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antibiotic resistance

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181. Cefepime Versus Cefepime Plus Amikacin as an Initial Antibiotic Choice for Pediatric Cancer Patients With Febrile Neutropenia in an Era of Increasing Cefepime Resistance. (Abstract)

Cefepime Versus Cefepime Plus Amikacin as an Initial Antibiotic Choice for Pediatric Cancer Patients With Febrile Neutropenia in an Era of Increasing Cefepime Resistance. We investigated the treatment outcomes before and after the addition of amikacin to cefepime monotherapy as an initial empirical antibiotic treatment in pediatric cancer patients with febrile neutropenia.This was a retrospective historical cohort study. The subjects were pediatric cancer patients who visited the emergency room (...) at the Samsung Medical Center, Seoul, Korea, due to chemotherapy-induced febrile neutropenia, between January 2011 and December 2016. Since September 2014, the empirical antimicrobial treatment regimen for febrile neutropenia was changed from high-dose cefepime monotherapy to combination therapy of adding a single dose of amikacin.Two hundred twenty-five bacteremia episodes in 164 patients were reported during the study period. Bacteremia caused by cefepime-resistant Gram-negative bacteria was observed in 16

2020 Pediatric Infectious Dsease Journal

182. Prevalence and Risk Factor for Antibiotic-resistant Escherichia coli Colonization at Birth in Premature Infants: A Prospective Cohort Study. (Abstract)

Prevalence and Risk Factor for Antibiotic-resistant Escherichia coli Colonization at Birth in Premature Infants: A Prospective Cohort Study. Escherichia coli causes neonatal early-onset sepsis (EOS) that is associated with high mortality and increasing antibiotic resistance. Thus, we estimated the prevalence, antibiotic susceptibility and risk factors for colonization of E. coli in premature infants at birth and characterized the pathogenicity of the isolates.A prospective surveillance study (...) in mothers was 47.6%, comprising 5.9% extended-spectrum beta-lactamase-producing E. coli (ESBL-E) and 20.0% ampicillin-resistant strains. Ten (2.4%) infants exhibited colonization; ESBL-E and ampicillin-resistant strains colonized three and four infants, respectively. Three antibiotic-resistant, strain-positive infants developed EOS. Pulsed-field gel electrophoresis revealed vertical transmission of bacteria in four infants. Multivariate logistic regression analysis revealed that ESBL-E-positive mothers

2020 Pediatric Infectious Dsease Journal

183. Antibiotic resistance is associated with morbidity and mortality after decortication for empyema. (Abstract)

Antibiotic resistance is associated with morbidity and mortality after decortication for empyema. Previous studies of decortication for empyema have demonstrated that patient characteristics are associated with mortality, but the relationship of infectious pathogen to outcome has not been described. Our objective was to analyze the association of microbiology and antibiotic resistance with post-operative mortality following decortication for empyema. We hypothesized that bacterial pathogens (...) , antibiotic resistance and patient characteristics would all contribute to perioperative morbidity and mortality.Patients undergoing pulmonary decortication for empyema from 1/1/2010-10/1/2017 were reviewed retrospectively. Cases were matched to microbiology cultures. The outcomes of interest was a composite of death, tracheostomy, initial ventilator support > 48 hours or unexpected ICU readmission. Antibiotic resistance was categorized as present or absent, and the number of antibiotics with resistance

2020 Annals of Thoracic Surgery

184. Efficacy and safety of topical resorcinol 15% as long-term treatment of mild-moderate hidradenitis suppurativa: a valid alternative to clindamycin in the panorama of antibiotic resistance. (Abstract)

Efficacy and safety of topical resorcinol 15% as long-term treatment of mild-moderate hidradenitis suppurativa: a valid alternative to clindamycin in the panorama of antibiotic resistance. Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the hair follicle in the apocrine gland-bearing regions. Although HS is not primarily caused by bacterial infection, antibiotics represent the first line treatment in the management of HS primarily for their anti-inflammatory (...) properties, with additional contributions via antimicrobial and immunomodulatory effects.This article is protected by copyright. All rights reserved.

