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61. Methylphenidate in Adults With Attention Deficit/Hyperactivity Disorder

Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by Hospital de Clinicas de Porto Alegre: ADHD Adults treatment Methylphenidate Additional relevant MeSH terms: Layout table for MeSH terms Disease Attention Deficit Disorder with Hyperactivity Hyperkinesis Pathologic Processes Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms Methylphenidate (...) ). Nevertheless, there is considerable interindividual variability regarding the dose required, tolerability and response rates to MPH. The aim of this study is to address the clinical and genetic predictors of MPH treatment outcomes in ADHD. Condition or disease Intervention/treatment Phase Attention Deficit Disorder With Hyperactivity Drug: Immediate-release Methylphenidate Phase 4 Detailed Description: Methylphenidate (MPH) is the most prescribed psychostimulant for children and adults with Attention

2016 Clinical Trials

62. Attention Deficit Hyperactivity Disorder: Nutrition and Environment

nutritional consultant No Intervention: No intervention Patients not subject to nutritional education Outcome Measures Go to Primary Outcome Measures : Change in Conners [ Time Frame: At 3 and 6 months ] Conners conduct questionnaire: attention deficit and disruptive behavior disorders; hyperactivity; and combined type. Secondary Outcome Measures : Change in sleep [ Time Frame: At 3 and 6 months ] Markers related to sleep: adapted Short Form Health Survey-36 for sleep quality. Change in exercise markers (...) , 2016 Sponsor: Hospital El Escorial Information provided by (Responsible Party): Blumenfeld Olivares JA, Hospital El Escorial Study Details Study Description Go to Brief Summary: In this study the investigators aim to investigate the relationship between environmental factors, lifestyle and symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Initially the investigators intend to measure the relationship between nutritional quality, exercise and sleep and ADHD symptoms. And then measure

2016 Clinical Trials

63. Modeled economic evaluation of alternative strategies to reduce sudden cardiac death among children treated for attention deficit/hyperactivity disorder Full Text available with Trip Pro

with attention deficit and hyperactivity disorder (ADHD). The authors concluded that adding an ECG to screening might be cost-effective, especially when referral to cardiology was based on this alone. The benefits arose mainly from children avoiding competitive sports. The methods were valid and various areas of uncertainty were considered. The authors’ conclusions appear to be robust. Type of economic evaluation Cost-utility analysis Study objective This study examined the cost-effectiveness of screening (...) , before stimulant medication, using an electrocardiogram (ECG), to reduce the risk of sudden cardiac death, in children with attention deficit and hyperactivity disorder (ADHD). Interventions There were three strategies. In strategy one, a history and physical examination were performed and children were referred to cardiology if the findings were abnormal. This was the usual care. In strategy two, a history and physical examination were performed, with an ECG if the findings were normal and referral

2010 NHS Economic Evaluation Database.

64. Safety, Tolerability, Pharmacokinetic, and Efficacy Study of SPD489 in Preschool Children With Attention-deficit/Hyperactivity Disorder

," the clinician asked questions 3-5. Active suicidal ideation included any participant who answered "yes" to questions 2-5. If the answers to ideation questions 1 and 2 were "No," then the clinician proceeded to 5 (yes/no) questions that addressed suicidal behavior, which was categorized as actual attempt, interrupted attempt, aborted attempt, preparatory acts or behaviors, and completed suicide. Secondary Outcome Measures : Change From Baseline in Attention Deficit/Hyperactivity Disorder Rating Scale (ADHD (...) of SPD489 in the preschool ADHD population. Condition or disease Intervention/treatment Phase Attention Deficit Hyperactivity Disorder (ADHD) Drug: SPD489 Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 20 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Phase 2, Open-label, Multicenter, Exploratory Safety, Tolerability, Pharmacokinetic

2015 Clinical Trials

65. Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder

Recruitment Status : Active, not recruiting First Posted : June 9, 2015 Last Update Posted : January 16, 2019 Sponsor: Shire Information provided by (Responsible Party): Shire Study Details Study Description Go to Brief Summary: To evaluate the long-term safety of SPD489 administered as a daily morning dose (5, 10, 15, 20, and 30 mg/day) in preschool children diagnosed with Attention-deficit/Hyperactivity Disorder (ADHD). Participants will be enrolled into this study from antecedent study SPD489-211 (...) (NCT02402166) or SPD489-347 (NCT03260205) (roll-over participants) or through direct enrollment (direct enrolled pariticpants). Condition or disease Intervention/treatment Phase Attention Deficit Hyperactivity Disorder (ADHD) Drug: SPD489 Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 115 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment

