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Yellow Nail Syndrome

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81. Paraneoplastic Diseases (Follow-up)

Paraneoplastic Diseases (Follow-up) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) of hyperkeratosis and papillomatosis of the epidermis. Acanthosis is seldom present, and hyperpigmentation is related to hyperkeratosis, not melanin deposition; therefore, the condition is misnamed. Not all patients with AN have a paraneoplastic syndrome. Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined

2014 eMedicine.com

82. Oral Manifestations of Systemic Diseases (Follow-up)

of other disorders, including sarcoidosis, Melkersson-Rosenthal syndrome, and tuberculosis. [ ] Thus, it is not surprising that some patients with orofacial granulomatoses may subsequently develop intestinal manifestations of Crohn disease, but histologic similarities between the oral lesions and the intestinal lesions are evident. Nonspecific oral findings of Crohn disease (ie, lesions for which histology does not reveal granulomatous change) are more common than the specific oral findings (...) : Hematologic Disorders Hematologic malignancies and blood cell dyscrasias are a remarkably diverse collection of diseases with numerous systemic sequelae. The etiology, diagnostic criteria, prognosis, and treatment of each condition is unique and complex. As such, a complete analysis is not within the scope of this review. The oral manifestations of numerous hematologic disorders are summarized. Please refer to the references for more detailed information. [ ] White blood cell disorders Leukemia Leukemia

2014 eMedicine.com

83. Nonneoplastic Epithelial Disorders of the Vulva (Follow-up)

. [ ] Congenital malformations involving the vulvar region include the following: Ambiguous external genitalia Congenital labial hypertrophy Atrophy of the vulva may also occur. Next: Etiology and Pathophysiology Nonneoplastic epithelial disorders are discussed below. Inflammatory diseases Lichen sclerosus The etiology of this condition is unknown. [ ] A higher prevalence of the disease in postmenopausal women suggests hormonal factors, but this has not been confirmed. [ , ] A 2008 study demonstrated that oral (...) nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia

2014 eMedicine.com

84. Milroy Disease (Follow-up)

, Lin YC. Verruciform xanthoma-like phenomenon in seborrheic keratosis. J Cutan Pathol . 2006 May. 33(5):373-7. . Chavda LK, Vaidya RA, Vaidya AD. Yellow nail syndrome: missed diagnosis of a rare syndrome. J Assoc Physicians India . 2011 Apr. 59:258-60. . Ghalamkarpour A, Morlot S, Raas-Rothschild A, Utkus A, Mulliken JB, Boon LM, et al. Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations. Clin Genet . 2006 Oct. 70(4):330-5. . Vignes S (...) of Kaposis sarcoma: report of a case and review of the literature. Int J Dermatol . 2006 May. 45(5):499-503. . Offori TW, Platt CC, Stephens M, Hopkinson GB. Angiosarcoma in congenital hereditary lymphoedema (Milroy's disease)--diagnostic beacons and a review of the literature. Clin Exp Dermatol . 1993 Mar. 18(2):174-7. . Sharma A, Schwartz RA. Stewart-Treves syndrome: Pathogenesis and management. J Am Acad Dermatol . 2012 Jun 7. . Atillasoy ES, Santoro A, Weinberg JM. Lymphoedema associated with Kaposi

2014 eMedicine.com

85. External Ear, Inflammatory Diseases

a fourth of individuals diagnosed with relapsing polychondritis develop a second autoimmune disorder. Associated diseases include rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, Hashimoto thyroiditis, pernicious anemia, Sjögren syndrome, and ulcerative colitis. Laboratory abnormalities that may support the diagnosis include mild anemia and an elevated erythrocyte sedimentation rate. In the early stages of the disease, 30-60% of patients have detectable levels of antibodies (...) . Table 2. Differential Diagnoses of Common External Ear Inflammatory Conditions Disease Etiology and Epidemiology Lesion Description Differential Diagnoses Atopic dermatitis Systemic disorder commonly seen in families with history of asthma, allergic rhinitis, or other atopic disorders Erythematous scaly crusts, fluid-filled lesions, or both Postauricular fissures may be present Allergic dermatitis Contact dermatitis Seborrheic dermatitis Neurodermatitis Psoriasis Allergic contact dermatitis Delayed

