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Yellow Nail Syndrome

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21. Yellow Nail Syndrome

Yellow Nail Syndrome Yellow Nail Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Yellow Nail Syndrome Yellow Nail Syndrome (...) Aka: Yellow Nail Syndrome From Related Chapters II. Epidemiology Rare III. Pathophysiology Delayed Results in nails heaping-up and thickening May be associated with microvascular permeability Hypoalbuminemia IV. Signs Convex (heaped-up) nails with loss of lunula Nail with yellow hue V. Associated Conditions (e.g. ) Thiol Medications (e.g. gold thiomalate) VI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Yellow

2015 FP Notebook

22. Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer Full Text available with Trip Pro

Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer 22605706 2013 02 12 2018 11 13 1757-790X 2012 2012 Mar 20 BMJ case reports BMJ Case Rep Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. 10.1136/bcr.11.2011.5183 bcr1120115183 Taki Hirofumi H First Department of Internal Medicine, University of Toyama, Toyama, Toyama, Japan. htaki-tym@umin.ac.jp Tobe Kazuyuki K eng Case Reports (...) Journal Article 2012 03 20 England BMJ Case Rep 101526291 1757-790X 0 Sulfhydryl Compounds IM Arthritis, Rheumatoid complications Bronchiectasis diagnosis Diagnosis, Differential Humans Lymphedema diagnosis Stomach Neoplasms complications diagnosis surgery Sulfhydryl Compounds adverse effects Yellow Nail Syndrome complications diagnosis 2012 5 19 6 0 2012 5 19 6 0 2013 2 13 6 0 epublish 22605706 bcr.11.2011.5183 10.1136/bcr.11.2011.5183 PMC3316821 Thorax. 1966 May;21(3):247-53 5914998 Chest. 1972 May

2012 BMJ case reports

23. Yellow-nail syndrome: report of three cases. Full Text available with Trip Pro

Yellow-nail syndrome: report of three cases. The yellow nail syndrome, a combination of yellow discolouration of and dystrophic changes in the nails, pleural effusions and lymphedema, is thought to be relatively rare; to date 44 cases have been reported. Of a further three patients with this syndrome, one had all three features, one had the yellow nails alone and the other had pleural effusions and lymphedema without classic nail changes. Each had recurrent lower respiratory tract infections (...) ; and of all 47, chronic pulmonary infections occurred in approximately one quarter and were frequently associated with chronic sinus infections. The underlying abnormality is presumed to be a congenital defect of the lymphatics, but so far this has not been demonstrated to be the cause of the nail changes, the pathogenesis of which remains obscure.

1976 Canadian Medical Association Journal

24. Cardiac infarction and yellow nail syndrome. Full Text available with Trip Pro

Cardiac infarction and yellow nail syndrome. 4835273 1974 09 03 2018 11 13 0035-9157 67 5 1974 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Cardiac infarction and yellow nail syndrome. 323 Scott J J eng Case Reports Journal Article England Proc R Soc Med 7505890 0035-9157 0 Antibodies 0 Diuretics 9PHQ9Y1OLM Prednisolone IM Aged Antibodies Blood Cell Count Diuretics therapeutic use Edema drug therapy Humans Lymphography Male Myocardial Infarction complications Nails (...) Pigmentation Prednisolone therapeutic use Radiography Syndrome 1974 5 1 1974 5 1 0 1 1974 5 1 0 0 ppublish 4835273 PMC1645549 Chest. 1972 May;61(5):452-8 5046843 Postgrad Med J. 1973 May;49(571):364-5 4804460 Br J Dermatol. 1964 Apr;76:153-7 14140738

1974 Proceedings of the Royal Society of Medicine

25. Yellow nail syndrome in rheumatoid arthritis: report of three cases. Full Text available with Trip Pro

Yellow nail syndrome in rheumatoid arthritis: report of three cases. We report the occurrence of the yellow nail syndrome in 3 patients with rheumatoid arthritis. In 2 patients the development of the syndrome was related to severe chest infections, and there was evidence of immunodeficiency, consisting in 1 case of a persistently low serum IgA level and in the other of a generalised marrow suppression. The third patient gave a history of recurrent sinusitis and showed evidence of previous chest (...) infections and pulmonary fibrosis, but has no gross evidence of immunodeficiency. We have found only 1 previous brief mention of a patient with the yellow nail syndrome and rheumatoid arthritis.

