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81. The Collaborative Assessment, OTCA12, on “C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing in primary care settings for acute respiratory tract infections (RTIs)

-reactive protein point-of-care testing to guide antibiotic prescribing for acute respiratory tract infections in primary care EUnetHTA Joint Action 3 WP4 3 Consultation of the draft Rapid Assessment External experts [V.1.3] Elizabeth Beech, National Project Lead – Healthcare Acquired Infection and Antimicrobial Resistance, NHS Improvement, England Dr Nuala O’Connor, Irish College of General Practitioners (ICGP) GP Lead HSE Clinical Programme HCAI-AMR Professor Martin Cormican, National Clinical Lead (...) ) RECOMMENDATIONS IN EUROPEAN COUNTRIES FOR CRP POCT 248 Figures FIGURE 1: ANATOMY OF THE RESPIRATORY TRACT 67 FIGURE 2: ANTIMICROBIAL RESISTANCE (COMBINED NON-SUSCEPTIBILITY FOR PENICILLINS AND MACROLIDES) VERSUS STREPTOCOCCUS PNEUMONIAE IN EU/EEA COUNTRIES, 2017 68 FIGURE 3: CONSUMPTION OF ANTIBIOTICS FOR SYSTEMIC USE IN THE COMMUNITY, EU/EEA COUNTRIES, 2016 (EXPRESSED AS DDD PER 1 000 INHABITANTS PER DAY) 69 FIGURE 4: FLOW CHART SYSTEMATIC REVIEW 1 (EFFECTIVENESS AND SAFETY) 83 C-reactive protein point

2019 EUnetHTA

82. FSRH CEU statement on antibiotic cover for urgent insertion of intrauterine contraception in women at high risk of STI

FSRH CEU statement on antibiotic cover for urgent insertion of intrauterine contraception in women at high risk of STI FSRH CEU statement on antibiotic cover for urgent insertion of intrauterine contraception in women at high risk of STI (May 2019) - Faculty of Sexual and Reproductive Healthcare FSRH CEU statement on antibiotic cover for urgent insertion of intrauterine contraception in women at high risk of STI (May 2019) FSRH CEU statement on antibiotic cover for urgent insertion (...) of intrauterine contraception in women at high risk of STI (May 2019) Share this article Published on: 22 May 2019 File size: 241kb PDF File type: Clinical Statements This statement provides guidance on antibiotic cover for urgent insertion of intrauterine contraception in women at high risk of STI. Download the full document here. Your download should start automatically. If not . Document types Thinking about taking a qualification? Registration is now quick and easy online. About FSRH FSRH is a faculty

2019 Faculty of Sexual & Reproductive Healthcare

83. HTA of C-reactive protein point-of-care testing to guide antibiotic prescribing

a range of health services, in conjunction with the Department of Health and the HSE. Health Technology Assessment (HTA) of CRP POCT Health Information and Quality Authority iv Foreword Antimicrobial resistance occurs when bacteria adapt in response to the use of medicines. When bacteria become antibiotic resistant, infections become more difficult to manage and treat. Antimicrobial resistance is a significant threat to public health, and widely acknowledged to be associated with the excessive (...) , but not for those with acute bronchitis. ? Overprescribing of antibiotics for RTIs in primary care is common in most industrialised countries, with high levels of inappropriate prescribing documented. Antibiotic treatment of RTIs can expose patients to an increased risk of an adverse event, with one out of five patients experiencing mostly minor and self-limiting adverse events. Antimicrobial resistance (AMR) is a growing and significant threat to public health, and it is widely recognised that antibiotic

2019 Health Information and Quality Authority

84. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects

and tendon rupture report suspected adverse drug reactions to fluoroquinolone antibiotics on the or via the Yellow Card app (download it from the , or ) New restricted indications Fluoroquinolones are antibiotics authorised for serious, life-threatening bacterial infections. As for all antibiotic medicines, consideration should be given to official guidance on the appropriate use of antibacterial agents (see section below on Prescribing guidance). Following an EU-wide review of safety, new restricted (...) Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports

