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41. Antibiotic therapy for adults with neurosyphilis. Full Text available with Trip Pro

Antibiotic therapy for adults with neurosyphilis. Neurosyphilis is an infection of the central nervous system, caused by Treponema pallidum, a spirochete capable of infecting almost any organ or tissue in the body causing neurological complications due to the infection. This disease is a tertiary manifestation of syphilis. The first-line treatment for neurosyphilis is aqueous crystalline penicillin. However, in cases such as penicillin allergy, other regimes of antibiotic therapy can be used.To (...) assess the clinical effectiveness and safety of antibiotic therapy for adults with neurosyphilis.We searched the Cochrane Library, CENTRAL, MEDLINE, Embase, LILACS, World Health Organization International Clinical Trials Registry Platform and Opengrey up to April 2019. We also searched proceedings of eight congresses to a maximum of 10 years, and we contacted trial authors for additional information.We included randomised clinical trials that included men and women, regardless of age, with definitive

2019 Cochrane

42. Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics Full Text available with Trip Pro

demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. Conclusion: In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates. Keywords: antibiotic cement; antibiotic elution; antibiotic synergy; dual (...) Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show account info Close Account

2020 EvidenceUpdates

43. Antibiotic prescribing - especially broad spectrum antibiotics

or moderately severe infections unless other antibacterial medicines commonly recommended for these infections cannot be used. Fluoroquinolone antibiotics should be avoided when treating infections in people who have previously experienced serious adverse events with fluoroquinolones. They should be used with Antimicrobial stewardship: prescribing antibiotics (KTT9) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 (...) Antibiotic prescribing - especially broad spectrum antibiotics Antimicrobial stewardship: prescribing Antimicrobial stewardship: prescribing antibiotics antibiotics Key therapeutic topic Published: 15 January 2015 nice.org.uk/guidance/ktt9 pathways K Ke ey points y points Antimicrobial resistance poses a significant global threat to public health, especially because antimicrobials underpin routine medical practice. Addressing antimicrobial resistance through improving stewardship is a national

2015 National Institute for Health and Clinical Excellence - Advice

44. COVID-19: Antibiotic Management in Ambulatory Patients

April 3 The CDC offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. Professional society guidance on antibiotic indications in COVID+ patients or patients under investigation (PUI) Source Recommendations IDSA April 13 The IDSA offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. ASP April 2 For patients in an ambulatory setting, antibacterial therapy (including azithromycin) is not routinely recommended (...) COVID-19: Antibiotic Management in Ambulatory Patients COVID-19: ANTIBIOTIC MANAGEMENT IN AMBULATORY PATIENTS A Rapid Guidance Summary from the Penn Medicine Center for Evidence-based Practice Last updated April 21, 2020 1:00 pm. Sources rechecked April 19 unless otherwise noted. Key questions answered in this summary • What are indications for antibiotic use in COVID-19 patients being cared for in the ambulatory setting? • What are best practices related to antibiotic management

2020 Centre for Evidence-Based Practice, Penn Medicine

45. Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? Full Text available with Trip Pro

Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 5, Pages 453–455 Are Antibiotics Effective in the Treatment of Children With Prolonged Wet Cough? x Brit Long , MD (EBEM Commentator) , x Michael D. April , MD, DPhil (EBEM (...) Commentator) Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX DOI: | Publication History Published online: November 13, 2018 Expand all Collapse all Article Outline Take-Home Message Antibiotics may improve clinical cure and reduce progression of illness in children with prolonged wet cough. Methods Data Sources Authors identified trials from the Cochrane Airways Trials Register, CENTRAL, MEDLINE OvidSP, and EMBASE OvidSP through September

2019 Annals of Emergency Medicine Systematic Review Snapshots

46. Pediatric hydrocephalus - Antibiotic-impregnated shunt systems versus conventional shunts in children: a systematic review and meta-analysis

