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Yellow Nail Syndrome

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181. Votrient - pazopanib

) and for patients who have received prior cytokine therapy for advanced disease.’ The EMA has waived the obligation to submit the results of studies with Votrient in all subsets of the paediatric population in renal cell carcinoma as the condition does not normally occur in the paediatric population. The applicant has received central Protocol Assistance by the CHMP on clinical issues in December 2006. In their response to the main clinical issue the CHMP suggested the conduction of an active comparator study (...) an application for Marketing Authorisation to the European Medicines Agency (EMEA) through the centralised procedure for Votrient, which was designated as an orphan medicinal product EU/3/06/382 on 29 June 2006. Votrient was designated as an orphan medicinal product in the following indication: treatment of renal cell carcinoma (RCC). The calculated prevalence of this condition was 3.5 per 100,000 EU population. In connection with the review of the orphan designation criteria by the Committee on Orphan

2010 European Medicines Agency - EPARs

182. Efficacy, Safety and Immunogenicity of Enerceptan Compared to Enbrel in Rheumatoid Arthritis

Biotech S.A. Collaborator: QUID Quality in Drugs and Devices Latin American Consulting SRL Information provided by (Responsible Party): Gema Biotech S.A. Study Details Study Description Go to Brief Summary: The purpose of this study is to asses the compared efficacy, safety and immunogenicity of ENERCEPTAN® with ENBREL® in combination with Methotrexate for the treatment of patients with rheumatoid arthritis. Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Biological: Etanercept (...) biologic treatment. Chronic antibiotic therapy, if the investigator considers this may affect the safety of the subject or the assessment of the study results. Any previous or current serious medical conditions that, in the opinion of the investigator, constitute a contraindication for the study treatment, as: Administration of vaccines: Subjects who have received a live attenuated vaccine within 3 months prior to the randomization Visit (for example, varicella-zoster, oral polio, rabies, yellow fever

2016 Clinical Trials

183. Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid Arthritis

, with the exception of basal cell or squamous cell carcinoma of the skin or carcinoma in situ of cervix which that has been fully excised/cured with no evidence of recurrence Concomitant diagnosis or history of diverticulitis, peptic ulcer disease, diverticulosis requiring antibiotic treatment or chronic ulcerative lower GI disease such as Crohn's disease, ulcerative colitis or other symptomatic lower GI conditions that might predispose to perforations Evidence of active or latent bacterial, viral, fungal (except (...) . ClinicalTrials.gov Identifier: NCT02837146 Recruitment Status : Recruiting First Posted : July 19, 2016 Last Update Posted : July 29, 2016 See Sponsor: Maria Stoenoiu Information provided by (Responsible Party): Maria Stoenoiu, Université Catholique de Louvain Study Details Study Description Go to Brief Summary: This study is aimed at assessing the kinetics of the ultrasound (US) response in DMARD-naive very early rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ) and methotrexate (MTX). Condition

2016 Clinical Trials

184. Evaluating the Safety, Tolerability and Preliminary Efficacy of Plasma in Improving the Appearance of Onychomycosis

dermatophytoma or "yellow spike/streak" primarily lateral or bi-lateral disease toenail thickness greater than 3 mm inability to become normal in the opinion of the investigator Subject with psoriasis, pincer nail, prior nail surgery, severe moccasin-type tinea pedis requiring treatment, symptomatic interdigital tinea pedis, lichen planus, or other abnormalities that could result in a clinically abnormal nail; Subject with peripheral vascular disease or peripheral circulatory impairment; Subject (...) . ClinicalTrials.gov Identifier: NCT02724384 Recruitment Status : Recruiting First Posted : March 31, 2016 Last Update Posted : September 14, 2017 See Sponsor: Moe Medical Devices Information provided by (Responsible Party): Moe Medical Devices Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the safety and preliminary efficacy of using electrical plasma to treat toenail fungus. Condition or disease Intervention/treatment Phase Onychomycosis Device: MOE Plasma Delivery

2016 Clinical Trials

185. Evaluation of the Suitability of PD P 506 A in the PDT of Distal Subungual Onychomycosis (DSO) of the Great Toenail.

: February 4, 2015 Last Update Posted : September 19, 2017 Sponsor: photonamic GmbH & Co. KG Information provided by (Responsible Party): photonamic GmbH & Co. KG Study Details Study Description Go to Brief Summary: This study evaluates the potential usefulness of photodynamic therapy with PD P 506 A in patients with distal subungual onychomycosis of the great toenail. Patients will receive four PDT treatments with PD P 506 A in weekly intervals. Condition or disease Intervention/treatment Phase (...) Dermatol. 2007 Jun;56(6):939-44): Residual changes of the nail plate compatible with dermatophyte infection White/yellow or orange brown/patches or streaks in or beneath the nail Lateral onycholysis with debris in an otherwise clear nail plate Hyperkeratoses on the lateral nail plate/nailfold edge. If the nail shows an improvement but still one of the above signs, it will be rated as "partially cleared". If the nail shows no improvement in comparison to the Screening Visit, it will be rated

