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Yellow Nail Syndrome

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61. Nonneoplastic Epithelial Disorders of the Vulva (Overview)

. [ ] Congenital malformations involving the vulvar region include the following: Ambiguous external genitalia Congenital labial hypertrophy Atrophy of the vulva may also occur. Next: Etiology and Pathophysiology Nonneoplastic epithelial disorders are discussed below. Inflammatory diseases Lichen sclerosus The etiology of this condition is unknown. [ ] A higher prevalence of the disease in postmenopausal women suggests hormonal factors, but this has not been confirmed. [ , ] A 2008 study demonstrated that oral (...) nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia

2014 eMedicine.com

62. Milroy Disease (Overview)

this defect is congenital or acquired is difficult to determine. As the rarest form of primary lymphedema, this disease accounts for only 10% of cases. Histologically, patients are likely to demonstrate a hyperplastic pattern, with tortuous lymphatics increased in caliber and number. Associated conditions As mentioned, primary lymphedema is seen in association with various cutaneous and genetic disorders. Distichiasis lymphedema syndrome is a form of hereditary early and late-onset lymphedema associated (...) , strabismus, thoracic duct abnormalities, and microphthalmia. Primary lymphedema has also been associated with yellow nail syndrome. This entity may be associated with recurrent pleural effusions and bronchiectasis. Other genetic syndromes and cutaneous conditions associated with primary lymphedema include the following: Turner syndrome Noonan syndrome Klinefelter syndrome Neurofibromatosis type 1 Hemangiomas Xanthomatosis Congenital absence of nails One case reportedly occurred in association with CHARGE

2014 eMedicine.com

63. Dermatologic Manifestations of Pulmonary Disease (Treatment)

of their disease with treatment, although relapses are common. Churg-Strauss syndrome is a rare multisystem disorder that primarily affects the lungs, peripheral nervous system, and skin. Churg and Strauss' initial description of the syndrome in 1951 required histologic criteria to establish the diagnosis. Clinical and laboratory criteria have been more difficult to establish. Asthma, peripheral blood eosinophilia, and extrapulmonary vasculitis affecting 2 or more organs are cardinal clinical manifestations (...) granuloma, characterized by a necrotic core surrounded by densely packed eosinophils. Treatment Most patients with Churg-Strauss syndrome respond well to high-dosage corticosteroids. For those who do not, alternate therapies include azathioprine, cyclophosphamide, and intravenous immunoglobulin (IVIG). Relapsing polychondritis is a rare multisystem disorder of unknown etiology. [ , ] The disease is characterized by recurrent, and typically progressive, bouts of inflammation of cartilaginous structures

2014 eMedicine.com

64. Dermatologic Manifestations of Hematologic Disease (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary (...) and secondary. [ , ] Secondary antiphospholipid syndrome is often associated with and infrequently with other diseases, such as lymphoproliferative disorders, autoimmune diseases, infections (eg, , HIV, ), and drugs (eg, procainamide, quinidine, hydralazine, phenytoin, chlorpromazine). Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. The APS diagnosis should meet the revised Sapporo criteria (also called the Sydney

2014 eMedicine.com

65. Dermatologic Manifestations of Cardiac Disease (Treatment)

with cyanotic congenital heart diseases (eg, tetralogy of Fallot, Eisenmenger syndrome). It is also seen in persons with infective endocarditis. The differential diagnosis may include hereditary, idiopathic, constitutional, or acquired conditions. The acquired causes include pulmonary conditions (ie, primary and metastatic lung cancer, bronchiectasis, lung abscess, cystic fibrosis, mesothelioma) or gastrointestinal diseases (ie, regional enteritis, ulcerative colitis, cirrhosis). Schematic representation (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NDI2OS1vdmVydmlldw== processing > Dermatologic Manifestations of Cardiac Disease Updated: Apr 26, 2016 Author: Stephanie M Gallitano, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Cardiac Disease Overview Overview Cardiovascular disorders and therapies are often associated with a variety of dermatologic manifestations. Frequently, these cutaneous signs can

