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81. Antibiotic prophylaxis for episiotomy repair following vaginal birth. Full Text available with Trip Pro

(e.g. endometritis) were reported in either the antibiotic or control group.The trial did not report on any of the secondary outcomes of interest for this review, including severe maternal infectious morbidity, discomfort or pain at the episiotomy wound site, sexual function postpartum, adverse effects of antibiotics, costs of care, women's satisfaction with care, and individual antimicrobial resistance.There was insufficient evidence to assess the clinical benefits or harms of routine antibiotic (...) Antibiotic prophylaxis for episiotomy repair following vaginal birth. Bacterial infections occurring during labour, childbirth, and the puerperium may be associated with considerable maternal and perinatal morbidity and mortality. Antibiotic prophylaxis might reduce wound infection incidence after an episiotomy, particularly in situations associated with a higher risk of postpartum perineal infection, such as midline episiotomy, extension of the incision, or in settings where the baseline risk

2017 Cochrane

82. Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Full Text available with Trip Pro

Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Pneumonia is a leading cause of childhood mortality from infectious disease, responsible for an estimated 1.3 million deaths annually in children under five years of age, many of which are in low-income countries. The World Health Organization recommends intravenous antibiotics for five days as first-line treatment for children (...) a significant burden on both patients and their families, including substantial expense, loss of routine, and decrease in quality of life. By reducing the duration of hospital treatment, healthcare burdens could potentially be reduced and treatment compliance may improve.This is an update of a review published in 2015.To evaluate the efficacy of short-course (two to three days) versus long-course (five days) intravenous therapy (alone or in combination with oral antibiotics) with the same antibiotic

2017 Cochrane

83. Pre-admission antibiotics for suspected cases of meningococcal disease. Full Text available with Trip Pro

Pre-admission antibiotics for suspected cases of meningococcal disease. Meningococcal disease can lead to death or disability within hours after onset. Pre-admission antibiotics aim to reduce the risk of serious disease and death by preventing delays in starting therapy before confirmation of the diagnosis.To study the effectiveness and safety of pre-admission antibiotics versus no pre-admission antibiotics or placebo, and different pre-admission antibiotic regimens in decreasing mortality (...) , clinical failure, and morbidity in people suspected of meningococcal disease.We searched CENTRAL (6 January 2017), MEDLINE (1966 to 6 January 2017), Embase (1980 to 6 January 2017), Web of Science (1985 to 6 January 2017), LILACS (1982 to 6 January 2017), and prospective trial registries to January 2017. We previously searched CAB Abstracts from 1985 to June 2015, but did not update this search in January 2017.Randomised controlled trials (RCTs) or quasi-RCTs comparing antibiotics versus placebo

2017 Cochrane

84. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Full Text available with Trip Pro

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection.To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following (...) method and incision type) for lens opacities due to any origin. We included trials that evaluated preoperative antibiotics, intraoperative (intracameral, subconjunctival or systemic), or postoperative antibiotic prophylaxis for acute endophthalmitis. We excluded studies that evaluated antiseptic preoperative preparations using agents such as povidone iodine or antibiotics for treating acute endophthalmitis after cataract surgery.Two review authors independently reviewed abstracts and full-text

2017 Cochrane

85. Antibiotic therapy for pelvic inflammatory disease. Full Text available with Trip Pro

Antibiotic therapy for pelvic inflammatory disease. Pelvic inflammatory disease (PID) is an infection that affects 4% to 12% of young women, and is one of the most common causes of morbidity in this age group. The main intervention for acute PID is the use of broad-spectrum antibiotics which cover Chlamydia trachomatis, Neisseria gonorrhoeae, and anaerobic bacteria, administered intravenously, intramuscularly, or orally. In this review, we assessed the optimal treatment regimen for PID.To (...) assess the effectiveness and safety of antibiotic regimens used to treat pelvic inflammatory disease.We searched the Cochrane Sexually Transmitted Infections Review Group's Specialized Register, which included randomized controlled trials (RCTs) from 1944 to 2016, located through electronic searching and handsearching; the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid platform (1991 to July 2016); MEDLINE (1946 to July 2016); Embase (1947 to July 2016); LILACS, iAHx interface (1982

2017 Cochrane

86. Impetigo: antimicrobial prescribing

T erms used in the guideline 11 Recommendation for research 13 1 Antiseptics compared with antibiotics for impetigo 13 Rationales 14 Advice to reduce the spread of impetigo 14 Initial treatment 14 Reassessment and further treatment 16 Referral and seeking specialist advice 17 Choice of antimicrobial 18 Context 21 Summary of the evidence 22 Antimicrobials 22 Choice of antibiotics 23 Course length 25 Route of administration 25 Other considerations 27 Medicines safety 27 Medicines adherence 27 (...) Resource implications 27 Impetigo: antimicrobial prescribing (NG153) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 28Overview Overview This guideline sets out an antimicrobial prescribing strategy for adults, young people and children aged 72 hours and over with impetigo. It aims to optimise antibiotic use and reduce antibiotic resistance. For managing other skin and soft tissue infections, see our web pages

