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Yellow Nail Syndrome

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181. Efficacy, Safety and Immunogenicity of Enerceptan Compared to Enbrel in Rheumatoid Arthritis

Biotech S.A. Collaborator: QUID Quality in Drugs and Devices Latin American Consulting SRL Information provided by (Responsible Party): Gema Biotech S.A. Study Details Study Description Go to Brief Summary: The purpose of this study is to asses the compared efficacy, safety and immunogenicity of ENERCEPTAN® with ENBREL® in combination with Methotrexate for the treatment of patients with rheumatoid arthritis. Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Biological: Etanercept (...) biologic treatment. Chronic antibiotic therapy, if the investigator considers this may affect the safety of the subject or the assessment of the study results. Any previous or current serious medical conditions that, in the opinion of the investigator, constitute a contraindication for the study treatment, as: Administration of vaccines: Subjects who have received a live attenuated vaccine within 3 months prior to the randomization Visit (for example, varicella-zoster, oral polio, rabies, yellow fever

2016 Clinical Trials

182. Richard Lehman’s journal review—20 February 2017

useful 50% diminution in hair loss. Sublingual grass Whenever I read an article about sublingual grass pollen for seasonal allergy, I’m reminded of William Blake’s amazing print of Nebuchadnezzar eating grass. Readers versed in the Holy Scriptures will remember that the Assyrian king continued in this state until “seven times” passed over him, by which time his hairs were grown like eagles’ feathers and his nails like birds’ claws ( Daniel 4;33). Adults who use two years of sublingual grass therapy (...) that, you just looked at their middle. This is, in fact, a better indicator of risk, as people have been pointing out for decades. Best of all, you can do both, . And then you can see how much of the risk appears to be genetic, as you have their full genome as well. The conclusion of this study is that “A genetic predisposition to higher waist-to-hip ratio adjusted for body mass index was associated with increased risk of type 2 diabetes and coronary heart disease. These results provide evidence

2017 The BMJ Blog

183. Quackery expands in the Dana Farber Cancer Institute and Children’s Hospital of Philadelphia

efforts fail, they come back again. And again. And again. They do not give up until they get what they want. So it is with quackademic medicine. CHOP was hostile to unscientific medicine: In the past, alternative options were not welcome at Children's Hospital. The institution removed most dietary supplements from its list of approved medications in 2013 because it could not guarantee their safety and effectiveness. Paul Offit, chief of infectious diseases, said the hospital's stance on supplements (...) integrating quackery with real medicine without concern for such niceties. It’s also depressing that this could happen at the institution where Dr. Offit is faculty. I’d be shocked if he didn’t fight this tooth and nail; indeed, you can tell from his quotes in this story that he’s probably holding back because it’s never a good idea to outright badmouth your employer in a news story. If acupuncture and a little woo are where CHOP is now, to see where CHOP could be in a few years: Massage therapist Maria

2016 Respectful Insolence

184. Votrient - pazopanib

) and for patients who have received prior cytokine therapy for advanced disease.’ The EMA has waived the obligation to submit the results of studies with Votrient in all subsets of the paediatric population in renal cell carcinoma as the condition does not normally occur in the paediatric population. The applicant has received central Protocol Assistance by the CHMP on clinical issues in December 2006. In their response to the main clinical issue the CHMP suggested the conduction of an active comparator study (...) an application for Marketing Authorisation to the European Medicines Agency (EMEA) through the centralised procedure for Votrient, which was designated as an orphan medicinal product EU/3/06/382 on 29 June 2006. Votrient was designated as an orphan medicinal product in the following indication: treatment of renal cell carcinoma (RCC). The calculated prevalence of this condition was 3.5 per 100,000 EU population. In connection with the review of the orphan designation criteria by the Committee on Orphan

2010 European Medicines Agency - EPARs

185. A Retrospective Analysis of the Effects of Low Level Laser Therapy on Toenail Onychomycosis

positive fungal potassium hydroxide preparation (KOH) testing results Exclusion Criteria: Spikes of disease extending to nail matrix in the great toenail Infection involving lunula of the great toenail, e.g. genetic nail disorders, primentary disorders Great toenail has less than 2mm clear (unaffected) nail plate length beyond the proximal fold Dermatophytoma or "yellow spike/streak" (defined as thick masses of fungal hyphae and necrotic keratin between the nail plate and nail bed) on the great toenail (...) : September 28, 2016 Sponsor: Erchonia Corporation Information provided by (Responsible Party): Erchonia Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether low level laser therapy (LLLT) using the Erchonia LUNULA device is effective in increasing clear nail in toenails with onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis Device: Erchonia LUNULA Not Applicable Detailed Description: Nail onychomycosis, or fungus