2014 eMedicine Surgery

86. Dermatologic Manifestations of Hematologic Disease (Follow-up)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary (...) and secondary. [ , ] Secondary antiphospholipid syndrome is often associated with and infrequently with other diseases, such as lymphoproliferative disorders, autoimmune diseases, infections (eg, , HIV, ), and drugs (eg, procainamide, quinidine, hydralazine, phenytoin, chlorpromazine). Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. The APS diagnosis should meet the revised Sapporo criteria (also called the Sydney

2014 eMedicine.com

87. Dermatologic Manifestations of Cardiac Disease (Follow-up)

with cyanotic congenital heart diseases (eg, tetralogy of Fallot, Eisenmenger syndrome). It is also seen in persons with infective endocarditis. The differential diagnosis may include hereditary, idiopathic, constitutional, or acquired conditions. The acquired causes include pulmonary conditions (ie, primary and metastatic lung cancer, bronchiectasis, lung abscess, cystic fibrosis, mesothelioma) or gastrointestinal diseases (ie, regional enteritis, ulcerative colitis, cirrhosis). Schematic representation (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NDI2OS1vdmVydmlldw== processing > Dermatologic Manifestations of Cardiac Disease Updated: Apr 26, 2016 Author: Stephanie M Gallitano, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Cardiac Disease Overview Overview Cardiovascular disorders and therapies are often associated with a variety of dermatologic manifestations. Frequently, these cutaneous signs can

2014 eMedicine.com

88. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Follow-up)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

89. Dermatologic Manifestations of Pulmonary Disease (Follow-up)

of their disease with treatment, although relapses are common. Churg-Strauss syndrome is a rare multisystem disorder that primarily affects the lungs, peripheral nervous system, and skin. Churg and Strauss' initial description of the syndrome in 1951 required histologic criteria to establish the diagnosis. Clinical and laboratory criteria have been more difficult to establish. Asthma, peripheral blood eosinophilia, and extrapulmonary vasculitis affecting 2 or more organs are cardinal clinical manifestations (...) granuloma, characterized by a necrotic core surrounded by densely packed eosinophils. Treatment Most patients with Churg-Strauss syndrome respond well to high-dosage corticosteroids. For those who do not, alternate therapies include azathioprine, cyclophosphamide, and intravenous immunoglobulin (IVIG). Relapsing polychondritis is a rare multisystem disorder of unknown etiology. [ , ] The disease is characterized by recurrent, and typically progressive, bouts of inflammation of cartilaginous structures

2014 eMedicine.com

90. Dermatologic Manifestations of Renal Disease (Follow-up)

Kaposi sarcoma Systemic sclerosis Malignant hypertension Diffuse scleroderma Amyloidosis Nephrotic syndrome Purpura Macroglossia Fabry disease Nephrotic syndrome Angiokeratomas Nail-patella syndrome Renal tubular defects Absent/displaced patella Absent/pitted nails Tuberous sclerosis Renal hamartomas Renal cell carcinoma Adenoma sebaceum Ash-leaf macule Periungual fibromas Shagreen patch ESRD = end-stage renal disease Diabetes mellitus Many cutaneous disorders are associated with diabetes mellitus (...) , primarily or membranous glomerulonephritis, results from glomerular damage from circulating immune complexes. Human immunodeficiency virus Cutaneous disease occurs in 60-100% of patients infected with human immunodeficiency virus (HIV). Seborrheic dermatitis, the most common cutaneous condition seen in individuals infected with HIV, usually develops early and increases in severity as the CD4 count falls. Other cutaneous disorders are relatively unique to patients with acquired immunodeficiency syndrome

2014 eMedicine.com

91. Dermatologic Manifestations of Pulmonary Disease (Diagnosis)

of their disease with treatment, although relapses are common. Churg-Strauss syndrome is a rare multisystem disorder that primarily affects the lungs, peripheral nervous system, and skin. Churg and Strauss' initial description of the syndrome in 1951 required histologic criteria to establish the diagnosis. Clinical and laboratory criteria have been more difficult to establish. Asthma, peripheral blood eosinophilia, and extrapulmonary vasculitis affecting 2 or more organs are cardinal clinical manifestations (...) granuloma, characterized by a necrotic core surrounded by densely packed eosinophils. Treatment Most patients with Churg-Strauss syndrome respond well to high-dosage corticosteroids. For those who do not, alternate therapies include azathioprine, cyclophosphamide, and intravenous immunoglobulin (IVIG). Relapsing polychondritis is a rare multisystem disorder of unknown etiology. [ , ] The disease is characterized by recurrent, and typically progressive, bouts of inflammation of cartilaginous structures

