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Yellow Nail Syndrome

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161. Distinct Patterns and Aetiology of Chromonychia. Full Text available with Trip Pro

Distinct Patterns and Aetiology of Chromonychia. Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20.9% (34/163) of cases. The most common subtype was melanonychia (54.0%; 88/163), followed by leukonychia (23.9%), red (8.6%), green (6.7%), yellow (4.9%) and blue (1.8%) nails (...) . Nail matrix naevus (33.3%; 29/88) was the most common cause of melanonychia, while skin diseases (41.0%; 16/39), such as psoriasis (75%, 12/16) and alopecia areata (18.8%; 3/16), in addition to systemic diseases (33.3%; 13/39) including anaemia (38.5%, 5/13) and chronic renal failure (15.4%; 2/13) were the dominant causes of leukonychia. As chromonychia may be the first or only sign of an underlying disorder, it should alert physicians and patients to the need for a prompt and thorough evaluation.

2017 Acta Dermato-Venereologica

162. Long Term Efficacy, Safety and Immunogenicity of Enerceptan in Rheumatoid Arthritis ( GEMENE002 )

23, 2018 Sponsor: Gema Biotech S.A. Collaborator: QUID Quality in Drugs and Devices Latin American Consulting SRL Information provided by (Responsible Party): Gema Biotech S.A. Study Details Study Description Go to Brief Summary: The purpose of this study is to asses the long term efficacy, safety and immunogenicity of ENERCEPTAN® in combination with Methotrexate for the treatment of patients with rheumatoid arthritis up to 104 weeks Condition or disease Intervention/treatment Phase Rheumatoid (...) or current serious medical conditions which had appeared during the study GEMENE001 that, in the opinion of the investigator, constitute a contraindication for the study treatment, as: Administration of vaccines: Subjects who have received a live attenuated vaccine within 3 months prior to the selection Visit (for example, varicella-zoster, oral polio, rabies, yellow fever vaccines.) Subjects who have received the BCG vaccine within the GEMENE001 study Presence of : a. At the time of the inclusion i

2017 Clinical Trials

163. Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR Full Text available with Trip Pro

, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region. Also, the patient presented tegumentary lesions on the scalp and lumbar region from which the histopathological examination was carried out, which evidenced yeasts cells. The drug of choice for therapy was Liposomal Amphotericin-B. At the end of the antifungal treatment, liver enzyme dosages were normalized (...) Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts

2017 Medical mycology case reports

164. A Study to See if Low Level Laser Light Can Help to Treat Toenail Fungus

the proximal fold Presence of dermatophytoma (thick masses of fungal hyphae and necrotic keratin between the nail plate and nail bed) Infection involving lunula e.g., genetic nail disorders, primentary disorders Severe plantar (moccasin) tinea pedis Psoriasis of the skin and/or nails, lichen planus, or other medical conditions known to induce nail changes Onychogryphosis Trauma from ill-fitting shoes, running, or overly-aggressive nail care Previous toenail surgery Uncontrolled diabetes mellitus Peripheral (...) , 2018 See Sponsor: Erchonia Corporation Information provided by (Responsible Party): Erchonia Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether low level laser therapy (LLLT) using the Erchonia LunulaLaser device is effective in clearing toenails with onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis of Toenail Device: Erchonia LunulaLaser Not Applicable Detailed Description: Nail onychomycosis, or fungus

2017 Clinical Trials

165. Patient Dignity (Formerly: Patient Modesty): Volume 93

to the unconscious but exposed patient? ..Maurice. AS OF JANUARY 6 2019 VOLUME 93 WILL BE CLOSE FOR FURTHER COMMENTS. GO TO FOR MAKING COMMENTS. posted by Maurice Bernstein, M.D. @ 175 Comments: At , said... Good Afternoon: Patient Modesty in Healthcare There’s an illness that’s moving like wildfire through our medical community. This illness effects everyone from the CEO down through the rank and file workers. We’ve seen illnesses like this before and they are very very strong however, there is a cure (...) for it. We have an antibiotic strong enough to kill it in its tracks but because the virus has spread so quickly throughout the medical community, the only way it will be effectively stopped, is if the entire medical community not just here and there to get inoculated. The illness is bad. Currently, the virus is showing up more everyday within the hallowed walls of our medical institutions. It rears its ugly head more often when dealing with male patients than female patients but it happens to both

