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antibiotic resistance

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101. Frequency of Rescreening of Patients Negative for Antibiotic Resistant Organisms

Frequency of Rescreening of Patients Negative for Antibiotic Resistant Organisms TITLE: Frequency of Rescreening of Patients Negative for Antibiotic Resistant Organisms: Clinical Evidence and Guidelines DATE: 22 December 2014 RESEARCH QUESTIONS 1. What is the clinical evidence regarding the frequency of rescreening following a negative antibiotic resistant organism (ARO) test result at admission in the acute care setting? 2. What are the evidence-based guidelines regarding the frequency (...) at admission in the acute care setting; therefore, no summary can be provided. Frequency of Rescreening of Patients Negative for Antibiotic Resistant Organisms 2 REFERENCES SUMMARIZED Health Technology Assessments No literature identified. Systematic Reviews and Meta-analyses No literature identified. Randomized Controlled Trials No literature identified. Non-Randomized Studies No literature identified. Guidelines and Recommendations No literature identified. PREPARED BY: Canadian Agency for Drugs

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

102. Contact Precautions for Patients Previously Positive for Antibiotic Resistant Organisms

Contact Precautions for Patients Previously Positive for Antibiotic Resistant Organisms TITLE: Contact Precautions for Patients Previously Positive for Antibiotic Resistant Organisms: Guidelines DATE: 05 January 2015 RESEARCH QUESTION What are the evidence-based guidelines regarding the management of patients in acute care who have previously tested positive, but are currently negative for antibiotic resistant organisms? KEY FINDINGS No evidence-based guidelines were identified regarding (...) the management of patients in acute care who have previously tested positive, but are currently negative for antibiotic resistant organisms. METHODS A limited literature search was conducted on key resources including PubMed, Medline, The Cochrane Library (2014, Issue 12), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology agencies, as well as a focused Internet search. Methodological filters were applied to limit retrieval to health

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

103. Frequency of Rescreening of Patients Positive for Antibiotic Resistant Organisms

setting [Internet]. Dublin (IE): Royal College of Physicians of Ireland; 2012 [cited 2014 Dec 19]. Available from: Frequency of Rescreening of Patients Positive for Antibiotic Resistant Organisms 4 http://www.hpsc.ie/A- Z/MicrobiologyAntimicrobialResistance/InfectionControlandHAI/Guidelines/File,12922,en.p df See: Third bullet, page 27 Additional References 11. McGeer A, Fleming CA. Antimicrobial resistance in common hospital pathogens in Ontario: report 2011. Toronto (ON): Ontario Medical Association (...) , Quality Management Program - Laboratory Services; 2012 Apr [cited 2014 Dec 19]. Available from: https://iqmh.org/Portals/0/Docs/Resources/Antimicrobial%20Resistance%20Report%2020 11.pdf See: 63. When are precautions discontinued?, page 23 Frequency of Rescreening of Patients Positive for Antibiotic Resistant Organisms 5

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

104. Development of Antibiotic Resistance to Norfloxacin in the Treatment of Urinary Tract Infections

tract infections in relation to demographic and clinical data. Clin Microbiol Infect. 2005 Mar;11(3):199-203. PubMed: PM15715717 PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: 1-866-898-8439 www.cadth.ca Development of Antibiotic Resistance to Norfloxacin in the Treatment of UTIs 3 APPENDIX – FURTHER INFORMATION: Non-Randomized Studies Population Level Resistance Over Time 2. Orrett FA, Davis GK. A comparison of antimicrobial susceptibility profile of urinary pathogens (...) Development of Antibiotic Resistance to Norfloxacin in the Treatment of Urinary Tract Infections Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

105. Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa. Full Text available with Trip Pro

Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa. We assessed the synergistic potential of fosfomycin and parenteral antibiotics among carbapenem-resistant Pseudomonas aeruginosa (CRP).Minimum inhibitory concentrations (MICs) were determined by broth microdilution for all antibiotics except fosfomycin, for which the gradient diffusion strip (GDS) method was used. The GDS cross method (...) was performed to assess interactions between fosfomycin and: aztreonam, cefepime, ceftazidime, ceftazidime/avibactam, ceftolozane/tazobactam, meropenem, piperacillin/tazobactam and tobramycin. Only organisms that were nonsusceptible to the second drug were assessed.Among 153 clinical isolates, the fosfomycin MIC50/90 was 48/≥1024 mg l-1 . Synergy was detected in 131/604 (21.7 %) fosfomycin-antibiotic combinations among 76 (49.7 %) isolates. Ceftazidime (42/81, 51.9%) and ceftolozane/tazobactam (7/14, 50.0

