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261. Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study. Full Text available with Trip Pro

Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study. To identify the frequency with which antibiotics are prescribed in the absence of a documented indication in the ambulatory care setting, to quantify the potential effect on assessments of appropriateness of antibiotics, and to understand patient, provider, and visit level characteristics associated with antibiotic prescribing without a documented indication.Cross sectional study (...) .2015 National Ambulatory Medical Care Survey.28 332 sample visits representing 990.9 million ambulatory care visits nationwide.Overall antibiotic prescribing and whether each antibiotic prescription was accompanied by appropriate, inappropriate, or no documented indication as identified through ICD-9-CM (international classification of diseases, 9th revision, clinical modification) codes. Survey weighted multivariable logistic regression was used to evaluate potential risk factors for receipt

2019 BMJ

262. Antimicrobial resistance (AMR): applying All Our Health

prevent ill health and promote wellbeing as part of their everyday practice. The information below will help front-line health and care staff use their trusted relationships with patients, families and communities to promote the benefits of preventing antimicrobial resistance ( of ‘All Our Health’ topics. Infections that cannot be treated continue to develop. The rapid spread of multidrug resistant organisms means that we may not be able to treat everyday infections or diseases with antibiotics (...) in the near future. Many existing antimicrobials are becoming less effective as bacteria, viruses, protozoa and fungi are adapting and becoming resistant to medicines. Inappropriate use of these valuable medicines has also added to the problem. Without effective antibiotics, even minor surgery and routine operations could become high risk procedures if serious infections can’t be treated. Access the antimicrobial resistance e-learning session An is now available to use. and 5 Year Action Plan set out

2019 Public Health England

263. Infectious Diseases Society of America Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually in the United States from 2012 through 2017, according to the 2019 Centers for Disease Control and Prevention (CDC) Antibiotic Resistant Threats Report [2]. The selection of effective antibiotics for the treatment of infections by resistant pathogens is challenging [3]. Although there has been an increase in the availability of novel antibiotics to combat resistant infections in recent years [3 (...) will be disseminated on multiple platforms and updated as new data emerge. Treatment of antimicrobial resistant Gram-negative bacterial infections was chosen as the initial topic for a guidance document. The overarching goal of this guidance document is to assist clinicians – including those with and without infectious diseases expertise – in selecting antibiotic therapy for infections caused by ESBL-E, CRE, and DTR- P. aeruginosa . Future iterations of this document will address other resistant pathogens

2020 Infectious Diseases Society of America

264. Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality

Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality BestBets: Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption with no increase in rates of treatment failure or mortality Use of a procalcitonin algorithim to guide antimicrobial therapy in COPD exacerbations can reduce antibiotic consumption (...) of procalcitonin and the presence of bacterial infection. What is less clear is whether using procalcitonin at predefined cut-offs in the emergency department is a safe and effective strategy to guide antibiotic prescription. The data reviewed here suggest that procalcitonin may be used to guide therapy without an increased rate of death or other adverse outcomes such as prolonged hospital stay, intensive care unit admission or re-exacerbation. This could serve to promote antimicrobial stewardship, decrease

2015 BestBETS

265. The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

266. Arikayce - antibiotic containing the active substance amikacin

Arikayce - antibiotic containing the active substance amikacin 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2016. Reproduction is authorised provided the source is acknowledged. 24 June 2016 EMA/430267/2016 EMEA/H/C/003936 Questions and answers Withdrawal of the marketing authorisation (...) application for Arikayce (amikacin) On 8 June 2016, Insmed Limited officially notified the Committee for Medicinal Products for Human Use (CHMP) that it wishes to withdraw its application for a marketing authorisation for Arikayce intended for the treatment of Mycobacterium avium complex (MAC) lung disease. What is Arikayce? Arikayce is an antibiotic containing the active substance amikacin. It was to be available as a suspension for inhalation. What was Arikayce expected to be used for? Arikayce

2016 European Medicines Agency - EPARs

267. Anthim (obiltoxaximab) - To treat inhalational anthrax in combination with appropriate antibacterial drugs

Anthim (obiltoxaximab) - To treat inhalational anthrax in combination with appropriate antibacterial drugs Anthim (obiltoxaximab) Injection U.S. Department of Health and Human Services Search FDA Submit search Anthim (obiltoxaximab) Injection Anthim (obiltoxaximab) Injection Company: Elusys Therapeutics, Inc. Application No.: 125509 Approval Date: 03/18/2016 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF

2016 FDA - Drug Approval Package

268. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial

Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

269. Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines

Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines | CADTH.ca Find the information you need Antibiotic Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines Antibiotic (...) Prophylaxis in Patients with Orthopedic Implants Undergoing Dental Procedures: A Review of Clinical Effectiveness, Safety, and Guidelines Published on: February 17, 2016 Project Number: RC0751-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness and safety of antibiotic prophylaxis in patients with orthopedic implants undergoing dental procedures? What are the evidence-based guidelines associated