2019 MHRA Drug Safety Update

87. Primary care: Single-dose fosfomycin is less effective than 5-day nitrofurantoin in women with uncomplicated urinary tract infection: closing the evidence gap for a new recommendation of an old antibiotic

Primary care: Single-dose fosfomycin is less effective than 5-day nitrofurantoin in women with uncomplicated urinary tract infection: closing the evidence gap for a new recommendation of an old antibiotic Single-dose fosfomycin is less effective than 5-day nitrofurantoin in women with uncomplicated urinary tract infection: closing the evidence gap for a new recommendation of an old antibiotic | BMJ Evidence-Based Medicine Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Single-dose fosfomycin is less effective than 5-day nitrofurantoin in women with uncomplicated urinary tract infection: closing the evidence gap for a new recommendation of an old antibiotic Article Text Commentary

2019 Evidence-Based Medicine

88. Primary care: Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics Full Text available with Trip Pro

of institutional accounts Username * Password * your user name or password? You are here Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics Article Text EBM analysis Primary care Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics Gloria Cordoba , Carl Llor . Statistics from Altmetric.com Introduction Unnecessary and excessive use of antibiotics is the main driver of antimicrobial resistance. The prospect of patients dying from common infections caused (...) prescribing antibiotics than antibiotic resistance. GPs are generally aware of and concerned about the threat that antimicrobial resistance poses and agree that this is a growing problem. However, antimicrobial resistance is considered more of a public health issue, whereas the GPs’ priority is to be responsive to the needs of the individual patient. This example shows the multidimensional factors that play a role in the decision whether to prescribe antibiotics. There is a patient expecting a solution

2019 Evidence-Based Medicine

89. Diarrhoea - antibiotic associated: Metronidazole

Diarrhoea - antibiotic associated: Metronidazole Metronidazole | Prescribing information | Diarrhoea - antibiotic associated | CKS | NICE Search CKS… Menu Metronidazole Diarrhoea - antibiotic associated: Metronidazole Last revised in March 2019 Metronidazole What are the cautions and contraindications with metronidazole? Do not prescribe metronidazole in people with: Known metronidazole or nitroimidazole hypersensitivity. Prescribe metronidazole with caution in people with: Cockayne syndrome

2019 NICE Clinical Knowledge Summaries

90. Acne vulgaris: Topical antibiotics

Acne vulgaris: Topical antibiotics Topical antibiotics | Prescribing information | Acne vulgaris | CKS | NICE Search CKS… Menu Topical antibiotics Acne vulgaris: Topical antibiotics Last revised in December 2019 Topical antibiotics Topical antibiotics Prescribing issues Topical antibiotics licenced in the UK for treatment of acne vulgaris include clindamycin and erythromycin. Application is usually once or twice a day and varies between agents — for information on specific products see (...) the (BNF) and the . Topical monotherapy with antibiotics is not recommended because of the risk of antibiotic resistance. Topical antibiotics should be prescribed in combination with benzoyl peroxide. Cautions and contraindications Hypersensitivity to the active ingredient or any of the excipients. History of inflammatory bowel disease or a history of antibiotic-associated colitis. If diarrhoea occurs, the product should be discontinued immediately. Caution is advised when prescribing to people

2019 NICE Clinical Knowledge Summaries

91. Acne vulgaris: Oral antibiotics

Acne vulgaris: Oral antibiotics Oral antibiotics | Prescribing information | Acne vulgaris | CKS | NICE Search CKS… Menu Oral antibiotics Acne vulgaris: Oral antibiotics Last revised in December 2019 Oral antibiotics Oral antibiotics Prescribing issues If acne fails to respond adequately to topical preparations alone an oral antibiotic such as lymecycline or doxycycline (for a maximum of 3 months) can be added. Minocycline is not recommended for use in acne as it is associated (...) with an increased risk of adverse effects such as drug-induced lupus, skin pigmentation and hepatitis. Macrolide antibiotics (such as erythromycin) should generally be avoided due to high levels of P. acnes resistance but can be used if tetracyclines are contraindicated (for example in pregnancy). A topical retinoid (if not contraindicated) or benzoyl peroxide should always be co-prescribed with oral antibiotics to reduce the risk of antibiotic resistance developing. Do not use topical and oral antibiotics

