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antibiotic resistance

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181. Are antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review. (Abstract)

Are antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review. Antimicrobial stewardship programs (ASPs) have been proposed as a solution for the global burden of antibiotic resistance, despite the lack of evidence on the subject.To analyze the role of ASPs in reducing bacterial resistance to antibiotics in hospital settings.A review in PubMed, Scopus, LILACS, and SciELO databases was performed. The period analyzed was January 1, 2012 (...) . The implementation of new infection control practices occurred in 7 studies.There are yet few studies on this matter, and most of them have inadequate study designs. Great heterogeneity between study features was detrimental to drawing evidence-based conclusions.There is no solid evidence that ASPs are effective in reducing antibiotic resistance in hospital settings. We uphold the need for more studies with appropriate study designs, standardized ASP interventions targeting common microorganism-antibiotic pairs

2018 American journal of infection control

182. Cost-Effectiveness of Antibiotic Prophylaxis Strategies for Transrectal Prostate Biopsy in an Era of Increasing Antimicrobial Resistance. Full Text available with Trip Pro

Cost-Effectiveness of Antibiotic Prophylaxis Strategies for Transrectal Prostate Biopsy in an Era of Increasing Antimicrobial Resistance. To determine the optimal antibiotic prophylaxis strategy for transrectal prostate biopsy (TRPB) as a function of the local antibiotic resistance profile.We developed a decision-analytic model to assess the cost-effectiveness of four antibiotic prophylaxis strategies: ciprofloxacin alone, ceftriaxone alone, ciprofloxacin and ceftriaxone in combination (...) of resistance.Directed or combination prophylaxis strategies were optimal for a wide range of resistance levels. Facilities using single-agent antibiotic prophylaxis strategies before TRPB should re-evaluate their strategies unless extremely low levels of antimicrobial resistance are documented.Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

2018 Value in Health

183. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities. Full Text available with Trip Pro

Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities. Antimicrobial resistance (AMR) is a major challenge for global health care. Pharmacists play a key role in the health care setting to help support the quality use of medicines. The education, training, and experiences of pharmacy students have the potential to impact on patterns of antibiotic use in community and hospital settings. The aim of this study (...) about antimicrobials. A comparison between junior and senior pharmacy students suggests that pharmacy education is associated with improved understanding of appropriate antibiotic use and AMR among undergraduate pharmacy students in Sri Lanka.

2018 BMC Infectious Diseases

184. Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. Full Text available with Trip Pro

Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions. To describe and compare the prescribing of antibiotics used for urinary tract infections and its correlation with resistance in Escherichia coli in urinary samples across two adjacent regions-the Capital Region and the Skaane Region-and their municipalities in Denmark and Sweden.The Capital Region consists of 29 municipalities and 725 960 female (...) /prescription. Correlation analyses between antibiotic prescribing and antibiotic resistance rates were performed.Antibiotic prescribing and resistance rates were significantly higher in the Capital Region compared with the Skaane Region. Large variations in prescription and resistance rates were found at the municipal level, but there were no correlations between the antibiotic prescription and resistance rates when each region was analysed separately.Although closely related, there are large differences

2018 Journal of Antimicrobial Chemotherapy

185. Sustainable reduction of antibiotic-induced antimicrobial resistance (ARena) in German ambulatory care: study protocol of a cluster randomised trial. Full Text available with Trip Pro

Sustainable reduction of antibiotic-induced antimicrobial resistance (ARena) in German ambulatory care: study protocol of a cluster randomised trial. Despite many initiatives to enhance the rational use of antibiotics, there remains substantial room for improvement. The overall aim of this study is to optimise the appropriate use of antibiotics in German ambulatory care in patients with acute non-complicated infections (respiratory tract infections, such as bronchitis, sinusitis, tonsillitis (...) and otitis media), community-acquired pneumonia and non-complicated cystitis, in order to counter the advancing antimicrobial resistance development.A three-armed cluster randomised trial will be conducted in 14 practice networks in two German federal states (Bavaria and North Rhine-Westphalia) and an added cohort that reflects standard care. The trial is accompanied by a process evaluation. Each arm will receive a different set of implementation strategies. Arm A receives a standard set, comprising of e

2018 Implementation Science Controlled trial quality: uncertain

186. Antibiotic consumption and antimicrobial resistance in Poland; findings and implications Full Text available with Trip Pro

