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adhd Bupropion

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201. Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

six months (except basal or squamous cell skin cancer); Other major medical condition; Suicidal ideation (within the past 10 years) or lifetime occurrence of attempted suicide; Pregnant or nursing mothers; Current psychiatric disease (with the exception of anxiety disorders, OCD and ADHD); Current depression; Bulimia or anorexia; Alcohol abuse; Significant adverse reaction to bupropion/Wellbutrin/Zyban, Chantix/Varenicline or nicotine patches in the past. Use (within the past 30 days (...) only nicotine patches. Drug: nicotine patches 21mg nicotine patch for first 11 weeks; 14mg nicotine patch for next 2 weeks; 7mg nicotine patch for final 2 weeks. Active Comparator: bupropion (Zyban) and nicotine patches This group will consist of smokers who, based on smoking behavior, DO NOT respond favorably to pre-cessation NRT (assessed the day before the scheduled quit day). They will receive bupropion with nicotine patches. Drug: bupropion (Zyban) After being switched from NRT (occurring

2012 Clinical Trials

202. Varenicline for Nicotine Dependence Among Those With HIV/AIDS

), irritability, speech content, disruptive, or aggressive behavior items score < 3 (past 4 weeks) No psychiatric hospitalization or Emergency Room visits for psychiatric issues in the past 6 months No aggressive or violent acts or behavior in the past 6 months Able to communicate fluently in English. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent/HIPAA form. Exclusion Criteria: Smoking Behavior Current enrollment (...) and counseling group, and there will be no significant differences between treatment arms in terms of the frequency of severe varenicline-related side effects; and 3) improved affect and reduced cognitive impairment will mediate the effect of varenicline therapy on quit rates. Condition or disease Intervention/treatment Phase Nicotine Dependence Drug: Varenicline Drug: Placebo Behavioral: Smoking Cessation Counseling Phase 3 Detailed Description: Among people diagnosed with HIV/AIDS, the widespread use

2012 Clinical Trials

203. Disrupted-In-Schizophrenia-1 Gln31Leu Polymorphism Results in Social Anhedonia Associated with Monoaminergic Imbalance and Reduction of CREB and β-arrestin-1,2 in the Nucleus Accumbens in a Mouse Model of Depression. Full Text available with Trip Pro

Disrupted-In-Schizophrenia-1 Gln31Leu Polymorphism Results in Social Anhedonia Associated with Monoaminergic Imbalance and Reduction of CREB and β-arrestin-1,2 in the Nucleus Accumbens in a Mouse Model of Depression. Disrupted-in-schizophrenia-1 (DISC1) is associated with mental disorders, including major depression. We previously showed that DISC1-Q31L mutant mice have depression-like behaviors and can therefore be used to study neurobiological mechanisms of depression and antidepressant (AD (...) ) medication action. First, we found reduced levels of dopamine, serotonin and norepinephrine in the nucleus accumbens (NAC) of DISC1-Q31L mutants. Next, we assessed social-conditioned place preference as a reward-dependent task and the capacity of distinct ADs to correct impaired social behavior in DISC1-Q31L mice. Bupropion, but not fluoxetine or desipramine, was able to correct deficient social facilitation, social reward, and social novelty in DISC1-Q31L mutants, whereas all three ADs were able

2012 Neuropsychopharmacology

204. Brain Neurotransmission SPET using 123I-labelled Dopamine Transporter Ligands

Background and definitions From animal studies, clinical investigations and post- mortem evaluations it is well known that the dopaminer- gic neurotransmitter system plays a major role in movement disorders and particularly in parkinsonism as well as in dementia with Lewy bodies. The nigrostriatal dopaminergic pathway is best analysed at the striatal level where the nigrostriatal neurons end and connect to the postsynaptic nerve terminals using dopamine as neurotransmitter which binds to the postsynaptic (...) –11]. A.2. [ 123 I]FP-CIT imaging is indicated for the differenti- ation of dementia with Lewy bodies from other dementias [12–14]. B. Other potential indications B.1. Establishment of early diagnosis of neurodegenera- tive parkinsonism. DAT SPECT imaging is suitable for assessing the presynaptic deficit in early PD [15, 16]. B.2. Assessment of disease severity. DAT binding is related to the clinical stage and severity of PD [17, 18]. B.3. Differentiating patients with presynaptic parkinsonism

2009 European Association of Nuclear Medicine

205. Depressive Disorders in Children and Adolescents

associated with childhood depression may manifest as overactivity and aggressive, antisocial behavior. In children with intellectual disability, depressive or other mood disorders may manifest as somatic symptoms and behavioral disturbances. Disruptive mood dysregulation disorder Disruptive mood dysregulation disorder involves persistent irritability and frequent episodes of behavior that is very out of control, with onset at age 6 to 10 yr. Many children also have other disorders, particularly , (ADHD (...) with functioning or cause considerable distress. Diagnosis is by history and examination. Treatment is with antidepressants, supportive and cognitive-behavioral therapy, or both. (See also discussion of in adults.) Depressive disorders in children and adolescents include Disruptive mood dysregulation disorder Major depressive disorder Persistent depressive disorder (dysthymia) The term depression is often loosely used to describe the low or discouraged mood that results from disappointment (eg, serious illness

