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antibiotic resistance

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81. Exploration of antibiotic resistance risks in a veterinary teaching hospital with Oxford Nanopore long read sequencing. Full Text available with Trip Pro

Exploration of antibiotic resistance risks in a veterinary teaching hospital with Oxford Nanopore long read sequencing. The Oxford Nanopore MinION DNA sequencing device can produce large amounts of long sequences, typically several kilobases, within a few hours. This long read capacity was exploited to detect antimicrobial resistance genes (ARGs) in a large veterinary teaching hospital environment, and to assess their taxonomic origin, genetic organisation and association with mobilisation (...) markers concurrently. Samples were collected on eight occasions between November 2016 and May 2017 (inclusive) in a longitudinal study. Nanopore sequencing was performed on total DNA extracted from the samples after a minimal enrichment step in broth. Many ARGs present in the veterinary hospital environment could potentially confer resistance to antimicrobials widely used in treating infections of companion animals, including aminoglycosides, extended-spectrum beta-lactams, sulphonamides, macrolides

2019 PLoS ONE

82. Epidemiology of antibiotic-resistant wound infections from six countries in Africa Full Text available with Trip Pro

Epidemiology of antibiotic-resistant wound infections from six countries in Africa Little is known about the antimicrobial susceptibility of common bacteria responsible for wound infections from many countries in sub-Saharan Africa.We performed a retrospective review of microbial isolates collected based on clinical suspicion of wound infection between 2004 and 2016 from Mercy Ships, a non-governmental organisation operating a single mobile surgical unit in Benin, Congo, Liberia, Madagascar (...) surveillance should be a priority and local antimicrobial resistance profiles should be used to guide empiric antibiotic selection.

2018 BMJ global health

83. Machine Learning Leveraging Genomes from Metagenomes Identifies Influential Antibiotic Resistance Genes in the Infant Gut Microbiome Full Text available with Trip Pro

Machine Learning Leveraging Genomes from Metagenomes Identifies Influential Antibiotic Resistance Genes in the Infant Gut Microbiome Antibiotic resistance in pathogens is extensively studied, and yet little is known about how antibiotic resistance genes of typical gut bacteria influence microbiome dynamics. Here, we leveraged genomes from metagenomes to investigate how genes of the premature infant gut resistome correspond to the ability of bacteria to survive under certain environmental (...) are those that encode subclass B2 beta-lactamases and transcriptional regulators of vancomycin resistance. This demonstrates that machine learning applied to genome-resolved metagenomics data can identify key genes for survival after antibiotics treatment and predict how organisms in the gut microbiome will respond to antibiotic administration. IMPORTANCE The process of reconstructing genomes from environmental sequence data (genome-resolved metagenomics) allows unique insight into microbial systems. We

2018 mSystems

84. Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery Full Text available with Trip Pro

Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery To report the resolution of a fluoroquinolone-resistant Escherichia coli keratitis with use of a prosthetic replacement of the ocular surface ecosystem (PROSE) device for enhanced targeted delivery of moxifloxiacin.A 62-year-old female presented with a 3-day history of pain, photophobia, and declining vision in left eye. The patient had a 2-year history of binocular (...) therapy. Frequent dosing to the PROSE reservoir is likely to increase fluoroquinolone bioavailability and may represent a valuable approach to overcome antibiotic resistance.

2018 American journal of ophthalmology case reports

85. Antibiotic resistance patterns of urinary tract pathogens in Turkish children Full Text available with Trip Pro

Antibiotic resistance patterns of urinary tract pathogens in Turkish children Knowledge of local antimicrobial resistance patterns is essential for evidence- based empirical antibiotic prescribing. We aimed to investigate the distribution and changes in causative agents of urinary tract infections in children and the resistance rates, and to recommend the most appropriate antibiotics.In this retrospective study, we evaluated causative agents and antimicrobial resistance in urine isolates from (...) the positive community from September 2014 to April 2016 in a single hospital in Ankara, Turkey.A total of 850 positive urine cultures were identified, of which 588 (69.2%) were from girls and 262 (30.8%) were from boys. Their mean age was 36.5 ± 45.0 months. The most common causative agent was Escherichia coli (64.2% of cases) followed by Klebsiella pneumoniae (14.9%). The overall resistance to ampicillin (62.6%), cephalothin (44.2%), co-trimoxazole (29.8%) and cefuroxime (28.7%) was significant