. Journal of neurosurgery Pediatrics. 2008;2(1):25-28. Sciubba DM, Lin LM, Woodworth GF, McGirt MJ, Carson B, Jallo GI. Factors contributing to the medical costs of cerebrospinal fluid shunt infection treatment in pediatric patients with standard shunt components compared with those in patients with antibiotic impregnated components. In: Neurosurg Focus. Vol 22. United States2007:E9. Stone J, Gruber TJ, Rozzelle CJ. Healthcare savings associated with reduced infection rates using antimicrobial suture (...) bacterial catheter-related infection. Journal of neurosurgery. 1997;87(2):247-251. Pattavilakom A, Kotasnas D, Korman TM, Xenos C, Danks A. Duration of in vivo antimicrobial activity of antibiotic-impregnated cerebrospinal fluid catheters. In: Neurosurgery. Vol 58. United States2006:930-935; discussion 930-935. Albanese A, De Bonis P, Sabatino G, et al. Antibiotic-impregnated ventriculo-peritoneal shunts in patients at high risk of infection. Acta neurochirurgica. 2009;151(10):1259-1263. Aryan HE

2020 Congress of Neurological Surgeons

47. Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines

Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines Last updated (...) : March 25, 2019 Project Number: RC1086-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of probiotics (with or without concurrent antibiotics) for preventing and treating antibiotic-associated diarrhea in the pediatric population? What are the evidence-based guidelines regarding the use of probiotics (with or without concurrent antibiotics) for the prevention and treatment of antibiotic-associated

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

48. Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness

Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review (...) of Comparative Clinical Effectiveness and Cost-Effectiveness Biologics versus Immunomodulators or Antibiotics for the Management of Fistulizing Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness Last updated: March 29, 2019 Project Number: RC1107-000 - RD0051-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of biologics (with or without concomitant immunomodulators

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

49. Antibiotic Stewardship in the Intensive Care Unit: An Official ATS Workshop Report in Collaboration with the ACCN, ACCP, CDC, and SCCM Full Text available with Trip Pro

for ASPs by intensivists ( – ), the philosophical approaches and priorities of critical care practitioners and ASPs can differ ( ). Although all involved desire the best patient outcomes, the potentially competing goals of adequate empirical antimicrobial therapy and antibiotic stewardship sometimes create tension. If stewardship efforts are to succeed, this conflict must be addressed. The goal of most critical care practitioners is rapid provision of the appropriate initial therapy. ASPs must work (...) . Tamma PD , Avdic E , Li DX , Dzintars K , Cosgrove SE . Association of adverse events with antibiotic use in hospitalized patients . JAMA Intern Med 2017 ;177: 1308 – 1315 . , , 31 . Hranjec T , Rosenberger LH , Swenson B , Metzger R , Flohr TR , Politano AD , et al . Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study . Lancet

2020 American Thoracic Society

50. FSRH CEU Response to study: Analysis of reports of unintended pregnancies associated with the combined use of non-enzyme inducing antibiotics and hormonal contraceptives

FSRH CEU Response to study: Analysis of reports of unintended pregnancies associated with the combined use of non-enzyme inducing antibiotics and hormonal contraceptives 1 FSRH CEU Response to study: Analysis of reports of unintended pregnancies associated with the combined use of non-enzyme inducing antibiotics and hormonal contraceptives 19 August 2020 The BMJ Evidence Based Medicine Journal has published a paper 1 suggesting that antibiotics may lessen the effectiveness of hormonal (...) contraception. The authors used the ‘Yellow Cards’ system where clinicians and patients can report adverse drug side-effects to the UK’s drug and medical devices regulator, the Medicines and Healthcare products Regulatory Agency (MHRA). Data between 1963 and July 2018 was analysed and researchers compared the number of unintended pregnancies reported in 74,623 Yellow Cards for antibiotics in general and in 32,872 for enzyme-inducing drugs with those reported in 65,578 other types of drugs in users of oral