1979 Annals of the Rheumatic Diseases

26. Yellow nail syndrome: with familiar primary hypoplasia of lymphatics, manifest late in life. Full Text available with Trip Pro

Yellow nail syndrome: with familiar primary hypoplasia of lymphatics, manifest late in life. 5933133 1966 07 28 2018 11 13 0035-9157 59 5 1966 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Yellow nail syndrome: with familiar primary hypoplasia of lymphatics, manifest late in life. 447 Wells G C GC eng Case Reports Journal Article England Proc R Soc Med 7505890 0035-9157 IM Humans Lymphedema genetics Male Middle Aged Nails Pigmentation Disorders genetics 1966 5 1 1966 5 1 0

1966 Proceedings of the Royal Society of Medicine

27. Yellow nail syndrome with bilateral bronchiectasis. Full Text available with Trip Pro

Yellow nail syndrome with bilateral bronchiectasis. 5933134 1966 07 28 2018 11 13 0035-9157 59 5 1966 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Yellow nail syndrome with bilateral bronchiectasis. 448 Zefras A J AJ eng Case Reports Journal Article England Proc R Soc Med 7505890 0035-9157 IM Bronchiectasis complications Child Female Humans Nails Pigmentation Disorders complications 1966 5 1 1966 5 1 0 1 1966 5 1 0 0 ppublish 5933134 PMC1900910 Proc R Soc Med. 1965 Dec;58

1966 Proceedings of the Royal Society of Medicine

28. Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis

. Patients with proximal subungual involvement (marker of immunosuppressed patient). Patients with severe plantar or moccasin tinea pedis (defined by blistering, pustules or inability to ambulate). Patients with nail abnormalities due to conditions like psoriasis, lichen planus, immune dysfunction, collagen-vascular diseases, peripheral vascular disease. Patients with life expectancy less than 2 years. Chemotherapy, immunosuppressive therapy in the 12 weeks prior to Screening visit (V1). Systemic (...) , 2017 Last Update Posted : January 10, 2018 Sponsor: Polichem S.A. Collaborator: Almirall, S.A. Information provided by (Responsible Party): Polichem S.A. Study Details Study Description Go to Brief Summary: The aim of this phase III study is to establish the efficacy and safety of P-3058 (terbinafine 10% nail solution) topically administered once weekly in patients with onychomycosis in comparison to the Vehicle in a double-blind fashion. The overall treatment period will be of 48 weeks. Condition

2017 Clinical Trials

29. Nail Discoloration

, Elszíneződés köröm , Discoloratio unguum Derived from the NIH UMLS ( ) Ontology: Leukonychia (C0240182) Definition (NCI) Any white discoloration of the nails or nail plates. Concepts Disease or Syndrome ( T047 ) SnomedCT 111202002 Dutch leuconychia French Leuconychie German Leukonychie Italian Leuconichia Portuguese Leuconíquia Spanish Leuconiquia , leuconiquia (trastorno) , leuconiquia Japanese 爪甲白斑 , ソウコウハクハン English nail discoloration white (leukonychia) , leukonychia , leukonychia (physical finding (...) melanonychie French Mélanonychie German Melanonychie Italian Melanonichia Portuguese Melanoníquia Spanish Melanoniquia , melanoniquia (trastorno) , melanoniquia Japanese 黒爪症 , コクソウショウ Czech Melanonychie English melanonychia , Melanonychia striata , Melanonychia , Melanonychia (disorder) Hungarian Melanonychia Derived from the NIH UMLS ( ) Ontology: Yellow nails (C1768507) Concepts Sign or Symptom ( T184 ) SnomedCT 247512005 , 45342007 English Yellow nails , yellow nails (symptom) , yellow nails , Yellow

2018 FP Notebook

30. Yellow nails and oedema. Full Text available with Trip Pro

Yellow nails and oedema. 5078443 1972 12 21 2018 11 13 0007-1447 4 5833 1972 Oct 21 British medical journal Br Med J Yellow nails and oedema. 130 eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Humans Lymphatic System abnormalities Lymphedema complications Nails, Malformed etiology Pigmentation Disorders etiology 1972 10 21 1972 10 21 0 1 1972 10 21 0 0 ppublish 5078443 PMC1786423 Thorax. 1966 May;21(3):247-53 5914998 Chest. 1972 May;61(5):452-8 5046843 Br J Dermatol. 1964 Apr;76

