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Summary: A Phase 2 study of SEP-225289 in adults with attentiondeficithyperactivitydisorder (ADHD). Condition or disease Intervention/treatment Phase Adult AttentionDeficitHyperactivityDisorder Drug: SEP-225289 Drug: Placebo Phase 2 Detailed Description: This is a Phase 2, randomized, double-blind, parallel-group, multicenter, outpatient study evaluating the efficacy and safety of SEP 225289 in adults with ADHD using 2 oral dosages (4 or 8 mg SEP 225289 once daily [QD]) versus placebo over a 4 (...) : Layout table for MeSH terms Disease AttentionDeficitDisorder with Hyperactivity Hyperkinesis Pathologic Processes AttentionDeficit and DisruptiveBehaviorDisorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms
Factors associated with attentiondeficit/hyperactivitydisorder among US children: results from a national survey. The purpose of this study was to investigate the association between AttentionDeficit/HyperactivityDisorder (ADHD) and various factors using a representative sample of US children in a comprehensive manner. This includes variables that have not been previously studied such as watching TV/playing video games, computer usage, family member's smoking, and participation (...) games, participation in sports, and participation in clubs/organizations.Approximately 10% of the sample was classified as having ADHD. We found depression, anxiety, healthcare coverage, and male sex of child to have increased odds of being diagnosed with ADHD. One of the salient features of this study was observing a significant association between ADHD and variables such as TV usage, participation in sports, two-parent family structure, and family members' smoking status. Obesity was not found
A randomized pilot study of the efficacy and safety of ABT-089, a novel Î±4Î²2 neuronal nicotinic receptor agonist, in adults with attention-deficit/hyperactivitydisorder. ABT-089, an α4β2 neuronal nicotinic receptor partial agonist (generic name pozanicline), has demonstrated efficacy in adults with attention-deficit/hyperactivitydisorder (ADHD) at doses of 40 mg once daily and 40 mg twice daily. The purpose of this exploratory pilot study was to obtain initial safety, tolerability (...) ratio to ABT-089 40 mg once daily, ABT-089 80 mg once daily, or placebo. The primary efficacy variable was reduction from baseline to the final evaluation in the investigator-rated Conners' Adult ADHD Rating Scale for each active treatment group versus placebo. Safety assessments and pharmacokinetic sampling were also conducted.A total of 160 subjects were randomized, with 137 (86%) completing the trial. No statistically significant treatment effects were observed with either ABT-089 dose for any
Effect of chronic physicalactivity on symptom severity and functional impairment of children with ADHD and DisruptiveBehaviorDisorders: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email
Randomized Controlled Trial of Exercise for ADHD and DisruptiveBehaviorDisorders. The objective of this study is to test the feasibility and impact of a 10-wk after-school exercise program for children with attentiondeficithyperactivitydisorder and/or disruptivebehaviordisorders living in an urban poor community.Children were randomized to an exercise program (n = 19) or a comparable but sedentary attention control program (n = 16). Cognitive and behavioral outcomes were collected pre (...) programs to benefit children with attentiondeficithyperactivitydisorder and disruptivebehaviordisorder living in urban poverty where health needs are high and services resources few.
or strength training components in the aerobic exercises. All participants will first perform 45-55 minutes of physicalexercise followed by 45-50 minutes of cognitive training. Investigators plan to assess the participants before and after the intervention programs. The primary outcome measures are cognitive functions, including visuospatial processing, attention, memory, and/or executive functions. The secondary outcome measures include physical functions and activities of daily living (ADLs (...) will practice tasks that involve the abilities of visuospatial processing, attention, memory, language, and/or executive functions for 45-50 minutes. Behavioral: Sequential training For cognitive training, the BrainHQ program, self-made teaching aids and board games will be used to train different cognitive functions of the participants. For physicalexercise, we design the programs that involve balance or strength training components in the aerobic exercises. All participants will first perform 60 minutes
of inattention, hyperactivity, and impulsivity. The 3 types of ADHD are predominantly inattentive, predominantly hyperactive/impulsive, and combined. Diagnosis is made by clinical criteria. Treatment usually includes drug therapy with stimulant drugs, behavioral therapy, and educational interventions. Attention-deficit/hyperactivitydisorder is considered a neurodevelopmental disorder. Neurodevelopmental disorders are neurologically based conditions that appear early in childhood, typically before school (...) comorbid behaviordisorders, particularly and , are common. ADHD affects an estimated 8 to 11% of school-aged children ( ). However, many experts think ADHD is overdiagnosed, largely because criteria are applied inaccurately. According to the Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition (DSM-5), there are 3 types: Overview of Attention-Deficit/HyperactivityDisorder (ADHD) VIDEO Predominantly inattentive Predominantly hyperactive/impulsive Combined Overall, ADHD is about twice
Effects of PhysicalActivity Intervention on Motor Proficiency and Physical Fitness in Children With ADHD: An Exploratory Study. This study explored how a 12-week simulated developmental horse-riding program (SDHRP) combined with fitness training influenced the motor proficiency and physical fitness of children with ADHD.Twelve children with ADHD received the intervention, whereas 12 children with ADHD and 24 typically developing (TD) children did not. The fitness levels and motor skills (...) of the participants were assessed using standardized tests before and after the 12-week training program.Significant improvements were observed in the motor proficiency, cardiovascular fitness, and flexibility of the ADHD training group following the intervention.Children with ADHD exhibit low levels of motor proficiency and cardiovascular fitness; thus, using the combined 12-week SDHRP and fitness training positively affected children with ADHD.
