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Yellow Nail Syndrome

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41. Psoriasis, Nails (Follow-up)

, a Critical Images slideshow, to help identify conditions associated with various nail abnormalities. For patient education information, see the and , as well as , , , and . Next: Pathophysiology of Nail Psoriasis The pathogenesis of the psoriatic nail disorder is not completely known. Nail psoriasis may be due to a combination of genetic, environmental, and immune factors. A well-known fact is that a familial aggregation of psoriasis exists. Studies have linked psoriasis with certain human leukocyte (...) starts distally and progresses proximally, causing a traumatic uplifting of the distal nail plate. Secondary microbial colonization may occur. Nail plate crumbling Nail plate weakening due to disease of the underlying structures causes this condition. Splinter hemorrhage/dilated tortuous capillaries in the dermal papillae Splinter hemorrhages are longitudinal black lines due to minute foci of capillary hemorrhage between the nail bed and the nail plate. This is analogous to the Auspitz sign

2014 eMedicine.com

42. Nail Surgery (Follow-up)

> Nail Surgery Treatment & Management Updated: Feb 15, 2019 Author: Neh Onumah, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Nail Surgery Treatment Approach Considerations Nail treatment and surgical options must be individualized based on the nail condition, extent of disease, type of organism, and medical comorbidities. Patients with factors that predispose to infection, such as uncontrolled diabetes, prior methicillin-resistant Staphylococcus aureus (...) , such as onychauxis, onychogryphosis, onycholysis, psoriatic nail, symptomatic onychomycosis that is unresponsive to aggressive antifungal therapy, and painful nail conditions, including pincer nail deformity. [ , , , ] For most of these conditions, matricectomy is the definitive cure. When a decision is made to perform matricectomy, a complete or partial procedure can be completed. Most commonly, a partial matricectomy (the removal of the diseased portion of the nail matrix with an attempt to preserve

2014 eMedicine.com

43. Nail Surgery (Treatment)

> Nail Surgery Treatment & Management Updated: Feb 15, 2019 Author: Neh Onumah, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Nail Surgery Treatment Approach Considerations Nail treatment and surgical options must be individualized based on the nail condition, extent of disease, type of organism, and medical comorbidities. Patients with factors that predispose to infection, such as uncontrolled diabetes, prior methicillin-resistant Staphylococcus aureus (...) , such as onychauxis, onychogryphosis, onycholysis, psoriatic nail, symptomatic onychomycosis that is unresponsive to aggressive antifungal therapy, and painful nail conditions, including pincer nail deformity. [ , , , ] For most of these conditions, matricectomy is the definitive cure. When a decision is made to perform matricectomy, a complete or partial procedure can be completed. Most commonly, a partial matricectomy (the removal of the diseased portion of the nail matrix with an attempt to preserve

2014 eMedicine.com

44. Psoriasis, Nails (Diagnosis)

, a Critical Images slideshow, to help identify conditions associated with various nail abnormalities. For patient education information, see the and , as well as , , , and . Next: Pathophysiology of Nail Psoriasis The pathogenesis of the psoriatic nail disorder is not completely known. Nail psoriasis may be due to a combination of genetic, environmental, and immune factors. A well-known fact is that a familial aggregation of psoriasis exists. Studies have linked psoriasis with certain human leukocyte (...) starts distally and progresses proximally, causing a traumatic uplifting of the distal nail plate. Secondary microbial colonization may occur. Nail plate crumbling Nail plate weakening due to disease of the underlying structures causes this condition. Splinter hemorrhage/dilated tortuous capillaries in the dermal papillae Splinter hemorrhages are longitudinal black lines due to minute foci of capillary hemorrhage between the nail bed and the nail plate. This is analogous to the Auspitz sign

2014 eMedicine.com

45. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011;2(1):2. doi: 10.1186/2040-2392-2-2. PMID: 21303513.X-1 653. Greer RD, Pistoljevic N, Cahill C, et al. Effects of conditioning voices as reinforcers for listener responses on rate of learning, awareness, and preferences for listening to stories in preschoolers with autism. Anal Verbal Behav. 2011;27(1):103- 24. PMID: 22532758.X-1, X-3, X-4 D-56 654. Griffith GM, Hastings RP, Oliver C, et al. Psychological well-being in parents (...) of children with Angelman, Cornelia de Lange and Cri du Chat syndromes. J Intellect Disabil Res. 2011 Apr;55(4):397-410. doi: 10.1111/j.1365-2788.2011.01386.x. PMID: 21323782.X-1 655. Grow LL, Carr JE, Kodak TM, et al. A comparison of methods for teaching receptive labeling to children with autism spectrum disorders. J Appl Behav Anal. 2011 Fall;44(3):475-98. doi: 10.1901/jaba.2011.44-475. PMID: 21941380.X-3, X-4 656. Guénolé F, Baleyte J-M. Melatonin for sleep-disturbed children with autism spectrum

