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Yellow Nail Syndrome

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141. Multiple abscesses in the lower extremities caused by Trichophyton rubrum. Full Text available with Trip Pro

Multiple abscesses in the lower extremities caused by Trichophyton rubrum. Dermatophytes are keratinophilic fungi, that usually infect the hair, stratum corneum, and nails. However, dermatophytes occasionally invade the dermis, subcutaneous tissues, and internal organs, resulting in a condition called deep dermatophytosis. We report a case of an unusual presentation of Trichophyton rubrum infection causing multiple fungal abscesses in the lower extremities of an immunocompromised patient.A 66 (...) -year-old male who had been receiving immunosuppressive drugs for 7 years developed numerous subcutaneous nodules in the lower extremities. The yellow purulent fluid obtained from the cyst was positive for T. rubrum. Topical bifonazole cream was effective for tinea pedis, but oral Sporanox 400 mg/day was discontinued after 2 months because the patient died from pneumonia after hospitalization for a lumbar fracture.Although deep dermatophytosis is very rare, dermatomycosis should be considered in any

2019 BMC Infectious Diseases

142. Nonimmune hydrops fetalis

of these are disorders associated with lymphatic dysfunction, such as Noonan and multiple pterygium syndrome, both of which frequently present with cystic hygroma; idiopathic chylothorax, in which a local pleuromediastinal lymph vessel disturbance occurs as the possible pathogenic mechanism; yellow nail syn- drome, a dominantly inherited congen- ital lymphedema syndrome; and congenitalpulmonary lymphangiectasia. Familial recurrence in some of these cases suggests a hereditary maldevelop- ment of lymphatic vessels (...) an- tigen A, also called anti-Ro, or the combinationantiSSA/RoorantiRo/SSA antibodies associated with maternal autoimmune disease. It may also result from structural abnormalities affecting cardiac conduction, as with endocardial cushion defects in the setting of a het- erotaxy syndrome. Once third-degree atrioventricular block has developed, treatment with corticosteroid therapy hasnotbeenshowntobebene?cial,and inthesettingofhydropstheprognosisis poor. 22 For thisreason, in-uterotherapy for fetal

2015 Society for Maternal-Fetal Medicine

143. Diagnosis and Management of Aplastic Anaemia

and exclude clonal evolution to myelodysplastic syndrome (MDS) or paroxysmal nocturnal haemoglobinuria (PNH), as this will influence the choice of conditioning. It is also vital not to miss constitutional AA so as to avoid (i) serious (and potentially lethal) toxicity from the transplant and (ii) inappropriate selection of a sibling donor. Grade 1C The Haematopoietic Cell Transplant Co‐morbidity Index or equivalent assessment should be documented. Grade 2B Alternatives to HSCT, including IST, should (...) putative drugs should be discontinued and the patient should not be re‐challenged. If a possible drug association is suspected, this must be reported to the Medicines and MHRA using the Yellow Card Scheme ( ). There is usually no hepatosplenomegaly or lymphadenopathy (except in infection). In young adults the presence of short stature, skin hyper/hypo pigmented areas and skeletal abnormalities, particularly affecting the thumb is suggestive of FA (Shimamura & Alter, ). The triad of nail dystrophy

2015 British Committee for Standards in Haematology

144. Guidelines for the treatment of malaria. Third edition

admission. The differential diagnosis of fever in a severely ill patient is broad. Coma and fever may be due to meningoencephalitis or malaria. Cerebral malaria is not associated with signs of meningeal irritation (neck stiffness, photophobia or Kernig’s sign), but the patient may be opisthotonic. As untreated bacterial meningitis is almost invariably fatal, a diagnostic lumbar puncture should be performed to exclude this condition. There is also considerable clinical overlap between septicaemia (...) , pneumonia and severe malaria, and these conditions may coexist. When possible, blood should always be taken on admission for bacterial culture. In malaria-endemic areas, particularly where parasitaemia is common in young age groups, it is difficult to rule out septicaemia immediately in a shocked or severely ill obtunded child. In all such cases, empirical parenteral broad-spectrum antibiotics should be started immediately, together with antimalarial treatment. 7.4 | TREATMENT OF SEVERE MALARIA