2014 eMedicine.com

92. Dermatologic Manifestations of Hematologic Disease (Diagnosis)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary (...) and secondary. [ , ] Secondary antiphospholipid syndrome is often associated with and infrequently with other diseases, such as lymphoproliferative disorders, autoimmune diseases, infections (eg, , HIV, ), and drugs (eg, procainamide, quinidine, hydralazine, phenytoin, chlorpromazine). Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. The APS diagnosis should meet the revised Sapporo criteria (also called the Sydney

2014 eMedicine.com

93. Dermatologic Manifestations of Cardiac Disease (Diagnosis)

with cyanotic congenital heart diseases (eg, tetralogy of Fallot, Eisenmenger syndrome). It is also seen in persons with infective endocarditis. The differential diagnosis may include hereditary, idiopathic, constitutional, or acquired conditions. The acquired causes include pulmonary conditions (ie, primary and metastatic lung cancer, bronchiectasis, lung abscess, cystic fibrosis, mesothelioma) or gastrointestinal diseases (ie, regional enteritis, ulcerative colitis, cirrhosis). Schematic representation (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NDI2OS1vdmVydmlldw== processing > Dermatologic Manifestations of Cardiac Disease Updated: Apr 26, 2016 Author: Stephanie M Gallitano, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Cardiac Disease Overview Overview Cardiovascular disorders and therapies are often associated with a variety of dermatologic manifestations. Frequently, these cutaneous signs can

2014 eMedicine.com

94. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Diagnosis)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

95. Dermatologic Manifestations of Renal Disease (Diagnosis)

Kaposi sarcoma Systemic sclerosis Malignant hypertension Diffuse scleroderma Amyloidosis Nephrotic syndrome Purpura Macroglossia Fabry disease Nephrotic syndrome Angiokeratomas Nail-patella syndrome Renal tubular defects Absent/displaced patella Absent/pitted nails Tuberous sclerosis Renal hamartomas Renal cell carcinoma Adenoma sebaceum Ash-leaf macule Periungual fibromas Shagreen patch ESRD = end-stage renal disease Diabetes mellitus Many cutaneous disorders are associated with diabetes mellitus (...) , primarily or membranous glomerulonephritis, results from glomerular damage from circulating immune complexes. Human immunodeficiency virus Cutaneous disease occurs in 60-100% of patients infected with human immunodeficiency virus (HIV). Seborrheic dermatitis, the most common cutaneous condition seen in individuals infected with HIV, usually develops early and increases in severity as the CD4 count falls. Other cutaneous disorders are relatively unique to patients with acquired immunodeficiency syndrome

2014 eMedicine.com

96. A prospective study of cutaneous abnormalities in patients with chronic kidney disease Full Text available with Trip Pro

at least one cutaneous abnormality attributable to CKD. The most prevalent finding was xerosis (66.7%), followed by pallor (45.45%), pruritus (43.4%), and cutaneous pigmentation (32.3%). Other cutaneous manifestations included dermatitis (27.27%); Kyrle's disease (17.17%); fungal (8.08%), bacterial (11.1%), and viral (5.05%) infections; purpura (10.1%); gynecomastia (4.04%); and yellow skin (5.05%). The common nail changes were half and half nails (36.36%) and onycholysis (13.13%). CKD is associated (...) A prospective study of cutaneous abnormalities in patients with chronic kidney disease There are diverse ways in which the skin is affected by chronic kidney disease (CKD). Various specific and nonspecific skin abnormalities are observed in patients with CKD. The aim of the study was to document the prevalence of skin diseases that commonly occur in patients with CKD on medical treatment and dialysis. A total of 99 patients with CKD were examined for evidence of skin diseases. Ninety-six had