2017 Effective Health Care Program (AHRQ)

46. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

of childhood that leads to coronary artery aneurysms in ≈25% of untreated cases. It has been reported worldwide and is the leading cause of acquired heart disease in children in developed countries. Methods and Results: To revise the previous American Heart Association guidelines, a multidisciplinary writing group of experts was convened to review and appraise available evidence and practice-based opinion, as well as to provide updated recommendations for diagnosis, treatment of the acute illness, and long (...) and current involvement. Patients with aneurysms require life-long and uninterrupted cardiology follow-up. Conclusions: These recommendations provide updated and best evidence-based guidance to healthcare providers who diagnose and manage Kawasaki disease, but clinical decision making should be individualized to specific patient circumstances. Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause that predominantly affects children <5 years of age. When initially described

2017 American Heart Association

47. Complex regional pain syndrome in adults. UK guidelines for diagnosis, referral and management in primary and secondary care 2018 (2nd edition)

trauma, atherosclerosis in older people or thrombangiitis obliterans (Burger’s disease)) ? Raynaud’s disease ? lymphatic or venous obstruction ? Gardner–Diamond syndrome (see the list of differential diagnoses in the Rheumatology, neurology, neurosurgery and SEM section) ? brachial neuritis or plexitis (Parsonage–Turner syndrome or neuralgic amyotrophy) ? erythromelalgia (may include all limbs) ? self-harm Table 2 Earlier names for CRPS Algodystrophy Causalgia Algoneurodystrophy Reflex sympathetic (...) dystrophy Sudeck’s atrophy Shoulder–hand syndrome Reflex neurovascular dystrophy Fracture disease CRPS can be divided into two types based on the absence (type 1, much more common) or presence (type 2) of a lesion to a major nerve. Currently this distinction has no relevance for management, ‡ but it can have importance in some medico-legal cases. CRPS type 1 is accompanied by minimal distal small nerve fibre injury in some cases. 24 Treatment approach Pain is typically the leading symptom of CRPS

2018 British Society of Rehabilitation Medicine

48. Nail Discoloration

, Elszíneződés köröm , Discoloratio unguum Derived from the NIH UMLS ( ) Ontology: Leukonychia (C0240182) Definition (NCI) Any white discoloration of the nails or nail plates. Concepts Disease or Syndrome ( T047 ) SnomedCT 111202002 Dutch leuconychia French Leuconychie German Leukonychie Italian Leuconichia Portuguese Leuconíquia Spanish Leuconiquia , leuconiquia (trastorno) , leuconiquia Japanese 爪甲白斑 , ソウコウハクハン English nail discoloration white (leukonychia) , leukonychia , leukonychia (physical finding (...) melanonychie French Mélanonychie German Melanonychie Italian Melanonichia Portuguese Melanoníquia Spanish Melanoniquia , melanoniquia (trastorno) , melanoniquia Japanese 黒爪症 , コクソウショウ Czech Melanonychie English melanonychia , Melanonychia striata , Melanonychia , Melanonychia (disorder) Hungarian Melanonychia Derived from the NIH UMLS ( ) Ontology: Yellow nails (C1768507) Concepts Sign or Symptom ( T184 ) SnomedCT 247512005 , 45342007 English Yellow nails , yellow nails (symptom) , yellow nails , Yellow

2015 FP Notebook

49. An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents

, ages >/= 6 years and nail); and with positive KOH and positive culture for T. rubrum or T. mentagrophytes from either great toenail Exclusion Criteria: the target toenail has proximal subungual onychomycosis, onychomycosis involving the nail lunula, superficial white onychomycosis, dermatophytoma, exclusively lateral disease, or yellow or brown spikes, or has (...) applied the topical solution to all 10 toenails and a small area of surrounding skin during the first 28 days. These subjects had blood samples analyzed to evaluate the pharmacokinetics (how the drug moves in the body) of tavaborole topical solution in children and adolescents. Condition or disease Intervention/treatment Phase Onychomycosis Tinea Unguium Drug: Tavaborole 5% Topical Solution Phase 4 Detailed Description: This was an open-label study to evaluate the safety, tolerability

