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1. Bupropion for attention deficit hyperactivity disorder (ADHD) in adults. (PubMed)

Bupropion for attention deficit hyperactivity disorder (ADHD) in adults. Attention deficit hyperactivity disorder (ADHD) is a prevalent neurobiological condition, characterised by behavioral and cognitive symptoms such as inattention, impulsivity and/or excessive activity. The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational and occupational underachievement.Although psychostimulant medications are the mainstay of treatment for ADHD, not all (...) adults respond optimally to, or can tolerate, these medicines. Thus, alternative non-stimulant treatment approaches for ADHD have been explored. One of these alternatives is bupropion, an aminoketone antidepressant and non-competitive antagonism of nicotinic acetylcholine receptors. Bupropion is registered for the treatment of depression and smoking cessation, but is also used off-label to treat ADHD.To assess the effects and safety of bupropion for the treatment of adults with ADHD.We searched

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2017 Cochrane

2. Bupropion

. But if you still have questions please contact us via jon.brassey@tripdatabase.com Top results for bupropion 1. Bupropion for attention deficit hyperactivity disorder (ADHD) in adults. BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurobiological condition, characterised by behavioral and cognitive symptoms such as inattention, impulsivity and/or excessive activity. The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational (...) and occupational underachievement.Although psychostimulant medications are the mainstay of treatment for ADHD (...) , not all adults respond optimally to, or can tolerate, these medicines. Thus, alternative non-stimulant treatment approaches for ADHD have been explored. One of these alternatives is bupropion , an aminoketone antidepressant and non-competitive antagonism of nicotinic acetylcholine receptors. Bupropion is registered for the treatment of depression and smoking cessation, but is also used off

2018 Trip Latest and Greatest

3. ADHD

examination by a physician/medical doctor - Psychological 2016 10. Bupropion for attention deficit hyperactivity disorder ( ADHD ) in adults. BACKGROUND: Attention deficit hyperactivity disorder ( ADHD ) is a prevalent neurobiological condition, characterised by behavioral and cognitive symptoms such as inattention, impulsivity and/or excessive activity. The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational and occupational underachievement.Although (...) psychostimulant medications are the mainstay of treatment for ADHD (...) , not all adults respond optimally to, or can tolerate, these medicines. Thus, alternative non-stimulant treatment approaches for ADHD have been explored. One of these alternatives is bupropion, an aminoketone antidepressant and non-competitive antagonism of nicotinic acetylcholine receptors. Bupropion is registered for the treatment of depression and smoking cessation, but is also used off-label to treat ADHD . OBJECTIVES: To assess

2018 Trip Latest and Greatest

4. Methylphenidate remains first-choice drug treatment for children and young people with ADHD

if they have not been directly compared in trials, as long as they have been in at least a placebo-controlled trial. What did this study do? The child and adolescent parts of this systematic review included 82 trials of 14,346 young people. The network meta-analysis compared amphetamines (including lisdexamfetamine), methylphenidate, atomoxetine, bupropion, clonidine, guanfacine and modafinil. It included unpublished data gathered from study authors and drug manufacturers. Core symptoms of ADHD were rated (...) search for published and unpublished double-blind randomised controlled trials comparing amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil with each other or placebo. We systematically contacted study authors and drug manufacturers for additional information. Primary outcomes were efficacy (change in severity of ADHD core symptoms based on teachers' and clinicians' ratings) and tolerability (proportion of patients who dropped out

2019 NIHR Dissemination Centre

5. Amphetamines probably the best first-choice treatment for adults with ADHD

We did a literature search for published and unpublished double-blind randomised controlled trials comparing amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil with each other or placebo. We systematically contacted study authors and drug manufacturers for additional information. Primary outcomes were efficacy (change in severity of ADHD core symptoms based on teachers' and clinicians' ratings) and tolerability (proportion (...) Amphetamines probably the best first-choice treatment for adults with ADHD Amphetamines probably the best first-choice treatment for adults with ADHD Discover Portal Discover Portal Amphetamines probably the best first-choice treatment for adults with ADHD Published on 30 October 2018 doi: There is further evidence to support the amphetamines as the most effective group of drugs for treating adults with attention deficit hyperactivity disorder in the short-term. Two of these drugs were shown

2019 NIHR Dissemination Centre

6. Medication for ADHD: what works for adults, adolescents and children

trials lasting at least one week Investigating children, adolescents or adults with a primary diagnosis of ADHD, assessed using DSM or ICD criteria Comparing amphetamines, atomoxetine, bupropion, clonidine, guanfacine, methylphenidate or modafinil against placebo or each other. Data were extracted by at least two independent investigators. The primary outcomes were efficacy (measured as a change in clinicians’ ratings of ADHD symptom severity) and tolerability (the proportion of participants who left (...) , amphetamines, methylphenidate, atomoxetine and bupropion were better than placebo at attenuating core ADHD symptoms. Modafinil was worse than placebo In all age groups, amphetamines had significantly greater efficacy to modafinil, atomoxetine and methylphenidate In children and adolescents, amphetamines and guanfacine were less well tolerated than placebo In adults, modafinil, amphetamines, methylphenidate and atomoxetine had inferior tolerability than placebo In children and adolescents, all medications