2015 Clinical Trials

186. Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants

-Barr virus, cytomegalovirus and herpes zoster, but excluding fungal infections of nail beds) Neuropathies or other conditions that might interfere with pain evaluation unless related to primary disease under investigation Any major episode of infection requiring hospitalization or treatment with intravenous antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening Active TB requiring treatment within the previous 3 years (participants previously treated for TB (...) randomization to Week 24 post-randomization, in participants with stable low disease activity [LDA] (DAS28 ESR score less than or equal to [<=] 3.2) who receive tocilizumab, and have been randomized to either continue or taper prednisone in a double-blinded fashion. Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Drug: Placebo matched to prednisone Drug: Prednisone Biological: Tocilizumab Phase 4 Study Design Go to Layout table for study information Study Type : Interventional

2015 Clinical Trials

187. Evaluation of the Suitability of PD P 506 A in the PDT of Distal Subungual Onychomycosis (DSO) of the Great Toenail.

: February 4, 2015 Last Update Posted : September 19, 2017 Sponsor: photonamic GmbH & Co. KG Information provided by (Responsible Party): photonamic GmbH & Co. KG Study Details Study Description Go to Brief Summary: This study evaluates the potential usefulness of photodynamic therapy with PD P 506 A in patients with distal subungual onychomycosis of the great toenail. Patients will receive four PDT treatments with PD P 506 A in weekly intervals. Condition or disease Intervention/treatment Phase (...) Dermatol. 2007 Jun;56(6):939-44): Residual changes of the nail plate compatible with dermatophyte infection White/yellow or orange brown/patches or streaks in or beneath the nail Lateral onycholysis with debris in an otherwise clear nail plate Hyperkeratoses on the lateral nail plate/nailfold edge. If the nail shows an improvement but still one of the above signs, it will be rated as "partially cleared". If the nail shows no improvement in comparison to the Screening Visit, it will be rated

2015 Clinical Trials

188. Current evidence on the effectiveness of systemic herbal medicine for psoriasis: A systematic review with meta-analysis Full Text available with Trip Pro

± 12.5 in treatment group and 36.40 ± 11.32 in placebo group Country and setting: China, single centre Inclusion criteria of the study • Diagnostic criteria: Principle for Directing Clinical Studies on New Drugs of Chinese Materia Medica for Treating Psoriasis, MOH, China • Blood-heat syndrome in traditional Chinese medicine Exclusion criteria of the study • Severe cardiovascular • Cerebrovascular • Pustular psoriasis • Hepatic diseases • Renal diseases • Mental disorders • Women in pregnancy (...) 1 months • Hepatic diseases • Renal diseases • Mental disorders • Women in pregnancy or breastfeeding Interventions • Treatment group: Xuebijing injection, 30 ml daily • Control group: Acitretin Tablets, 30 mg/d Outcomes PASI score Notes Ingredients used in control group Xiao Yin Pian Tablets was not stated. Concomittent treatment: permitted emollients. Ho et al. 2009 Methods Design: randomised, placebo-controlled Duration: 6 months Interval of assessment: every 2 months Number randomised: 61

2015 Global dermatology

189. Study of Erchonia Low Level Laser Light Therapy to Treat Toenail Fungus

pedis. History of current or past psoriasis of the skin and/or nails. Concurrent lichen planus. Onychogryphosis. Any of the following conditions of the affected great toenail(s) is present: proximal subungual onychomycosis; white superficial onychomycosis; dermatophytoma or "yellow spike/streak"; exclusively lateral disease Confounding problems/abnormalities of the great toenail(s). Any abnormality of the affected great toenail(s) that could prevent a normal appearing nail if clearing of infection (...) provided by (Responsible Party): Erchonia Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether low level laser light therapy is effective in the treatment of toenail onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis Device: Erchonia LUNULA Not Applicable Detailed Description: An infection of toenail fungus, or onychomycosis, typically occurs when fungi (most commonly dermatophytes) infect the nail, but may also

2014 Clinical Trials

190. Dermoscopic features in fungal melanonychia. (Abstract)

was observed in 19 of the nails. The main dermoscopic pattern was homogeneous pigmentation; however, black pigmented aggregates, presenting as either coarse granules or pigmented clumps, accompanied this homogeneous pigmentation in 16 lesions. Matt black pigmentation, matt white pigmentation, yellow to brown pigmentation, black reverse triangle (wider at the distal than the proximal end), superficial transverse striation and blurred appearance were the other features.We have identified a number (...) Dermoscopic features in fungal melanonychia. Data on the dermoscopic features of fungal melanonychia are limited.To identify the dermoscopic features of fungal melanonychia.We reviewed patient files, clinical history and dermoscopic images of all cases with a diagnosis of fungal melanonychia seen at our dermoscopy unit within the past year.In total, 14 cases with 20 involved nails were reviewed. The most common type of melanonychia was melanonychia striata (7/20). Multicoloured pigmentation