2019 Bioethics Discussion Blog

166. Preserving Patient Dignity (Formerly: Patient Modesty):Volume 103

pharmaceutical “research” (choke) and how the public and physicians have been hoodwinked into believing that dangerous drugs/devices are the solution for just about every ill, and that for the most part these drugs are safe, or, at least better than the “disease” they are supposedly managing (never curing of course, for it is foundational to profit that people remain ill). We’ve seen that the makemsick industry is founded on the principle of poisoning as a path to “health,” and it is a vicious monopoly (...) of a building is rotten and said building is full of mold/rot/vermin (most makemsick minions) then it must be burned to the ground and built from scratch. A new medical model would involve real healing based on non poisonous methods. No, one can't do one's own kidney dialysis but looking at the broader picture much kidney disease is caused by allopathic drugs, so, one has to really look at the root causes of illness in the later 20th and now the 21st centuries. You stated previously that we should do our

2019 Bioethics Discussion Blog

167. Patient Dignity (Formerly: Patient Modesty): Volume 93

to the unconscious but exposed patient? ..Maurice. AS OF JANUARY 6 2019 VOLUME 93 WILL BE CLOSE FOR FURTHER COMMENTS. GO TO FOR MAKING COMMENTS. posted by Maurice Bernstein, M.D. @ 175 Comments: At , said... Good Afternoon: Patient Modesty in Healthcare There’s an illness that’s moving like wildfire through our medical community. This illness effects everyone from the CEO down through the rank and file workers. We’ve seen illnesses like this before and they are very very strong however, there is a cure (...) for it. We have an antibiotic strong enough to kill it in its tracks but because the virus has spread so quickly throughout the medical community, the only way it will be effectively stopped, is if the entire medical community not just here and there to get inoculated. The illness is bad. Currently, the virus is showing up more everyday within the hallowed walls of our medical institutions. It rears its ugly head more often when dealing with male patients than female patients but it happens to both

2019 Bioethics Discussion Blog

168. Preserving Patient Dignity (Formerly: Patient Modesty):Volume 106

totally agree with your answers, except there is no mention about what form of atonement they owe society. These are not only ill-gotten gains in their education, but are also crimes against humanity. The other issue that I have is no where have I seen in ANY medical education text or syllabus to owning up to past transgressions. Do you teach this to your students? You can NOT say the profession of medicine is unaware, just look at the history of PEs on anesthetized women without consent. But why (...) a doctor respect us, each and every one ? Why is compassion something doctors always hide? Why has humility never ev’n been tried? Ordering me to take their silly pills. Why don't they try to help me cure my ills? Why can't a doctor behave like a patient? If I was a doctor who'd been offered no hope, Received as a heartbreak to all within my scope. Would I walk casually to the next case? And act as if the prior man didn’t really need an embrace? Would I begin the next exam and really never see? Why

2019 Bioethics Discussion Blog

169. Family Practice Notebook Updates 2017

males Early disease (Stage Ia) responds well to local resection, but 75% of cases present with distant metastases (Stage IV) (ortho, wrist, neuro) motor deficit suggests severe, longstanding (or alternative condition) Neutral , avoidance of provocative activities and s are beneficial is very effective for more than 10 weeks and >1 year in some cases may be used instead of EMG prior to surgery Spectrum Disorder (peds, neuro, develop) Spectrum Disorder (ASD) has increased significantly over time (1 (...) in early pregnancy Newborn (neonatal abstinence syndrome) if maternal use No evidence of safety (gi, esophagus) Immune mediated esophagitis ( of the esophagus) that does not respond to management May present with solid , food impaction, anterior , and refractory Strongly associated with allergic conditions If management ineffective, try activating steroid MDI (e.g. HFA) and swallowing, not inhaling IV. Updates: October 2017 (geri, prevent) Approach falls as a sentinel event, a predictor of future falls

2018 FP Notebook

170. Blast Injury

Blast Injury Blast Injury Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Blast Injury Blast Injury Aka: Blast Injury , Explosion (...) Fragmentation occurs when projectiles (e.g. nails, bolts, nuts) are housed within the bomb Typically result in most significant secondary injuries Pressure and fragmentation effects fall off exponentially with distance from the blast Doubling the distance from the blast, results in a 9 fold drop in experienced force V. Adverse Effects: Primary Blast Injury Mechanism Injuries result from blast's direct pressure effects (especially high order explosives) Greatest injuries are to gas containing organs (middle

2018 FP Notebook

171. Onychomadesis

Related Chapters II. Definition Spontaneous separation of nail plate from nail matrix III. Epidemiology Uncommon IV. Pathophysiology Temporary cessation of nail matrix growth Results in and nail loss V. Signs Brittle nails Nail bed region may have white or yellow streaks Transverse nail splitting Spontaneous loss of multiple nails VI. Causes Post-infectious in first 3-12 weeks (esp. Coxsackie virus) Nail VII. References Jhun, Raam and DeClerck in Herbert (2015) EM:Rap 15(12): 3-4 Images: Related links (...) to external sites (from Bing) These images are a random sampling from a Bing search on the term "Onychomadesis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Onychomadesis (C0263540) Definition (NCI) Loss of all or a portion of a nail. Definition (NCI_CTCAE) A disorder characterized by loss of all or a portion of the nail. Concepts Sign or Symptom ( T184 ) SnomedCT 22743000 English Spont shed nail from matrix