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

270. Evaluation of the preventive efficacy of three dentin tubule occlusion methods against discoloration caused by triple-antibiotic paste. (Abstract)

Evaluation of the preventive efficacy of three dentin tubule occlusion methods against discoloration caused by triple-antibiotic paste. The aim of this in vitro study was to evaluate the preventive efficacy of three dentin tubule occlusion methods against discoloration caused by triple-antibiotic paste (TAP). Sixty extracted human incisors were sectioned, and the access was opened. The specimens were randomly allocated to the following four groups (n = 15): bonding application (BD), teethmate

2018 Odontology Controlled trial quality: uncertain

271. [Generation of Antibiotic Tolerant Bacterial Persisters in Immunocompromized Patients with Hematologic and Malignant Diseases: A New Problem of Health-Care Associated Infections]. (Abstract)

[Generation of Antibiotic Tolerant Bacterial Persisters in Immunocompromized Patients with Hematologic and Malignant Diseases: A New Problem of Health-Care Associated Infections]. Antibiotic tolerance (AT) represents one of the causes of the phenomenon of antibiotic resistance that allows escape of non-replicating metabolically inert microorganisms (persisters) from any antibiotics attack because molecular targets of antibiotics are lacking thereby creating the potential for chronic (...) infections.Determine the heterogeneity of the strains of opportunistic pathogens E. coli and P. aeruginosa isolates from children with hematologic malignancies containing bacterial persisters that cause the AT phenomenon.Children with hematological malignancies were divided into 2 groups according to the intensity of antibiotic treatment of infectious complications. Ciprofloxacin-induced persisters were quantitatively determined in the biological materials obtained from sick children.Within the clinical isolates

2018 Vestnik Rossiiskoi akademii meditsinskikh nauk Controlled trial quality: uncertain

272. Sensitivity and specificity of using trial-of-antibiotics versus sputum mycobacteriology for diagnosis of tuberculosis: protocol for a systematic literature review. Full Text available with Trip Pro

those with PTB will not-has minimal evidence base for such a widely used intervention. Numerous potential causes of misclassification include bacterial super-infection of active PTB, placebo effect, and antimicrobial resistance (AMR). The main aim of this systematic review is to collate available evidence on the performance of trial-of-antibiotics as a diagnostic test and to explore the timing, interpretation, and decision-making process.We will search MEDLINE, Embase, and Global Health using (...) Sensitivity and specificity of using trial-of-antibiotics versus sputum mycobacteriology for diagnosis of tuberculosis: protocol for a systematic literature review. Suboptimal diagnostics for pulmonary tuberculosis (PTB) drives use of 'trial-of-antibiotics (non-tuberculosis)' in an attempt to distinguish PTB patients from those with bacterial lower respiratory tract infection (LRTI). The underlying assumption-that patients with LRTI will report 'response' to broad-spectrum antibiotics, while

2018 Systematic Reviews

273. Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery Full Text available with Trip Pro

Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery To report the resolution of a fluoroquinolone-resistant Escherichia coli keratitis with use of a prosthetic replacement of the ocular surface ecosystem (PROSE) device for enhanced targeted delivery of moxifloxiacin.A 62-year-old female presented with a 3-day history of pain, photophobia, and declining vision in left eye. The patient had a 2-year history of binocular (...) therapy. Frequent dosing to the PROSE reservoir is likely to increase fluoroquinolone bioavailability and may represent a valuable approach to overcome antibiotic resistance.

2018 American journal of ophthalmology case reports

274. Responses of the Human Gut Escherichia coli Population to Pathogen and Antibiotic Disturbances Full Text available with Trip Pro

Responses of the Human Gut Escherichia coli Population to Pathogen and Antibiotic Disturbances Studies of Escherichia coli in the human gastrointestinal tract have focused on pathogens, such as diarrhea-causing enterotoxigenic E. coli (ETEC), while overlooking the resident, nonpathogenic E. coli community. Relatively few genomes of nonpathogenic E. coli strains are available for comparative genomic analysis, and the ecology of these strains is poorly understood. This study examined (...) the diversity and dynamics of resident human gastrointestinal E. coli communities in the face of the ecological challenges presented by pathogen (ETEC) challenge, as well as of antibiotic treatment. Whole-genome sequences obtained from E. coli isolates from before, during, and after ETEC challenge were used in phylogenomic and comparative genomic analyses to examine the diversity of the resident E. coli communities, as well as the dynamics of the challenge strain, H10407, a well-studied ETEC strain

2018 mSystems

275. Isolation and genomic characterization of six endophytic bacteria isolated from Saccharum sp (sugarcane): Insights into antibiotic, secondary metabolite and quorum sensing metabolism Full Text available with Trip Pro

Isolation and genomic characterization of six endophytic bacteria isolated from Saccharum sp (sugarcane): Insights into antibiotic, secondary metabolite and quorum sensing metabolism Six endophytic bacteria were isolated from Saccharum sp (sugarcane) grown in the parish of Westmoreland on the island of Jamaica located in the West Indies. Whole genome sequence and annotation of the six bacteria show that three were from the genus Pseudomonas and the other three were from the genera Pantoea (...) , Pseudocitrobacter, and Enterobacter. A scan of each genome using the antibiotics and secondary metabolite analysis shell (antiSMASH4.0) webserver showed evidence that the bacteria were able to produce a variety of secondary metabolites. In addition, we were able to show that one of the organisms, Enterobacter sp RIT418 produces N-acyl-homoserine lactones (AHLs), which is indicative of cell-cell communication via quorum sensing (QS).