2014 Clinical & Experimental Dermatology

191. The moment I became a passionate doctor

, and keep searching until you are confident you have the best answer. Her eyes were closed, her face calm. Her lips were dry and cracked, and her teeth yellowed with plaque. Her trach bubbled noisily with saliva. It was then that I noticed her soft blonde hair. Her mother, I presumed, had plaited it into two perfect French braids. Not a single strand was awry. They ended in delicate, lacy, pink ribbons tied into bows. Then her hands — each dainty, tapered finger — ended in a perfectly manicured nail (...) , lovingly painted a shade of girly pink. It dawned on me unexpectedly — this child means something to her mother. Despite her condition, she means the world to someone — her mother, her father, her extended family. Suddenly, I understood. My fears that had gripped me just moments before vanished. I suddenly became aware that I had no frame of reference for this. I was not yet a mother, much less a mother of a medically complex child. In that moment, I clearly saw the reality of truly caring for patients

2017 KevinMD blog

192. Briefs: Butt worms

. So reports estimate only ⅓ of patients have pruritus. There are case reports of patients who had abdominal pain but no itching. The worms may be found at the anal verge or in the vagina as well. The disease is spread amongst humans, usually by fecal-oral contact, and it can take 4 to 8 weeks for the eggs to reach the anus, for the larvae to hatch and for patients to become symptomatic. “although transmission is often attributed to the ingestion of infective eggs by nail biting and inadequate hand (...) (under a microscope – they are tiny and transparent otherwise) and/or the organism itself (see video above). The worms themselves are about 1 centimeter in length and are white/pale-yellow in color. You can “catch” eggs on transparent adhesive tape to aid in the diagnosis. So, in a patient who suspects they have pinworms but doesn’t see them the tape method can aid in identification since you’ll at least get the eggs. You may need to have a few applications of tape though… Instruct patients to apply

2017 PEM Blog

193. Patient Modesty: Volume 81

I'm hospitalized. Will my Medicare payments be given for this? Please consider what Medicare can do to prevent this from happening to me when I'm hospitalized. Will my care and safety be jeopardized because medical staff are viewing my genitals instead of caring for my injury/ illness? Creating new rules which are not respected or enforced obviously does not work. Medicare must insist that same-gender care be provided to anyone upon request. The shortage of male nurses must be addressed (...) state of affairs we are in. What I find most disgusting and distressing about the "Denver 5" episode is most people view it as being funny. What should have been a wake up call to the public is just a joke. Sad. I understand the next of kin was notified of the episode. I hope they sue the pants of the hospital & the 5 degenerates. Regards, NTT At , Anonymous said... Hello again, In my original note to Ms Jackson, I yellow highlighted the "3 weeks" and "return to work". Unfortunately, this site

2017 Bioethics Discussion Blog

194. Dermoscopy (Treatment)

% for the examination by naked eye and 90% for dermoscopy. The equipment; technologic methods; diagnostic features; and primary aspects of melanoma, common nevi, atypical nevi, and other nonmelanocytic pigmented skin lesions are discussed in this article. The technique is also commonly used to assist in the evaluation of nail fold capillaries and features of alopecia. [ , ] Next: Technical Procedures and Equipment Dermoscopy involves an evaluation of the skin surface. During a dermoscopy assessment, the pigmented (...) of the colors within the lesion are the most important elements of a dermoscopy examination. The epidermis usually appears white, but acanthosis results in a grayish-brown or brownish-yellow color. Melanin is the most important pigment in determining different structural and chromatic patterns. The pigmented skin lesion can have a different degree and distribution of pigmentation depending on the location of melanin in different layers of the skin. Melanin location and lesion color See the list below: Upper


195. Cutaneous Manifestations of Smoking (Treatment)

abrasions [ ] Oral leukoplakia Nail and hair disorders Smoking has been associated with several hair and nail disorders, such as the following: Smoker’s nails - Yellow and brown discolored fingernails Harlequin nail or quitter’s nail - Demarcation between distal pigmented nail and proximal normal nail upon smoking cessation [ ] Androgenetic alopecia [ ] Premature gray hair Smoker's mustache - Analogous to smoker's nails; yellow or brown discolored facial hair [ ] Hidradenitis suppurativa , a chronic (...) smoking-related dermatologic surgical complications and severity of skin disorders. This article reviews skin conditions associated with or influenced by cigarette smoking. [ ] Next: Wound Healing and Premature Skin Aging Poor wound healing Smoking has repeatedly been shown to have deleterious effects on healing skin wounds. Cigarette smoking has been linked with numerous postoperative complications, including wound infections, dehiscence, flap and graft necrosis, and decreased wound tensile strength