2013 Merck Manual (19th Edition)

206. Smoking Cessation

warning has been removed. † The longer duration of treatment may increase the likelihood of long-term abstinence among patients who have stopped smoking after 12 wk of varenicline use. MAOI = monoamine oxidase inhibitor. Drug safety Contraindications to bupropion include a history of seizures, an eating disorder, and monoamine oxidase inhibitor use within 2 wk. Postmarketing reports of serious or clinically significant neuropsychiatric adverse events when taking bupropion SR or varenicline have (...) included changes in behavior, hostility, agitation, depressed mood, suicidal thoughts, attempted suicide, and completed suicide. Clinicians should observe patients attempting to quit smoking with varenicline or bupropion SR for the occurrence of such symptoms and advise them to stop taking varenicline or bupropion SR and contact a healthcare provider immediately if they experience such adverse events. If treatment is stopped due to neuropsychiatric symptoms, patients should be monitored until

2013 Merck Manual (19th Edition)

207. Obesity

program similar to that for any other chronic disorder. Treatment Dietary management Physical activity Behavioral interventions Drugs (eg, phentermine , orlistat , lorcaserin , phentermine / topiramate , naltrexone / bupropion extended-release, liraglutide ) Bariatric surgery Weight loss of even 5 to 10% improves overall health, helps reduce risk of developing cardiovascular complications (eg, hypertension, dyslipidemia, insulin resistance) and helps lessen their severity, and may lessen the severity (...) obese patients for common comorbid disorders, such as obstructive sleep apnea, diabetes, dyslipidemia, hypertension, fatty liver, and depression. Encourage patients to lose even 5 to 10% of body weight by changing their diet, increasing physical activity, and using behavioral interventions if possible. Try treating patients with orlistat , phentermine , phentermine / topiramate , lorcaserin , naltrexone / bupropion , or liraglutide if BMI is ≥ 30 or if BMI is ≥ 27 and they have complications (eg

2013 Merck Manual (19th Edition)

208. Specific Poisons

(unfractionated) Dalteparin Enoxaparin Tinzaparin Bleeding secondary to decreased thrombin and fibrin clot formation Supportive care (eg, whole blood transfusion) Protamine sulfate (to reverse unfractionated heparin , but only partially neutralizes low mol wt heparins) Anticoagulants, warfarins Dicumarol Superwarfarins Warfarin See Warfarin — Antidepressants See Bupropion , Mirtazapine , SSRIs, Trazodone , Tricyclic antidepressants, Venlafaxine — Antifreeze See Alcohol, methyl and Ethylene glycol (...) Benzene — Beta-blockers Hypotension, bradycardia, seizures, cardiac arrhythmias, hypoglycemia, altered mental status Close monitoring and attention to airway maintenance For symptomatic patients, consideration of dopamine , epinephrine , other vasopressors, glucagon 3–5 mg IV followed by infusion, CaCl 2 , IV insulin and glucose, cardiac pacing, intra-aortic balloon pump, and IV lipid emulsion Bichloride of mercury See Mercury — Bichromates See Chromic acid — Bidrin (dicrotophos) See Organophosphates

2013 Merck Manual (19th Edition)

209. Pharmacologic-based strategies for smoking cessation: clinical and cost-effectiveness analyses

, watering eyes, abdominal pain, acne, back pain, confusion, cough, dental problems, difficulty breathing, gas, gum problems, headache, itching, joint pain, menstrual pain or disorders, muscle aches, nausea, and palpitations. Caution should be exercised in prescribing these nicotine replacement products to pregnant women or patients with certain medical conditions. 1.2.2 Bupropion Bupropion (amfebutamone), which has been available as an antidepressant (Wellbutrin), is also prescribed as a smoking (...) at 150 mg per day during the first three days, followed by a dose increase to 150 mg twice daily if needed. It is not indicated for use by children less than 18 years of age. Caution should be exercised when using bupropion as cessation treatment in pregnant women, elderly patients, patients with a history of seizures, patients with hepatic and renal impairment, and those with eating disorders. The use of sustained-released bupropion is associated with a risk of seizures (approximately one in 1,000