1972 British medical journal

31. Generalized lymphoedema with yellow nails, pleural effusions, and macroglobulinemia. Full Text available with Trip Pro

Generalized lymphoedema with yellow nails, pleural effusions, and macroglobulinemia. 4989238 1970 10 13 2018 11 13 0035-9157 63 5 1970 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Generalized lymphoedema with yellow nails, pleural effusions, and macroglobulinemia. 456 D'Souza M F MF Mahon W E WE eng Journal Article England Proc R Soc Med 7505890 0035-9157 27O7W4T232 Spironolactone IM Aged Blood Protein Electrophoresis Female Humans Lymphedema complications drug therapy (...) Nails Pigmentation Disorders complications Pleural Effusion complications Proteinuria Spironolactone therapeutic use Waldenstrom Macroglobulinemia complications 1970 5 1 1970 5 1 0 1 1970 5 1 0 0 ppublish 4989238 PMC1811839 Thorax. 1966 May;21(3):247-53 5914998 JAMA. 1968 May 20;204(8):670-3 5694508 Harvey Lect. 1960-1961;56:211-31 14004528 Radiology. 1964 Feb;82:246-8 14115303 Br J Dermatol. 1964 Apr;76:153-7 14140738

1970 Proceedings of the Royal Society of Medicine

32. Pleural effusions and yellow nails of late onset Full Text available with Trip Pro

Pleural effusions and yellow nails of late onset 4804460 1975 04 19 2018 11 13 0032-5473 49 571 1973 May Postgraduate medical journal Postgrad Med J Pleural effusions and yellow nails of late onset. 364-5 Eastwood H D HD Williams T J TJ eng Journal Article England Postgrad Med J 0234135 0032-5473 IM Aged Humans Lymphatic Diseases complications Lymphedema etiology Male Nails Pigmentation Disorders etiology Pleural Effusion etiology 1973 5 1 1973 5 1 0 1 1973 5 1 0 0 ppublish 4804460 PMC2495862

1973 Postgraduate medical journal

33. Unequal breasts, yellow nails, bronchiectasis and lymphedema. Full Text available with Trip Pro

Unequal breasts, yellow nails, bronchiectasis and lymphedema. 5767837 1969 06 25 2018 11 13 0008-4409 100 9 1969 Mar 01 Canadian Medical Association journal Can Med Assoc J Unequal breasts, yellow nails, bronchiectasis and lymphedema. 437-8 Bowers D D eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 AIM IM Adult Breast Diseases complications Bronchiectasis complications Female Humans Lymphedema complications Nails, Malformed complications 1969 3 1 1969 3 1 0 1 1969 3 1 0 0 ppublish

1969 Canadian Medical Association Journal

34. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology Full Text available with Trip Pro

and collecting specimens for analysis for a disease process. It is very easy to access critical information about a specific body site just by consulting the table of contents. Within each chapter, there is a table describing the specimen needs regarding a variety of etiologic agents that one may suspect as causing the illness. The test methods in the tables are listed in priority order according to the recommendations of the authors and reviewers. When room temperature is specified for a certain time period (...) A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious

2018 Infectious Diseases Society of America

35. Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Toenail Onychomycosis

Last Update Posted : September 26, 2018 Sponsor: Polichem S.A. Information provided by (Responsible Party): Polichem S.A. Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether P-3058 nail solution is a safe and effective treatment for onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis Drug: P-3058 10% Drug: vehicle of P-3058 10% Drug: amorolfine 5% Phase 3 Study Design Go to Layout table for study information Study Type (...) " on the target nail. Presence of dermatophytoma on the target nail. Presence of nail thickness exceeding 2 mm. Patients with proximal subungual involvement Patients with severe plantar or moccasin tinea pedis Patients with nail abnormalities due to other conditions Patients with life expectancy less than 2 years. Chemotherapy, immunosuppressive therapy in the 12 weeks prior to Screening visit (V1). Systemic corticosteroids, antimetabolites and immune-stimulants therapy in the 4 weeks prior to Screening visit