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

87. Leg ulcer infection: antimicrobial prescribing

26 Medicines safety 26 Medicines adherence 27 Resource implications 27 Leg ulcer infection: antimicrobial prescribing (NG152) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 28Overview Overview This guideline sets out an antimicrobial prescribing strategy for adults with leg ulcer infection. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 2-page visual summary (...) antibiotic use. 1.1.4 Give oral antibiotics if the person can take oral medicines, and the severity of their condition does not require intravenous antibiotics. 1.1.5 If intravenous antibiotics are given, review by 48 hours and consider switching to oral antibiotics if possible. T o find out why the committee made the recommendations on treatment for adults with an infected leg ulcer, see the rationales. Leg ulcer infection: antimicrobial prescribing (NG152) © NICE 2020. All rights reserved. Subject

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

88. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes Full Text available with Trip Pro

Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes Journals Library An error has occurred in processing the XML document An error occurred retrieving content

2014 NIHR HTA programme

89. Antibiotics in Acute Uncomplicated Diverticulitis

Antibiotics in Acute Uncomplicated Diverticulitis Emergency Medicine > Journal Club > Archive > March 2016 Toggle navigation March 2016 Antibiotics in Acute Uncomplicated Diverticulitis Vignette You are halfway through an average weekday shift in EM-2 when you encounter a very pleasant 50-year-old gentleman with abdominal pain. He reports the pain began three days ago and has progressively worsened. It is a dull, moderate pain located in the left lower quadrant with no radiation. He denies (...) check basic labs and order a CT scan of the abdomen and pelvis with IV contrast. His WBC is 14K and his CT reveals uncomplicated sigmoid diverticulitis without perforation of abscess formation. As you are ordering antibiotics, you remember seeing a recent article in suggesting that antibiotics may not actually be necessary to treat diverticulitis. You had previously scoffed at the suggestion and tossed the magazine in the trash, but now wonder if the assertion was based on real science. Aware

2017 Washington University Emergency Medicine Journal Club

90. Maternal and child health: Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis

Maternal and child health: Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings (...) in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Article Text Commentary Maternal and child health Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Meret Merker 1 , 2 , Rebekka Bolliger 1 , 2 , Philipp Schuetz 1 , 2 Statistics from Altmetric.com Commentary on : Stocker M, van Herk W, El Helou S, et al . Procalcitonin-guided decision making

2018 Evidence-Based Medicine

91. Antimicrobial stewardship: Systems and processes for effective antimicrobial medicine use within human health and healthcare in New Zealand

and Contextualisation Group (GRCG) for each guideline. The GRCG will carefully consider the NICE guideline recommendations, taking into account the differences between the UK and New Zealand health care systems to produce a guideline that is relevant to those delivering and managing care in New Zealand. The development of a profusion of antimicrobial medicines since the middle of the twentieth century has been one of the greatest advances of medical science. Antibiotic therapy has reduced the mortality (...) ‘antimicrobial resistance’ is defined as the ‘loss of effectiveness of any anti infective medicine, including antiviral, antifungal, antibacterial and antiparasitic medicines’. Antimicrobials and antimicrobial medicines The term ‘antimicrobials’ and ‘antimicrobial medicines’ includes all anti infective therapies, (antiviral, antifungal, antibacterial and antiparasitic medicines) and all formulations (oral, parenteral and topical agents). Organisations The term ‘organisations’ (also known as the ‘service

2017 Best Practice Advocacy Centre New Zealand

92. Antibiotic Therapy in Preterm Premature Rupture of the Membranes

Antibiotic Therapy in Preterm Premature Rupture of the Membranes No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 9, Pages e207–e212 No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes x Mark H. Yudin , MD Toronto, ON x Julie van Schalkwyk , MD Vancouver, BC x Nancy Van Eyk , MD Halifax, NS No. 233, September 2017 (...) DOI: To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (PPROM). Outcomes Outcomes evaluated include the effect of antibiotic treatment on maternal infection, chorioamnionitis, and neonatal morbidity and mortality. Evidence Published literature was retrieved through searches of Medline, EMBASE, CINAHL