2020 Faculty of Sexual & Reproductive Healthcare

51. Diarrhoea - antibiotic associated

Diarrhoea - antibiotic associated Diarrhoea - antibiotic associated | Topics A to Z | CKS | NICE Search CKS… Menu Diarrhoea - antibiotic associated Diarrhoea - antibiotic associated Last revised in March 2019 Diarrhoea is a common consequence of treatment with antibiotics, occurring in 2–25% of people taking antibiotics Management Prescribing information Background information Diarrhoea - antibiotic associated: Summary Diarrhoea is a common consequence of treatment with antibiotics, occurring (...) in 2–25% of people taking antibiotics, depending on the antibiotic prescribed. Around 20% to 30% of cases of antibiotic-associated diarrhoea are due to Clostridium difficile . Antibiotics frequently associated with C. difficile infection include clindamycin, cephalosporins (especially third and fourth generation), fluoroquinolones, and broad-spectrum penicillins. Factors that increase the risk of C. difficile infection include increased age, history of C. difficile infection, exposure to other

2020 NICE Clinical Knowledge Summaries

52. Chronic obstructive pulmonary disease: Antibiotics

Chronic obstructive pulmonary disease: Antibiotics Antibiotics | Prescribing information | Chronic obstructive pulmonary disease | CKS | NICE Search CKS… Menu Antibiotics Chronic obstructive pulmonary disease: Antibiotics Last revised in November 2019 Antibiotics Azithromycin Contraindications and cautions Do not prescribe azithromycin in people: With severe hepatic impairment. Prescribe azithromycin with caution in people: Who may be predisposed to prolongation of the QT interval. For example (...) any muscle pain, tenderness, or weakness. Typhoid vaccine — antibacterials might reduce the immune response. The World Health Organization (WHO) recommends that the antibacterial is stopped from 3 days before to 3 days after receiving live oral typhoid vaccine. Warfarin — concurrent use may increase the international normalized ratio (INR). Consider increasing INR monitoring as this interaction appears to develop over the first 7 days. Drugs that prolong the QT interval (such as amiodarone

2020 NICE Clinical Knowledge Summaries

53. Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Full Text available with Trip Pro

Centers for Disease Control and Prevention. Telebriefing on today's drug-resistant health threats. ( Available at: ) . , x 16 Centers for Disease Control and Prevention. Joint Statement on Importance of Outpatient Antibiotics Stewardship From 12 National Health Organizations. ( Available at: ) . , x 17 Centers for Disease Control and Prevention. Antibiotic/antimicrobial resistance (AR/AMR): the AMR challenge. ( Available at: ) . , x 18 White House Office of the Press Secretary. Fact sheet: over 150 (...) Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling - The Journal of the American Dental Association Email/Username: Password: Remember me Search Terms Search within Search Access provided by Volume 150, Issue 11, Pages 906–921.e12 Evidence-based clinical practice guideline

2020 American Dental Association Guidelines

54. Respiratory tract infections (self-limiting) – reducing antibiotic prescribing

in the event of a significant clinical deterioration. Sore throat/pharyngitis/tonsillitis has been excluded from the contextualised guideline for two reasons: (i) in contrast to the UK, New Zealand has a relatively high incidence of rheumatic fever and therefore the risks of not prescribing an antibiotic treatment for many patients with sore throat are very much greater; and (ii) in New Zealand there are widely used guidelines that recommend antimicrobial treatment for patients with sore throat who (...) Otitis Media. Diagnosis and Management of Acute Otitis Media. Pediatrics, 2004 113(5), 1451-65. 2. McGregor A, Dovey S, Tilyard M. Antibiotic use in upper respiratory tract infections in New Zealand. Family Practice 1995;12:166-70. 3. Thomas MG, Smith AJ, Tilyard M. Rising antimicrobial resistance: a strong reason to reduce antimicrobial consumption in New Zealand. NZ Med J 2014;127:1394:72-84. 4. Heart Foundation of New Zealand: Guidelines for Group A Streptococcal Sore Throat Management Guideline

2019 Best Practice Advocacy Centre New Zealand

55. COPD exacerbation: no systematic use of antibiotics

COPD exacerbation: no systematic use of antibiotics Prescrire IN ENGLISH - Spotlight ''COPD exacerbation: no systematic use of antibiotics'', 1 January 2019 {1} {1} {1} | | > > > COPD exacerbation: no systematic use of antibiotics Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight COPD exacerbation: no systematic use of antibiotics For episodes (...) of moderate aggravation in patients with chronic obstructive pulmonary disease (COPD), it is preferable to prescribe antibiotics as a first-line treatment only when the suspicion of bacterial infection is reinforced by an increase in sputum purulence. Patients with chronic obstructive pulmonary disease (COPD) are subject to exacerbations of their disease, i.e. episodes of prolonged aggravation. The known causes are mainly viral and bacterial infections. Some exacerbations justify hospitalisation: severe