Antibiotic consumption and antimicrobial resistance in Poland; findings and implications The problem of inappropriate use of antibiotics and the resulting growth in antimicrobial resistance (AMR) has implications for Poland and the world. The objective of this paper was to compare and contrast antibiotic resistance and antibiotic utilisation in Poland in recent years versus other European countries, including agreed quality indicators, alongside current AMR patterns and ongoing policies (...) and initiatives in Poland to influence and improve antibiotic prescribing.A quantitative ten-year analysis (2007-2016) of the use of antibiotics based on European Centre for Disease Prevention and Control (ECDC) data combined with a literature review on AMR rates and antimicrobial stewardship initiatives.The system of monitoring AMR and appropriate strategies to address AMR rates remain underdeveloped in Poland. The role of microbiological diagnostics and efforts to prevent infections is currently

2018 Antimicrobial resistance and infection control

187. Antimicrobial Activity of a Bacteriocin Produced by Enterococcus faecalis KT11 against Some Pathogens and Antibiotic-Resistant Bacteria Full Text available with Trip Pro

Antimicrobial Activity of a Bacteriocin Produced by Enterococcus faecalis KT11 against Some Pathogens and Antibiotic-Resistant Bacteria In this study, the antimicrobial activity of a bacteriocin produced by Enterococcus faecalis KT11, isolated from traditional Kargı Tulum cheese, was determined, and bacteriocin KT11 was partially characterized. The results showed that bacteriocin KT11 was antagonistically effective against various Gram-positive and Gram-negative test bacteria, including (...) the bacteriocin KT11, isolated from E. faecalis KT11, exhibits a broad antimicrobial spectrum, heat stability and stability over a wide pH range, this bacteriocin can be used as a potential bio-preservative in foods. Additionally, bacteriocin KT11 alone or in combination with conventional antibiotics may provide a therapeutic option for the treatment of multidrug-resistant clinical pathogens after further in vivo studies.

2018 Korean journal for food science of animal resources

188. Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots. Full Text available with Trip Pro

Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots. Biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. Biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. Antimicrobial peptides (AMPs) are a ubiquitous facet (...) of innate immunity in animals. However, AMPs activity was studied mainly on planktonic bacteria and little is known about their effects on biofilms. We studied structure and anti-biofilm activity of AMP complex produced by the maggots of blowfly Calliphora vicina living in environments extremely contaminated by biofilm-forming germs. The complex exhibits strong cell killing and matrix destroying activity against human pathogenic antibiotic resistant Escherichia coli, Staphylococcus aureus

2017 PLoS ONE

189. Respiratory tract infections (self-limiting) – reducing antibiotic prescribing

Otitis Media. Diagnosis and Management of Acute Otitis Media. Pediatrics, 2004 113(5), 1451-65. 2. McGregor A, Dovey S, Tilyard M. Antibiotic use in upper respiratory tract infections in New Zealand. Family Practice 1995;12:166-70. 3. Thomas MG, Smith AJ, Tilyard M. Rising antimicrobial resistance: a strong reason to reduce antimicrobial consumption in New Zealand. NZ Med J 2014;127:1394:72-84. 4. Heart Foundation of New Zealand: Guidelines for Group A Streptococcal Sore Throat Management Guideline (...) in cases where the antibiotic is clinically necessary, patients, and their families and friends, may get the message from healthcare professionals that antibiotics are helpful for most infections. This is because patients will understandably attribute their symptom resolution to antibiotics, and thus maintain a cycle of ‘medicalising’ self-limiting illness. Third, international comparisons make it clear that antibiotic resistance rates are strongly related to antibiotic use in primary care. 3

2019 Best Practice Advocacy Centre New Zealand

190. Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Full Text available with Trip Pro

Centers for Disease Control and Prevention. Telebriefing on today's drug-resistant health threats. ( Available at: ) . , x 16 Centers for Disease Control and Prevention. Joint Statement on Importance of Outpatient Antibiotics Stewardship From 12 National Health Organizations. ( Available at: ) . , x 17 Centers for Disease Control and Prevention. Antibiotic/antimicrobial resistance (AR/AMR): the AMR challenge. ( Available at: ) . , x 18 White House Office of the Press Secretary. Fact sheet: over 150 (...) effective against various gram-negative anaerobes and is associated with lower incidence of gastrointestinal adverse effects. # Bacterial resistance rates for azithromycin are higher than for other antibiotics, and clindamycin substantially increases the risk of developing Clostridioides difficile infection even after a single dose. Owing to concerns about antibiotic resistance, patients who receive azithromycin should be instructed to closely monitor their symptoms and call a dentist or primary care

2020 American Dental Association Guidelines

191. COPD exacerbation: no systematic use of antibiotics

COPD, rapid increase in respiratory signs, presence of associated diseases (e.g. diabetes, cardiovascular diseases). When exacerbation is moderate, the results of available trials show that seven out of ten patients recover in less than four weeks without antibiotics. About one in ten patients heals faster with antibiotic therapy, which may also extend the interval until the next exacerbation. Antibiotic therapies expose patients to the carrying of resistant bacteria, which are sources of harder (...) COPD exacerbation: no systematic use of antibiotics Prescrire IN ENGLISH - Spotlight ''COPD exacerbation: no systematic use of antibiotics'', 1 January 2019 {1} {1} {1} | | > > > COPD exacerbation: no systematic use of antibiotics Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight COPD exacerbation: no systematic use of antibiotics For episodes