2018 FP Notebook

172. Family Practice Notebook Updates 2017

males Early disease (Stage Ia) responds well to local resection, but 75% of cases present with distant metastases (Stage IV) (ortho, wrist, neuro) motor deficit suggests severe, longstanding (or alternative condition) Neutral , avoidance of provocative activities and s are beneficial is very effective for more than 10 weeks and >1 year in some cases may be used instead of EMG prior to surgery Spectrum Disorder (peds, neuro, develop) Spectrum Disorder (ASD) has increased significantly over time (1 (...) in early pregnancy Newborn (neonatal abstinence syndrome) if maternal use No evidence of safety (gi, esophagus) Immune mediated esophagitis ( of the esophagus) that does not respond to management May present with solid , food impaction, anterior , and refractory Strongly associated with allergic conditions If management ineffective, try activating steroid MDI (e.g. HFA) and swallowing, not inhaling IV. Updates: October 2017 (geri, prevent) Approach falls as a sentinel event, a predictor of future falls

2018 FP Notebook

173. Onychomycosis

are Onychomycosis Infection Candida ( ) l ( ) Periungual wart ( ) Local nail (e.g. tight footwear, manicures or pedicures) Skin conditions (especially s) Variant: Twenty- (children) Nail bed tumor Fibroma or (benign) Bowen Disease ( ) Miscellaneous causes References XI. Management: General Measures Keep feet dry Wear cotton socks and change 2-3 times per day Wear shoes that are breathable Reduce fungus exposure Wear foot protection in shared showers (locker room) Treat Consider nail removal in severe Optimize (...) are a random sampling from a Bing search on the term "Onychomycosis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Onychomycosis (C0040261) Definition (MSH) A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS. Definition (NCI) Fungal infection of a fingernail or toenail. Concepts Disease or Syndrome ( T047 ) MSH ICD9 110.1 ICD10 SnomedCT 186988000 , 30757001 , 266149008

2018 FP Notebook

174. Hypothyroidism

, resulting in deficiency of thyroid hormone. Definition (MSH) A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips. Concepts Disease or Syndrome ( T047 ) MSH ICD10 SnomedCT 190274003 , 154660000 , 267465007 , 43153006 English Myxedema , Myxedemas (...) , soles, elbows and knees Skin may show yellow-orange discoloration Dry coarse brittle hair (76%) Dry, longitudinally ridged nails Lateral eyebrow thinning Cardiopulmonary Faint cardiac impulse Indistinct heart tones Cardiac enlargement (severe Hypothyroidism) (severe Hypothyroidism) Variable effect on may be present Diastolic Gastrointestinal VII. Pearls: TSH Screening Indications All elderly with depression All elderly entering long term care VIII. Labs: Thyroid Function Tests See ing TSH

2018 FP Notebook

175. Acute Otitis Externa

Excessive ear canal hair canal Cotton swabs Matchsticks pins Earplugs s Finger nails Ear plugs VII. Symptoms Pain (85%) Skin tightly adherent to cartilage No room for inflammation compresses nerve fibers against cartilage Exacerbated by chewing and other auricle movement (66%) Precedes pain in acute inflammation Predominant symptom in chronic disease Acute Scant white mucus (may be thick) Chronic Bloody discharge with granulation tissue ( ) Fluffy discharge Color: white, black, gray, blue-green (...) EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE. Concepts Disease or Syndrome ( T047 ) MSH ICD10 , , SnomedCT 155215003 , 194224008 , 155209003 , 267667005 , 267751009 , 3135009 English Externa, Otitis , OTITIS EXTERNA , Otitis externa NOS , Otitis externa, unspecified , External Otitis , Otitides, External , Otitis, External , External Otitides , otitis externa (diagnosis) , otitis externa , External Ear Inflammation , Inflammation