2015 Clinical Trials

186. A Retrospective Analysis of the Effects of Low Level Laser Therapy on Toenail Onychomycosis

positive fungal potassium hydroxide preparation (KOH) testing results Exclusion Criteria: Spikes of disease extending to nail matrix in the great toenail Infection involving lunula of the great toenail, e.g. genetic nail disorders, primentary disorders Great toenail has less than 2mm clear (unaffected) nail plate length beyond the proximal fold Dermatophytoma or "yellow spike/streak" (defined as thick masses of fungal hyphae and necrotic keratin between the nail plate and nail bed) on the great toenail (...) : September 28, 2016 Sponsor: Erchonia Corporation Information provided by (Responsible Party): Erchonia Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether low level laser therapy (LLLT) using the Erchonia LUNULA device is effective in increasing clear nail in toenails with onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis Device: Erchonia LUNULA Not Applicable Detailed Description: Nail onychomycosis, or fungus

2015 Clinical Trials

187. Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants

-Barr virus, cytomegalovirus and herpes zoster, but excluding fungal infections of nail beds) Neuropathies or other conditions that might interfere with pain evaluation unless related to primary disease under investigation Any major episode of infection requiring hospitalization or treatment with intravenous antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening Active TB requiring treatment within the previous 3 years (participants previously treated for TB (...) randomization to Week 24 post-randomization, in participants with stable low disease activity [LDA] (DAS28 ESR score less than or equal to [<=] 3.2) who receive tocilizumab, and have been randomized to either continue or taper prednisone in a double-blinded fashion. Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Drug: Placebo matched to prednisone Drug: Prednisone Biological: Tocilizumab Phase 4 Study Design Go to Layout table for study information Study Type : Interventional

2015 Clinical Trials

188. Quackery expands in the Dana Farber Cancer Institute and Children’s Hospital of Philadelphia

efforts fail, they come back again. And again. And again. They do not give up until they get what they want. So it is with quackademic medicine. CHOP was hostile to unscientific medicine: In the past, alternative options were not welcome at Children's Hospital. The institution removed most dietary supplements from its list of approved medications in 2013 because it could not guarantee their safety and effectiveness. Paul Offit, chief of infectious diseases, said the hospital's stance on supplements (...) integrating quackery with real medicine without concern for such niceties. It’s also depressing that this could happen at the institution where Dr. Offit is faculty. I’d be shocked if he didn’t fight this tooth and nail; indeed, you can tell from his quotes in this story that he’s probably holding back because it’s never a good idea to outright badmouth your employer in a news story. If acupuncture and a little woo are where CHOP is now, to see where CHOP could be in a few years: Massage therapist Maria

2016 Respectful Insolence

189. Study of Erchonia Low Level Laser Light Therapy to Treat Toenail Fungus

pedis. History of current or past psoriasis of the skin and/or nails. Concurrent lichen planus. Onychogryphosis. Any of the following conditions of the affected great toenail(s) is present: proximal subungual onychomycosis; white superficial onychomycosis; dermatophytoma or "yellow spike/streak"; exclusively lateral disease Confounding problems/abnormalities of the great toenail(s). Any abnormality of the affected great toenail(s) that could prevent a normal appearing nail if clearing of infection (...) provided by (Responsible Party): Erchonia Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether low level laser light therapy is effective in the treatment of toenail onychomycosis. Condition or disease Intervention/treatment Phase Onychomycosis Device: Erchonia LUNULA Not Applicable Detailed Description: An infection of toenail fungus, or onychomycosis, typically occurs when fungi (most commonly dermatophytes) infect the nail, but may also

2014 Clinical Trials

190. Dermoscopic features in fungal melanonychia. (Abstract)

was observed in 19 of the nails. The main dermoscopic pattern was homogeneous pigmentation; however, black pigmented aggregates, presenting as either coarse granules or pigmented clumps, accompanied this homogeneous pigmentation in 16 lesions. Matt black pigmentation, matt white pigmentation, yellow to brown pigmentation, black reverse triangle (wider at the distal than the proximal end), superficial transverse striation and blurred appearance were the other features.We have identified a number (...) Dermoscopic features in fungal melanonychia. Data on the dermoscopic features of fungal melanonychia are limited.To identify the dermoscopic features of fungal melanonychia.We reviewed patient files, clinical history and dermoscopic images of all cases with a diagnosis of fungal melanonychia seen at our dermoscopy unit within the past year.In total, 14 cases with 20 involved nails were reviewed. The most common type of melanonychia was melanonychia striata (7/20). Multicoloured pigmentation