2019 Prescrire

56. Antibacterial-coated sutures versus non-antibacterial-coated sutures for the prevention of abdominal, superficial and deep, surgical site infection (SSI)

low risk of bias RCTs 83 Table 19: The length of hospital stay in triclosan-coated vs non-antibacterial coated sutures patient groups 85 Table 20: The proportion of patients requiring secondary surgery for wound-related complications of surgery 86 Table 21: The incidence of complete abdominal wound dehiscence within 30 days of surgery and incisional hernia during the period of study follow-up 87 Table 22: Causative microorganism of SSI and the use of systemic antibiotic therapy within 30 days (...) Controlled Trial REA Relative Effectiveness Assessment RoB Risk of Bias RR Relative risk SAE Serious Adverse Event SAF Safety domain Antibacterial-coated sutures for the prevention of abdominal SSI Version 1.4, March 2017 EUnetHTA Joint Action 3 WP4 10 SAP Surgical antibiotic prophylaxis SDGC Study Center of the German Surgical Society SHEA The Society for Healthcare Epidemiology of America SHEA/IDSA Society for Healthcare Epidemiology of America/Infectious Diseases Society of America SI Superficial

2017 EUnetHTA

57. Cohort study: Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children Full Text available with Trip Pro

Cohort study: Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia

2017 Evidence-Based Medicine

58. Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants. Full Text available with Trip Pro

Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants. Late-onset sepsis is associated with increased rates of mortality and morbidity in newborn infants, in addition to poorer long-term developmental outcomes and increased length of stay and hospital costs. Central line-associated blood stream infection (CLABSI) is the most common cause of late-onset sepsis in hospitalised infants, and prevention of CLABSI is a key objective (...) in neonatal care. Increased frequency of CLABSI around the time of removal of central venous catheters (CVCs) has been reported, and use of antibiotics at the time of removal may reduce the incidence and impact of late-onset sepsis in vulnerable newborn infants.To determine the efficacy and safety of giving antibiotics at the time of removal of a central venous catheter (CVC) for reduction of morbidity and mortality in newborn infants, in particular effects on late-onset sepsis.We used the standard search

2018 Cochrane

59. Antibiotics for treating gonorrhoea in pregnancy. Full Text available with Trip Pro

Antibiotics for treating gonorrhoea in pregnancy. Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review (...) on antibiotics for treating this infectious condition.To assess the clinical effectiveness and harms of antibiotics for treating gonorrhoea in pregnant women.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2017), LILACS database (1982 to April 5, 2017), the WHO International Clinical Trials Registry Platform (ICTRP; April 5, 2017), ClinicalTrials.gov (April 5, 2017), the ISRCTN Registry (April 5, 2017), and Epistemonikos (April 5, 2017). We also searched reference lists

2018 Cochrane

60. Short-course versus long-course therapy of the same antibiotic for community-acquired pneumonia in adolescent and adult outpatients. Full Text available with Trip Pro

Short-course versus long-course therapy of the same antibiotic for community-acquired pneumonia in adolescent and adult outpatients. Community-acquired pneumonia (CAP) is a lung infection that can be acquired during day-to-day activities in the community (not while receiving care in a hospital). Community-acquired pneumonia poses a significant public health burden in terms of mortality, morbidity, and costs. Shorter antibiotic courses for CAP may limit treatment costs and adverse effects (...) , but the optimal duration of antibiotic treatment is uncertain.To evaluate the efficacy and safety of short-course versus longer-course treatment with the same antibiotic at the same daily dosage for CAP in non-hospitalised adolescents and adults (outpatients). We planned to investigate non-inferiority of short-course versus longer-term course treatment for efficacy outcomes, and superiority of short-course treatment for safety outcomes.We searched CENTRAL, which contains the Cochrane Acute Respiratory

2018 Cochrane

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