2019 Prescrire

192. Uropathogenic Escherichia coli in the Urine Samples of Iranian Dogs: Antimicrobial Resistance Pattern and Distribution of Antibiotic Resistance Genes Full Text available with Trip Pro

Uropathogenic Escherichia coli in the Urine Samples of Iranian Dogs: Antimicrobial Resistance Pattern and Distribution of Antibiotic Resistance Genes Resistant uropathogenic Escherichia coli is the most common cause of urinary tract infections in dogs. The present research was done to study the prevalence rate and antimicrobial resistance properties of UPEC strains isolated from healthy dogs and those which suffered from UTIs. Four-hundred and fifty urine samples were collected and cultured. E (...) %). We found that 21.50% of UPEC strains had simultaneously resistance against more than 10 antibiotics. Aac(3)-IV (77%), CITM (52.5%), tetA (46.5%), and sul1 (40%) were the most commonly detected antibiotic resistance genes. Findings showed considerable levels of antimicrobial resistance among UPEC strains of Iranian dogs. Rapid identification of infected dogs and their treatment based on the results of disk diffusion can control the risk of UPEC strains.

2017 BioMed research international

193. Correlation of Aminoglycoside Consumption and Amikacin- or Gentamicin-Resistant Pseudomonas aeruginosa in Long-Term Nationwide Analysis: Is Antibiotic Cycling an Effective Policy for Reducing Antimicrobial Resistance? Full Text available with Trip Pro

Correlation of Aminoglycoside Consumption and Amikacin- or Gentamicin-Resistant Pseudomonas aeruginosa in Long-Term Nationwide Analysis: Is Antibiotic Cycling an Effective Policy for Reducing Antimicrobial Resistance? 29214765 2019 02 20 2019 03 20 2234-3814 38 2 2018 03 Annals of laboratory medicine Ann Lab Med Correlation of Aminoglycoside Consumption and Amikacin- or Gentamicin-Resistant Pseudomonas aeruginosa in Long-Term Nationwide Analysis: Is Antibiotic Cycling an Effective Policy (...) for Reducing Antimicrobial Resistance? 176-178 10.3343/alm.2018.38.2.176 Kim Young Ah YA Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea. Park Yoon Soo YS Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea. Youk Taemi T Department of Statistics, Korea University, Seoul, Korea. Lee Hyukmin H Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine

2017 Annals of laboratory medicine

194. Use of and microbial resistance to antibiotics in China: a path to reducing antimicrobial resistance Full Text available with Trip Pro

Use of and microbial resistance to antibiotics in China: a path to reducing antimicrobial resistance We analyzed China's current use of and microbial resistance to antibiotics, and possible means of reducing antimicrobial resistance. Interventions like executive orders within clinical settings and educational approach with vertical approaches rather than an integrated strategy to curb the use of antimicrobials remain limited. An underlying problem is the system of incentives that has resulted (...) in the intensification of inappropriate use by health professionals and patients. There is an urgent need to explore the relationship between financial and non-financial incentives for providers and patients, to eliminate inappropriate incentives. China's national health reforms have created an opportunity to contain inappropriate use of antibiotics through more comprehensive and integrated strategies. Containment of microbial resistance may be achieved by strengthening surveillance at national, regional

2017 The Journal of international medical research

195. A strategy of 'delayed antibiotic prescribing' for respiratory infections may reduce antibiotic use

Health England; 2015. Public Health England. London: Public Health England; 2017. Delayed antibiotic prescriptions for respiratory infections Published on 8 September 2017 Spurling, G. K.,Del Mar, C. B.,Dooley, L.,Foxlee, R.,Farley, R. Cochrane Database Syst Rev Volume 9 , 2017 BACKGROUND: Concerns exist regarding antibiotic prescribing for respiratory tract infections (RTIs) owing to adverse reactions, cost, and antibacterial resistance. One proposed strategy to reduce antibiotic prescribing (...) not affect patient satisfaction compared with immediate prescribing of antibiotics. Increasing antibiotic resistance is a global health concern. Many people don’t realise that viruses cause most respiratory infections and that antibiotics won’t help. The strategy allows some time for symptoms to improve naturally. This review of the latest evidence on delayed prescribing for self-limiting respiratory infections is in line with current guidance. On the whole delaying antibiotics made little difference