2018 FP Notebook

176. Childhood Hematopoietic Cell Transplantation (PDQ®): Health Professional Version

A, von Stackelberg A, Schrappe M, et al.: Allogeneic hematopoietic SCT in children with ALL: current concepts of ongoing prospective SCT trials. Bone Marrow Transplant 41 (Suppl 2): S71-4, 2008. [ ] Bertaina A, Merli P, Rutella S, et al.: HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders. Blood 124 (5): 822-6, 2014. [ ] Handgretinger R, Chen X, Pfeiffer M, et al.: Feasibility and outcome of reduced-intensity conditioning (...) Risk of graft rejection Low Low–moderate Moderate–high Moderate–high Moderate–high Time to immune reconstitution a Rapid (6–12 mo) Moderate (6–18 mo) Slow (6–24 mo) Slow (6–24 mo) Slow (9–24 mo) b Risk of acute GVHD Moderate Moderate Moderate Low Low Risk of chronic GVHD High Moderate Low Low Low BM = bone marrow; EBV-LPD = Epstein-Barr virus–associated lymphoproliferative disorder; GVHD = graft-versus-host disease; HCT = hematopoietic cell transplantation; PBSCs = peripheral blood stem cells

2016 PDQ - NCI's Comprehensive Cancer Database

177. Jevtana - cabazitaxel

level NOEL: No observable effect level ORR Overall response rate OS Overall survival PD Progressive disease PFS Progression free survival PK Pharmacokinetic PP Per protocol PPI Present pain intensity PSA Prostate specific antigen SAE Serious adverse event SD Standard Deviation SmPC Summary of product characteristics SOP Standard operating procedure TEAE Treatment emergent adverse event TP Tumour progression TT Tumour type TTP Time to tumour progression VLDL Very low-density lipoprotein CHMP (...) based on applicants’ own tests and studies. Information on Paediatric requirements Pursuant to Article 7 of Regulation (EC) No 1901/2006, the application included an EMA Decision P/146/2009 for the following conditions: ? treatment of prostate carcinoma on the granting of a class waiver. Information relating to orphan market exclusivity Similarity Not applicable. Market Exclusivity Not applicable. Scientific Advice: The applicant received Scientific Advice from the CHMP on 19 March 2009

2011 European Medicines Agency - EPARs

178. Ivermectin Lotion 0.5% (Sklice)

Interactions 99 7.5.4 Drug-Disease Interactions 99 7.5.5 Drug-Drug Interactions 99 7.6 Additional Safety Evaluations 99 7.6.1 Human Carcinogenicity 99 7.6.2 Human Reproduction and Pregnancy Data 99 7.6.3 Pediatrics and Assessment of Effects on Growth 102 7.6.4 Overdose, Drug Abuse Potential, Withdrawal and Rebound 105 Reference ID: 3067484Clinical Review {Insert Reviewer Name} {Insert Application Type and Number} {Insert Product Trade and Generic Name} 4 7.7 Additional Submissions / Safety Issues 107 8 (...) erythema and application site irritation (from the approved product labeling). . Pharmaceutical products that are used off-label to treat head lice include oral ivermectin (discussed further in Section 7.2.6) with a potential for neurotoxicity and trimethoprim/ sulfamethoxazole with a risk of allergic rash and of Stevens Johnson syndrome. Physical, non-pharmacologic methods for treating lice include hair removal and occlusion (petroleum jelly, olive oil, mayonnaise, etc.). Another non-pharmacologic

2011 FDA - Drug Approval Package

179. Richard Lehman’s journal review—20 February 2017

useful 50% diminution in hair loss. Sublingual grass Whenever I read an article about sublingual grass pollen for seasonal allergy, I’m reminded of William Blake’s amazing print of Nebuchadnezzar eating grass. Readers versed in the Holy Scriptures will remember that the Assyrian king continued in this state until “seven times” passed over him, by which time his hairs were grown like eagles’ feathers and his nails like birds’ claws ( Daniel 4;33). Adults who use two years of sublingual grass therapy (...) that, you just looked at their middle. This is, in fact, a better indicator of risk, as people have been pointing out for decades. Best of all, you can do both, . And then you can see how much of the risk appears to be genetic, as you have their full genome as well. The conclusion of this study is that “A genetic predisposition to higher waist-to-hip ratio adjusted for body mass index was associated with increased risk of type 2 diabetes and coronary heart disease. These results provide evidence

2017 The BMJ Blog

180. Patient Modesty: Volume 91

a patient enters the procedure (except in critical ER presence) with with the autonomy capacity and opportunity to express in advance their gender requirements. Yet, there are patients who ask about gender attendance in advance or set their anticipated goal as a "cure" of their illness and not any physical modesty issues they bear. Is this an example of the profession's "lack of respect" toward the elements of the patient's fundamental dignity? What I am trying to do here in this posting is to separate (...) physicians that exposed this abhorrent behavior have ever apologized. In fact, just as is happening here, physicians attempt to justify the behavior by referring to lack of training opportunities and other paternalistic fallacies. You also continue to hold the position that it is the patients' faults for NOT speaking up. This is blatant VICTIM BLAMING. Just as with Women are made to feel ashamed for not fighting hard Patients labelled mentally ill Women are threatened into silence and punished

2018 Bioethics Discussion Blog

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