2014 eMedicine.com

66. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Treatment)

?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen (...) by urologists. For most of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made

2014 eMedicine.com

67. Dermatologic Manifestations of Renal Disease (Treatment)

Kaposi sarcoma Systemic sclerosis Malignant hypertension Diffuse scleroderma Amyloidosis Nephrotic syndrome Purpura Macroglossia Fabry disease Nephrotic syndrome Angiokeratomas Nail-patella syndrome Renal tubular defects Absent/displaced patella Absent/pitted nails Tuberous sclerosis Renal hamartomas Renal cell carcinoma Adenoma sebaceum Ash-leaf macule Periungual fibromas Shagreen patch ESRD = end-stage renal disease Diabetes mellitus Many cutaneous disorders are associated with diabetes mellitus (...) , primarily or membranous glomerulonephritis, results from glomerular damage from circulating immune complexes. Human immunodeficiency virus Cutaneous disease occurs in 60-100% of patients infected with human immunodeficiency virus (HIV). Seborrheic dermatitis, the most common cutaneous condition seen in individuals infected with HIV, usually develops early and increases in severity as the CD4 count falls. Other cutaneous disorders are relatively unique to patients with acquired immunodeficiency syndrome

2014 eMedicine.com

68. Paraneoplastic Diseases (Treatment)

Paraneoplastic Diseases (Treatment) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) of hyperkeratosis and papillomatosis of the epidermis. Acanthosis is seldom present, and hyperpigmentation is related to hyperkeratosis, not melanin deposition; therefore, the condition is misnamed. Not all patients with AN have a paraneoplastic syndrome. Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined

2014 eMedicine.com

69. Oral Manifestations of Systemic Diseases (Treatment)

of other disorders, including sarcoidosis, Melkersson-Rosenthal syndrome, and tuberculosis. [ ] Thus, it is not surprising that some patients with orofacial granulomatoses may subsequently develop intestinal manifestations of Crohn disease, but histologic similarities between the oral lesions and the intestinal lesions are evident. Nonspecific oral findings of Crohn disease (ie, lesions for which histology does not reveal granulomatous change) are more common than the specific oral findings (...) : Hematologic Disorders Hematologic malignancies and blood cell dyscrasias are a remarkably diverse collection of diseases with numerous systemic sequelae. The etiology, diagnostic criteria, prognosis, and treatment of each condition is unique and complex. As such, a complete analysis is not within the scope of this review. The oral manifestations of numerous hematologic disorders are summarized. Please refer to the references for more detailed information. [ ] White blood cell disorders Leukemia Leukemia

2014 eMedicine.com

70. Milroy Disease (Treatment)

, Lin YC. Verruciform xanthoma-like phenomenon in seborrheic keratosis. J Cutan Pathol . 2006 May. 33(5):373-7. . Chavda LK, Vaidya RA, Vaidya AD. Yellow nail syndrome: missed diagnosis of a rare syndrome. J Assoc Physicians India . 2011 Apr. 59:258-60. . Ghalamkarpour A, Morlot S, Raas-Rothschild A, Utkus A, Mulliken JB, Boon LM, et al. Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations. Clin Genet . 2006 Oct. 70(4):330-5. . Vignes S (...) of Kaposis sarcoma: report of a case and review of the literature. Int J Dermatol . 2006 May. 45(5):499-503. . Offori TW, Platt CC, Stephens M, Hopkinson GB. Angiosarcoma in congenital hereditary lymphoedema (Milroy's disease)--diagnostic beacons and a review of the literature. Clin Exp Dermatol . 1993 Mar. 18(2):174-7. . Sharma A, Schwartz RA. Stewart-Treves syndrome: Pathogenesis and management. J Am Acad Dermatol . 2012 Jun 7. . Atillasoy ES, Santoro A, Weinberg JM. Lymphoedema associated with Kaposi