Sweat it out? The effects of physicalexercise on cognition and behavior in children and adults with ADHD: a systematic literature review As attention-deficit/hyperactivitydisorder (ADHD) is one of the most frequently diagnosed developmental disorders in childhood, effective yet safe treatment options are highly important. Recent research introduced physicalexercise as a potential treatment option, particularly for children with ADHD. The aim of this review was to systematically analyze (...) potential acute and chronic effects of cardio and non-cardio exercise on a broad range of functions in children with ADHD and to explore this in adults as well. Literature on physicalexercise in patients with ADHD was systematically reviewed based on categorizations for exercise type (cardio versus non-cardio), effect type (acute versus chronic), and outcome measure (cognitive, behavioral/socio-emotional, and physical/(neuro)physiological). Furthermore, the methodological quality of the reviewed papers
Effects of PhysicalExercise Intervention on Motor Skills and Executive Functions in Children With ADHD: A Pilot Study. This study examined the effect of a 12-week table tennis exercise on motor skills and executive functions in children with ADHD.Fifteen children with ADHD received the intervention, whereas 15 children with ADHD and 30 typically developing children did not. The Test of Gross Motor Development-2, Stroop, and Wisconsin Card Sorting Test (WCST) were conducted before and after (...) the intervention.After the intervention, the ADHD training group scored significantly higher in the locomotor as well as object-control skills, Stroop Color-Word condition, and WCST total correct performance compared with the ADHD non-training group, and we noted improvements in the locomotor as well as object-control skills, Stroop Color-Word condition, and three aspects of the WCST performances of the ADHD training group over time.A 12-week table tennis exercise may have clinical relevance in motor skills
Effects of combined exercise on physical fitness and neurotransmitters in children with ADHD: a pilot randomized controlled study. [Purpose] The purpose of the present study was to determine the effect of a jump rope and ball combined exercise program on the physical fitness the neurotransmitter (epinephrine, serotonin) levels of children with attention-deficithyperactivitydisorder. [Subjects and Methods] The subjects were 12 boys attending elementary school, whose grade levels ranged from 1 (...) in the epinephrine level was observed in the exercise group. [Conclusion] The 12-week combined exercise program in the current study (jump rope and ball exercises) had a positive effect on overall fitness level, and neurotransmission in children with attention-deficithyperactivitydisorder.