2020 British Journal of Dermatology

185. Trends in Antibiotic Resistance Among Ocular Microorganisms in the United States From 2009 to 2018. Full Text available with Trip Pro

Trends in Antibiotic Resistance Among Ocular Microorganisms in the United States From 2009 to 2018. Antibiotic resistance in ocular infections can affect treatment outcomes. Surveillance data on evolving antibacterial susceptibility patterns inform the treatment of such infections.To assess overall antibiotic resistance profiles and trends among bacterial isolates from ocular sources collected during 10 years.This cross-sectional study of longitudinal data from the ongoing, nationwide (...) , prospective, laboratory-based surveillance study, the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) study, included clinically relevant isolates of Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae cultured from patients with ocular infections at US centers from January 1, 2009, to December 31, 2018.Minimum inhibitory concentrations were determined for various combinations of antibiotics

2020 JAMA ophthalmology

186. Helicobacter pylori resistance to antibiotics at the An-Najah National University Hospital: a cross-sectional study. Full Text available with Trip Pro

Helicobacter pylori resistance to antibiotics at the An-Najah National University Hospital: a cross-sectional study. Bacterial resistance to antibiotics is considered the most important determinant of treatment failure. Monitoring the evolution of antimicrobial resistance to common antibiotics is therefore of special importance for clinicians. The frequency of resistance to antibiotics in Helicobacter pylori isolates is increasing. The aim of this study was to determine the pattern of H pylori (...) %). Metronidazole and clarithromycin were the least effective drugs, with resistance rates of 100% and 47%, respectively.H pylori isolates from the Palestinian patients included in this study were highly resistant to the traditional first-line antibiotics clarithromycin and metronidazole. However, fluoroquinolones and amoxicillin are still effective antimicrobial choices. This could be the result of the unjustified wide use of antibiotics in the Palestinian community and the use of clarithromycin-based therapy

2018 Lancet

187. Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial. Full Text available with Trip Pro

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial. The effects of chlorhexidine (CHX) mouthwash, selective oropharyngeal decontamination (SOD), and selective digestive tract decontamination (SDD) on patient outcomes in ICUs with moderate to high levels of antibiotic resistance are unknown.To determine associations between CHX 2%, SOD, and SDD and the occurrence of ICU-acquired bloodstream infections (...) with multidrug-resistant gram-negative bacteria (MDRGNB) and 28-day mortality in ICUs with moderate to high levels of antibiotic resistance.Randomized trial conducted from December 1, 2013, to May 31, 2017, in 13 European ICUs where at least 5% of bloodstream infections are caused by extended-spectrum β-lactamase-producing Enterobacteriaceae. Patients with anticipated mechanical ventilation of more than 24 hours were eligible. The final date of follow-up was September 20, 2017.Standard care was daily CHX 2

2018 JAMA

188. E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review Full Text available with Trip Pro

E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review Antibiotics | Free Full-Text | E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review Next Article in Journal Next Article in Special Issue Previous Article in Journal Previous Article in Special Issue Information Initiatives Notice You can make submissions to other journals . You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without (...) allows you to learn more about MDPI. JSmol Viewer Open Access Review E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review by 1 , 1 , 2,3 , 2,3,4 , 5,6 and 1,* 1 iBiMED–Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, 3800 Aveiro, Portugal 2 Department of Preventive Medicine and Public Health, University of Santiago de Compostela, 15702 Santiago de Compostela, Spain 3 Consortium for Biomedical Research in Epidemiology and Public Health (CIBER

2020 Antibiotics

189. Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review Full Text available with Trip Pro

Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review IJERPH | Free Full-Text | Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review Next Article in Journal Previous Article in Journal Previous Article in Special Issue Information Initiatives Notice You can make submissions to other journals . You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected (...) provides allows you to learn more about MDPI. JSmol Viewer Open Access Review Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates—A Systematic Review by 1,2,† , 3,† , 3 , 1 , 3 and 1,* 1 Department of Biomedical Sciences, University of West Attica, 12243 Egaleo, Greece 2 Central Public Health Laboratory, National Public Health Organization, EL-15123 Athens, Greece 3 Laboratory of Clinical Microbiology and Microbial Pathogenesis, School of Medicine, University of Crete, 71500

2020 International journal of environmental research and public health

190. Antibiotic-resistant pathogens associated with urinary tract infections in nursing homes: Summary of data reported to the National Healthcare Safety Network Long-Term Care Facility Component, 2013-2017. (Abstract)

Antibiotic-resistant pathogens associated with urinary tract infections in nursing homes: Summary of data reported to the National Healthcare Safety Network Long-Term Care Facility Component, 2013-2017. Antibiotic resistance (AR) is a growing and highly prevalent problem in nursing homes. We describe selected AR phenotypes from pathogens causing urinary tract infections (UTIs) reported by nursing homes to the National Healthcare Safety Network (NHSN).Pathogens and antibiotic susceptibility (...) testing results for UTI events in nursing homes between January 2013 and December 2017 were analyzed. The pathogen distribution and pooled mean proportion of isolates that tested resistant to select antibiotic agents are reported.US nursing homes voluntarily participating in the Long-Term Care Facility component of the NHSN.Overall, 243 nursing homes reported 1 or more UTIs: 121 (50%) were nonprofit facilities, median bed size was 91 (range: 9-801), and average occupancy was 87%. In total, 6,157