2019 Journal of Medical Microbiology

106. Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study. Full Text available with Trip Pro

Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study. Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic (...) resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae.The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were

2019 BMC Infectious Diseases

107. Non-inferiority versus superiority trial design for new antibiotics in an era of high antimicrobial resistance: the case for post-marketing, adaptive randomised controlled trials. Full Text available with Trip Pro

Non-inferiority versus superiority trial design for new antibiotics in an era of high antimicrobial resistance: the case for post-marketing, adaptive randomised controlled trials. Antimicrobial resistance is one of the most important threats to global health security. A range of Gram-negative bacteria associated with high morbidity and mortality are now resistant to almost all available antibiotics. In this context of urgency to develop novel drugs, new antibiotics for multidrug-resistant Gram (...) a major challenge in the development, registration, and post-marketing implementation of new antibiotics. Using an example of the development process of ceftazidime-avibactam, we propose a strategy for a new research framework based on adaptive randomised clinical trials. The operational research strategy has the aim of assessing the efficacy of new antibiotics in special groups of patients, such as those infected with multidrug-resistant bacteria, who were not included in earlier phase studies

2019 Lancet infectious diseases

108. Impact of antimicrobial stewardship managed by clinical pharmacists on antibiotic use and drug resistance in a Chinese hospital, 2010-2016: a retrospective observational study. Full Text available with Trip Pro

Impact of antimicrobial stewardship managed by clinical pharmacists on antibiotic use and drug resistance in a Chinese hospital, 2010-2016: a retrospective observational study. 'National Special Stewardship in the Clinical Use of Antibiotics' was put forward in July 2011 in China. We aimed to retrospectively evaluate the impact of antimicrobial stewardship (AMS) managed by clinical pharmacists on antibiotic utilisation, prophylaxis and antimicrobial resistance (AMR).This was a retrospective (...) management, advising on antibacterial prescriptions and training.The proportion of antibiotic prescriptions among outpatients and inpatients, intensity of consumption in defined daily dose (DDD)/100 bed-days, antibiotic prophylaxis in type I incision operations and resistance rates of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were retrospectively analysed.The proportion of antibiotic prescriptions decreased in outpatients (from 19.38% to 13.21%) and in inpatients (from 64.34

2019 BMJ open

109. Targets for the reduction of antibiotic use in humans in the Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) partner countries. Full Text available with Trip Pro

Targets for the reduction of antibiotic use in humans in the Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) partner countries. Unnecessary and inappropriate use of antibiotics in human healthcare is a major driver for the development and spread of antimicrobial resistance; many countries are implementing measures to limit the overuse and misuse of antibiotics e.g. through the establishment of antimicrobial use reduction targets. We performed a review of antimicrobial use reduction (...) indicated that they have established targets to reduce antimicrobial use in humans. Twenty-one countries replied that no target had been established. However, 17 of these 21 countries indicated that work to establish such targets is currently underway, often in the context of developing a national action plan against antimicrobial resistance. The reported targets varied greatly between countries and can be a useful resource for countries willing to engage in the reduction of antibiotic use in humans.

2019 Euro Surveillance

110. Using a period incidence survey to compare antibiotic use in children between a university hospital and a district hospital in a country with low antimicrobial resistance: a prospective observational study. Full Text available with Trip Pro

Using a period incidence survey to compare antibiotic use in children between a university hospital and a district hospital in a country with low antimicrobial resistance: a prospective observational study. To describe and compare antibiotic use in relation to indications, doses, adherence rate to guidelines and rates of broad-spectrum antibiotics (BSA) in two different paediatric departments with different academic cultures, and identify areas with room for improvement.Prospective (...) observational survey of antibiotic use.Paediatric departments in a university hospital (UH) and a district hospital (DH) in Norway, 2017. The registration period was 1 year at the DH and 4 months at the UH.201 children at the DH (mean age 3.8: SD 5.1) and 137 children at the UH (mean age 2.0: SD 5.9) were treated with systemic antibiotics by a paediatrician in the study period and included in the study.Main outcome variables were prescriptions of antibiotics, treatments with antibiotics, rates of BSA