2019 The Mental Elf

7. Pharmacological and non-pharmacological treatment of adults with ADHD: a meta-review

, atomoxetine) and non-pharmacological interventions (such as behavioural therapies). Indeed, different countries can have licensed different medications and regulations may change between children/adolescents and adults. Extended-release clonidine and extended-release guanfacine have been approved by the FDA for the treatment of ADHD, but not specifically for adults. Other pharmacological options that have been used off-label include modafinil and a number of antidepressants (venlafaxine, bupropion (...) database of multicenter placebo-controlled trials . Asherson P , Stes S , Nilsson Markhed M , et al . The effects of atomoxetine on emotional control in adults with ADHD: An integrated analysis of multicenter studies . Hazell PL , Kohn MR , Dickson R , et al . Core ADHD symptom improvement with atomoxetine versus methylphenidate: a direct comparison meta-analysis . Maneeton N , Maneeton B , Intaprasert S , et al . A systematic review of randomized controlled trials of bupropion versus methylphenidate

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2017 Evidence-Based Mental Health

8. Bupropion for Attention Deficit Hyperactivity Disorder (ADHD) in adults [Cochrane protocol]

Bupropion for Attention Deficit Hyperactivity Disorder (ADHD) in adults [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2017 PROSPERO

9. High Dose Bupropion for Smoking Cessation

High Dose Bupropion for Smoking Cessation High Dose Bupropion for Smoking Cessation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. High Dose Bupropion for Smoking Cessation The safety and scientific (...) of California, Los Angeles University of California, San Diego Information provided by (Responsible Party): Adam Leventhal, University of Southern California Study Details Study Description Go to Brief Summary: This study aims to investigate the benefit of administering Bupropion XL (BUP-XL) to heavy smokers who also experience psychiatric symptoms. Condition or disease Intervention/treatment Phase Smoking Cessation Smoking, Tobacco Smoking (Tobacco) Addiction Cessation, Tobacco Anhedonia Drug: Bupropion

2017 Clinical Trials

10. Bupropion

malformation overall, cardiac malformation overall, intrauterine death, low birth weight or preterm delivery following maternal bupropion use in pregnancy. Although single case-control studies have suggested possible associations with specific cardiac malformations including coarctation of the aorta and ventricular septal defects, these observations have not been replicated in other studies. One study has provided evidence that bupropion may be associated with an increased risk of ADHD in the offspring (...) of women who were treated with bupropion for depression. However, this finding was based on a small number of exposed infants with ADHD resulting in an imprecise risk estimate which may have been confounded by the underlying maternal condition. This observation therefore requires confirmation in further studies. Due to the limited efficacy and pregnancy safety data, bupropion is not routinely recommended as a smoking cessation aid for pregnant women. However, each patient needs to be assessed on a case

2014 UK Teratology Information Service

11. Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate

heart disease. Use of any psychotropic medication within 28 days of the Baseline visit except for ADHD medication. (Sedative hypnotics prescribed as a sleep aid at a stable dose for at least 28 days prior to Baseline, at bedtime only, are allowed during the study.) Has used prohibited drugs or agents within 28 days of the Baseline visit through Study Visit 7. (Stimulant medications are allowed until 7 days before the Baseline visit.) Non-stimulant ADHD medications (guanfacine, bupropion, clonidine (...) Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

12. Transcranial Magnetic Stimulation for Attention Deficit/Hyperactivity Disorder (ADHD)

medications Any medication for the treatment of ADHD Benzodiazepines Any medication that is known to lower the seizure threshold (e.g.,clozapine, bupropion, tramadol, carbapenems, stimulants) Any medication that could compromise participant safety as determined by the Principal Investigator and/or Study Physician Current use or recent discontinuation (within the last 14 days at the time of Intake) of: Anti-psychotic medications Nicotine replacement therapy (NRT) Daily use of: Opiate-containing medications (...) Transcranial Magnetic Stimulation for Attention Deficit/Hyperactivity Disorder (ADHD) Transcranial Magnetic Stimulation for Attention Deficit/Hyperactivity Disorder (ADHD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