2015 Clinical Trials

66. Cross-sectional survey on prevalence of attention deficit hyperactivity disorder symptoms at a tertiary care health facility in Nairobi Full Text available with Trip Pro

countries.This was a questionnaire based cross-sectional survey whose primary objective was to determine prevalence of attention deficit hyperactivity disorder (ADHD) symptoms in children aged 6-12 years attending a tertiary care hospital Accidents and Emergency unit. Secondary objectives were to: (i) ascertain if physical injury and poor academic performance were associated with ADHD, (ii) compare diagnostic utility of parent-filled Vanderbilt Assessment Scale (VAS) against Statistical Manual of Mental (...) Cross-sectional survey on prevalence of attention deficit hyperactivity disorder symptoms at a tertiary care health facility in Nairobi Attention deficit hyperactivity disorder is the most common childhood neurobehavioral disorder with well documented adverse consequences in adolescence and adulthood, yet 60-80% of cases go undiagnosed. Routine screening is not practiced in most pediatric outpatient services and little information exists on factors associated with the condition in developing

2015 Child and adolescent psychiatry and mental health

67. Cognitive Behavioral Therapy for Adolescents With Attention-Deficit / Hyperactivity Disorder

adolescents with ADHD, it can be made widely available to these adolescents in the community. This would help them improve their academic, social, and emotional functioning and ultimately their long term outcomes. Condition or disease Intervention/treatment Phase Attention Deficit Hyperactivity Disorder Behavioral: Cognitive Behavioural & Skills Training Behavioral: Supportive Group Therapy Other: Treatment as Usual - community resources Drug: Methylphenidate or amphetamine product Phase 4 Detailed (...) : October 2, 2015 Last Update Posted : July 31, 2018 See Sponsor: McGill University Health Center Collaborator: Canadian Institutes of Health Research (CIHR) Information provided by (Responsible Party): Lily Hechtman, McGill University Health Center Study Details Study Description Go to Brief Summary: Attention Deficit/ Hyperactivity Disorder (ADHD) is a common childhood psychiatric condition, which often persists into adolescence. In adolescence ADHD is associated with poor academic, social

2015 Clinical Trials

68. Aerobic exercise and attention deficit hyperactivity disorder: brain research. Full Text available with Trip Pro

to one of two groups in a 1/1 ratio; methylphenidate treatment + 6-wk exercise (sports-ADHD) or methylphenidate treatment + 6-wk education (edu-ADHD). At baseline and after 6 wk of treatment, symptoms of ADHD, cognitive function, and brain activity were evaluated using the Dupaul attention deficit hyperactivity disorder rating scale--Korean version (K-ARS), the Wisconsin Card Sorting Test, and 3-T functional magnetic resonance imaging, respectively.The K-ARS total score and perseverative errors (...) Aerobic exercise and attention deficit hyperactivity disorder: brain research. As adjuvant therapy for enhancing the effects of stimulants and thereby minimizing medication doses, we hypothesized that aerobic exercise might be an effective adjunctive therapy for enhancing the effects of methylphenidate on the clinical symptoms, cognitive function, and brain activity of adolescents with attention deficit hyperactivity disorder (ADHD).Thirty-five adolescents with ADHD were randomly assigned

2014 Medicine and science in sports and exercise Controlled trial quality: uncertain

69. Association of symptoms of attention-deficit/hyperactivity disorder with symptoms of excessive exercising in an adult general population sample. Full Text available with Trip Pro

Association of symptoms of attention-deficit/hyperactivity disorder with symptoms of excessive exercising in an adult general population sample. An increasing number of studies suggest that physical activity can alleviate symptoms of ADHD in children. In adults there are currently insufficient data available on this subject. Interestingly, ADHD and forms of excessive exercising have both been shown to occur more frequently in adult athletes. The aim of the present study was to empirically (...) into adulthood. We thus hypothesize that a subgroup of individuals might suppress ADHD symptoms by excessive sporting activities. Although in healthy adults physical activity has been associated with immediate and long term improvements in cognitive functioning, studies empirically investigating associations between the effects of physical activity and adult ADHD are rare. Further studies are warranted to explore the potential role of physical activity in the treatment of ADHD in adults.