2012 Indian Journal of Nephrology

97. COVID-19: infection prevention and control

or yellow bag waste; local guidance will be provided depending on the impact of the disease) 5.4.1 Disposable apron/gown Disposable plastic aprons must be worn to protect staff uniform or clothes from contamination when providing direct patient care and during environmental and equipment decontamination. Fluid-resistant gowns must be worn when a disposable plastic apron provides inadequate cover of staff uniform or clothes for the procedure/task being performed and when there is a risk of COVID-19 (...) Appendix 5: Best Practice - Management of blood and body fluid spillages 44 Appendix 6: Facial hair and FFP3 respirators 45 Appendix 7 Glossary 46 COVID-19: Guidance for infection prevention and control in healthcare settings. Version 1.1, 27/03/20 Page 5 of 52 References 52 Abbreviations ABHR Alcohol based hand rub AGP CDC DHSC Aerosol generating procedure Centers for Disease Control and Prevention Department of Health and Social Care FRSM FFP3 Fluid-resistant (Type IIR) surgical mask Filtering face

2020 Public Health England

98. Trastuzumab (Ogivri) - breast cancer or stomach cancer

for solution for infusion (powder for concentrate). White to pale yellow lyophilised powder. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Breast cancer Metastatic breast cancer Ogivri is indicated for the treatment of adult patients with HER2 positive metastatic breast cancer (MBC): - as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. Prior chemotherapy must have included at least an anthracycline and a taxane unless (...) of such a late onset and should be instructed to contact their physician if these symptoms occur. Pulmonary events Severe pulmonary events have been reported with the use of trastuzumab in the post-marketing setting (see section 4.8). These events have occasionally been fatal. In addition, cases of interstitial lung disease including lung infiltrates, acute respiratory distress syndrome, pneumonia, pneumonitis, pleural effusion, respiratory distress, acute pulmonary oedema and respiratory insufficiency have

2019 European Medicines Agency - EPARs

99. Dermatophyte infections

, vesicles, and maceration vesicles, pustules with or without bullae on the soles fissuring, maceration, and scaling in the interdigital spaces of the fourth and fifth toes chronically scaly, hyperkeratotic plantar skin with erythema of the soles, heels, and sides of the feet folliculitis with nodules thickened nail with subungual hyperkeratosis, onycholysis, and white-yellow to brown discoloration small, white speckled patches on the surface of the nail plate with crumbling nail lymphadenopathy absence (...) of distal pulses black-dot alopecia milky white nail plate area of leukonychia in the proximal nail plate exposure to infected people, animals, or soil exposure to fomites including hat, combs, hairbrushes, and upholstery wrestling chronic topical or oral corticosteroid use HIV diabetes mellitus and other metabolic disorders occlusive clothing hot, humid weather obesity hyperhidrosis frequenting public bathing areas while barefoot deformities of the feet recurrent trauma to the skin atopic dermatitis

2018 BMJ Best Practice

100. Neratinib (Nerlynx) - Breast cancer, breast neoplasms

efficacy 113 2.5.4. Conclusions on the clinical efficacy 118 2.6. Clinical safety 119 2.6.1. Discussion on clinical safety 136 2.6.2. Conclusions on the clinical safety 139 2.7. Risk Management Plan 139 2.8. Pharmacovigilance 142 2.9. New Active Substance 142 Assessment report EMA/CHMP/525204/2018 Page 3/169 2.10. Product information 142 2.10.1. User consultation 142 2.10.2. Additional monitoring 142 3. Benefit-Risk Balance 142 3.1. Therapeutic Context 142 3.1.1. Disease or condition 142 3.1.2 (...) 3.8. Conclusions 147 4. Recommendations 147 5. Re-examination of the CHMP opinion of 22 February 2018 148 5.1. Risk Management Plan 155 5.2. Pharmacovigilance 159 5.3. Product information 159 5.3.1. User consultation 159 5.3.2. Additional monitoring 159 6. Benefit-risk balance following re-examination 159 6.1. Therapeutic Context 159 6.1.1. Disease or condition 159 6.1.2. Available therapies and unmet medical need 160 6.1.3. Main clinical studies 160 6.2. Favourable effects 160 6.3. Uncertainties

2018 European Medicines Agency - EPARs

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