (13.2%) patients received prophylactic antibiotics. 56/67 (83.5%) patients had a pre-operative catheter and 11/67 (16.4%) had pre-operative pyuria in which a fluoroquinolone-resistance (FQ-R) rate of 69.2% in Escherichia coli (EC) was observed. Clinical infectious

2019 World journal of urology

120. [Clinical guides in antibiotic treatment - 1st series (update)]

[Clinical guides in antibiotic treatment - 1st series (update)] Guides cliniques en antibiothérapie - Série I (mise à jour du guide RSA chez l'adulte) [Clinical guides in antibiotic treatment – 1st series (update)] Guides cliniques en antibiothérapie - Série I (mise à jour du guide RSA chez l'adulte) [Clinical guides in antibiotic treatment – 1st series (update)] INESSS Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA (...) . No evaluation of the quality of this assessment has been made for the HTA database. Citation INESSS. Guides cliniques en antibiothérapie - Série I (mise à jour du guide RSA chez l'adulte). [Clinical guides in antibiotic treatment – 1st series (update)] Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). 2016 Authors' objectives First published in January 2005, the first series of clinical guides on antibiotic treatment were revised and updated in fall 2009. These guides outline

2017 Health Technology Assessment (HTA) Database.

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