2015 World Health Organisation Guidelines

145. National hepatitis B testing policy

with a person with HBV infection, have a higher risk of acquiring hepatitis B. The virus can be transmitted by sharing personal or sharp objects such as razors, toothbrushes, ear-rings and nail clippers; it cannot be transmitted by casual contact through kissing, touching or sharing food utensils. Because HBV has the potential given the right environmental conditions to survive for at least 7 days on surfaces and objects contaminated with traces of blood, these objects remain infectious for a long time (...) Society for HIV Medicine, Viral Hepatitis and Sexual Health Medicine (ASHM). The views expressed in this Testing Policy are not necessarily those of the Commonwealth. The Commonwealth and the Blood Borne Virus and Sexually Transmissible Infections Standing Committee of the Australian Health Protection Committee do not accept any liability for any injury, illness, damage or loss incurred by any person arising from the use of or reliance on the information or advice that is provided in this Testing

2015 Clinical Practice Guidelines Portal

146. Prevention of skin cancer

not only serve for the structured transfer of © German Guideline Program in Oncology | Evidence-based Guideline on Prevention of Skin Cancer | April 2014 1.9 Other documents relating to this guideline 9 knowledge, but can also play a part in formulating health system structures. Examples that may be mentioned here are those of evidence-based guidelines as a basis for compiling and updating Disease Management Programmes or the use of quality indicators derived from guidelines for certifying organ tumour (...) involved Representative German Society of Pathology (DGP) PD Dr. Christian Rose* German Society of Paediatric and Adolescent Medicine (DGKJ) Prof. Dr. Peter Höger German Society of Urology (DGU) Prof. Dr. Jürgen Gschwend German Working Party for the Assistance of Persons with Disabilities and Chronic Diseases and their Relatives (BAG Selbsthilfe) Christiane Regensburger Otorhinolaryngology, Oral and Maxillofacial Surgical Oncology Working Group (AHMO) Prof. Dr. Jochen A. Werner (retired), PD Dr

2014 German Guideline Program in Oncology

147. HIV, viral hepatitis and STIs - a guide for primary care

– A GUIDE FOR PRIMARY HEALTH CARE iii HIV , VIRAL HEPATITIS & STIs A GUIDE FOR PRIMARY CARE 2014 EDITION EXPERT REFERENCE GROUP (EDITORIAL OVERSIGHT) Dr Michael Burke Nepean Sexual Health & HIV Clinic Ms Tracey Cabrie Victorian Infectious Diseases Service, Melbourne Health Associate Professor Ben Cowie Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, University of Melbourne Professor Greg Dore The Kirby Institute, UNSW Australia Dr Seamus Duffy Tuggerah Medical Centre Dr (...) , Tracey Cabrie, Benjamin Cowie, Gregory Dore, Seamus Duffy, Gail Matthews, Ronald McCoy, Anna McNulty, Simone Strasser, Catriona Ooi, David Youds and Iryna Zablotska COPY EDITOR Mary Sinclair PRINTED BY TTR Print Management INCLUDES INDEX HIV (Viruses) – Handbooks, manuals, etc. HIV infections – Handbooks, manuals, etc. Hepatitis, Viral – Handbooks, manuals, etc. Sexually transmitted diseases – Handbooks, manuals, etc. 616.9792 © Australasian Society for HIV Medicine Inc. 2014 ABN 48 264 545 457 CFN