2018 Global health research and policy

86. What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol Full Text available with Trip Pro

of Open Access Journals. Drug Resistance Updates. IngentaConnect. JSTOR. Scopus. Wiley Online Library. Internet searches Google Scholar. Specialist searches for grey literature When the complete search strings cannot be used in the previous publication databases, a broad search will be made with the following terms: (antibiotic OR antimicrobial OR “antimicrobial resistance” OR “antibiotic resistance”) AND environment. Specialist organization websites that will be searched are listed below (...) (not exhaustive): Alliance for the Prudent Use of Antibiotics. Bielefeld Academic Search Engine. BIVI database of AFNOR. Centre for Antibiotic Resistance Research. Centers for Disease Control and Prevention. EFFORT against antimicrobial resistance. European Antimicrobial Resistance Surveillance Network (EARS-Net) of European Centre for Disease Prevention and Control. European Commission Environment. European Committee on Antimicrobial Susceptibility Testing. European Food Safety Authority. Food

2018 Environmental evidence

87. The Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Gram-positive Bacteria in Africa: A Systematic Review and Meta-Analysis from a One Health Perspective Full Text available with Trip Pro

The Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Gram-positive Bacteria in Africa: A Systematic Review and Meta-Analysis from a One Health Perspective Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Gram-positive Bacteria in Africa: A Systematic Review and Meta-Analysis from a One Health Perspective | bioRxiv Search for this keyword New Results Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Gram-positive Bacteria in Africa: A Systematic (...) in Tropical medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi , Ghana . ABSTRACT A systematic review and meta-analysis of antibiotic-resistant Gram-positive bacteria in Africa, showing the molecular epidemiology of resistant species from animal, human and environmental sources, is lacking. Thus, the current burden, type, and sources of Gram-positive bacterial resistance and their dissemination routes from farm to fork is absent. To fill this One Health

2018 Cold Spring Harbor Laboratory

88. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. (Abstract)

are resistant to many common antibiotics and able to acquire resistance against many more. Following patient segregation in cystic fibrosis medical care, the more virulent epidemic strains are not as frequent, and new infections are more likely to be with less virulent environmentally-acquired strains. Although evidence-based guidelines exist for treating respiratory exacerbations involving Pseudomonas aeruginosa, these cannot be extended to Burkholderia cepacia complex infections. This review, which (...) Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with a fulminant necrotising pneumonia. Burkholderia cepacia complex bacteria

2020 Cochrane

89. Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. (Abstract)

Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. Stenotrophomonas maltophilia is one of the most common emerging multi-drug resistant organisms found in the lungs of people with cystic fibrosis and its prevalence is increasing. Chronic infection with Stenotrophomonas maltophilia has recently been shown to be an independent predictor of pulmonary exacerbation requiring hospitalization and antibiotics. However, the role of antibiotic treatment (...) of Stenotrophomonas maltophilia infection in people with cystic fibrosis is still unclear. This is an update of a previously published review.The objective of our review is to assess the effectiveness of antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. The primary objective is to assess this in relation to lung function and pulmonary exacerbations in the setting of acute pulmonary exacerbations. The secondary objective is to assess this in relation to the eradication

2020 Cochrane

90. Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients. Full Text available with Trip Pro

antibiotics in preventing surgical site infections in solid organ transplant recipients at any time point after transplantation.Two authors independently determined study eligibility, assessed quality, and extracted data. Primary outcomes were surgical site infections and antimicrobial resistance. Other outcomes included urinary tract infections, pneumonias and septicaemia, death (any cause), graft loss, graft rejection, graft function, adverse reactions to antimicrobial agents, and outcomes identified (...) Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients. Solid organ transplant recipients are at high risk for infections due to the complexity of surgical procedures combined with the impact of immunosuppression. No consensus exists on the role of antibiotics for surgical site infections in solid organ transplant recipients.To assess the benefits and harms of prophylactic antimicrobial agents for preventing surgical site infections in solid