2014 eMedicine.com

71. Nonneoplastic Epithelial Disorders of the Vulva (Treatment)

. [ ] Congenital malformations involving the vulvar region include the following: Ambiguous external genitalia Congenital labial hypertrophy Atrophy of the vulva may also occur. Next: Etiology and Pathophysiology Nonneoplastic epithelial disorders are discussed below. Inflammatory diseases Lichen sclerosus The etiology of this condition is unknown. [ ] A higher prevalence of the disease in postmenopausal women suggests hormonal factors, but this has not been confirmed. [ , ] A 2008 study demonstrated that oral (...) nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia

2014 eMedicine.com

72. Paraneoplastic Diseases (Overview)

Paraneoplastic Diseases (Overview) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) of hyperkeratosis and papillomatosis of the epidermis. Acanthosis is seldom present, and hyperpigmentation is related to hyperkeratosis, not melanin deposition; therefore, the condition is misnamed. Not all patients with AN have a paraneoplastic syndrome. Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined

2014 eMedicine.com

73. Naegeli-Franceschetti-Jadassohn Syndrome (Overview)

is entry 161000 in the database. [ ] The syndrome is allelic to . In 1927, Naegeli first described the syndrome as familiärer Chromatophoren-Naevus in a Swiss family. In 1954, Franceschetti and Jadassohn further analyzed the syndrome, as did Itin and colleagues in 1993. NFJ syndrome is a reticulate pigmentary disorder. Other reticulate pigmentary diseases include X-linked reticulate pigmentary disorder, dermatopathia pigmentosa reticularis, , dyschromatosis, , and reticulated acropigmentation (...) . Close encoded search term (Naegeli-Franceschetti-Jadassohn Syndrome) and Naegeli-Franceschetti-Jadassohn Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Most Popular Articles According to Dermatologists Recommended 2002 1117926-overview Diseases & Conditions Diseases & Conditions 2002 1116793-overview Diseases & Conditions Diseases & Conditions 2001 /viewarticle/888224 Journal Article Journal Article 2002 1110595-overview Diseases

2014 eMedicine.com

74. Oral Manifestations of Systemic Diseases (Overview)

of other disorders, including sarcoidosis, Melkersson-Rosenthal syndrome, and tuberculosis. [ ] Thus, it is not surprising that some patients with orofacial granulomatoses may subsequently develop intestinal manifestations of Crohn disease, but histologic similarities between the oral lesions and the intestinal lesions are evident. Nonspecific oral findings of Crohn disease (ie, lesions for which histology does not reveal granulomatous change) are more common than the specific oral findings (...) : Hematologic Disorders Hematologic malignancies and blood cell dyscrasias are a remarkably diverse collection of diseases with numerous systemic sequelae. The etiology, diagnostic criteria, prognosis, and treatment of each condition is unique and complex. As such, a complete analysis is not within the scope of this review. The oral manifestations of numerous hematologic disorders are summarized. Please refer to the references for more detailed information. [ ] White blood cell disorders Leukemia Leukemia

2014 eMedicine.com

75. Loose Anagen Syndrome (Overview)

consistently associated with any other disorder; however, individual cases associated with the following syndromes have been reported (associations were most likely coincidental): Noonan syndrome [ ] Ocular coloboma syndrome [ ] Trichorhinophalangeal syndrome Nail-patella syndrome Hypohidrotic ectodermal dysplasia and ectrodactyly-ectodermal dysplasia-clefting syndrome [ ] Acquired immunodeficiency syndrome Woolly hair [ ] Alopecia areata Loose anagen syndrome with features resembling uncombable hair (...) Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Loose Anagen Syndrome) and Loose Anagen Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Most Popular Articles According to Dermatologists Recommended 2002 1072899-overview Diseases & Conditions Diseases

