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Zaleplon

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1. Zaleplon in HIV Patients With Depression

Zaleplon in HIV Patients With Depression Zaleplon in HIV Patients With Depression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Zaleplon in HIV Patients With Depression The safety and scientific validity (...) to Brief Summary: In HIV positive patients with sleep onset insomnia and receiving pharmacologic treatment for comorbid depression, the proposed study aims to evaluate the impact of zaleplon on sleep measures determined by insomnia severity index (ISI) and Epworth sleepiness scale (ESS). Condition or disease Intervention/treatment Phase HIV/AIDS Clinical Depression Drug: Zaleplon Phase 2 Detailed Description: An estimated >50% of HIV positive individuals report insomnia. Insomnia and other sleep

2018 Clinical Trials

2. Effects of Zolpidem and Zaleplon on Cognitive Performance After Emergent Tmax and Morning Awakenings: a Randomized Placebo-Controlled Trial. (PubMed)

Effects of Zolpidem and Zaleplon on Cognitive Performance After Emergent Tmax and Morning Awakenings: a Randomized Placebo-Controlled Trial. Prescription sleep aids are frequently used in the general population, and even more frequently in spaceflight. To evaluate the risk to operational safety, a ground-based, double-blind, placebo-controlled study on the emergent awakening effects of zolpidem and zaleplon was conducted.N=34 subjects (age M=42.1±9.7; 25 males; 9 Astronauts, 7 Astronaut (...) candidates, 18 Flight Controllers) were investigated for 3 nights separated by M=10 days. They were randomized to ingestion of one of the following at lights out: placebo, 10 mg zaleplon, and either 5 mg (N=20) or 10 mg (N=14) zolpidem. They were awakened abruptly by alarm at the expected PK,max (1h after lights out for zaleplon; 1.5h for placebo/zolpidem). Subjects were required to turn off the alarm and perform a cognitive test battery twice, separated by a 20-30 min reading break. They then returned

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2018 Sleep

3. Investigation of the usefulness of zaleplon at two doses to induce afternoon-sleep under noise interference and its effects on psychomotor performance and vestibular function. (PubMed)

Investigation of the usefulness of zaleplon at two doses to induce afternoon-sleep under noise interference and its effects on psychomotor performance and vestibular function. Military operation personnel often suffer from sleep difficulty because of their work requirements. In this study, we investigated the efficacy of zaleplon at two doses to induce afternoon-sleep under noise interference and its effects on psychomotor performance and vestibular function; we subsequently established (...) the optimal dosage regimen for military operation personnel.Twenty-two healthy young male volunteers were recruited for the study. Eight subjects took 10 mg or 15 mg of zaleplon and placebo alternately and then were exposed to noise. Changes in polysomnography (PSG) indices, including sleep latency (SL), sleep efficiency (SE) and sleep structure, were recorded after drug administration. After awakening, the volunteers' subjective judgments of sleep quality and sleepiness were measured. Eight volunteers

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2016 Military Medical Research

4. Zaleplon

Zaleplon Zaleplon Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Zaleplon Zaleplon Aka: Zaleplon , Sonata From Related Chapters II (...) links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Zaleplon." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Cost: Medications zaleplon (on 5/17/2017 at ) ZALEPLON 10 MG CAPSULE Generic $0.29 each ZALEPLON 5 MG CAPSULE Generic $0.24 each sonata (on 6/1/2017 at ) SONATA 10 MG CAPSULE Generic $0.29 each FPNotebook does not benefit financially from showing this medication

2018 FP Notebook

5. The acute cognitive effects of zopiclone, zolpidem, zaleplon, and eszopiclone: a systematic review and meta-analysis. (PubMed)

The acute cognitive effects of zopiclone, zolpidem, zaleplon, and eszopiclone: a systematic review and meta-analysis. The "z-drugs" zopiclone, zolpidem, eszopiclone, and zaleplon were introduced in the 1980s for the treatment of insomnia, as it was observed that the side effect profile associated with these medications were more benign than those related to the benzodiazepines. This meta-analysis set out to ascertain which domains of cognitive function, if any, were affected by the ingestion (...) a specific rather than a generalized negative effect on cognitive function. However, there were only enough studies to evaluate the individual cognitive effects of the zolpidem and zopiclone medications; the specific effects of zaleplon and eszopiclone cannot be ascertained because only one study met the inclusion and exclusion criteria for the review.

