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181. Clostridium difficile infection: risk with broad-spectrum antibiotics

or based on the sensitivities of causative bacteria. The Department of Health Advisory Committee on Antimicrobial Resistance and Healthcare Associated Infection (ARHAI) recommends the Start smart - then focus approach. This recommends that, if immediate antibiotic treatment is necessary, the clinical diagnosis and continuing need for antibiotics should be reviewed within 48-72 hours. When antibiotics are considered necessary to treat common infections in primary care, Public Health England's guidance (...) on managing common infections recommends suitable options and advises that broad-spectrum antibiotics should be used only when narrow-spectrum antibiotics are ineffective. Appropriate use of antimicrobials is also important to reduce the serious threat of antimicrobial resistance. A cross-governmental UK 5 year antimicrobial resistance strategy was launched in 2013. Full text of introduction and current guidance. Evidence review This evidence review outlines 1 meta-analysis of hospital-associated C

2015 National Institute for Health and Clinical Excellence - Advice

182. Are there significant interactions between oral combined contraceptives and non-rifampin antibiotics?

Are there significant interactions between oral combined contraceptives and non-rifampin antibiotics? Q&A - Are there significant interactions between oral combined contraceptives and non-rifampin antibiotics? - Trip Database NEW! or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere (...) in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Asked 23 Oct 2019 · , Physician assistant, BR Are there significant interactions between oral combined contraceptives and non-rifampin antibiotics? 1 Please log in to post a reply Your response: Reply Notes about answers If you

2019 Trip Community Q&A

183. How to adjust antibiotics dose in acute kidney injury (AKI) patient?

How to adjust antibiotics dose in acute kidney injury (AKI) patient? Q&A - How to adjust antibiotics dose in acute kidney injury (AKI) patient? - Trip Database NEW! or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search (...) numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Asked 21 Oct 2019 · , Pharmacist, SA How to adjust antibiotics dose in acute kidney injury (AKI) patient? 1 Please log in to post a reply Your response: Reply Notes about answers If you see something you feel is wrong, don’t criticise (that misses the point of Triple) courteously

2019 Trip Community Q&A

184. Evaluation of a clinical decision rule to guide antibiotic prescription in children with suspected lower respiratory tract infection in The Netherlands: A stepped-wedge cluster randomised trial (Full text)

Evaluation of a clinical decision rule to guide antibiotic prescription in children with suspected lower respiratory tract infection in The Netherlands: A stepped-wedge cluster randomised trial Evaluation of a Clinical Decision Rule to Guide Antibiotic Prescription in Children With Suspected Lower Respiratory Tract Infection in The Netherlands: A Stepped-Wedge Cluster Randomised Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) : Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation PLoS Med Actions . 2020 Jan 31;17(1):e1003034. doi: 10.1371/journal.pmed.1003034. eCollection 2020 Jan. Evaluation of a Clinical Decision Rule to Guide Antibiotic Prescription in Children With Suspected Lower Respiratory Tract Infection in The Netherlands: A Stepped-Wedge Cluster

2020 EvidenceUpdates PubMed abstract

185. Prophylactic antibiotics for anterior nasal packing in emergency department: A systematic review and meta-analysis of clinically-significant infections (Abstract)

Prophylactic antibiotics for anterior nasal packing in emergency department: A systematic review and meta-analysis of clinically-significant infections Patients presenting to emergency departments with spontaneous anterior epistaxis may undergo anterior nasal packing and sometimes receive systemic prophylactic antibiotics. There has not been sufficient evidence to support or refute this practice. The main objective of this study was to compare the likelihood of clinically significant infection (...) (CSI) between patients with or without prophylactic antibiotics for anterior nasal packing due to spontaneous epistaxis.We performed a meta-analysis of the literature to assess whether prophylactic antibiotics prevented CSI among patients with anterior nasal packing by searching PubMed, Embase, and Scopus databases for original articles. We also looked at the secondary outcome of non-infectious complications. We reported the outcomes using random effect models. Human studies in English, randomized

2020 EvidenceUpdates

186. Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial

Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy (...) to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Ann Surg Actions 2019 Dec 9 [Online ahead of print] Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized

2020 EvidenceUpdates

187. Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis (Full text)

Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) : Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Mar 4;dc191162. doi: 10.2337/dc19-1162. Online ahead of print. Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis

2020 EvidenceUpdates PubMed abstract

188. Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial (Abstract)

Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial Postoperative infection after hand-assisted laparoscopic donor nephrectomy (HALDN) confers significant morbidity to a healthy patient group. Current UK guidelines cite a lack of evidence for routine antibiotic prophylaxis. This trial assessed if a single preoperative antibiotic dose could reduce post HALDN infections.Eligible donors were randomly and blindly (...) allocated to preoperative single-dose intravenous co-amoxiclav or saline. The primary composite endpoint was clinical evidence of any postoperative infection at 30 days, including surgical site infection (SSI), urinary tract infection (UTI), and lower respiratory tract infection (LRTI).In all, 293 participants underwent HALDN (148 antibiotic arm and 145 placebo arm). Among them, 99% (291/293) completed follow-up. The total infection rate was 40.7% (59/145) in the placebo group and 23% (34 of 148

2020 EvidenceUpdates

189. Beta lactam antibiotic use with history of serum sickness with amoxicillin

Beta lactam antibiotic use with history of serum sickness with amoxicillin Beta lactam antibiotic use with history of serum sickness with amoxicillin ') Cookie Notice This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our for more details. OK Menu Search Main navigation Utility navigation / Search navigation Search Search AAAAI Breadcrumb navigation ▸ ▸ Beta lactam antibiotic use with history of serum sickness with amoxicillin | Beta lactam (...) antibiotic use with history of serum sickness with amoxicillin Q: 2/10/2020 A 28 year-old female with history of serum sickness like reaction to Amoxicillin with history of hives with Keflex at age 12. I would like to challenge her to Keflex as I do not believe the history is consistent with type I IgE mediated reaction and patient has idiopathic urticaria. Given her Type III Hypersensitivity reaction to Amoxicillin, should I worry about a serum sickness like reaction with other Beta lactams? A: Serum

2020 American Academy of Allergy, Asthma & Immunology - Ask the Expert

190. In utero exposure to systemic antibiotics vs reference penicillins was not linked to congenital malformations. (Abstract)

In utero exposure to systemic antibiotics vs reference penicillins was not linked to congenital malformations. Damkier P, Brønniche LM, Korch-Frandsen JF, Broe A. In utero exposure to antibiotics and risk of congenital malformations: a population-based study. Am J Obstet Gynecol. 2019;221:648.e1-648.e15. 31260651.

2020 Annals of Internal Medicine

191. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. (Abstract)

Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. Antibiotic overuse drives antibiotic resistance. Gram-negative bacteremia is a common infection that results in substantial antibiotic use.To compare the clinical effectiveness of C-reactive protein (CRP)-guided, 7-day, and 14-day antibiotic durations 30, 60, and 90 days after (...) treatment initiation.Multicenter, noninferiority, point-of-care randomized clinical trial including adults hospitalized with gram-negative bacteremia conducted in 3 Swiss tertiary care hospitals between April 2017 and May 2019, with follow-up until August 2019. Patients and physicians were blinded between randomization and antibiotic discontinuation. Adults (aged ≥18 years) were eligible for randomization on day 5 (±1 d) of microbiologically efficacious therapy for fermenting, gram-negative bacteria

2020 JAMA

192. Clinicians prescribe antibiotics for childhood respiratory tract infection based on assessment, rather than parental expectation. (Abstract)

Clinicians prescribe antibiotics for childhood respiratory tract infection based on assessment, rather than parental expectation. The studyCabral C, Horwood J, Symonds J, et al. Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach. BMC Fam Pract 2019;20:102.This project was funded by the NIHR School for Primary Care Research (...) Programme (project number SPCR204).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000829/gps-assessment-not-parental-expectation-drives-antibiotic-prescribing.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2020 BMJ

193. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. (Full text)

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) , 1.14 to 2.19, mainly hypospadias). Erythromycin in the first trimester was associated with an increased risk of any major malformation (27.39 v 17.65 per 1000, 1.50, 1.13 to 1.99). No statistically significant associations were found for other system specific malformations or for neurodevelopmental disorders. Findings were robust to sensitivity analyses.Prescribing macrolide antibiotics during the first trimester of pregnancy was associated with an increased risk of any major malformation

2020 BMJ PubMed abstract

194. Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial

Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features (...) in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation JAMA Surg Actions . 2020 Feb 19;e196028. doi: 10.1001/jamasurg.2019.6028. Online ahead of print. Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Turku

2020 EvidenceUpdates

195. Antibiotic prophylaxis in primary and revision shoulder replacement: a systematic review (Full text)

of hair, therefore a greater risk of P. acnes. in surface cultures. Patients were assessed at an average follow-up period of 20 months ranging from 9 weeks to 53 months. Conclusion: The optimal perioperative antimicrobial regimen is controversial. The clinical guidelines recommend the use of only one antibiotic as prophylaxis but considering the increase in the rates of antibiotic-resistant infections, the question arises whether antibiotic prophylaxis should be extended for adequate coverage (...) Antibiotic prophylaxis in primary and revision shoulder replacement: a systematic review Antibiotic prophylaxis in primary and revision shoulder replacement: a systematic review - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information