2010 EvidenceUpdates

210. Cognitive Enhancement as a Target for Cocaine Pharmacotherapy

DSM-IV psychiatric classifications for lifetime schizophrenia or bipolar disorder, or have a depressive or anxiety disorder with current use of a prescribed psychotropic medication that cannot be discontinued Current DSM-IV diagnosis of drug or alcohol dependence (other than cocaine, or tobacco) Demonstrate significant medical conditions, including asthma or chronic obstructive lung disease, history or current gastrointestinal ulcer, hepatic or renal deficit and cardiac rhythm disturbances or any (...) ) Information provided by (Responsible Party): Yale University Study Details Study Description Go to Brief Summary: Specific Aim #1: To determine if galantamine (8 or 16 mg/day) is more effective than placebo in reducing cocaine use as measured by cocaine urine results and self-report days of use. Specific Aim # 2: To determine if galantamine (8 or 16 mg/day) is more effective than placebo in improving attention, assessed with the Rapid Visual Information Processing (RVIP) and the Simple Reaction Time (SRT

2011 Clinical Trials

211. Meclizine as a Potential Smoking Cessation Treatment

treated with insulin; non-insulin treated diabetes (unless glucose is less than 180mg/dcl and HbA1c is less than 7%); Current cancer or treatment for cancer in the past six months (except basal or squamous cell skin cancer); Other major medical condition; Current psychiatric disease (with the exception of anxiety disorders, obsessive compulsive disorder (OCD) and ADHD); Current depression; Bulimia or anorexia; Pregnant or nursing; Smokes more than one cigar a month; Regular alcohol use; Significant (...) with no previous diagnosis of hypertension may have a screening blood pressure up to 160/100. Hypotension with symptoms (systolic <90 mm Hg, diastolic <60 mm Hg). Participants with a history of hypertension may, however, be allowed to participate in the study if the study physician or physician assistant determines that the condition is stable, controlled by medication, and in no way jeopardizes the individual's safety. Coronary heart disease; Lifetime history of heart attack; Cardiac rhythm disorder

2011 Clinical Trials

212. Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder

Responsible Party: Forest Laboratories ClinicalTrials.gov Identifier: Other Study ID Numbers: RGH-MD-75 First Posted: November 10, 2011 Results First Posted: May 1, 2018 Last Update Posted: May 1, 2018 Last Verified: March 2018 Keywords provided by Forest Laboratories: Major depressive disorder Depression Additional relevant MeSH terms: Layout table for MeSH terms Disease Depressive Disorder Depression Depressive Disorder, Major Pathologic Processes Mood Disorders Mental Disorders Behavioral Symptoms (...) Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

213. Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking

criteria), except for the following: Current or lifetime Marijuana Abuse or dependence Current or lifetime Nicotine Dependence Current or lifetime Alcohol Abuse or dependence ADHD or conduct disorders Neurological: Neurological status that is not within normal limits as determined by a physician and as indicated in self-report. have serious cardiovascular disease, including uncontrolled hypertension, coronary artery disease, serious cardiac arrhythmias, vasospastic disease, or angina, due to potential (...) Collaborator: Philip Morris USA, Inc. Information provided by (Responsible Party): Edythe London, University of California, Los Angeles Study Details Study Description Go to Brief Summary: Cigarette smoking is an important public health concern, and it is most often initiated in adolescence. Despite substantial research on smoking cessation in adults, however, relatively little effort has focused on therapeutic approaches to reduce adolescent smoking. Behavioral interventions, such as contingency

2011 Clinical Trials

214. Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

); Migraine headaches that occur more frequently than once per week; Recent, unexplained fainting spells; Problems giving blood samples; Diabetes; Current cancer or treatment for cancer in the past six months (except basal or squamous cell skin cancer); Other major medical condition; Current psychiatric disease (with the exception of anxiety disorders, Obsessive-compulsive disorder (OCD) and Attention deficit hyperactivity disorder (ADHD)); Bulimia or anorexia; Suicidal ideation (within the past 10 years (...) Additional relevant MeSH terms: Layout table for MeSH terms Tobacco Use Disorder Substance-Related Disorders Chemically-Induced Disorders Mental Disorders Nicotine Varenicline Bupropion Ganglionic Stimulants Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Nicotinic Agonists Cholinergic Agonists Cholinergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Antidepressive Agents, Second-Generation Antidepressive Agents Psychotropic Drugs Dopamine

2011 Clinical Trials

215. Venlafaxine

the efficacy of venlafaxine in the treatment of (ADHD). Clinical trials have found possible efficacy in those with (PTSD). Depression A comparative meta-analysis of 21 major antidepressants found that venlafaxine, , , , , , and were more effective than other antidepressants although the quality of many comparisons was assessed as low or very low. Venlafaxine was similar in efficacy to the atypical antidepressant ; however, the remission rate was lower for venlafaxine. In a double-blind study, patients who (...) : Venlafaxine can increase eye pressure, so those with may require more frequent eye checks. Suicide The US Food and Drug Administration body (FDA) requires all antidepressants, including venlafaxine, to carry a with a generic warning about a possible suicide risk. A 2014 meta analysis of 21 clinical trials of venlafaxine for the treatment of depression in adults found that compared to placebo, venlafaxine reduced the risk of suicidal thoughts and behavior. A study conducted in Finland followed more than