2019 BMJ open

111. A systematic review on the relationship between international migration and antimicrobial resistance Full Text available with Trip Pro

A systematic review on the relationship between international migration and antimicrobial resistance A systematic review on the relationship between international migration and antimicrobial resistance | Research Square Browse Tools & Services Your Cart This preprint is under consideration at Antimicrobial Resistance and Infection Control . A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior (...) to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research A systematic review on the relationship between international migration and antimicrobial resistance Anne Sophie Peters, Báltica Cabieses, Orlando Ramirez, Eleonora Uphoff, María Paz Acuña, Sofía Astorga, Rafael Araos, José Manuel Munita Anne Sophie Peters Universidad del Desarrollo

2020 Research Square

112. Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis Full Text available with Trip Pro

has been reported [ , ]. Previous antibiotic use was recognized as one of the risk factors for developing CDI through an alteration of gut microbiota. The accumulation of antimicrobial resistance mechanisms may provide an advantage to C. difficile as it is not affected by antimicrobials present in the gut [ ]. An antibiotic stewardship intervention, that limited the use of the fluoroquinolones, clindamycin, amoxicillin/clavulanate, and cephalosporins, was shown to be effective in reducing (...) ; and antimicrobials reserved for the treatment of multidrug pathogens. Methods Search strategy and study selection Five bibliographic databases, including international databases (MEDLINE [PubMed], Scopus, Embase, Cochrane Library and Web of Science) were searched for relevant articles (Until October 2019) using the following keywords: (“ Clostridium difficile ” OR “ Clostridioides difficile” OR C. difficile ) AND (“Antimicrobial-Drug Resistance” OR “drug resistance” OR “antibiotic resistance” OR “aminoglycosides

2020 Antimicrobial Resistance & Infection Control

113. Antimicrobial resistance and conflict in the Middle East: A systematic review Full Text available with Trip Pro

-conflict affected countries. Conclusions: There is a lack of standardization in the methodological approach to AMR research in the Middle East. The proportion of antibiotic resistances among specific GLASS pathogens is high, particularly among Acinetobacter spp. Keywords Antibiotic resistance, Antimicrobial resistance, Middle East, conflict Figures Figure 1 Figure 2 Background Methods Results Discussion Conclusions List Of Abbreviations Declarations References Tables Due to technical limitations, all (...) Antimicrobial resistance and conflict in the Middle East: A systematic review Antimicrobial resistance and conflict in the Middle East: A systematic review | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should

2020 Research Square

114. Antimicrobial-resistant genes among Klebsiella pneumoniae in the Arabian Gulf Countries: A systemic review and meta-analysis Full Text available with Trip Pro

subjected to meta-analysis. Critical appraisal of studies or quality assessment revealed mean quality score was 4.2, with an SD of 1.6. The analysis revealed predominant antimicrobial resistance genes were OXA followed by CTX-M, SHV, TEM, NDM, and VIM in the Arabian Gulf region. Conclusion The antibiotic resistance gene prevalences in Klebsiella pneumoniae in countries of the Arabian Gulf have been reviewed in this study. These countries share a high prevalence of OXA, CTX-M followed by SHV, TEM, NDM (...) and were subjected to meta-analysis. Critical appraisal of studies or quality assessment revealed mean quality score was 4.2, with an SD of 1.6. The analysis revealed predominant antimicrobial resistance genes were OXA followed by CTX-M, SHV, TEM, NDM, and VIM in the Arabian Gulf region. Conclusion The antibiotic resistance gene prevalences in Klebsiella pneumoniae in countries of the Arabian Gulf have been reviewed in this study. These countries share a high prevalence of OXA, CTX-M followed by SHV

2020 Research Square

115. Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: A systematic review Full Text available with Trip Pro

. A median of 50% of the strains of S. pneumoniae showed non-susceptibility to penicillin. 2. Similar trends were observed in conflict and non-conflict affected countries. Conclusions: There is a lack of standardization in the methodological approach to AMR research in the Middle East. The proportion of antibiotic resistances among specific GLASS pathogens is high, particularly among Acinetobacter spp. Keywords Antibiotic resistance, Antimicrobial resistance, Middle East, conflict Figures Figure 1 Figure (...) Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: A systematic review Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: A systematic review | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does