2020 EvidenceUpdates PubMed abstract

196. Antibiotic Prophylaxis Is Not Required for Endoscopic Ultrasonography-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions, Based on a Randomized Trial (Full text)

Antibiotic Prophylaxis Is Not Required for Endoscopic Ultrasonography-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions, Based on a Randomized Trial Antibiotic Prophylaxis Is Not Required for Endoscopic Ultrasonography-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions, Based on a Randomized Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Gastroenterology Actions . 2020 May;158(6):1642-1649.e1. doi: 10.1053/j.gastro.2020.01.025. Epub 2020 Jan 20. Antibiotic Prophylaxis Is Not Required for Endoscopic Ultrasonography-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions, Based on a Randomized Trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1

2020 EvidenceUpdates PubMed abstract

197. Antimicrobial prescribing: meropenem with vaborbactam

/50) of people receiving Antimicrobial prescribing: meropenem with vaborbactam (ES21) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 7meropenem with vaborbactam, and 44.0% (11/25) of people receiving best available antibiotic treatment. Adverse events leading to study treatment discontinuation occurred in 10.0% (5/50) and 12.0% (3/25) of people respectively. Statistical analyses were not reported for safety (...) for injection (Drug T ariff, October 2019). The cost of 1 day's treatment with 2 g (2 vials) every 8 hours is £106.68. The manufacturer of meropenem with vaborbactam (Menarini) anticipates that usage will be low, following the principles of good antimicrobial stewardship, and will be under the guidance of a microbiologist. A wide range of antibiotics, alone or in combination, are used for treating cUTI, acute pyelonephritis, cIAI, HAP and VAP , and regimens may be changed based on response to treatment

2019 National Institute for Health and Clinical Excellence - Advice

198. The widely used antimicrobial triclosan induces high levels of antibiotic tolerance <i>in vitro</i> and reduces antibiotic efficacy up to 100-fold <i>in vivo</i>. (Full text)

The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo. The antimicrobial triclosan is used in a wide range of consumer products ranging from toothpaste, cleansers, socks, and baby toys. A bacteriostatic inhibitor of fatty acid synthesis, triclosan is extremely stable and accumulates in the environment. Approximately 75% of adults in the US have detectable levels of the compound (...) in their urine, with a sizeable fraction of individuals (>10%) having urine concentrations equal to or greater than the minimal inhibitory concentration for Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA). Previous work has identified connections between defects in fatty acid synthesis and accumulation of the alarmone guanosine tetraphosphate (ppGpp), which has been repeatedly associated with antibiotic tolerance and persistence. Based on these data, we hypothesized that triclosan

2019 Antimicrobial Agents and Chemotherapy PubMed abstract

199. Antibiotic resistance is lower in Staphylococcus aureus isolated from antibiotic-free raw meat as compared to conventional raw meat. (Full text)

Antibiotic resistance is lower in Staphylococcus aureus isolated from antibiotic-free raw meat as compared to conventional raw meat. The frequent use of antibiotics contributes to antibiotic resistance in bacteria, resulting in an increase in infections that are difficult to treat. Livestock are commonly administered antibiotics in their feed, but there is current interest in raising animals that are only administered antibiotics during active infections. Staphylococcus aureus (SA) is a common (...) pathogen of both humans and livestock raised for human consumption. SA has achieved high levels of antibiotic resistance, but the origins and locations of resistance selection are poorly understood. We determined the prevalence of SA and MRSA in conventional and antibiotic-free (AF) meat products, and also measured rates of antibiotic resistance in these isolates. We isolated SA from raw conventional turkey, chicken, beef, and pork samples and also from AF chicken and turkey samples. We found that SA

2018 PLoS ONE PubMed abstract

200. Antibiotic susceptibility testing of Mycoplasma hyopneumoniae field isolates from Central Europe for fifteen antibiotics by microbroth dilution method. (Full text)

performances of the animals. Antibiotic susceptibility testing of M. hyopneumoniae is time-consuming and complicated; therefore, it is not accomplished routinely. The aim of this study was to determine the in vitro susceptibility to 15 different antibiotics of M. hyopneumoniae isolates originating from Hungarian slaughterhouses and to examine single-nucleotide polymorphisms (SNPs) in genes affecting susceptibility to antimicrobials. Minimum inhibitory concentration (MIC) values of the examined antibiotics (...) Antibiotic susceptibility testing of Mycoplasma hyopneumoniae field isolates from Central Europe for fifteen antibiotics by microbroth dilution method. Mycoplasma hyopneumoniae infections are responsible for significant economic losses in the swine industry. Commercially available vaccines are not able to inhibit the colonisation of the respiratory tract by M. hyopneumoniae absolutely, therefore vaccination can be completed with antibiotic treatment to moderate clinical signs and improve

2018 PLoS ONE PubMed abstract

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