2020 Cochrane

91. Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis. (Abstract)

and near-significant reductions in Pseudomonas aeruginosa, but the quality of this evidence is again very low.We could not identify an antibiotic adjuvant therapy that we could recommend for treating of lung infection in people with cystic fibrosis. The emergence of increasingly resistant bacteria makes the reliance on antibiotics alone challenging for cystic fibrosis teams. There is a need to explore alternative strategies, such as the use of adjuvant therapies. Further research is required to provide (...) Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis. Cystic fibrosis is a multi-system disease characterised by the production of thick secretions causing recurrent pulmonary infection, often with unusual bacteria. This leads to lung destruction and eventually death through respiratory failure. There are no antibiotics in development that exert a new mode of action and many of the current antibiotics are ineffective in eradicating the bacteria once chronic infection

2020 Cochrane

92. Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Full Text available with Trip Pro

aureus versus no prophylaxis in people with cystic fibrosis, we tested the following hypotheses to investigate whether prophylaxis: 1. improves clinical status, lung function and survival; 2. leads to fewer isolates of Staphylococcus aureus; 3. causes adverse effects (e.g. diarrhoea, skin rash, candidiasis); 4. leads to fewer isolates of other common pathogens from respiratory secretions; 5. leads to the emergence of antibiotic resistance and colonisation of the respiratory tract with Pseudomonas (...) Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Staphylococcus aureus causes pulmonary infection in young children with cystic fibrosis. Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might lead to infection with Pseudomonas aeruginosa. This is an update of a previously published review.To assess continuous oral antibiotic prophylaxis to prevent the acquisition of Staphylococcus

2020 Cochrane

93. Antimicrobial resistance: summary report on progress made in implementing resolution WHA67.25 on antimicrobial resistance: report by the Secretariat

Antimicrobial resistance: summary report on progress made in implementing resolution WHA67.25 on antimicrobial resistance: report by the Secretariat Antimicrobial resistance: summary report on progress made in implementing resolution WHA67.25 on antimicrobial resistance: report by the Secretariat JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Antimicrobial resistance: summary (...) report on progress made in implementing resolution WHA67.25 on antimicrobial resistance: report by the Secretariat View/ Open View Statistics Altmetrics Share Citation World Health Assembly, 68 . (‎2015)‎. Antimicrobial resistance: summary report on progress made in implementing resolution WHA67.25 on antimicrobial resistance: report by the Secretariat. World Health Organization. Gov't Doc # A68/19 Collections Language English Metadata Related items Showing items related by title and MeSH subject

2015 WHO

94. Antimicrobial resistance: Draft global action plan on antimicrobial resistance: report by the Secretariat

Antimicrobial resistance: Draft global action plan on antimicrobial resistance: report by the Secretariat Antimicrobial resistance: draft global action plan on antimicrobial resistance: report by the Secretariat JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Antimicrobial resistance: draft global action plan on antimicrobial resistance: report by the Secretariat View/ Open (...) View Statistics Altmetrics Share Citation World Health Assembly, 68 . (‎2015)‎. Antimicrobial resistance: draft global action plan on antimicrobial resistance: report by the Secretariat. World Health Organization. Gov't Doc # A68/20 Collections Language English Metadata Related items Showing items related by title and MeSH subject.  Executive Board, 136 (‎ EB136/20 , 2015 )‎  World Health Assembly, 68 (‎ A68/19 , 2015 )‎  Executive Board, 136 (‎ EB136/19 , 2015 )‎ View Item

2015 WHO

95. Effectiveness of Screening for Endemic Antibiotic Resistant Organisms (AROs) in Hospital Settings

Effectiveness of Screening for Endemic Antibiotic Resistant Organisms (AROs) in Hospital Settings application/octet-stream