2020 Research Square

116. Antimicrobial Resistance of Pseudomonas Aeruginosa Isolated From Patients With Wound Infection in Ethiopia. A Systematic Review Article  Full Text available with Trip Pro

Corresponding Author Gebrehiwet Tesfahuneygn Tigray Health Research Institute Aderajew Gebrewahd Adigrat University Abraham Aregay Tigray Health Research Institute DOI: License: This work is licensed under a CC BY 4.0 License. Abstract Background: Infectious diseases have been major cause of morbidity and mortality all over the globe. The ability of bacterial pathogens to adapt and overcoming to treat by different antibiotics has been challenging in patient management. The antimicrobial resistance rates (...) of Pseudomonas aeruginosa are known to fluctuate extensively in different settings. Active inspection of trends in antibiotic resistance of Pseudomonas aeruginosa is essential for the selection of suitable antimicrobial agent for empirical therapy. The objective of our systematic review was to determine the national antimicrobial resistance profile of Pseudomonas aeruginosa isolated from patients with wound infection in Ethiopia. Methods: We searched the Pub Med database in July and August 2018. We used

2020 Research Square

117. The potential for developing new antimicrobial resistance from the use of medical devices containing chlorhexidine, minocycline, rifampicin and their combinations: a systematic review Full Text available with Trip Pro

The potential for developing new antimicrobial resistance from the use of medical devices containing chlorhexidine, minocycline, rifampicin and their combinations: a systematic review Validate User We are sorry, but we are experiencing unusual traffic at this time. Please help us confirm that you are not a robot and we will take you to your content. Could not validate captcha. Please try again. Take me to my Content

2020 JAC-Antimicrobial Resistance

118. What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? Full Text available with Trip Pro

on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation . 2008 ; 79 : 350–379 | | | | | Consequently, prophylactic antibiotics may seem reasonable in this population. However, it is important to balance this against the need for antimicrobial stewardship. Although this study demonstrated (...) . The duration of antibiotic administration was not available for any of the studies. It is also possible that the infection may have been resistant to the chosen antibiotic and that a different antibiotic may have been more effective. Moreover, studies were conducted over a wide range of time, with several of them conducted before modern advances in resuscitation, including therapeutic hypothermia. There was also significant statistical heterogeneity for all of the outcomes except overall mortality. Studies

2020 Annals of Emergency Medicine Systematic Review Snapshots

119. Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? Full Text available with Trip Pro

with inhaled β-agonists and corticosteroids. A minority of asthma exacerbations are due to bacterial infection. Antibiotics stewardship means being judicious about their use to limit adverse events, resistance, and unnecessary cost. Although the guidance is clear on administering antibiotics for asthma only when physical examination signs or ancillary testing is suggestive of bacterial infection, x 2 British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management (...) . There was significant clinical heterogeneity between studies and patient populations (despite low statistical heterogeneity), including different treatment settings and different antibiotic regimens (type of drug and route). Furthermore, one of the aims of the meta-analysis was to assess adverse events, but too few were reported, rendering the studies underpowered. Also, there is no mechanism to identify the effect of antibiotics given in these studies on development of drug-resistant organisms. This review

2020 Annals of Emergency Medicine Systematic Review Snapshots

120. Cefiderocol (Fetcroja) - antibiotic

involved 152 adults with various serious infections caused by bacteria that were resistant to carbapenems (could not be killed by antibiotics called carbapenems). For lung infections, 50% of patients treated with Fetcroja were cured based on a lack of symptoms, compared with 53% of Fetcroja (cefiderocol) EMA/115665/2020 Page 2/2 those treated with the best alternative treatment. For bloodstream infections, these figures were 44% and 43%, respectively. For complicated urinary tract infections, 53 (...) Cefiderocol (Fetcroja) - antibiotic Official address Domenico Scarlattilaan 6 ? 1083 HS Amsterdam ? The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. EMA/115665/2020 EMEA/H/C/004829 Fetcroja (cefiderocol) An overview of Fetcroja and why

2020 European Medicines Agency - EPARs

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