2019 NIHR Dissemination Centre

196. Antibacterial-coated sutures versus non-antibacterial-coated sutures for the prevention of abdominal, superficial and deep, surgical site infection (SSI)

low risk of bias RCTs 83 Table 19: The length of hospital stay in triclosan-coated vs non-antibacterial coated sutures patient groups 85 Table 20: The proportion of patients requiring secondary surgery for wound-related complications of surgery 86 Table 21: The incidence of complete abdominal wound dehiscence within 30 days of surgery and incisional hernia during the period of study follow-up 87 Table 22: Causative microorganism of SSI and the use of systemic antibiotic therapy within 30 days (...) Controlled Trial REA Relative Effectiveness Assessment RoB Risk of Bias RR Relative risk SAE Serious Adverse Event SAF Safety domain Antibacterial-coated sutures for the prevention of abdominal SSI Version 1.4, March 2017 EUnetHTA Joint Action 3 WP4 10 SAP Surgical antibiotic prophylaxis SDGC Study Center of the German Surgical Society SHEA The Society for Healthcare Epidemiology of America SHEA/IDSA Society for Healthcare Epidemiology of America/Infectious Diseases Society of America SI Superficial

2017 EUnetHTA

197. Antibiotics for acute rhinosinusitis in adults. Full Text available with Trip Pro

failure, control group).The potential benefit of antibiotics to treat acute rhinosinusitis diagnosed either clinically (low risk of bias, high-quality evidence) or confirmed by imaging (low to unclear risk of bias, moderate-quality evidence) is marginal and needs to be seen in the context of the risk of adverse effects. Considering antibiotic resistance, and the very low incidence of serious complications, we conclude there is no place for antibiotics for people with uncomplicated acute rhinosinusitis (...) Antibiotics for acute rhinosinusitis in adults. Acute rhinosinusitis is an acute infection of the nasal passages and paranasal sinuses that lasts less than four weeks. Diagnosis of acute rhinosinusitis is generally based on clinical signs and symptoms in ambulatory care settings. Technical investigations are not routinely performed, nor are they recommended in most countries. Some trials show a trend in favour of antibiotics, but the balance of benefit versus harm is unclear.We merged two

2018 Cochrane

198. Head-to-head trials of antibiotics for bronchiectasis. Full Text available with Trip Pro

eradication, but their use is tempered against potential adverse effects and concerns regarding antibiotic resistance. The comparative effectiveness, cost-effectiveness, and safety of different antibiotics have been highlighted as important issues, but currently little evidence is available to help resolve uncertainty on these questions.To evaluate the comparative effects of different antibiotics in the treatment of adults and children with bronchiectasis.We identified randomised controlled trials (RCTs (...) Head-to-head trials of antibiotics for bronchiectasis. The diagnosis of bronchiectasis is defined by abnormal dilation of the airways related to a pathological mechanism of progressive airway destruction that is due to a 'vicious cycle' of recurrent bacterial infection, inflammatory mediator release, airway damage, and subsequent further infection. Antibiotics are the main treatment option for reducing bacterial burden in people with exacerbations of bronchiectasis and for longer-term

2018 Cochrane

199. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Full Text available with Trip Pro

by local, operative measures, and that systemic antibiotics are currently only recommended for situations where there is evidence of spreading infection (cellulitis, lymph node involvement, diffuse swelling) or systemic involvement (fever, malaise). Despite this, there is evidence that dentists frequently prescribe antibiotics in the absence of these signs. There is concern that this could contribute to the development of antibiotic-resistant bacterial colonies within both the individual (...) Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis and acute apical abscess are common causes of dental pain and arise from an inflamed or necrotic dental pulp, or infection of the pulpless root canal system. Clinical guidelines recommend that the first-line treatment for teeth with these conditions should be removal of the source of inflammation or infection

2018 Cochrane

200. Antibiotics for treating scrub typhus. Full Text available with Trip Pro

Antibiotics for treating scrub typhus. Scrub typhus, an important cause of acute fever in Asia, is caused by Orientia tsutsugamushi, an obligate intracellular bacterium. Antibiotics currently used to treat scrub typhus include tetracyclines, chloramphenicol, macrolides, and rifampicin.To assess and compare the effects of different antibiotic regimens for treatment of scrub typhus.We searched the following databases up to 8 January 2018: the Cochrane Infectious Diseases Group specialized trials (...) register; CENTRAL, in the Cochrane Library (2018, Issue 1); MEDLINE; Embase; LILACS; and the metaRegister of Controlled Trials (mRCT). We checked references and contacted study authors for additional data. We applied no language or date restrictions.Randomized controlled trials (RCTs) or quasi-RCTs comparing antibiotic regimens in people with the diagnosis of scrub typhus based on clinical symptoms and compatible laboratory tests (excluding the Weil-Felix test).For this update, two review authors re

2018 Cochrane

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