2014 Journal of clinical and experimental neuropsychology

6. A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation. (PubMed)

A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation. The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2) after 30 h of SD; (3) upon sudden awakening, also called 2 h post-drug; (4) 4 h post-drug; and (5) 6 (...) h post-drug. Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions. However, no difference was observed between the zaleplon condition and the placebo condition. In event-related potential (ERP) reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD

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2014 PloS one

7. The pharmacokinetics and pharmacodynamics of zaleplon delivered as a thermally generated aerosol in a single breath to volunteers. (PubMed)

The pharmacokinetics and pharmacodynamics of zaleplon delivered as a thermally generated aerosol in a single breath to volunteers. Pharmacokinetics, pharmacodynamics, safety, and tolerability of inhaled zaleplon were assessed in healthy volunteers. Forty participants received 0.5, 1, 2, or 4 mg zaleplon or placebo as a thermally generated aerosol in a randomized, double-blind, parallel-group, dose escalation study. Blood was collected up to 24 hours after dosing, and sedation was assessed up (...) to 8 hours. Following inhalation, the observed median time to maximum plasma concentrations (25%, 75%) was 1.89 (1.45, 3.08) minutes and the mean (SD) elimination half-life was 1.24 (0.24) hours. The equilibration half-life for sedation (t(1/2) k(e0) ) was 1.16 (0.62, 2.17) minutes. The zaleplon AUC was dose proportional across doses, with a slope (90% confidence interval) of log-AUC versus log-dose of 0.92 (0.82, 1.02). No clinically significant changes were noted in laboratory values, vital signs

2013 Journal of clinical pharmacology

8. Impact of zaleplon on continuous positive airway pressure therapy compliance. (PubMed)

Impact of zaleplon on continuous positive airway pressure therapy compliance. To determine whether pretreatment with zaleplon immediately before CPAP titration improves 1-month CPAP adherence in subjects newly diagnosed with OSA.Prospective, randomized, double-blinded, placebo-controlled trial of a single dose of zaleplon 10 mg or matching placebo at the start of CPAP titration during laboratory-based, split-night polysomnography (PSG). Baseline sleep symptoms were assessed with the Functional (...) Outcomes of Sleep Questionnaire (FOSQ) and Epworth Sleepiness Scale (ESS). CPAP usage and change in symptom questionnaire responses were assessed at 1-month follow-up.One hundred thirty-four newly diagnosed OSA patients undergoing their initial split-night PSG (49.8 ± 11.3 years old with an apnea-hypopnea index of 16.5 (7, 32) [median (interquartile range)] were randomized to zaleplon (n = 73) or placebo (n = 63). Complete follow-up data were available in 83 subjects (44 zaleplon group; 39 placebo

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2013 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

9. Zaleplon

Zaleplon Zaleplon Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Zaleplon Zaleplon Aka: Zaleplon , Sonata From Related Chapters II (...) links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Zaleplon." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Cost: Medications zaleplon (on 5/17/2017 at ) ZALEPLON 10 MG CAPSULE Generic $0.29 each ZALEPLON 5 MG CAPSULE Generic $0.24 each sonata (on 6/1/2017 at ) SONATA 10 MG CAPSULE Generic $0.29 each FPNotebook does not benefit financially from showing this medication

2015 FP Notebook

10. A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia

A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01277107

2011 Clinical Trials

11. A double-blind, randomized, comparative study to evaluate the efficacy and safety of zaleplon versus zolpidem in shortening sleep latency in primary insomnia. (PubMed)

A double-blind, randomized, comparative study to evaluate the efficacy and safety of zaleplon versus zolpidem in shortening sleep latency in primary insomnia. Benzodiazepines cause a high proportion of adverse effects while non-benzodiazepine compounds have demonstrated high efficacy and less adverse effects in patients with insomnia. The objective of this study was to compare the effectiveness and safety of non-BZ zaleplon and zolpidem in primary insomnia.This was a randomized, double-blind (...) revealed a significant decrease in sleep latency from baseline to Week 2 for patients receiving zaleplon 10 mg and zolpidem 10 mg. Patients receiving zaleplon exhibited a marginally greater, but not statistically significant, reduction in sleep latency than those who received zolpidem. There was no significant difference in the frequency of adverse effects between the zaleplon and zolpidem groups; however, during this clinical trial there was one lethal event caused by a traffic accident

2011 Chang Gung medical journal

12. Pharmacokinetic profile of SKP-1041, a modified release formulation of zaleplon. (PubMed)

Pharmacokinetic profile of SKP-1041, a modified release formulation of zaleplon. Two investigations aimed to define the pharmacokinetic profile of a modified-release preparation of zaleplon (SKP-1041).Protocol SOM001 was a 5-way crossover, double-blind, randomized trial comparing three novel modified-release formulations of zaleplon 15 mg (SKP-1041A, SKP-1041B, SKP-1041C) to placebo and immediate-release zaleplon 10 mg. Protocol SOM002 was a randomized, crossover, open-label trial to compare (...) zaleplon were not significantly different; peak plasma concentrations were similar for A and B, and both were significantly higher than C. Time to peak plasma concentration for A, B, and C were 4-5 h compared to 1.5 h for immediate-release zaleplon; mean terminal phase half-life was in the range 1-2 h for A, B and immediate-release zaleplon. No significant differences were noted between day and night administration in the SOM002 study.Zaleplon, 15 mg, in a novel, modified-release formulation (SKP-1041