2018 Clinical Trials

50. Monitoring of Nonsteroidal Immunosuppressive Drugs in Patients With Lung Disease and Lung Transplant Recipients

controlled trial; SIRS 5 systemic in? ammatory response syndrome; TNF 5 tumor necrosis factor; TPMT 5 thiopurine methyltransferase Monitoring of Nonsteroidal Immunosuppressive Drugs in Patients With Lung Disease and Lung Transplant Recipients American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Robert P . Baughman , MD , FCCP ; Keith C . Meyer , MD , FCCP ; Ian Nathanson , MD , FCCP ; Luis Angel , MD , FCCP ; Sangeeta M . Bhorade , MD , FCCP ; Kevin M . Chan , MD , FCCP (...) with no history of demyelin- ating disease who undergo anti-TNF- a therapy and experience symptoms or display signs of a demyelinating process, discontinuation of ther- apy is suggested (Grade 2C) . 3.1k. For patients who undergo anti-TNF- a therapy and develop symptoms of a lupus-like disorder, discontinuation of therapy is suggested (Grade 2C) . 3.1l. For patients who will undergo anti-TNF- a therapy and who are at risk for viral hepatitis, serologic screening for hepatitis B is recom- mended prior

2012 American College of Chest Physicians

51. Nail Deformities and Dystrophies

triangular lunulae and partially absent thumb nails. Patients with Darier disease can have nails with red and white streaks and a distal V-shaped nick. Deformities and dystrophies associated with systemic problems In (esophageal webs caused by severe, untreated iron deficiency), 50% of patients have koilonychia (concave, spoon-shaped nails). Koilonychia DR P. MARAZZI/SCIENCE PHOTO LIBRARY Yellow nail syndrome (characterized by hard, hypercurved, transversely thickened, yellow nails) occurs in patients (...) with lymphedema of limbs and/or chronic respiratory disorders. Yellow Nail Syndrome © Springer Science+Business Media Half-and-half nails (Lindsay nails) occur usually with ; the proximal half of the nail is white, and the distal half is pink or pigmented. Lindsay Nails (Half-and-Half Nails) © Springer Science+Business Media White nails occur with , although the distal third may remain pinker. Terry Nails © Springer Science+Business Media Beau Lines Due to Chemotherapy © Springer Science+Business Media Beau

2013 Merck Manual (19th Edition)

52. Yellow nail syndrome in association with renal cell carcinoma in an elderly patient. Full Text available with Trip Pro

Yellow nail syndrome in association with renal cell carcinoma in an elderly patient. A case of yellow nail syndrome in an 88-year-old man in association with renal cell carcinoma was reported.

2010 Age and ageing

53. Titanium, Sinusitis, and the Yellow Nail Syndrome Full Text available with Trip Pro

Titanium, Sinusitis, and the Yellow Nail Syndrome Yellow nail syndrome is characterized by nail changes, respiratory disorders, and lymphedema. In a yellow nail patient with a skeletal titanium implant and with gold in her teeth, we found high levels of titanium in nail clippings. This study aims to examine the possible role of titanium in the genesis of the yellow nail syndrome. Nail clippings from patients with one or more features of the yellow nail syndrome were analyzed by energy (...) was derived from titanium dioxide in drugs and confectionary. Stopping galvanic release of titanium ions or canceling exposure to titanium dioxide led to recovery. In one patient with a titanium implant, the symptoms recurred after renewed exposure to titanium. Yellow nail syndrome is caused by titanium.

2010 Biological trace element research

54. Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Study Of PF-04447943, Co-Administered With And Without Hydroxyurea, In Subjects With Stable Sickle Cell Disease

of an investigational drug, PF-04447943, in subjects with stable sickle cell disease with and without co-administration with hydroxyurea. This study will also aid in selecting the doses for future studies and evaluation of substances in the blood which may help access the effectiveness of the drug. Condition or disease Intervention/treatment Phase Phase 1 Sickle Cell Drug: PDE9i Drug: placebo for PDE9i Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual (...) ; fatigue; chronic pain; acute pain; infections; fever; swelling hands; swelling feet; abdominal swelling; pale skin; pale nail beds; yellow tint to skin; whites of eyes turned yellow; stroke. Number of participants with changes from baseline deemed potentially clinically important by the investigator is presented. Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) [ Time Frame: Day 1 to 30 days post last dose on Day 29 ] An adverse event (AE) was any

2014 Clinical Trials

55. Paraneoplastic Diseases (Treatment)

Paraneoplastic Diseases (Treatment) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) of hyperkeratosis and papillomatosis of the epidermis. Acanthosis is seldom present, and hyperpigmentation is related to hyperkeratosis, not melanin deposition; therefore, the condition is misnamed. Not all patients with AN have a paraneoplastic syndrome. Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined

2014 eMedicine.com

56. Paraneoplastic Diseases (Overview)

Paraneoplastic Diseases (Overview) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) of hyperkeratosis and papillomatosis of the epidermis. Acanthosis is seldom present, and hyperpigmentation is related to hyperkeratosis, not melanin deposition; therefore, the condition is misnamed. Not all patients with AN have a paraneoplastic syndrome. Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined

2014 eMedicine.com

57. Oral Manifestations of Systemic Diseases (Overview)

of other disorders, including sarcoidosis, Melkersson-Rosenthal syndrome, and tuberculosis. [ ] Thus, it is not surprising that some patients with orofacial granulomatoses may subsequently develop intestinal manifestations of Crohn disease, but histologic similarities between the oral lesions and the intestinal lesions are evident. Nonspecific oral findings of Crohn disease (ie, lesions for which histology does not reveal granulomatous change) are more common than the specific oral findings (...) : Hematologic Disorders Hematologic malignancies and blood cell dyscrasias are a remarkably diverse collection of diseases with numerous systemic sequelae. The etiology, diagnostic criteria, prognosis, and treatment of each condition is unique and complex. As such, a complete analysis is not within the scope of this review. The oral manifestations of numerous hematologic disorders are summarized. Please refer to the references for more detailed information. [ ] White blood cell disorders Leukemia Leukemia

2014 eMedicine.com

58. Milroy Disease (Overview)

this defect is congenital or acquired is difficult to determine. As the rarest form of primary lymphedema, this disease accounts for only 10% of cases. Histologically, patients are likely to demonstrate a hyperplastic pattern, with tortuous lymphatics increased in caliber and number. Associated conditions As mentioned, primary lymphedema is seen in association with various cutaneous and genetic disorders. Distichiasis lymphedema syndrome is a form of hereditary early and late-onset lymphedema associated (...) , strabismus, thoracic duct abnormalities, and microphthalmia. Primary lymphedema has also been associated with yellow nail syndrome. This entity may be associated with recurrent pleural effusions and bronchiectasis. Other genetic syndromes and cutaneous conditions associated with primary lymphedema include the following: Turner syndrome Noonan syndrome Klinefelter syndrome Neurofibromatosis type 1 Hemangiomas Xanthomatosis Congenital absence of nails One case reportedly occurred in association with CHARGE

2014 eMedicine.com

59. Naegeli-Franceschetti-Jadassohn Syndrome (Overview)

is entry 161000 in the database. [ ] The syndrome is allelic to . In 1927, Naegeli first described the syndrome as familiärer Chromatophoren-Naevus in a Swiss family. In 1954, Franceschetti and Jadassohn further analyzed the syndrome, as did Itin and colleagues in 1993. NFJ syndrome is a reticulate pigmentary disorder. Other reticulate pigmentary diseases include X-linked reticulate pigmentary disorder, dermatopathia pigmentosa reticularis, , dyschromatosis, , and reticulated acropigmentation (...) . Close encoded search term (Naegeli-Franceschetti-Jadassohn Syndrome) and Naegeli-Franceschetti-Jadassohn Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Most Popular Articles According to Dermatologists Recommended 2002 1117926-overview Diseases & Conditions Diseases & Conditions 2002 1116793-overview Diseases & Conditions Diseases & Conditions 2001 /viewarticle/888224 Journal Article Journal Article 2002 1110595-overview Diseases

2014 eMedicine.com

60. Dermatologic Manifestations of Pulmonary Disease (Overview)

circulation) and fat embolism syndrome (a systemic disorder that may be life threatening) is critical. Fat embolism occurs in as many as 90% of patients with long bone fractures; fat embolism syndrome is much less common (estimated rate of 1-2%). Treatment The mortality rate for patients with fat embolism syndrome is substantial (approximately 5-10%), and therapy is primarily supportive. Prognosis is primarily dependent upon the degree of respiratory compromise. Previous Next: Yellow Nail Syndrome First (...) ) into the right atrium. occurs when blood flow through the SVC is impeded, either by extrinsic compression or intraluminal narrowing. A 1992 review underscores the importance of observing and interpreting the dermatologic findings in this condition. [ ] Many patients with this syndrome were initially diagnosed by dermatologists after referral for evaluation of a rash on the upper chest. Malignant neoplasm is by far the most common cause. Thrombosis of the SVC is encountered more frequently in critically ill

2014 eMedicine.com

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