2014 Clinical Practice Guidelines Portal

148. Assessment and Management of Foot Ulcers for People with Diabetes, Second Edition

and a significant risk factor for chronic kidney disease for people with diabetes (Scottish Intercollegiate Guidelines Network [SIGN], 2010). It may also be a risk factor for retinopathy in type 1 diabetes. Smoking cessation reduces these risks and may optimize conditions for wound healing (SIGN, 2010).20 REGISTERED NURSES’ ASSOCIATION OF ONTARIO RECOMMENDATIONS Assessment and Management of Foot Ulcers for People with Diabetes, Second Edition Glycemic Control (Level of Evidence = Ib) Improved glycemic control (...) and depth of wound bed . Ia – IV ? 1 . 2 Assess bed of foot ulcer(s) for exudate, odour, condition of peri-ulcer skin and pain . IV ? 1 . 3 Assess affected limb(s) for vascular supply and facilitate appropriate diagnostic testing, as indicated . III – IV ? 1 . 4 Assess foot ulcer(s) for infection G using clinical assessment techniques, based on signs and symptoms, and facilitate appropriate diagnostic testing, if indicated . Ia ? 1 . 5 Assess affected limb(s) for sensory, autonomic and motor changes

2013 Registered Nurses' Association of Ontario

149. Tavaborole in Difficult-to-Treat Onychomycosis Cases: A Post-hoc Assessment of Phase III Subjects. (Abstract)

Tavaborole in Difficult-to-Treat Onychomycosis Cases: A Post-hoc Assessment of Phase III Subjects. Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment (...) application of either tavaborole 5% solution or vehicle. Our post-hoc analysis identified 84 difficult-to-treat cases (tavaborole 5%; n=60; vehicle, n=24) in subjects with toenail onychomycosis due to Trichophyton rubrum or Trichophyton mentagrophytes. No subjects identified as difficult-to-treat and treated with vehicle achieved a complete cure, while 6 subjects treated with tavaborole 5% attained a completely clear nail and negative mycology. Similarly, 7 subjects treated with tavaborole 5% solution

2018 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

150. Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects. (Abstract)

Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects. Dermatophytoma is a little-known, difficult to treat fungal infection that complicates onychomycosis. First described by Roberts and Evans in the late 1990's, dermatophytoma presents as a dense concentration of fungal hyphae within or under the nail plate and is generally white or yellow/brown in color, and linear (streaks) or round (patches) in shape; primary (...) into the use of topical tavaborole for dermatophytoma, a condition previously thought to respond only to oral or combination therapy.

J Drugs Dermatol. 2018;17(3):347-354.

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2018 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

151. Votrient (pazopanib hydrochloride)

in view of its observed benefits. The following matters need to be further investigated via post-marketing surveillance: (1) the occurrence of hepatic function disorder, hypertension, cardiovascular events (including venous thromboembolic events), hemorrhagic events, pneumothorax, thyroid function abnormal, gastrointestinal perforations and gastrointestinal fistula, proteinuria and nephrotic syndrome, wound healing delayed, infections, posterior reversible encephalopathy syndrome, and interstitial (...) lung disease and (2) further safety information on the product in the patients with hepatic impairment and patients with soft tissue sarcoma of tumor types not evaluated in clinical studies. As a result of its regulatory review, the Pharmaceuticals and Medical Devices Agency has concluded that the product may be approved for the following indications and dosage and administration, with the following conditions for approval. [Indications] Soft tissue sarcoma [Dosage and administration] The usual

2012 Pharmaceuticals and Medical Devices Agency, Japan

152. Mirabegron (Myrbetriq)

in the NDA, both with possible concomitant allergic phenomena. Both of these cases had confounding factors. In one of these cases, Stevens-Johnson syndrome with reported, along with increased serum ALT, AST and builirubin in a patient taking mirabegron 100 mg and an acetaminophen-containing herbal medication. The risk benefit analysis is, in my opinion, satisfactory for NDA approval. The data provided in the Sponsor’s submissions support adequate directions for use, including the data to describe (...) with renal impairment were compared pharmacokinetically to healthy control volunteers who were matched for sex, age and weight. Following single dose administration of 100 mg mirabegron in volunteers with mild renal impairment (estimated glomerular filtration rate [eGFR] 60 to 89 mL/min/1.73 m2 as estimated using the Modification of Diet in Renal Disease [MDRD] equation), mean mirabegron C max and AUC inf were increased by 6% and 31% relative to volunteers with normal renal function. In volunteers