2011 Biopharmaceutics & drug disposition

13. Zolpidem

. But if you still have questions please contact us via jon.brassey@tripdatabase.com Top results for zolpidem 1. The acute cognitive effects of zopiclone, zolpidem , zaleplon, and eszopiclone: a systematic review and meta-analysis. 24931450 2014 10 21 2015 07 06 2016 11 25 1744-411X 36 7 2014 Journal of clinical and experimental neuropsychology J Clin Exp Neuropsychol The acute cognitive effects of zopiclone, zolpidem , zaleplon, and eszopiclone: a systematic review and meta-analysis. 691-700 10.1080 (...) /13803395.2014.928268 The "z-drugs" zopiclone, zolpidem , eszopiclone, and zaleplon were introduced (...) in the 1980s for the treatment of insomnia, as it was observed that the side effect profile associated with these medications were more benign than those related to the benzodiazepines. This meta-analysis set out to ascertain which domains of cognitive function, if any, were affected by the ingestion of these medications. A total of 20 studies met the study inclusion criteria. Results revealed medium effect

2018 Trip Latest and Greatest

14. Trazodone

that certain classes of hypnotics that target GABA(A) receptors impair sleep-dependent brain plasticity. However, the effects of hypnotics acting at monoamine receptors (e.g (...) ., the antidepressant trazodone ) on this process are unknown. We therefore assessed the effects of commonly-prescribed medications for the treatment of insomnia ( trazodone and the non-benzodiazepine GABA(A) receptor agonists zaleplon and eszopiclone) in a canonical model of sleep-dependent, in vivo synaptic plasticity

2018 Trip Latest and Greatest

15. Temazepam

in middle-aged people is currently not known. To establish whether the effects of prolonged-release 2015 2. Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam . 15198277 2004 06 16 2004 08 26 2016 11 24 0095-6562 75 6 2004 Jun Aviation, space, and environmental medicine Aviat Space Environ Med Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam . 512-9 Current military operations often require pharmaceutical methods (...) to sustain alertness and facilitate sleep in order to maintain operational readiness. This study (...) was designed to compare the sleep-inducing power of four medications. There were 9 men and 14 women, ages 21-53 yr, who were assessed for psychomotor performance before and for 7 h after ingestion of a single dose of placebo, zaleplon 10 mg, zopiclone 7.5 mg, temazepam 15 mg, or time-released melatonin 6 mg. The experimental design was a double-blind crossover with counterbalanced treatment order

2018 Trip Latest and Greatest

16. Insomnia

: a systematic review and economic evaluation Dundar Y, Boland A, Strobl J, Dodd S, Haycox A, Bagust A, Bogg J, Dickson R, Walley T CRD summary This review compared zaleplon, zolpidem and zopiclone with benzodiazepines (...) (licensed and used in the UK) for the short-term management of insomnia . The authors concluded that short-acting drugs (Z-drugs) seemed equally effective and safe, but that there was a clear need for further research in this area. The authors suggested interpreting the findings (...) with considerable caution, and their recommendation for further research seems appropriate. Authors' objectives To compare the clinical and cost-effectiveness of zaleplon, zolpidem and zopiclone with benzodiazepines for the short 2004 17. Insomnia with objective short sleep duration is associated with longer duration of insomnia in the Freiburg Insomnia Cohort compared to insomnia with normal sleep duration, but not with hypertension. STUDY OBJECTIVES: To replicate the association between insomnia

2018 Trip Latest and Greatest

17. Pneumonia induced by benzodiazepines

sleeping agents (Note 2), namely eszopiclone, zaleplon, zolpidem, and ramelteon [2]. The study dealt with the frequency of all infectious diseases. As a result of comparing 8,828 participants in hypnotic drug groups and 4,383 participants in placebo groups who were involved in 36 RCTs, increased risk of infection was observed. The total risk (risk ratio: RR) was Adverse Reactions Adverse Reactions Pneumonia induced by benzodiazepines Evidence shows causal relations Yasuda Y., Hama R Note1: In addition (...) -dependency, and the causality is certain. Never use them uncritically. 1) INCB: Report of the International Narcotics Control Board on the Availability of Internationally Controlled Drugs: http://www.benzo-case-japan.com/docs/International_Narcotics_Control_Board. pdf 2) Joya FL et al, Meta-Analyses of Hypnotics and Infections: Eszopiclone, Ramelteon, Zaleplon, and Zolpidem. J Clin Sleep Med, 2009: (4):377-83. PMID: 19968019 3) Chen TY et al, The Use of Benzodiazepine Receptor Agonists and the Risk

2018 Med Check - The Informed Prescriber

19. CRACKCast E165 – Sedative Hypnotics

those ASA and acetaminophen levels!!) Diphenhydramine and doxylamine are antihistamines that also have hypnotic, antimuscarinic, and weak local anesthetic properties. They act as competitive antagonists of H1 histamine receptors and cause sedation by inhibiting the actions of acetylcholine on muscarinic receptors in the CNS. Other special sedatives: Flunitrazepam (Rohypnol) – Not sold in the USA, but purchased online and commonly associated as a “date” rape drug the Zzzzs Zolpidem (Ambien), zaleplon

2018 CandiEM

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