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5081. Prospective Memory in Children With Traumatic Brain Injury

) the impact of PM deficits on a child's daily functioning, both at school and at home. The study will also evaluate children without TBI (control group). Each child will participate in one study evaluation. The evaluation will last approximately 4 hours, with a lunch break and other rest breaks as necessary. Assessments will include neuropsychological tests of attention, memory, and general intellectual functioning. Experimental tasks will include measures of metacognition for prospective memory (...) physical disorders (cancer, uncontrolled diabetes, cystic fibrosis, etc.) Note: siblings of participants with TBI or orthopedically-injured comparison children will not be enrolled to maintain the independence of the groups Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov

2003 Clinical Trials

5082. Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

and emotional disturbances, including symptoms of attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). MRI and MRS show chemical substances in the brain. Findings in normal volunteers will be compared with those of patients. Healthy volunteers and patients with Tourette s syndrome 14 years of age and older may be eligible for this study. Volunteers will be screened with a medical history and physical and neurological examinations. Patients will be screened through NINDS (...) by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) ) Study Details Study Description Go to Brief Summary: This study will use magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of the brain to try to gain a better understanding of the disease process in Tourette s syndrome, a neuropsychiatric disorder characterized by motor and vocal tics. Tourette s syndrome is also associated with behavioral

2002 Clinical Trials

5083. Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Menstrual Cycle Study

carry an altered BRCA1 or BRCA2 gene and 25 non-carriers matched by age and family mutation type) with regular menstrual cycling (documented by menstrual history and premenopausal FSH level). A physical exam including exam of the breast and pelvis, a standard four view mammogram, breast MRI and PET scan will be scheduled initially during either the follicular or mid-luteal phase of the menstrual cycle. A unilateral cranio-caudal mammogram, and bilateral MRI and PET scan will be repeated three months (...) and three-month visit, all participants will undergo breast duct lavage to investigate if there are consistent menstrual cycle differences in breast ductal cytologies. Participants will be seen annually thereafter for an additional three years of follow-up. A physical exam, standard four-view mammography, breast MRI, CA 125, transvaginal color doppler ultrasonography and breast duct lavage will be done annually. Consent for a PET study will be requested if an abnormality is detected on mammography

2000 Clinical Trials

5084. Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement

will be established by a psychiatrist using below listed scales and criteria. Structure Clinical Interview for (DSMIV SCID) will be administered to all subjects to ensure that strict DSM-IV criteria for Tourette Syndrome have been met and to assess for possible comorbid psychiatric disorders. Given the high rate of comorbidity of Obsessive Compulsive Disorder (OCD) and Attention Deficit/Hyperactivity Disorder (ADHD) in Tourette's syndrome, it may not be possible to exclude persons with these disorders. Hence (...) to a monitor that records the brain activity. EMG records muscle activity using electrodes placed on the skin over muscles on the fingers or above the outer corner of the eyes. Healthy normal volunteers and patients with Tourette's syndrome and chronic motor tic disorder between 21 and 65 years of age may be eligible for this 2- to 3-hour study. Each candidate will be screened with a medical history, physical and neurological examinations, and a questionnaire that screens for psychiatric disorders. During

2003 Clinical Trials

5085. Coping Skills Training for Early Rheumatoid Arthritis

of early coping skills training (CST) to enhance self-efficacy, prepare patients to cope with future pain, and prevent the development of behaviors that may increase long-term psychological distress and physical disability. The comprehensive CST intervention combines traditional CST with CST components tailored to rheumatoid arthritis patients. It is designed to teach traditional coping skills such as attention diversion, cognitive restructuring, and changes in activity to control and decrease pain (...) will learn about the nature and treatment of rheumatoid arthritis as well as the benefits of exercise and joint protection. Active Comparator: 3 Participants will receive standard care. Behavioral: Standard Care Usual care from participants' rheumatologists but no treatment sessions. Outcome Measures Go to Primary Outcome Measures : Pain [ Time Frame: Measured at Week 10 ] Psychological disability [ Time Frame: Measured at Week 10 ] Physical disability [ Time Frame: Measured at Week 10 ] Secondary