2014 BMC Psychiatry

70. A Randomized Trial Examining the Effects of Aerobic Physical Activity on Attention-Deficit/Hyperactivity Disorder Symptoms in Young Children. Full Text available with Trip Pro

A Randomized Trial Examining the Effects of Aerobic Physical Activity on Attention-Deficit/Hyperactivity Disorder Symptoms in Young Children. The goal of this study was to compare the effects of before school physical activity (PA) and sedentary classroom-based (SC) interventions on the symptoms, behavior, moodiness, and peer functioning of young children (M age = 6.83) at risk for attention-deficit/hyperactivity disorder (ADHD-risk; n = 94) and typically developing children (TD; n = 108 (...) ). Children were randomly assigned to either PA or SC and participated in the assigned intervention 31 min per day, each school day, over the course of 12 weeks. Parent and teacher ratings of ADHD symptoms (inattention, hyperactivity/impulsivity), oppositional behavior, moodiness, behavior toward peers, and reputation with peers, were used as dependent variables. Primary analyses indicate that the PA intervention was more effective than the SC intervention at reducing inattention and moodiness in the home

2014 Journal of abnormal child psychology Controlled trial quality: uncertain

71. Cognitive Rehabilitation for Attention Deficit/Hyperactivity Disorder (ADHD): Promises and Problems Full Text available with Trip Pro

Cognitive Rehabilitation for Attention Deficit/Hyperactivity Disorder (ADHD): Promises and Problems Cognitive training entails the repeated exercise of a specific cognitive process over a period of time to improve performance on the trained task as well as on tasks that were not specifically trained (transfer effect). Cognitive training shows promise in remediating deficits in children with attention deficit/hyperactivity disorder (ADHD) - a disorder believed to stem from deficient cognitive (...) assumptions and their weaknesses. We also draw attention to design limitations that may be contributing to lack of transfer.Although the overall pattern of findings from these studies is promising, the methodological and theoretical limitations associated with the literature limit conclusions about the efficacy of cognitive training as a rehabilitation method for ADHD. We hypothesize several suggestions that may improve training effects and summarize the evidence which led to our hypotheses.

2014 Journal of the Canadian Academy of Child and Adolescent Psychiatry

72. In a randomized case-control trial with 10-years olds suffering from attention deficit/hyperactivity disorder (ADHD) sleep and psychological functioning improved during a 12-week sleep-training program. (Abstract)

In a randomized case-control trial with 10-years olds suffering from attention deficit/hyperactivity disorder (ADHD) sleep and psychological functioning improved during a 12-week sleep-training program. We tested the hypothesis that sleep training would improve emotional, social and behavioural functioning in children with attention-deficit/hyperactivity disorder (ADHD) compared to children with ADHD without such intervention and to healthy controls.Forty children with ADHD were randomly (...) assigned to intervention and control conditions. Parents of 20 children with ADHD were instructed and thoroughly supervised in improving their children's sleep schedules and sleep behaviour. Parents of the other 20 children with ADHD and parents of 20 healthy children received general information about sleep hygiene. At baseline and 12 weeks later, parents and children completed questionnaires related to children's sleep and psychological functioning.Relative to the control groups, children

2014 The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Controlled trial quality: uncertain

73. Vayarin® Medical Food Study for Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Information provided by (Responsible Party): Enzymotec Study Details Study Description Go to Brief Summary: The primary study objective is to evaluate the efficacy of Vayarin in ADHD adults. Condition or disease Intervention/treatment Phase Attention Deficit Hyperactivity Disorder (ADHD) Other: Vayarin® Other: Placebo Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 171 participants Allocation: Randomized Intervention (...) Verified: January 2017 Additional relevant MeSH terms: Layout table for MeSH terms Disease Attention Deficit Disorder with Hyperactivity Hyperkinesis Pathologic Processes Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms

2014 Clinical Trials

74. Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD)

: December 2015 Keywords provided by Vernalis (R&D) Ltd: ADHD Attention Deficit/ Hyperactivity Disorder Additional relevant MeSH terms: Layout table for MeSH terms Attention Deficit Disorder with Hyperactivity Hyperkinesis Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms (...) Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD) Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

75. Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. Full Text available with Trip Pro

Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. The degree of functional impairment and adverse developmental outcomes in individuals with attention-deficit/hyperactivity disorder (ADHD) likely reflect interplay between genes and environment. To establish whether physical exercise might reduce the level of ADHD symptoms or ADHD-related impairments, we conducted a comprehensive review of the effect of exercise in children (...) with ADHD. Findings on the impact of exercise in animals and typically developing human beings, and an overview of putative mechanisms involved, are also presented to provide the context in which to understand this review.The electronic databases PubMed, OVID, and Web of Knowledge were searched for all studies investigating the effect of exercise in children and adolescents with ADHD, as well as animal models of ADHD behaviors (available in January 2013). Of 2,150 initially identified records, 16 were