2020 Infection control and hospital epidemiology

191. A process for developing a sustainable and scalable approach to community engagement: community dialogue approach for addressing the drivers of antibiotic resistance in Bangladesh. Full Text available with Trip Pro

A process for developing a sustainable and scalable approach to community engagement: community dialogue approach for addressing the drivers of antibiotic resistance in Bangladesh. Community engagement approaches that have impacted on health outcomes are often time intensive, small-scale and require high levels of financial and human resources. They can be difficult to sustain and scale-up in low resource settings. Given the reach of health services into communities in low income countries (...) , the health system provides a valuable and potentially sustainable entry point that would allow for scale-up of community engagement interventions. This study explores the process of developing an embedded approach to community engagement taking the global challenge of antibiotic resistance as an example.The intervention was developed using a sequential mixed methods study design. This consisted of: exploring the evidence base through an umbrella review, and identifying key international standards

2020 BMC Public Health

192. Assessment of antibiotic-resistant organism transmission among rooms of hospitalized patients, healthcare personnel, and the hospital environment utilizing surrogate markers and selective bacterial cultures. (Abstract)

Assessment of antibiotic-resistant organism transmission among rooms of hospitalized patients, healthcare personnel, and the hospital environment utilizing surrogate markers and selective bacterial cultures. To assess potential transmission of antibiotic-resistant organisms (AROs) using surrogate markers and bacterial cultures.Pilot study.A 1,260-bed tertiary-care academic medical center.The study included 25 patients (17 of whom were on contact precautions for AROs) and 77 healthcare personnel

2020 Infection control and hospital epidemiology

193. Subsequent carbapenem-resistant Enterobacteriaceae (CRE)-associated infections among hospitalized patients with CRE colonization: Impact of antibiotic use and other factors. (Abstract)

Subsequent carbapenem-resistant Enterobacteriaceae (CRE)-associated infections among hospitalized patients with CRE colonization: Impact of antibiotic use and other factors. We demonstrated a 20% rate of subsequent carbapenem-resistant Enterobacteriaceae (CRE)-associated infections among hospitalized CRE carriers. Independent factors associated with the infections were number of colonization sites, central-line insertion, and receiving vancomycin before colonization. These findings underscore (...) the importance of antibiotic stewardship and device-related infection control measures to prevent CRE infections.

2020 Infection control and hospital epidemiology

194. Antibiotic use and resistance: an unprecedented assessment of university students' knowledge, attitude and practices (KAP) in Lebanon. Full Text available with Trip Pro

Antibiotic use and resistance: an unprecedented assessment of university students' knowledge, attitude and practices (KAP) in Lebanon. The emergence and spread of pathogenic bacteria that is resistant to antibiotics has become a major public health concern. The incorrect prescription, inappropriate consumption and excess use of antimicrobial drugs, specifically antibiotics, are possibly the main factors contributing to the widespread of antibiotic resistant bacteria. This study aims to evaluate (...) the knowledge, attitude and practices (KAP) towards the use of antibiotics as well as their resistance among Lebanese university students in health and non-health related majors.This cross-sectional study was conducted between May and June 2019 in Beirut (Lebanon) in which 750 students completed a questionnaire made up of four dimensions: Socio-demographic characteristics, 3 questions; assessment of knowledge, attitude and practices, 7, 10 and 1 question, respectively. The data was collected in spreadsheets

2020 BMC Public Health

195. Antibiotic resistance in acne: changes, consequences and concerns. (Abstract)

Antibiotic resistance in acne: changes, consequences and concerns. Antibiotic resistance in acne was first observed in the 1970s and has been a major concern in dermatology since the 1980s. The resistance rates and types of antimicrobials have subsequently shown great variations in regions and countries. Illustrative of this is the resistance to topical erythromycin and clindamycin which continues to be a problem worldwide, while resistance to systemic treatment with tetracyclines has remained (...) low during the past decade. The resistance for the newer macrolides like azithromycin and clarithromycin has been increasing. The results of antibiotic resistance may include treatment failure of acne, disturbance of skin microbiota, induction of opportunistic pathogens locally and systemically, and dissemination of resistant strains to both healthcare personnel and the general population. The ensuing complications, such as aggravated opportunistic infections caused by Propionibacterium acnes