2014 eMedicine.com

76. Dermatologic Manifestations of Pulmonary Disease (Overview)

circulation) and fat embolism syndrome (a systemic disorder that may be life threatening) is critical. Fat embolism occurs in as many as 90% of patients with long bone fractures; fat embolism syndrome is much less common (estimated rate of 1-2%). Treatment The mortality rate for patients with fat embolism syndrome is substantial (approximately 5-10%), and therapy is primarily supportive. Prognosis is primarily dependent upon the degree of respiratory compromise. Previous Next: Yellow Nail Syndrome First (...) ) into the right atrium. occurs when blood flow through the SVC is impeded, either by extrinsic compression or intraluminal narrowing. A 1992 review underscores the importance of observing and interpreting the dermatologic findings in this condition. [ ] Many patients with this syndrome were initially diagnosed by dermatologists after referral for evaluation of a rash on the upper chest. Malignant neoplasm is by far the most common cause. Thrombosis of the SVC is encountered more frequently in critically ill

2014 eMedicine.com

77. Dermatologic Manifestations of Hematologic Disease (Overview)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary (...) and secondary. [ , ] Secondary antiphospholipid syndrome is often associated with and infrequently with other diseases, such as lymphoproliferative disorders, autoimmune diseases, infections (eg, , HIV, ), and drugs (eg, procainamide, quinidine, hydralazine, phenytoin, chlorpromazine). Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. The APS diagnosis should meet the revised Sapporo criteria (also called the Sydney

2014 eMedicine.com

78. Dermatologic Manifestations of Cardiac Disease (Overview)

with cyanotic congenital heart diseases (eg, tetralogy of Fallot, Eisenmenger syndrome). It is also seen in persons with infective endocarditis. The differential diagnosis may include hereditary, idiopathic, constitutional, or acquired conditions. The acquired causes include pulmonary conditions (ie, primary and metastatic lung cancer, bronchiectasis, lung abscess, cystic fibrosis, mesothelioma) or gastrointestinal diseases (ie, regional enteritis, ulcerative colitis, cirrhosis). Schematic representation (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NDI2OS1vdmVydmlldw== processing > Dermatologic Manifestations of Cardiac Disease Updated: Apr 26, 2016 Author: Stephanie M Gallitano, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Cardiac Disease Overview Overview Cardiovascular disorders and therapies are often associated with a variety of dermatologic manifestations. Frequently, these cutaneous signs can

2014 eMedicine.com

79. Dermatologic Diseases of the Male Genitalia: Nonmalignant (Overview)

=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDU1MDIxLW92ZXJ2aWV3 processing > Nonmalignant Dermatologic Diseases of the Male Genitalia Updated: Feb 11, 2017 Author: Douglas C Parker, MD, DDS; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Nonmalignant Dermatologic Diseases of the Male Genitalia Introduction, Definition of Terms, and Anatomy Nonmalignant lesions account for most dermatologic disorders seen by urologists. For most (...) of these conditions, the diagnosis can be ascertained through clinical history and presentation, but, on occasion, biopsy may be necessary. This review focuses on cutaneous diseases that are either specific to the male genitalia or frequently involve this body region. Topics in this article are divided into groups based on their initial clinical presentation and most common clinical appearance. The discussion focuses on diagnosis, treatment, and clinical outcome. Attempts are made to include the most recent

2014 eMedicine.com

80. Dermatologic Manifestations of Renal Disease (Overview)

Kaposi sarcoma Systemic sclerosis Malignant hypertension Diffuse scleroderma Amyloidosis Nephrotic syndrome Purpura Macroglossia Fabry disease Nephrotic syndrome Angiokeratomas Nail-patella syndrome Renal tubular defects Absent/displaced patella Absent/pitted nails Tuberous sclerosis Renal hamartomas Renal cell carcinoma Adenoma sebaceum Ash-leaf macule Periungual fibromas Shagreen patch ESRD = end-stage renal disease Diabetes mellitus Many cutaneous disorders are associated with diabetes mellitus (...) , primarily or membranous glomerulonephritis, results from glomerular damage from circulating immune complexes. Human immunodeficiency virus Cutaneous disease occurs in 60-100% of patients infected with human immunodeficiency virus (HIV). Seborrheic dermatitis, the most common cutaneous condition seen in individuals infected with HIV, usually develops early and increases in severity as the CD4 count falls. Other cutaneous disorders are relatively unique to patients with acquired immunodeficiency syndrome

2014 eMedicine.com

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