2003 Clinical Trials

5086. Yoga: Effect on Attention in Aging & Multiple Sclerosis

and Integrative Health (NCCIH) Study Details Study Description Go to Brief Summary: Changes in visual attention are common among elders and people with multiple sclerosis. The visual attention changes contribute to difficulty with day to day functioning including falls, driving and even finding one's keys on the kitchen counter as well as contributing to deficits in other cognitive domains. Yoga emphasizes the ability to focus attention and there is some evidence that the practice of yoga may improve one's (...) attention outcome measures include the ability to sustain attention (decrement in reaction time) and ability to divide attention (Useful Field of View). Other secondary outcome measures include flexibility, balance, mood, quality of life, fatigue (in MS cohort) and decreased markers of lipid, protein, and DNA oxidative injury. Condition or disease Intervention/treatment Phase Multiple Sclerosis Procedure: Yoga Phase 2 Study Design Go to Layout table for study information Study Type : Interventional

2001 Clinical Trials

5087. Natural History of West Nile Virus Infection

on people thought to have WNV to better understand the disease. Patients 18 years of age and older diagnosed with or suspected of having West Nile virus infection may be eligible for this study. Patients will be hospitalized until they are well enough to go home and will undergo the following tests and procedures: Medical history and physical examination: A thorough history and physical examination will be done on the first day of the study. Then, brief physical exams, including measures of blood (...) : Participants will be tested to see if the West Nile virus has affected their thinking and ability to perform normal daily activities. These tests will be done at the start of the study, on days 3 and 7 (also days 2, 4, 5, and 6 if patients are still in the hospital), at discharge, and at follow-up visits. The tests involve answering a number of questions and performing simple tasks, such as squeezing a hand or lifting a foot. Patients who develop weakness in their arms or legs will also have the following

2003 Clinical Trials

5088. Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder

. Neurophysiological testing in PTSD reveals deficits in memory and attention. Neuroimaging studies report increased amygdala and decreased anterior cingulate activation and reduced hippocampal volume. Clinical observations, psychophysiological measures and animal studies suggest that facilitated fear conditioning, delayed extinction, inescapable shock, sensitization and protracted habituation may contribute to the onset and persistence of PTSD. We propose to use fMRI and the psychophysiology lab to examine (...) to vulnerability to PTSD. Patients taking paroxetine will be offered up to 3 months of additional drug therapy following completion of the study and will be offered participation in other NIH studies for evaluation and treatment of PTSD. Condition or disease Stress Disorders, Post-Traumatic Detailed Description: Posttraumatic stress disorder (PTSD) is characterized by intrusive recollections, avoidant behavior, anxiety and exaggerated fear response. The pathophysiology of PTSD is largely unknown

2003 Clinical Trials

5089. Natural History Study of Smith-Magenis Syndrome

by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ) Study Details Study Description Go to Brief Summary: This study will examine how a rare disease called Smith-Magenis syndrome (SMS) affects people and how they change over time. SMS is caused by a small chromosome 17p11.2 deletion (missing piece). The syndrome is associated with distinct physical, developmental and behavioral characteristics, but it is not fully understood. To learn (...) for this study. They will be evaluated by a team of medical specialists at the NIH Clinical Center over the course of several days. Parents of patients will be asked to provide copies of past medical records and tests results for review. They will provide a family medical history and information on the child s prenatal, developmental, behavioral and medical histories. The study may involve the following evaluations: physical, neurological and psychological exams; ear, nose and throat evaluation; speech

2001 Clinical Trials

5090. Effect of Activity on Sleep of Cognitively-Impaired Veterans

are related significantly to sleep-activity rhythm disturbance. Medical treatment for sleep and behavior disturbances with benzodiazepines or antipsychotic medications has proven minimally effective and has serious side effects such as impairments in cognition, memory, coordination, and balance, tolerance and severe rebound insomnia, and tardive dyskinesia. Condition or disease Intervention/treatment Phase Alzheimer's Disease Sleep Disorders Behavioral: social activity Not Applicable Detailed Description (...) , arts and crafts, and games. We also tested the effect of the intervention on psychological well-being and disruptive behavior, and measured its cost. After the collection of baseline sleep, disruptive behavior, and psychological well-being data for five days, residents were randomly assigned to the Individualized Activity Intervention or to a usual care control condition for 21 days. On days 17-21, the research assistant repeated the outcome measures. Status: Secondary data analysis