2012 FDA - Drug Approval Package

153. Preserving Patient Dignity (Formerly: Patient Modesty):Volume 103

pharmaceutical “research” (choke) and how the public and physicians have been hoodwinked into believing that dangerous drugs/devices are the solution for just about every ill, and that for the most part these drugs are safe, or, at least better than the “disease” they are supposedly managing (never curing of course, for it is foundational to profit that people remain ill). We’ve seen that the makemsick industry is founded on the principle of poisoning as a path to “health,” and it is a vicious monopoly (...) of a building is rotten and said building is full of mold/rot/vermin (most makemsick minions) then it must be burned to the ground and built from scratch. A new medical model would involve real healing based on non poisonous methods. No, one can't do one's own kidney dialysis but looking at the broader picture much kidney disease is caused by allopathic drugs, so, one has to really look at the root causes of illness in the later 20th and now the 21st centuries. You stated previously that we should do our

2019 Bioethics Discussion Blog

154. Patient Dignity (Formerly: Patient Modesty): Volume 93

to the unconscious but exposed patient? ..Maurice. AS OF JANUARY 6 2019 VOLUME 93 WILL BE CLOSE FOR FURTHER COMMENTS. GO TO FOR MAKING COMMENTS. posted by Maurice Bernstein, M.D. @ 175 Comments: At , said... Good Afternoon: Patient Modesty in Healthcare There’s an illness that’s moving like wildfire through our medical community. This illness effects everyone from the CEO down through the rank and file workers. We’ve seen illnesses like this before and they are very very strong however, there is a cure (...) for it. We have an antibiotic strong enough to kill it in its tracks but because the virus has spread so quickly throughout the medical community, the only way it will be effectively stopped, is if the entire medical community not just here and there to get inoculated. The illness is bad. Currently, the virus is showing up more everyday within the hallowed walls of our medical institutions. It rears its ugly head more often when dealing with male patients than female patients but it happens to both

2019 Bioethics Discussion Blog

155. Preserving Patient Dignity (Formerly: Patient Modesty):Volume 106

totally agree with your answers, except there is no mention about what form of atonement they owe society. These are not only ill-gotten gains in their education, but are also crimes against humanity. The other issue that I have is no where have I seen in ANY medical education text or syllabus to owning up to past transgressions. Do you teach this to your students? You can NOT say the profession of medicine is unaware, just look at the history of PEs on anesthetized women without consent. But why (...) a doctor respect us, each and every one ? Why is compassion something doctors always hide? Why has humility never ev’n been tried? Ordering me to take their silly pills. Why don't they try to help me cure my ills? Why can't a doctor behave like a patient? If I was a doctor who'd been offered no hope, Received as a heartbreak to all within my scope. Would I walk casually to the next case? And act as if the prior man didn’t really need an embrace? Would I begin the next exam and really never see? Why

2019 Bioethics Discussion Blog

156. Patient Dignity (Formerly: Patient Modesty): Volume 93

to the unconscious but exposed patient? ..Maurice. AS OF JANUARY 6 2019 VOLUME 93 WILL BE CLOSE FOR FURTHER COMMENTS. GO TO FOR MAKING COMMENTS. posted by Maurice Bernstein, M.D. @ 175 Comments: At , said... Good Afternoon: Patient Modesty in Healthcare There’s an illness that’s moving like wildfire through our medical community. This illness effects everyone from the CEO down through the rank and file workers. We’ve seen illnesses like this before and they are very very strong however, there is a cure (...) for it. We have an antibiotic strong enough to kill it in its tracks but because the virus has spread so quickly throughout the medical community, the only way it will be effectively stopped, is if the entire medical community not just here and there to get inoculated. The illness is bad. Currently, the virus is showing up more everyday within the hallowed walls of our medical institutions. It rears its ugly head more often when dealing with male patients than female patients but it happens to both