2017 Society of Obstetricians and Gynaecologists of Canada

93. Antibiotic Prophylaxis in Obstetric Procedures

Antibiotic Prophylaxis in Obstetric Procedures No. 247-Antibiotic Prophylaxis in Obstetric Procedures - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 9, Pages e293–e299 No. 247-Antibiotic Prophylaxis in Obstetric Procedures x Julie van Schalkwyk , MD Vancouver, BC x Nancy Van Eyk , MD Halifax, NS No. 247, September 2017 DOI: To view the full text, please login as a subscribed user or . Click to view the full (...) text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on antibiotic prophylaxis for obstetrical procedures. Outcomes Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in obstetrical procedures. Evidence Published literature was retrieved through searches of Medline and The Cochrane Library on the topic of antibiotic prophylaxis in obstetrical procedures. Results were restricted to systematic reviews, randomized controlled

2017 Society of Obstetricians and Gynaecologists of Canada

94. Cystitis: taking an antibiotic

Cystitis: taking an antibiotic Decision aid for cystitis: taking an antibiotic © NICE 2018. All rights reserved. Subject to Notice of rights. Last updated November 2018 Page 1 of 2 Decision aid Cystitis: taking an antibiotic Information to help women who are not pregnant discuss the options with their healthcare professionals. Cystitis is usually caused by bacteria (germs) from your gut getting into your bladder (also called lower urinary tract infection, UTI). Sometimes symptoms get better (...) by themselves, but many people will need antibiotic treatment. What are the options? It’s not always clear when an antibiotic is needed so, for some women with cystitis, NICE recommends that you could either: ? start taking an antibiotic straightaway, or ? wait, and see if your symptoms start to get better by themselves. If they don’t get better within 48 hours, or get worse at any time, you should start taking the antibiotic. You can choose whether to wait and see if your symptoms improve on their own

2018 Health Information and Quality Authority

95. The Timing of Early Antibiotics and Hospital Mortality in Sepsis

The Timing of Early Antibiotics and Hospital Mortality in Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

96. Game Changer? How Many Days of Antibiotics is Best for Treating Community Acquired Pneumonia?

Game Changer? How Many Days of Antibiotics is Best for Treating Community Acquired Pneumonia? Game Changer? How Many Days of Antibiotics is Best for Treating Community Acquired Pneumonia? – Clinical Correlations Search Game Changer? How Many Days of Antibiotics is Best for Treating Community Acquired Pneumonia? January 16, 2018 6 min read By Calvin Ngai, MD Peer Reviewed A 71-year-old Caucasian woman with hypertension presented with a 2-day history of productive cough and fever. She was living (...) alone and had no history of any recent hospitalizations. On examination, she was alert and oriented but slightly tachypneic; her lungs were clear to auscultation bilaterally. Laboratory tests were significant for a white blood cell count of 18,000 m L with 89% neutrophils. The chest x-ray showed a right lower lobe infiltrate. She was admitted and started on antibiotics for treatment of community acquired pneumonia (CAP). She improved clinically, and after remaining afebrile for 48 hours, she

2018 Clinical Correlations

97. Are Latino Cultural Beliefs Increasing Antibiotic Resistance in the US?

of the excessive use of antibiotics, as exposure to multiple antibacterial agents provides the selective pressure for the rise and spread of these pathogens. 1 Studies have shown that the overuse of antibiotics is a consequence of the increased worldwide availability of these agents and 1 This issue is particularly relevant in Latin American countries, . 2 Given the increase in the numbers of Latino immigrants, it is important to examine their perceptions of medicine and antibiotic use in order to devise (...) better strategies to control the rise of antimicrobial resistant pathogens—a major global public health problem. Latin American countries have fewer restrictions on the sale of antimicrobial agents, and the existing . 3 This enables the self-diagnosing and self-medicating practices that many members of the Latino community are accustomed to. Furthermore, cultural beliefs and misconceptions regarding the purpose and function of antibiotics play a major role in their misuse among the Latino population

2018 Clinical Correlations

98. Primary care: Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs

Primary care: Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser (...) injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs Article Text Commentary Primary care Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs Oghenekome Gbinigie Statistics from Altmetric.com Commentary on : Crellin E, Mansfield KE, Leyrat C, et al . Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study. BMJ

2018 Evidence-Based Medicine

99. General medicine: Antibiotic prescribing does not decrease complications in adult patients with lower respiratory tract infections

General medicine: Antibiotic prescribing does not decrease complications in adult patients with lower respiratory tract infections Antibiotic prescribing does not decrease complications in adult patients with lower respiratory tract infections | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Antibiotic prescribing does not decrease complications in adult patients with lower respiratory tract infections Article Text Commentary General

2018 Evidence-Based Medicine

100. Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines

Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Published on: March 30, 2017 Project Number: RC0854-000 (...) Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of topical antibiotics for patients to prevent skin or wound infection? What are the evidence-based guidelines regarding the use of topical antibiotics for the prevention of skin or wound infection? Key Message Two systematic reviews and one non-randomized study showed that in non-surgical patients, exit site infection rates were statistically significantly

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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