196. Chylous Ascites (Treatment)

carcinoid, [ , ] and sclerosing mesenteritis. [ ] In children, the most common causes of chylous ascites are congenital abnormalities, such as lymphangiectasia, mesenteric cyst, and idiopathic "leaky lymphatics." Other congenital causes include primary lymphatic hypoplasia associated with Turner syndrome and yellow nail syndrome, and the lymphatic malformations associated with Klippel-Trenaunay syndrome. [ ] Neoplasia is an uncommon cause of pediatric chylous ascites. The incidence of spontaneous (...) -42. . Widjaja A, Gratz KF, Ockenga J, Wagner S, Manns MP. Octreotide for therapy of chylous ascites in yellow nail syndrome. Gastroenterology . 1999 Apr. 116(4):1017-8. . Zhou DX, Zhou HB, Wang Q, Zou SS, Wang H, Hu HP. The effectiveness of the treatment of octreotide on chylous ascites after liver cirrhosis. Dig Dis Sci . 2009 Aug. 54(8):1783-8. . Olivieri C, Nanni L, Masini L, Pintus C. Successful management of congenital chylous ascites with early octreotide and total parenteral nutrition


197. Cirrhosis (Treatment)

(eg, Amanita phalloides, the yellow death-cap mushroom), autoimmune hepatitis, Wilson disease, or a variety of less common etiologies. Cryptogenic causes are responsible for one third of fulminant cases. Patients with the syndrome of FHF have a 50-80% mortality rate unless they are salvaged by liver transplantation. International data Worldwide, cirrhosis is the 14th most common cause of death, but in Europe, it is the 4th most common cause of death. [ ] Previous Next: Hepatic Fibrosis (...) the liver, with resulting hepatic congestion and portal hypertension. These symptoms include hepatomegaly, abdominal pain, and ascites. Cirrhosis ensues only later in the course of disease. Differentiating Budd-Chiari syndrome from cirrhosis by history or physical examination may be difficult. Thus, Budd-Chiari syndrome must be included in the differential diagnosis of conditions that produce ascites and varices. Hepatic vein patency is checked most readily by performing abdominal ultrasonography


198. Bronchiectasis (Treatment)

, Gurses H, Mehta AC. Clinical features of the yellow nail syndrome. Cleve Clin J Med . 1990 Jul-Aug. 57(5):472-6. . Shin MS, Ho KJ. Bronchiectasis in patients with alpha 1-antitrypsin deficiency. A rare occurrence?. Chest . 1993 Nov. 104(5):1384-6. . Chan E, Feldman N, Chmura K. Do mutations of the alpha-1-antitrypsin gene predispose to non-tuberculous mycobacterial infection?. Am J Respir Crit Care Med . 2004. 169:A132. Parr DG, Guest PG, Reynolds JH, Dowson LJ, Stockley RA. Prevalence and impact (...) antibiotics, bronchodilators, aggressive physiotherapy, and supplemental nutrition is not uncommon. Aggressively pursue and treat any associated or known causal condition of the bronchiectasis. The scope of therapies for these associated medical conditions, such as mycobacterial disease and CF, is beyond the scope of this article. See and . Next: Supportive Treatment The following general measures are recommended: Smoking cessation Avoidance of second-hand smoke Adequate nutritional intake


199. Benign Vulvar Lesions (Treatment)

malformations involving the vulvar region include the following: Ambiguous external genitalia Congenital labial hypertrophy Atrophy of the vulva may also occur. Next: Etiology and Pathophysiology Nonneoplastic epithelial disorders are discussed below. Inflammatory diseases Lichen sclerosus The etiology of this condition is unknown. [ ] A higher prevalence of the disease in postmenopausal women suggests hormonal factors, but this has not been confirmed. [ , ] A 2008 study demonstrated that oral (...) nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia


200. Keratosis Palmaris et Plantaris (Treatment)

mutations. Treatment includes emollients and keratolytics in mild cases and oral retinoids in more severe disease. Surgical excision of severely deformed nails offers a temporary solution, but nail dystrophy recurs. Injection of botulinum toxin has shown relief for hyperhidrosis and pain. Also see . Striate PPK with woolly hair and left-sided dilated cardiomyopathy (Carvajal-Huerta syndrome) This condition is inherited in an autosomal recessive pattern. Both this disease and Naxos disease are autosomal (...) filament network. Molecular biology findings include homozygous mutations of the gene encoding desmoplakin, which maps to 6p24 and is the most abundant protein of the desmosome. Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome [ ] A synonym is PPK with erythroderma and hyperimmunoglobulin E. This condition is inherited in an autosomal recessive manner. Clinical features include striate PPK at birth or during early infancy. Patients have erythroderma, ichthyosis, nail


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