2019 Bioethics Discussion Blog

157. How “they” view “us”: Colton Berrett edition

the disconnect between how we view ourselves and how those whose misinformation we combat view us. Earlier this week, I wrote about the , the 17-year-old boy who four years ago developed transverse myelitis. The disease initially rendered him quadriplegic and landed him in the hospital for a month and a half. Prior to his illness, Colton was a highly active 13-year-old who enjoyed motocross and a variety of other sports. By all reports, he was happy, healthy, and on his way to a fantastic life. After his (...) is not a mistake. Michael J. Dochniak (MJD) Panacea writes, Researching a promising idea is not a mistake. MJD says, Orac has taught MJD that proving a negative is medically unethical, therefore, I’ve used common-sense teachings to induce exclusionary measures that may affect the disease/disorder incidence thereafter. In simplicity, stop what you’re doing and see what happens. I like Orac, although, once a decade. Panacea MJD: If that’s what you think Orac taught you, then you didn’t understand him

2018 Respectful Insolence

158. Oprah Winfrey for President? Does anyone remember all the pseudoscience and quackery she’s promoted?

this blog longer than seven years, because that’s the last time I wrote about Ms. Tinkham. Basically, Ms. Tinkham was diagnosed with breast cancer. Unfortunately, she was also inspired by Oprah and her promotion of The Secret to . It , though. It was of , whom you might remember as the man responsible for the “pH Miracle Living” quackery, where acid was The One True Cause of All Disease, particularly but also and , and who is now in . Tinkham was fortunate in that she did fairly well for three years (...) program said, “We don’t take positions on the opinions of our guests. Rather, we offer a platform for guests to share their first-person stories in an effort to inform the audience and put a human face on topics relevant to them.” When McCarthy’s views have been discussed on the air, statements from the Centers for Disease Control and Prevention and the American Academy of Pediatrics saying that there’s no scientific evidence of a vaccine-autism link have been read. Overall, Oprah had a malign

2018 Respectful Insolence

159. Childhood Hematopoietic Cell Transplantation (PDQ®): Health Professional Version

A, von Stackelberg A, Schrappe M, et al.: Allogeneic hematopoietic SCT in children with ALL: current concepts of ongoing prospective SCT trials. Bone Marrow Transplant 41 (Suppl 2): S71-4, 2008. [ ] Bertaina A, Merli P, Rutella S, et al.: HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders. Blood 124 (5): 822-6, 2014. [ ] Handgretinger R, Chen X, Pfeiffer M, et al.: Feasibility and outcome of reduced-intensity conditioning (...) Risk of graft rejection Low Low–moderate Moderate–high Moderate–high Moderate–high Time to immune reconstitution a Rapid (6–12 mo) Moderate (6–18 mo) Slow (6–24 mo) Slow (6–24 mo) Slow (9–24 mo) b Risk of acute GVHD Moderate Moderate Moderate Low Low Risk of chronic GVHD High Moderate Low Low Low BM = bone marrow; EBV-LPD = Epstein-Barr virus–associated lymphoproliferative disorder; GVHD = graft-versus-host disease; HCT = hematopoietic cell transplantation; PBSCs = peripheral blood stem cells

2016 PDQ - NCI's Comprehensive Cancer Database

160. Onychomadesis

Related Chapters II. Definition Spontaneous separation of nail plate from nail matrix III. Epidemiology Uncommon IV. Pathophysiology Temporary cessation of nail matrix growth Results in and nail loss V. Signs Brittle nails Nail bed region may have white or yellow streaks Transverse nail splitting Spontaneous loss of multiple nails VI. Causes Post-infectious in first 3-12 weeks (esp. Coxsackie virus) Nail VII. References Jhun, Raam and DeClerck in Herbert (2015) EM:Rap 15(12): 3-4 Images: Related links (...) to external sites (from Bing) These images are a random sampling from a Bing search on the term "Onychomadesis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Onychomadesis (C0263540) Definition (NCI) Loss of all or a portion of a nail. Definition (NCI_CTCAE) A disorder characterized by loss of all or a portion of the nail. Concepts Sign or Symptom ( T184 ) SnomedCT 22743000 English Spont shed nail from matrix

2018 FP Notebook

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