2001 Clinical Trials

5091. Mohawk Culture, Behavior, Toxicant Exposure and Health

Sciences (NIEHS) Study Details Study Description Go to Brief Summary: This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and socially significant outcomes. Condition or disease Thyroid Diseases Cognition Disorders Detailed Description: Considerable concern now exists over possible effects on human physical and psychological development (...) of endocrine disrupting environmental contaminants such as polychlorinated biphenyls (PCBs). Native American communities are particularly at risk owing to subsistence systems and a cultural ethos involving greater contact with the physical environment. The proposed study follows-up 220 Mohawk adolescents aged 17-21 years, who participated in a previous study when they were 10-16 years old. All adolescents are members of the Mohawk Nation at Akwesasne which is located on the St. Lawrence River

2002 Clinical Trials

5092. Specific Interventions for Agitation in Alzheimer's Disease

Description Go to Brief Summary: This study is aimed at investigating specific pharmacological interventions in the treatment of the disruptive, agitated behavior associated with Alzheimer's patients. In addition, it is hoped that specific clinical profiles will be found to predict which treatment is most effective for these particular patients. Condition or disease Intervention/treatment Phase Alzheimer's Disease Dementia Drug: Risperidone Drug: Gabapentin Not Applicable Detailed Description: Alzheimer's (...) of life because of excess use of physical restraints, and drain the financial resources of the facilities. This study proposes to design specific interventions designed to decrease disruptive, agitated behavior in patients with AD residing in long-term care facilities. This 12-week study will assess the efficacy of two pharmacological agents, an atypical neuroleptic (risperidone) and an anticonvulsant and mood stabilizer (gabapentin) while identifying moderators of differential treatment response

2001 Clinical Trials

5093. Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes

electing medication, any condition that increases risk of SSRI treatment. (All patients will have complete physical examination and history. Healthy volunteer participants will be medication- free and have no current serious medical conditions, based on a review of their medical history.) Pregnancy Current use of any psychoactive substance; current suicidal ideation; current diagnosis of attention deficit hyperactivity disorder (ADHD) of sufficient severity to require pharmacotherapy. Current diagnoses (...) and anxiety disorders. The primary goal of the project is to document, in pediatric anxiety disorders and major depression, perturbations in brain systems mediating attention biases, fear conditioning, emotional memory, and response to various forms of motivational stimuli. As one secondary goal, the project measures the relationship between these factors and treatment response to either fluoxetine, a specific serotonin reuptake inhibitor (SSRI), cognitive behavioral therapy (CBT), or interpersonal

2001 Clinical Trials

5094. Motor Training to Treat Hand Dystonia

for 25 minutes each day during week 1 and 50 minutes each day for the remaining 3 weeks. Fingers not being trained will be splinted. Condition or disease Intervention/treatment Phase Focal Dystonia Behavioral: constraint-induced movement therapy Phase 2 Detailed Description: Dystonia is a movement disorder characterized by sustained muscle contractions generating twisting and repetitive movements or abnormal postures. Abnormalities of the motor cortex have been shown in patients with focal hand (...) to excessive cortical activity and possibly to co-contraction of agonist-antagonist groups of muscles of the forearm resulting in dystonic posturing. Furthermore, studies in other basal ganglia disorders as well as dystonia have suggested that the movement related cortical potentials might show plastic changes that reflect the degree of "successful" performance of a motor task. We therefore would like to evaluate the excitability of the motor cortex before and after the training with TMS and movement

2001 Clinical Trials

5095. Motor Learning in Stroke Patients and Healthy Volunteers

electrodes to the skin over the muscle. Before and after each session, subjects' muscle strength will be tested with a pinch gauge. They will also be asked to make a mark on a line drawn on paper, to rate their test performance and levels of attentiveness and fatigue. Condition or disease Stroke Healthy Detailed Description: The purpose of this protocol is to characterize dynamics of motor learning over a 5-day period in chronic stroke patients relative to healthy age-matched controls. Motor learning (...) motivational capacity Serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less). Inability to understand instructions for the Jebsen-Taylor test. Uncontrolled medical problems including cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, uncontrolled epilepsy Contraindications for transcranial magnetic stimulation: pacemaker