2019 NICE Clinical Knowledge Summaries

92. Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radological Society of Europe and the Canadian Association for

procedures, including the increasing prevalence of pediatric IR procedures, and the increasing repertoire of antibacterial agents. As was the case for the original guidelines (1), the availability of randomized controlled data regarding antibiotic prophylaxis is lacking in the IR literature. Much data are derived from retrospective reviews From the Department of Diagnostic Radiology (M.A.C.), Oakland University William Beaumont School of Medicine, Royal Oak, Michigan; Department of Radiology (A.S.T (...) to oropharyngeal ?ora, which can potentially seed the skin entry site. This procedure carries a peristomal infection rate of approximately 30% (156). Prophylactic antibiotic therapy is therefore recommended for all patients undergoing this procedure with antimicrobial agents targeting skin and oropharyngeal bacteria, eg, cefazolin followed by oral/enteric cephalexin (156). (New data reviewed, recommendations updated.) Liver Tumor Ablation In 2015, Bhatia et al (157) described a very low incidence of hepatic ab

2019 Society of Interventional Radiology

93. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Full Text available with Trip Pro

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Acute respiratory infections (ARIs) comprise of a large and heterogeneous group of infections including bacterial, viral, and other aetiologies. In recent years, procalcitonin (PCT), a blood marker for bacterial infections, has emerged as a promising tool to improve decisions about antibiotic therapy (PCT-guided antibiotic therapy). Several randomised controlled trials (RCTs) have demonstrated (...) the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with ARIs and different settings ranging from primary care settings to emergency departments, hospital wards, and intensive care units. However, the effect of using procalcitonin on clinical outcomes is unclear. This is an update of a Cochrane review and individual participant data meta-analysis first published in 2012 designed to look at the safety of PCT-guided antibiotic stewardship.The aim

2017 Cochrane

94. Interventions to improve antibiotic prescribing practices for hospital inpatients. Full Text available with Trip Pro

Interventions to improve antibiotic prescribing practices for hospital inpatients. Antibiotic resistance is a major public health problem. Infections caused by multidrug-resistant bacteria are associated with prolonged hospital stay and death compared with infections caused by susceptible bacteria. Appropriate antibiotic use in hospitals should ensure effective treatment of patients with infection and reduce unnecessary prescriptions. We updated this systematic review to evaluate the impact (...) of interventions to improve antibiotic prescribing to hospital inpatients.To estimate the effectiveness and safety of interventions to improve antibiotic prescribing to hospital inpatients and to investigate the effect of two intervention functions: restriction and enablement.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library), MEDLINE, and Embase. We searched for additional studies using the bibliographies of included articles and personal files. The last search

2017 Cochrane

95. Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. Full Text available with Trip Pro

Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. Bronchiolitis is a common acute respiratory condition with high prevalence worldwide. This clinically diagnosed syndrome is manifested by tachypnoea (rapid breathing), with crackles or wheeze in young children. In the acute phase of bronchiolitis (≤ 14 days), antibiotics are not routinely prescribed unless the illness is severe or a secondary bacterial infection is suspected. Although bronchiolitis is usually (...) self-limiting, some young children continue to have protracted symptoms (e.g. cough and wheezing) beyond the acute phase and often re-present to secondary care.To compare the effectiveness of antibiotics versus controls (placebo or no treatment) for reducing or treating persistent respiratory symptoms following acute bronchiolitis within six months of acute illness.We searched the following databases: the Cochrane Airways Group Register of Trials, the Cochrane Central Register of Controlled Trials