2015 Clinical Trials

36. Meconium aspiration syndrome

in the presence of maternal and fetal risk factors. Soon after birth, infants present with respiratory distress (tachypnoea, chest retractions, and hypoxia). Some may be asymptomatic and apparently vigorous at birth, and develop severe respiratory distress hours later. Signs of post-maturity, a strong risk factor, include green/yellow-coloured skin; long, stained nails; and dry, scaling skin. Diagnosis is confirmed by chest x-ray. Management is largely supportive. Infants should be monitored closely to ensure (...) Meconium aspiration syndrome Meconium aspiration syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Meconium aspiration syndrome Last reviewed: February 2019 Last updated: January 2019 Summary Defined as respiratory distress in the newborn due to the presence of meconium in the trachea. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome, particularly

2019 BMJ Best Practice

37. Meconium aspiration syndrome

in the presence of maternal and fetal risk factors. Soon after birth, infants present with respiratory distress (tachypnoea, chest retractions, and hypoxia). Some may be asymptomatic and apparently vigorous at birth, and develop severe respiratory distress hours later. Signs of post-maturity, a strong risk factor, include green/yellow-coloured skin; long, stained nails; and dry, scaling skin. Diagnosis is confirmed by chest x-ray. Management is largely supportive. Infants should be monitored closely to ensure (...) Meconium aspiration syndrome Meconium aspiration syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Meconium aspiration syndrome Last reviewed: February 2019 Last updated: January 2019 Summary Defined as respiratory distress in the newborn due to the presence of meconium in the trachea. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome, particularly

2018 BMJ Best Practice

38. Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease Full Text available with Trip Pro

of the manuscript was performed by the BSH Guidelines Committee General Haematology Task Force, the BSH Guidelines Committee and the General Haematology sounding board of BSH. It was also placed on the members section of the BSH website for comment. The manuscript was also reviewed by the Sickle Cell Society; this organisation does not necessarily approve or endorse the contents. Introduction Sickle cell disease (SCD) is a generic term for an inherited group of disorders that includes homozygous sickle cell (...) ). Recommendations Hydroxycarbamide therapy should be considered in adults and children with sickle cell disease (SCD) with genotypes other than SS and Sβ 0 thalassaemia who have recurrent acute pain, acute chest syndrome or episodes of hospitalisation (2C) Hydroxycarbamide therapy should be considered in adults and children with SCD with genotypes other than SS and Sβ 0 thalassaemia for other indications on a case‐by‐case basis (2D) Concerns of hydroxycarbamide Short‐term complications Hydroxycarbamide is well

2018 British Committee for Standards in Haematology

39. Psoriasis, Nails (Diagnosis)

, a Critical Images slideshow, to help identify conditions associated with various nail abnormalities. For patient education information, see the and , as well as , , , and . Next: Pathophysiology of Nail Psoriasis The pathogenesis of the psoriatic nail disorder is not completely known. Nail psoriasis may be due to a combination of genetic, environmental, and immune factors. A well-known fact is that a familial aggregation of psoriasis exists. Studies have linked psoriasis with certain human leukocyte (...) starts distally and progresses proximally, causing a traumatic uplifting of the distal nail plate. Secondary microbial colonization may occur. Nail plate crumbling Nail plate weakening due to disease of the underlying structures causes this condition. Splinter hemorrhage/dilated tortuous capillaries in the dermal papillae Splinter hemorrhages are longitudinal black lines due to minute foci of capillary hemorrhage between the nail bed and the nail plate. This is analogous to the Auspitz sign

2014 eMedicine.com

40. Psoriasis, Nails (Overview)

, a Critical Images slideshow, to help identify conditions associated with various nail abnormalities. For patient education information, see the and , as well as , , , and . Next: Pathophysiology of Nail Psoriasis The pathogenesis of the psoriatic nail disorder is not completely known. Nail psoriasis may be due to a combination of genetic, environmental, and immune factors. A well-known fact is that a familial aggregation of psoriasis exists. Studies have linked psoriasis with certain human leukocyte (...) starts distally and progresses proximally, causing a traumatic uplifting of the distal nail plate. Secondary microbial colonization may occur. Nail plate crumbling Nail plate weakening due to disease of the underlying structures causes this condition. Splinter hemorrhage/dilated tortuous capillaries in the dermal papillae Splinter hemorrhages are longitudinal black lines due to minute foci of capillary hemorrhage between the nail bed and the nail plate. This is analogous to the Auspitz sign

2014 eMedicine.com

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