2001 Clinical Trials

5096. Learning a Motor Task Through Observation

of alcohol and drug abuse, psychiatric illness (depression, attention deficit disorder, or dementia). Patients with severe uncontrolled medical problems (e.g. cardiovascular diseases, hypertension, diabetes mellitus, arthritis, active cancer, renal, liver, severe pulmonary diseases, infectious diseases). Patients with epilepsy or history of loss of consciousness. Patients with use of medications that influence synaptic plasticity as evaluated by the investigator, like antipsychotic, antidepressant acting (...) that they have a residual motor deficit but can perform the required tasks, and those in whom isolated thumb movements can be evoked by TMS. Handedness will be assessed by the Edinburgh inventory scale. Subjects should be able to sustain attention to the task over 30 minutes. EXCLUSION CRITERIA History of surgery with metallic implants or known history of metallic particles in the eye. Patients with cardiac pacemaker, neural stimulators, cochlear implants, implanted medication pumps. Patients with history

2002 Clinical Trials

5097. Eye-Hand Coordination in Children With Spastic Diplegia

with more severe involvement of the legs than of the arms. Healthy subjects must be free from all neurologic and psychiatric disorders with normal scores on the Connor's attention deficit hyperactivity disorder (ADHD) checklist and the Child Behavior Check List (CBCL). Neurological history and examination must be normal. EXCLUSION CRITERIA FOR SPECIFIC AIM #1: Patients with sapstic diplegia who were born at term will be excluded from the study as these form a separate diagnostic cohort. Children (...) of periventricular leucomalacia (PVL) on their clinical MRIs. We will study the group of patients with pathology extending from occipital to frontal regions, as this appears to be most common in diplegic children. Healthy subjects must be free from all neurologic and psychiatric disorders with normal scores on the Connor's attention deficit hyperactivity disorder (ADHD) checklist and the Child Behavior Check List (CBCL). Neurological history and examination must be normal. EXCLUSION CRITERIA FOR SPECIFIC AIM #2

2001 Clinical Trials

5098. Transcranial Magnetic Stimulation in Parkinson's Disease

: Paired pulse transcranial magnetic stimulation (TMS) provides a measure of the balance of inhibitory and facilitatory activity evokable in the motor cortex. Studies in several diverse disorders of basal ganglia outflow and cortical regulation show an alteration in the direction of decreased inhibition or increased facilitation. In general, these have been quite small, data from different interstimulus intervals have been pooled for analysis, and, therefore, disease and state-specific information may (...) by National Institutes of Health Clinical Center (CC): Natural History Motor Cortex Behavior Healthy Volunteers Motor Control Parkinson Disease Parkinson's Healthy Volunteer HV Normal Control Additional relevant MeSH terms: Layout table for MeSH terms Parkinson Disease Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases

2001 Clinical Trials

5099. Biofeedback vs. video games: effects on impulsivity, locus of control and self-concept with incarcerated juveniles. (Abstract)

Biofeedback vs. video games: effects on impulsivity, locus of control and self-concept with incarcerated juveniles. Research has found hyperactivity, poor impulse control, impaired sustained attention and low self-concept to be behavioral deficits common to juvenile delinquents. Limited opportunities for exercising self-control while incarcerated may encourage helplessness. If biofeedback training enhances self-regulation skills, then perhaps these behaviors can be taught in confinement

1985 Journal of clinical psychology Controlled trial quality: uncertain

5100. Genetic Aspects of Neurologic and Psychiatric Disorders

Details Study Description Go to Brief Summary: The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder. The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several (...) for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms. Condition or disease Attention Deficit Disorder With Hyperactivity Bipolar Disorder Mental Disorder Diagnosed in Childhood Mental Retardation Schizophrenia Detailed Description: We propose to use DNA probes to study patients having specific neurologic and psychiatric disorders, especially focusing on patients with early onset or extreme phenotypes such as childhood onset schizophrenia

1999 Clinical Trials

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