The Acute Effects of Aerobic Exercise on Cognitive Flexibility and Task-Related Heart Rate Variability in Children With ADHD and Healthy Controls. To investigate cognitive flexibility and task-related heart rate variability following moderately intense aerobic exercise and after watching a video in both children with ADHD and healthy controls.Using a cross-over design, participants completed cognitive assessments following exercise and a physically inactive control condition. Behavioral (...) performance was assessed using the Alternate Uses task. Heart rate variability was recorded via electrocardiography during the cognitive task.The statistical analysis revealed that in comparison with the control condition, both groups showed higher cognitive flexibility following aerobic exercise. Moreover, decreased low frequency and high frequency power was observed in the exercise condition.The findings suggest that exercise elicits similar benefits for cognitive flexibility in children with ADHD
period). This outcome is expected to have an important positive impact because physicalexercise may serve as an effective treatment for college students with ADHD that is less risky than stimulants, less time-consuming than therapy, and provides ancillary health benefits (i.e., increasing physical fitness, decreasing obesity). Condition or disease Intervention/treatment Phase AttentionDeficitHyperactivityDisorder Effects of; Exertion Working Memory Change in Sustained AttentionBehavioral: Sprint (...) for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms AttentionDeficitDisorder with HyperactivityAttentionDeficit and DisruptiveBehaviorDisorders Neurodevelopmental Disorders Mental Disorders
Bone mineral density changes after physical training and calcium intake in students with attentiondeficit and hyper activitydisorders. In this study we investigate the effects of weight bearing exercise and calcium intake on bone mineral density (BMD) of students with attentiondeficit and hyper activity (ADHD) disorder. For this reason 54 male students with ADHD (age 8-12 years old) were assigned to four groups with no differences in age, BMD, calcium intake, and physicalactivity: exercise (...) of training and calcium on BMD. All groups showed greater femoral neck BMD after 9 months. The increase in femoral neck BMD was significantly different between all groups (p < 0.05). Ex+Ca+ group has greater increase in BMD than other groups. Apparently, the effect of training was greater than calcium intake (p < 0.05). These results help to provide more evidence for public health organizations to deal with both exercise and nutrition issues in children with ADHDdisorder for the achievement of peak
for treating ADHD. The primary outcome measure is behaviour (symptoms of ADHD). Secondary outcome measures include neurocognition and cortical regulation. This research project will give answer to the question if neurofeedback and exercise are as effective as MPH. Furthermore, it will give insight in how these interventions will give rise to improvements in behavior. Condition or disease Intervention/treatment Phase AttentionDeficitHyperactivityDisorder (ADHD) Other: Neurofeedback Behavioral: Exercise (...) neurofeedback exercise neurophysiology Additional relevant MeSH terms: Layout table for MeSH terms AttentionDeficitDisorder with Hyperactivity Hyperkinesis AttentionDeficit and DisruptiveBehaviorDisorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms Methylphenidate Central Nervous System Stimulants Physiological Effects of Drugs Dopamine Uptake Inhibitors Neurotransmitter Uptake Inhibitors Membrane Transport Modulators
; and parents' stress. The study include a sample of 60 children randomly allocate to the intervention or to the control condition (wait-list control sample). Repeated measures of children's and parents' and teachers' reported measures will be used. Condition or disease Intervention/treatment Phase DisruptiveBehaviorDisorder Oppositional Defiant DisorderAttentionDeficit and DisruptiveBehaviorDisordersBehavioral: Mindfulness-based program Not Applicable Study Design Go to Layout table for study (...) Verified: January 2019 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by IRCCS Fondazione Stella Maris: Mindfulness ADHD Oppositional Defiant Disorder Additional relevant MeSH terms: Layout table for MeSH terms Disease AttentionDeficitDisorder with Hyperactivity Mental Disorders Problem BehaviorAttentionDeficit
Acute PhysicalActivity Enhances Executive Functions in Children with ADHD Acute physicalactivity of moderate to vigorous intensity has been shown to improve cognitive functions in children. However, the empirical evidence associated with AttentionDeficitHyperactivityDisorder (ADHD) in children is still limited, in particular regarding which specific cognitive functions benefit. This study investigated the effects of an acute bout of physicalactivity on multiple aspects of executive (...) functions (inhibition, switching, and visual working memory) in children with ADHD. Forty-six children (8-12 years old; 82.6% boys) were randomly assigned to either 15 minutes of acute exergaming (physicalactivity of moderate intensity) or to a control condition (sedentary). Executive function performance in inhibition, switching and visual working memory were assessed before and after each condition, using a modified version of both the Flanker and the Color Span Backwards Task. The results revealed
are more effective than either usual care or other approaches. • Depression is the most studied mental health condition in collaborative-care models that also include a physical health condition, although anxiety is sometimes included in interventions for depression. • Emerging research is investigating collaborative-care models for bipolar disorder and physical multimorbidity, however it remains much less developed than for depression. • There was significant variation in the components (...) ) The frequency of co-occurrence means that the lifetime prevalence at a population level is high. For example, one study estimated the lifetime prevalence of a psychiatric disorder was 42.2% among persons with one or more medical conditions, compared to 33% for persons with no medical condition.(5) In Ontario alone, it is estimated that approximately 1.3 million people experience comorbid mental health and physical health conditions.(6) Despite this, mental health care has traditionally been delivered
a variety of play including racing, puzzle solving, collaborative play, team play and competitive play. We will be comparing whether a 'multi-player' condition has a greater adherence compared to a 'single-player' condition. Condition or disease Intervention/treatment Phase PhysicalActivityBehavioral: Multi-player condition Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 72 participants Allocation: Non-Randomized (...) Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Prevention Official Title: Exercise Games and PhysicalActivity: Does Multi-player Online Play Improve Adherence? Study Start Date : September 2013 Actual Primary Completion Date : January 2015 Actual Study Completion Date : January 2015 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Multi-player condition The multi-player