2015 Institute of Health Economics

96. Global action plan on antimicrobial resistance: options for establishing a global development and stewardship framework to support the development, control, distribution and appropriate use of new antimicrobial medicines, diagnostic tools, vaccines and ot

Global action plan on antimicrobial resistance: options for establishing a global development and stewardship framework to support the development, control, distribution and appropriate use of new antimicrobial medicines, diagnostic tools, vaccines and ot Global action plan on antimicrobial resistance: options for establishing a global development and stewardship framework to support the development, control, distribution and appropriate use of new antimicrobial medicines, diagnostic tools (...) , vaccines and other interventions: report by the Secretariat JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Global action plan on antimicrobial resistance: options for establishing a global development and stewardship framework to support the development, control, distribution and appropriate use of new antimicrobial medicines, diagnostic tools, vaccines and other interventions

2016 WHO

97. SIVEXTRO (tedizolid), antibiotic of the oxazolidinone class - non-serious infections of staphylococcal aetiology that are resistant to methicillin

SIVEXTRO (tedizolid), antibiotic of the oxazolidinone class - non-serious infections of staphylococcal aetiology that are resistant to methicillin SIVEXTRO SUMMARY CT14395

2016 Haute Autorite de sante

98. MALDI-TOF for detection of antibiotic resistant bacteria

commercially available. HealthPACT does not support public investment in MALDI-TOF for the identification of antimicrobial resistance bacteria in clinical practice at this time. When the evidence base for this technology matures it would be identified for further assessment via normal horizon scanning activities. MALDI-TOF for detection of antibiotic resistant bacteria: Update December 2016 1 Technology, Company and Licensing Register ID WP206 Technology name MALDI-TOF for detection of antibiotic resistant (...) bacteria Patient indication Patients with suspected vancomycin-resistant enterococci Reason for assessment In 2014, a Technology Brief was completed to investigate the use of matrix-assisted laser desorption ionisation-time of flight mass spectrometry (MALDI-TOF) for the detection of antibiotic resistant bacteria. MALDI-TOF is already in use in Australia for its ability to rapidly and cheaply identify bacteria, but more recently, the technology has been used for identifying antimicrobial resistance

2016 COAG Health Council - Horizon Scanning Technology Briefs

99. Contact Isolation Precautions for Ambulatory Oncology Patients Positive for Antibiotic Resistant Organisms: A Review of Clinical Effectiveness and Guidelines

Contact Isolation Precautions for Ambulatory Oncology Patients Positive for Antibiotic Resistant Organisms: A Review of Clinical Effectiveness and Guidelines Contact Isolation Precautions for Ambulatory Oncology Patients Positive for Antibiotic Resistant Organisms: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Contact Isolation Precautions for Ambulatory Oncology Patients Positive for Antibiotic Resistant Organisms: A Review of Clinical Effectiveness (...) and Guidelines Contact Isolation Precautions for Ambulatory Oncology Patients Positive for Antibiotic Resistant Organisms: A Review of Clinical Effectiveness and Guidelines Published on: October 6, 2015 Project Number: RC0712-000 Product Line: Research Type: Other Diagnostics Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of contact isolation precautions versus routine infection prevention practices for ambulatory oncology patients

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

100. Universal Screening for Antibiotic-Resistant Organisms in Long-Term Care Facilities

Universal Screening for Antibiotic-Resistant Organisms in Long-Term Care Facilities TITLE: Universal Screening for Antibiotic-Resistant Organisms in Long-Term Care Facilities: Clinical Effectiveness and Guidelines DATE: 18 December 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of universal screening for antibiotic-resistant organisms (AROs) upon admission to a long-term care or continuing care facility? 2. What are the evidence-based guidelines regarding screening residents (...) for AROs upon admission to long-term care or continuing care facilities? KEY FINDINGS One systematic review was identified regarding the clinical effectiveness of universal screening for antibiotic-resistant organisms upon admission to a long-term care or continuing care facility. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 12), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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