13. A Systematic Review of the Use of Bupropion for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. (PubMed)

A Systematic Review of the Use of Bupropion for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders of childhood and adolescence. Stimulants are usually the first choice of drug; however, as many as 20% of patients do not respond to them. Stimulants may also worsen comorbid sleep, mood, and anxiety disorders, and they are associated with problems of misuse and diversion (...) . Bupropion, a dopamine and norepinephrine reuptake inhibitor, is a promising nonstimulant alternative with reports of positive outcomes for ADHD management in both adolescent and adult populations. This study systematically reviews clinical trials on the subject.Using the keywords bupropion or Wellbutrin or Zyban or Elontril and attention deficit hyperactivity disorder or ADHD or ADDH, a preliminary search on the PubMed and Ovid databases yielded 25,455 articles published in English between January 1

2016 Journal of Child and Adolescent Psychopharmacology

14. Causal Factors of Increased Smoking in ADHD: A Systematic Review. (PubMed)

relations was ranked using the Bradford Hill criteria.ADHD medication reduces early smoking initiation and alleviates smoking withdrawal. Nicotine patches, bupropion and (probably) varenicline ameliorate ADHD symptoms. Imitation of and interaction with peers and genetic and environmental determinants may contribute to the comorbidity, but seem to contribute less than self-medication.Smoking is probably best explained by a combination of imitation, peer pressure and typical traits of ADHD. In contrast (...) Causal Factors of Increased Smoking in ADHD: A Systematic Review. ADHD is a highly prevalent disorder and poses a risk for a variety of mental disorders and functional impairments into adulthood. One of the most striking comorbidities of ADHD is nicotine dependence. Youth diagnosed with ADHD are 2-3 times more likely to smoke than their peers without ADHD, initiate smoking earlier in life and progress more quickly and more frequently to regular use and dependence. Possible explanations

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2017 Substance use & misuse

15. CX717 in the Treatment of Adult ADHD

had a history of development delay in milestones By history, the subject had an IQ less than 80 In the opinion of the Investigator, the subject had not derived significant therapeutic benefit from 2 or more appropriately dosed ADHD therapies Subject was currently taking medication specifically for treatment of ADHD symptoms (e.g., stimulants, atomoxetine, tricyclic antidepressants, or bupropion). NOTE: subjects were off of stimulants for 2 weeks and off non-stimulant ADHD therapies for 4 weeks (...) CX717 in the Treatment of Adult ADHD CX717 in the Treatment of Adult ADHD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. CX717 in the Treatment of Adult ADHD The safety and scientific validity

2017 Clinical Trials

16. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years Old With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting.

A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years Old With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years Old With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years Old With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2017 Clinical Trials

17. Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults

Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01270555 Recruitment Status : Completed First Posted : January 5, 2011 Results First Posted : February 25, 2011 Last Update Posted : March 8, 2013 Sponsor

2011 Clinical Trials

18. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting.

A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results (...) information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing

2016 Clinical Trials

19. Bupropion for adults with attention deficit hyperactivity disorder: a review of the clinical effectiveness and harms of misuse

health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Canadian Agency for Drugs and Technologies in Health. Bupropion for adults with attention deficit hyperactivity disorder: a review of the clinical effectiveness and harms of misuse . Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2010 Authors' conclusions RCTs examining the efficacy of bupropion in adult ADHD frequently reported (...) no statistically significant differences between bupropion and placebo; however, studies were hampered by small sample sizes. Meta-analyses suggest that bupropion treatment results in greater reductions in ADHD symptoms compared with no treatment; however, bupropion appears to be less effective than short-acting stimulants. Observational studies of patients presenting to poison control centres reported that seizure was frequently observed among patients with bupropion overdose; death was infrequent

2010 Health Technology Assessment (HTA) Database.

20. A systematic review of randomized controlled trials of bupropion versus methylphenidate in the treatment of attention-deficit/hyperactivity disorder. (PubMed)

A systematic review of randomized controlled trials of bupropion versus methylphenidate in the treatment of attention-deficit/hyperactivity disorder. Some trials have suggested that bupropion, as well as methylphenidate, is beneficial in the treatment of attention-deficit/hyperactivity disorder (ADHD).The purpose of this systematic review was to summarize the efficacy, acceptability, and tolerability of bupropion in comparison with methylphenidate for ADHD treatment. Included studies were (...) randomized controlled trials (RCTs) that compared bupropion and methylphenidate. Clinical studies conducted between January 1991 and January 2014 were reviewed.MEDLINE(®), EMBASE™, CINAHL, PsycINFO(®), and the Cochrane Controlled Trials Register were searched in January 2014. Additionally, clinical trials were identified from the databases of ClinicalTrials.gov and the EU Clinical Trials Register.All RCTs of bupropion and methylphenidate reporting final outcomes relevant to 1) ADHD severity, 2) response

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2014 Neuropsychiatric disease and treatment

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