2012 Wikipedia

216. Treatment of Tourette syndrome

. Robertson MM. Tourette syndrome, associated conditions and the complexities of treatment. Brain . 2000;123 Pt 3:425–462. : Sukhodolsky DG, Scahill L, Zhang H, et al. Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry . 2003 Jan;42(1):98–105. * Hoekstra PJ, Steenhuis MP, Troost PW, et al. Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder (...) , and tic severity to social and behavioral problems in tic disorders. J Dev Behav Pediatr . 2004 Aug;25(4):272–9. * Carter AS, O'Donnell DA, Schultz RT, et al. Social and emotional adjustment in children affected with Gilles de la Tourette's syndrome: associations with ADHD and family functioning. Attention Deficit Hyperactivity Disorder. J Child Psychol Psychiatry . 2000 Feb;41(2):215–23. * Spencer T, Biederman J, Harding M, et al. Disentangling the overlap between Tourette's disorder and ADHD. J

2012 Wikipedia

217. Antidepressant

as an alternative or additional first step to self-help programs in the treatment of . SSRIs (fluoxetine in particular) are preferred over other antidepressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials. Long-term efficacy remains poorly characterized. is not recommended for the treatment of eating disorders due to an increased risk of seizure. Similar recommendations apply to . SSRIs provide short-term reductions in binge eating behavior, but have (...) with major depressive disorder antidepressants were more efficacious than placebo Effect sizes measured at 8-weeks after treatment onset were modest with a summary standard mean difference of 0.3. A 2018 of trials found that antidepressants showed little or no effect for treating depression in dementia. A 2017 meta analysis comparing the efficacy of SSRIs against placebo found the mean reduction in (HDRS) to be -1.94 points over 49 studies. This was statistically significant, but failed to meet

2012 Wikipedia

218. Major depressive disorder Full Text available with Trip Pro

decreases, with resulting weight loss, although increased appetite and weight gain occasionally occur. Family and friends may notice that the person's behavior is either or . Older depressed people may have symptoms of recent onset, such as forgetfulness, and a more noticeable slowing of movements. Depression often coexists with physical disorders common among the elderly, such as , other , , and . Depressed children may often display an irritable mood rather than a depressed one, and show varying (...) episodes of major depression (sometimes referred to as ). is a mood disturbance appearing as a psychological response to an identifiable event or stressor, in which the resulting emotional or behavioral symptoms are significant but do not meet the criteria for a major depressive episode. , also known as manic–depressive disorder , is a condition in which depressive phases alternate with periods of or . Although depression is currently categorized as a separate disorder, there is ongoing debate because

2012 Wikipedia

219. Neurobiology and Pharmacokinets of Acute MDMA Administration

(CC) Study Details Study Description Go to Brief Summary: Background: 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a synthetic psychoactive drug that has shown a steep increase in recreational use and abuse by young people in recent years. Research studies have reported that chronic MDMA users who also consume other legal and illegal substance show memory deficits; however, because of the combination of drugs often involved, it is difficult to determine MDMA s (...) contribution to these effects. Only a few studies have examined the immediate physical and behavioral effects of MDMA given at dose levels commonly used in young adults. Researchers are interested in using functional magnetic resonance imaging (fMRI) to examine changes in brain activity and function in MDMA users compared with users of other drugs and non-drug-using individuals. Objectives: - To evaluate the effects of MDMA on thinking and brain function. Eligibility: - Individuals between 18 and 30 years

2010 Clinical Trials

220. Adding Sleep Intervention to Traditional Diet and Exercise Approach to Weight Loss

plus sessions that are of general interest, but unrelated to diet, exercise, or sleep. Behavioral: Diet and exercise Standardized instruction to eat less and exercise more to create an energy balance deficit to promote weight loss (16 classes) Behavioral: Passion and Balance Attention-match sessions of general interest, but unrelated to diet, exercise, or sleep (8 sessions) Outcome Measures Go to Primary Outcome Measures : Change from baseline in weight at 8 months [ Time Frame: Baseline and 8 (...) Heart, Lung, and Blood Institute (NHLBI) Information provided by (Responsible Party): Christopher Gardner, Stanford University Study Details Study Description Go to Brief Summary: The goal is to determine if improved sleep will increase/enhance weight loss among overweight adults with insomnia. Condition or disease Intervention/treatment Phase Sleep Initiation and Maintenance Disorders Obesity Behavioral: Diet and exercise Behavioral: Cognitive Behavioral Therapy Behavioral: Passion and Balance

2010 Clinical Trials

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