2020 Journal of the European Academy of Dermatology and Venereology

196. Longitudinal assessment of antibiotic resistance gene profiles in gut microbiomes of infants at risk of eczema. Full Text available with Trip Pro

understanding of the naïve infant gut resistome may build the evidence base for antimicrobial stewardship in both humans and in the food industry. Given the high carriage rate of extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in Asia, we aimed to evaluate community prevalence, dynamics, and longitudinal changes in antibiotic resistance gene (ARG) profiles and prevalence of ESBL-producing E. coli and K. pneumoniae in the intestinal microbiome of infants participating in the Growing Up (...) point in the first year of life. Few ARGs persisted throughout the first year of life. Beta-lactam resistant Escherichia coli and Klebsiella pneumoniae were detected in 4 (5.3%) and 32 (42.7%) of subjects respectively.In this longitudinal cohort study of infants living in a region with high endemic antibacterial resistance, we demonstrate that majority of the infants harboured several antibiotic resistance genes in their gut and showed that the infant gut resistome is diverse and dynamic over

2020 BMC Infectious Diseases

197. Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014. Full Text available with Trip Pro

Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014. The purpose of the study is to discuss the correlation between the resistance rate of gram negative bacteria to fluoroquinolones (FQ) and antibiotic consumption intensity of 145 China tertiary hospitals in 2014.This retrospective study adopted national monitoring data from 2014. Each participating hospital required to report annual (...) consumption of each antibiotic, and the resistance rate of gram negative bacteria to FQ. Then the correlation between antibiotic usage and fluoroquinolones -resistant (FQR) rate was consequently investigated.One hundred forty-five hospitals were included in the study, and the median antibiotic consumption intensity was 46.30 (23.93-115.39) defined daily dosages (DDDs) per 100 patient-days. Cephalosporins ranks first in the antibiotics consumption, followed by fluoroquinolones, penicillins, and carbapenems

2020 BMC Infectious Diseases

198. Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention. Full Text available with Trip Pro

Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention. Evaluate the effect of bacteria drug resistance profile on the success rates of debridement, antibiotics and implant retention.All early acute periprosthetic infections in hip and knee arthroplasties treated with DAIR at our institution over the period from 2011 to 2015 were retrospectively analyzed. The success rate was evaluated according (...) to the type of organism identified in culture: multidrug-sensitive (MSB), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Gram-negative bacteria (MRB) and according to other risk factors for treatment failure. The data were analyzed using univariate and multivariate statistics.Fifty-seven patients were analyzed; there were 37 in the multidrug-sensitive bacteria (MSB) group, 11 in the methicillin-resistant Staphylococcus aureus (MRSA) group and 9 in the other multidrug-resistant

2020 BMC Musculoskeletal Disorders

199. <p>Primary Resistance Pattern of <em>Helicobacter pylori</em> to Antibiotics in Adult Population: A Systematic Review</p> Full Text available with Trip Pro

Primary Resistance Pattern of Helicobacter pylori to Antibiotics in Adult Population: A Systematic Review

Primary Resistance Pattern of Helicobacter pylori to Antibiotics in Ad | IDR Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. open access to scientific and medical research Journal Email Alerts About Dove Press Open access peer-reviewed scientific and medical journals. Open Access Dove Medical (...) Press is a member of the OAI. Reprints Bulk reprints for the pharmaceutical industry. Favored Authors We offer real benefits to our authors, including fast-track processing of papers. Promotional Article Monitoring Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. Social Media Back to » » Review Primary Resistance Pattern of Helicobacter pylori to Antibiotics

2020 Infection and drug resistance

200. Antibiotic resistance, hospitalizations, and mortality related to prostate biopsy: first report from the Norwegian Patient Registry. Full Text available with Trip Pro

Antibiotic resistance, hospitalizations, and mortality related to prostate biopsy: first report from the Norwegian Patient Registry. A 68-year-old man died of cerebral arterial embolism 6 days after transrectal prostate biopsy with a single p.o. dose of trimethoprim sulfamethoxazole (TMP-SMX) as prophylaxis. The case precipitated analysis of local antibiotic resistance and complication rates.Data on E. coli resistance from Oslo University Hospital and national data on hospitalizations (...) and mortality after biopsy were retrieved from local microbiology files and the Norwegian Patient Registry (NPR) 2011-2017.Urine E. coli resistance against TMP-SMX increased from 35% in 2013 to more than 60% in 2015. For ciprofloxacin, the resistance increased from 15% in 2013 to about 45% in 2016. The highest annual E. coli resistance in blood cultures for TMP-SMX and ciprofloxacin was 37% and 28%, respectively. 10% of patients were hospitalized with a diagnosis of infection within the first 60 days after

2020 World journal of urology

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