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Zeolite Mineral Dressing

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1. Zeolite Mineral Dressing

Zeolite Mineral Dressing Zeolite Mineral Dressing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Zeolite Mineral Dressing Zeolite (...) Mineral Dressing Aka: Zeolite Mineral Dressing , Zeolite II. Mechanism Increases and platelet concentration at wound sites via water absorption III. Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure IV. Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) V. References Kheirabadi (2011) US Army Med Dep J p. 25-37 Swaminathan and van de Leuv (2013) Crit Dec in Emerg Med 27(8): 11-17 Images: Related links to external sites

2018 FP Notebook

2. Zeolite Mineral Dressing

Zeolite Mineral Dressing Zeolite Mineral Dressing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Zeolite Mineral Dressing Zeolite (...) Mineral Dressing Aka: Zeolite Mineral Dressing , Zeolite II. Mechanism Increases and platelet concentration at wound sites via water absorption III. Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure IV. Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) V. References Kheirabadi (2011) US Army Med Dep J p. 25-37 Swaminathan and van de Leuv (2013) Crit Dec in Emerg Med 27(8): 11-17 Images: Related links to external sites

2015 FP Notebook

3. Toxicity of Aluminum Silicates Used in Hemostatic Dressings Toward Human Umbilical Veins Endothelial Cells, HeLa Cells, and RAW267.4 Mouse Macrophages. (PubMed)

than kaolin and zeolite present in QC+, respectively, at equivalent doses. The cytotoxic effect seemed to be caused by the direct contact of the minerals with the cells present in wounds. These data suggest that the future clearance of mineral-based hemostatic agents should require more extensive cytotoxicity testing than the current Food and Drug Administration requirements. (...) Toxicity of Aluminum Silicates Used in Hemostatic Dressings Toward Human Umbilical Veins Endothelial Cells, HeLa Cells, and RAW267.4 Mouse Macrophages. Aluminum silicates have been used to control bleeding after severe traumatic injury. QuikClot (QC) was the first such product, and WoundStat (WS) is the most recent. We recently observed that WS caused vascular thrombosis when applied to stop bleeding. This study investigated the cellular toxicity of WS in different cell types that may

2011 Journal of Trauma

4. Topical Hemostatic Agent

. Preparations: Zeolite Mineral Dressing (QuickClot) Mechanism Factor Concentrator Increases and platelet concentration at wound sites via water absorption Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure Effective for low pressure, venous bleeding Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) XV. Preparations: Mineral Dressing with Impregnated Kaolin Mechanism (similar to s) Factor Concentrator Increases and platelet (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2018 FP Notebook

5. Topical Hemostatic Agent

. Preparations: Zeolite Mineral Dressing (QuickClot) Mechanism Factor Concentrator Increases and platelet concentration at wound sites via water absorption Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure Effective for low pressure, venous bleeding Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) XV. Preparations: Mineral Dressing with Impregnated Kaolin Mechanism (similar to s) Factor Concentrator Increases and platelet (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2015 FP Notebook

6. Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in Swine. (PubMed)

Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in Swine. Techniques for better hemorrhage control after injury could change outcome. We have previously shown that a zeolite mineral hemostatic agent (ZH) can control aggressive bleeding through adsorption of water, which is an exothermic process. Increasing the residual moisture content (RM) of ZH can theoretically decrease heat generation, but its effect on the hemostatic properties (...) is unknown. We tested ZH with increasing RM against controls and other hemostatic agents in a swine model of battlefield injury.A complex groin injury was created in 72 swine (37 +/- 0.8 kg). This included semitransection of the proximal thigh and complete division of the femoral artery and vein. After 3 minutes, the animals were randomized to 1 of 10 groups: group 1, no dressing (ND); group 2, standard dressing (SD); group 3, SD + 3.5 oz ZH with 1% RM (1% ZH); group 4, SD + 3.5 oz ZH with 4% RM (4% ZH

2004 Journal of Trauma

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