2018 Journal of genomics

276. Straw Wine Melanoidins as Potential Multifunctional Agents: Insight into Antioxidant, Antibacterial, and Angiotensin-I-Converting Enzyme Inhibition Effects Full Text available with Trip Pro

Straw Wine Melanoidins as Potential Multifunctional Agents: Insight into Antioxidant, Antibacterial, and Angiotensin-I-Converting Enzyme Inhibition Effects Numerous studies provide robust evidence for a protective effect of red wine against many diseases. This bioactivity has been mainly associated with phenolic fractions of wines. However, the health effects of melanoidins in red sweet wines has been ignored. The goal of the present work was to unravel the antioxidant, antimicrobial (...) , and angiotensin-I-converting enzyme (ACE) inhibitory properties of straw sweet wine melanoidins. Results demonstrated that melanoidins have a potential antioxidant activity, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) assays. The antimicrobial activity of melanoidins was also tested against Listeria monocytogenes, Salmonella Enteritidis, and Escherichia coli. Minimum inhibitory concentration (MIC) of isolated melanoidins against three bacterial strains

2018 Biomedicines

277. Differential antibacterial control by neutrophil subsets Full Text available with Trip Pro

Differential antibacterial control by neutrophil subsets Neutrophils comprise a heterogeneous population of cells essential for bacterial eradication, and defects in neutrophil function are associated with increased susceptibility to infection. In this study, neutrophils from healthy controls were shown to prevent bacterial proliferation for at least 48 hours when cocultured with methicillin-resistant Staphylococcus aureus (MRSA) in tissue-like scaffolds by establishing a bacteriostatic (...) intracellularly. Conversely, CD16dim-banded neutrophils were the only neutrophil subset that adequately contained MRSA. These findings demonstrate a clear neutrophil heterogeneity in their antimicrobial capacity and the appearance of neutrophil subsets with a clear differentiation in functionality during acute inflammation. Furthermore, this study provides an evolutionary basis for the rapid release of banded neutrophils into the circulation during acute inflammation.© 2018 by The American Society

2018 Blood advances

278. Biosynthesis of Ag nanoparticles using Salicornia bigelovii and its antibacterial activity Full Text available with Trip Pro

Biosynthesis of Ag nanoparticles using Salicornia bigelovii and its antibacterial activity In recent years, the field of nanotechnology has become the most active area of research in modern material science. While many chemical- as well as physical methods are also used, green synthesis of nanoparticles is becoming the most evolved method of synthesis. In this study, we synthesized silver nanoparticles from the seed extract of Salicornia bigelovii.This experimental study was conducted from (...) December 2017 to January 2018 in Kerman University of Medical Sciences, Kerman, Iran. The effects of two concentrations (1m M and 4mM) on the synthesis of nanoparticles were studied. Characterizations were done using different methods including ultraviolet (UV) visible spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Antibacterial activity of Ag nanoparticles against Staphylococcus aureus and Escherichia coli was studied

2018 Electronic physician

279. Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing Full Text available with Trip Pro

Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial (...) investigated the antibacterial activity and biocompatibility of GO-QAS in vitro and in vivo.GO-QAS exhibited synergistic antibacterial activity against bacteria through not only mechanical membrane perturbation, including wrapping, bacterial membrane insertion, and bacterial membrane perforation, but also oxidative stress induction. In addition, it was found that GO-QAS could eradicate multidrug-resistant bacteria more effectively than conventional antibiotics. The in vitro and in vivo toxicity tests

2018 Burns & trauma

280. Epidemiology of antibiotic-resistant wound infections from six countries in Africa Full Text available with Trip Pro

Epidemiology of antibiotic-resistant wound infections from six countries in Africa Little is known about the antimicrobial susceptibility of common bacteria responsible for wound infections from many countries in sub-Saharan Africa.We performed a retrospective review of microbial isolates collected based on clinical suspicion of wound infection between 2004 and 2016 from Mercy Ships, a non-governmental organisation operating a single mobile surgical unit in Benin, Congo, Liberia, Madagascar (...) surveillance should be a priority and local antimicrobial resistance profiles should be used to guide empiric antibiotic selection.

2018 BMJ global health

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