2013 Journal of the American Academy of Child and Adolescent Psychiatry

76. Physical activity for improving the symptoms of attention deficit hyperactivity disorder in children and adolescents [Cochrane Protocol]

Physical activity for improving the symptoms of attention deficit hyperactivity disorder in children and adolescents [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2016 PROSPERO

77. A Phase II, Adaptive Trial Design Examining the Pharmacokinetic and Pharmacodynamic Effects of Modified Release Amphetamine (HLD100, Formulations B, C and E)) in Adolescents and Children With Attention-Deficit Hyperactivity Disorder (ADHD)

): Ironshore Pharmaceuticals and Development, Inc Study Details Study Description Go to Brief Summary: The main purpose of this study is to determine the rate and extent of absorption of one or more modified release formulations of amphetamine (HLD100) in both adolescents and children with ADHD. Condition or disease Intervention/treatment Phase Attention-Deficit Hyperactivity Disorder Drug: HLD100-B Drug: HLD100-C Drug: HLD100-E Phase 1 Phase 2 Study Design Go to Layout table for study information Study (...) with Hyperactivity Hyperkinesis Pathologic Processes Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms Amphetamine Central Nervous System Stimulants Physiological Effects of Drugs Sympathomimetics Autonomic Agents Peripheral Nervous System Agents Dopamine Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Adrenergic Uptake Inhibitors

2013 Clinical Trials

78. Physical activity for persons with ADHD or autism

deficit hyperactivity disorder; PA = Physical activity * ;intensity of their maximum heart rate Included studies Population/Intervention Outcome Bremer et al (2016) [1] 13 studies Population: Individuals with autism spectrum disorder aged ⩽16 years. Intervention: Exercise interventions Effect: Numerous behavioural outcomes including stereotypic behaviours, social-emotional functioning, cognition and attention Adverse effect: Not reported Authors' conclusion: Results demonstrated that exercise (...) found below this term in the MeSH hierarchy; [MAJR] = MeSH Major Topic; [TIAB] = Title or abstract; [TI] = Title; [AU] = Author; [TW] = Text Word; Systematic[SB] = Filter for retrieving systematic reviews; * = Truncation Search terms Items found Population: 1. “Attention Deficit and Disruptive Behavior Disorders”/ 2747 2. Attention Deficit Disorder with Hyperactivity/ 27226 3. "Attention deficit* ".ab,kw,ti. 27852 4. ("Attention deficit*" adj6 hyper*).ab,kw,ti. 24598 5. ("ADHD" or "ADDH").ab,kw,ti

2019 Swedish Council on Technology Assessement

79. Exercise Improves Behavioral, Neurocognitive, and Scholastic Performance in Children with Attention-Deficit/Hyperactivity Disorder. Full Text available with Trip Pro

Exercise Improves Behavioral, Neurocognitive, and Scholastic Performance in Children with Attention-Deficit/Hyperactivity Disorder. To examine the effect of a single bout of moderate-intensity aerobic exercise on preadolescent children with attention-deficit/hyperactivity disorder (ADHD) using objective measures of attention, brain neurophysiology, and academic performance.Using a within-participants design, task performance and event-related brain potentials were assessed while participants (...) performed an attentional-control task following a bout of exercise or seated reading during 2 separate, counterbalanced sessions.Following a single 20-minute bout of exercise, both children with ADHD and healthy match control children exhibited greater response accuracy and stimulus-related processing, with the children with ADHD also exhibiting selective enhancements in regulatory processes, compared with after a similar duration of seated reading. In addition, greater performance in the areas

2012 Journal of Pediatrics

80. Effect of acute exercise on executive function in children with attention deficit hyperactivity disorder. Full Text available with Trip Pro

Effect of acute exercise on executive function in children with attention deficit hyperactivity disorder. This study was conducted to determine the effect of acute aerobic exercise on executive function in children with attention deficit hyperactivity disorder (ADHD). Forty children with ADHD were randomly assigned into exercise or control groups. Participants in the exercise group performed a moderate intensity aerobic exercise for 30 min, whereas the control group watched a running/exercise (...) group. Tentative explanations for the exercise effect postulate that exercise allocates attention resources, influences the dorsolateral prefrontal cortex, and is implicated in exercise-induced dopamine release. These findings are promising and additional investigations to explore the efficacy of exercise on executive function in children with ADHD are encouraged.

2012 Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists Controlled trial quality: uncertain

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