2017 Cochrane

96. Pre-admission antibiotics for suspected cases of meningococcal disease. Full Text available with Trip Pro

Pre-admission antibiotics for suspected cases of meningococcal disease. Meningococcal disease can lead to death or disability within hours after onset. Pre-admission antibiotics aim to reduce the risk of serious disease and death by preventing delays in starting therapy before confirmation of the diagnosis.To study the effectiveness and safety of pre-admission antibiotics versus no pre-admission antibiotics or placebo, and different pre-admission antibiotic regimens in decreasing mortality (...) , clinical failure, and morbidity in people suspected of meningococcal disease.We searched CENTRAL (6 January 2017), MEDLINE (1966 to 6 January 2017), Embase (1980 to 6 January 2017), Web of Science (1985 to 6 January 2017), LILACS (1982 to 6 January 2017), and prospective trial registries to January 2017. We previously searched CAB Abstracts from 1985 to June 2015, but did not update this search in January 2017.Randomised controlled trials (RCTs) or quasi-RCTs comparing antibiotics versus placebo

2017 Cochrane

97. Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Full Text available with Trip Pro

Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Pneumonia is a leading cause of childhood mortality from infectious disease, responsible for an estimated 1.3 million deaths annually in children under five years of age, many of which are in low-income countries. The World Health Organization recommends intravenous antibiotics for five days as first-line treatment for children (...) a significant burden on both patients and their families, including substantial expense, loss of routine, and decrease in quality of life. By reducing the duration of hospital treatment, healthcare burdens could potentially be reduced and treatment compliance may improve.This is an update of a review published in 2015.To evaluate the efficacy of short-course (two to three days) versus long-course (five days) intravenous therapy (alone or in combination with oral antibiotics) with the same antibiotic

2017 Cochrane

98. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Full Text available with Trip Pro

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection.To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following (...) method and incision type) for lens opacities due to any origin. We included trials that evaluated preoperative antibiotics, intraoperative (intracameral, subconjunctival or systemic), or postoperative antibiotic prophylaxis for acute endophthalmitis. We excluded studies that evaluated antiseptic preoperative preparations using agents such as povidone iodine or antibiotics for treating acute endophthalmitis after cataract surgery.Two review authors independently reviewed abstracts and full-text

2017 Cochrane

99. Antibiotic therapy for pelvic inflammatory disease. Full Text available with Trip Pro

Antibiotic therapy for pelvic inflammatory disease. Pelvic inflammatory disease (PID) is an infection that affects 4% to 12% of young women, and is one of the most common causes of morbidity in this age group. The main intervention for acute PID is the use of broad-spectrum antibiotics which cover Chlamydia trachomatis, Neisseria gonorrhoeae, and anaerobic bacteria, administered intravenously, intramuscularly, or orally. In this review, we assessed the optimal treatment regimen for PID.To (...) assess the effectiveness and safety of antibiotic regimens used to treat pelvic inflammatory disease.We searched the Cochrane Sexually Transmitted Infections Review Group's Specialized Register, which included randomized controlled trials (RCTs) from 1944 to 2016, located through electronic searching and handsearching; the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid platform (1991 to July 2016); MEDLINE (1946 to July 2016); Embase (1947 to July 2016); LILACS, iAHx interface (1982

2017 Cochrane

100. [KOKUSAI]Third tripartite meeting held between EMA, FDA and PMDA towards enhancing development for Antibacterial Agents posted

the text. Tripartite Meeting held between EMA, FDA and PMDA towards enhancing development for Antibacterial Agents In response to the discussions at the G7 summits (in Schloss Elmau and Ise-Shima) on the countermeasures taken against antimicrobial resistant infections, EMA, FDA and PMDA held a tripartite face-to-face meeting. Date Location SUMMARY 1 1-2 September 2016, London At this meeting, in addition to sharing information on current situation regarding the data requirements for the approval of new (...) [KOKUSAI]Third tripartite meeting held between EMA, FDA and PMDA towards enhancing development for Antibacterial Agents posted Tripartite Meeting held between EMA, FDA and PMDA towards enhancing development for Antibacterial Agents | Pharmaceuticals and Medical Devices Agency Please make JavaScript on and see this site. Navigation of each product type Our recommended contents Navigation of each product type Our recommended contents Tripartite Meeting (for Antibacterial Agents) Here begins

2017 Pharmaceuticals and Medical Devices Agency, Japan

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