2014 Clinical & Experimental Dermatology

191. Wasp Stings (Follow-up)

vascular resistance, while its beta effect has a positive inotropic and chronotropic effect on the heart. This produces an increase in the heart's work and increases the myocardial oxygen demand. This may have a deleterious effect in patients with preexisting heart disease or coronary artery disease. The patient may present with airway obstruction due to angioedema, respiratory compromise due to bronchospasm, or circulatory collapse or with a combination of these 3 conditions. Follow the ABCs (...) with No Structural Lesions after a Wasp Sting. J Emerg Med . 2009 Mar 26. . Jairam A, Kumar RS, Ghosh AK, Hasija PK, Singh JI, Mahapatra D, et al. Delayed Kounis syndrome and acute renal failure after wasp sting. Int J Cardiol . 2008 Aug 13. . Sun Z, Yang X, Ye H, Zhou G, Jiang H. Delayed encephalopathy with movement disorder and catatonia: A rare combination after wasp stings. Clin Neurol Neurosurg . 2012 Dec 21. . Ito K, Imafuku S, Nakayama J. Rhabdomyolysis due to Multiple Wasp Stings. Case Rep Dermatol Med

2014 eMedicine.com

192. Teratology and Drug Use During Pregnancy (Diagnosis)

, maternal health, and prenatal prescription records were linked to neonatal records, representing all live births in British Columbia during a 39-month period (1998-2001). Even after controlling for maternal illness profiles, infants exposed to prenatal serotonin reuptake inhibitors in combination with benzodiazepines had an increased incidence of congenital heart disease versus controls who had not been exposed. Serotonin reuptake inhibitor monotherapy was not associated with an increased risk (...) neonate presented with gum hypertrophy, digitalization of the thumbs, hypoplasia of the distal phalanges and nails, epicanthal folds, pseudohypertelorism, epidermoid cyst, and geographic tongue. Onychopathy can be a monosymptomatic or mild form of this syndrome. This syndrome may be associated with neonatal acne. Clinical Consideration: An increase in seizure frequency may occur during pregnancy because of altered pharmacokinetics. Periodic measurement of plasma phenytoin concentrations may

2014 eMedicine.com

193. Tinea Capitis (Diagnosis)

and medium chains in postpubertal sebum. Causative agents of tinea capitis include keratinophilic fungi termed dermatophytes. These molds usually are present in nonliving cornified layers of skin and its appendages and sometimes are capable of invading the outermost layer of skin, stratum corneum, or other keratinized skin appendages derived from epidermis, such as hair and nails. Dermatophytes are among the most common infectious agents of humans, causing a variety of clinical conditions (...) below) commonly are associated with T tonsurans infection. Typical lesions of kerion celsi on the vertex scalp of a young Chinese boy. Note numerous bright yellow purulent areas on skin surface, surrounded by adjacent edematous, erythematous, alopecic areas. Culture from the lesion grew Trichophyton mentagrophytes. Courtesy of Skin Diseases in Chinese by Yau-Chin Lu, MD. Permission granted by Medicine Today Publishing Co, Taipei, Taiwan, 1981. In ectothrix infection, fragmentation of the mycelium

2014 eMedicine.com

194. Benign Vulvar Lesions (Follow-up)

malformations involving the vulvar region include the following: Ambiguous external genitalia Congenital labial hypertrophy Atrophy of the vulva may also occur. Next: Etiology and Pathophysiology Nonneoplastic epithelial disorders are discussed below. Inflammatory diseases Lichen sclerosus The etiology of this condition is unknown. [ ] A higher prevalence of the disease in postmenopausal women suggests hormonal factors, but this has not been confirmed. [ , ] A 2008 study demonstrated that oral (...) nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia

2014 eMedicine.com

195. Lymphedema (Diagnosis)

this defect is congenital or acquired is difficult to determine. As the rarest form of primary lymphedema, this disease accounts for only 10% of cases. Histologically, patients are likely to demonstrate a hyperplastic pattern, with tortuous lymphatics increased in caliber and number. Associated conditions As mentioned, primary lymphedema is seen in association with various cutaneous and genetic disorders. Distichiasis lymphedema syndrome is a form of hereditary early and late-onset lymphedema associated (...) , strabismus, thoracic duct abnormalities, and microphthalmia. Primary lymphedema has also been associated with yellow nail syndrome. This entity may be associated with recurrent pleural effusions and bronchiectasis. Other genetic syndromes and cutaneous conditions associated with primary lymphedema include the following: Turner syndrome Noonan syndrome Klinefelter syndrome Neurofibromatosis type 1 Hemangiomas Xanthomatosis Congenital absence of nails One case reportedly occurred in association with CHARGE

2014 eMedicine.com

196. Prostate Cancer: Nutrition (Diagnosis)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDUzMTkxLW92ZXJ2aWV3 processing > Prostate Cancer, Nutrition, and Dietary Supplements Updated: Aug 23, 2018 Author: Mark A Moyad, MD, MPH; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Prostate Cancer, Nutrition, and Dietary Supplements Overview Overview Although nutrition plays a role in the development of , no specific diet can prevent or eradicate this disease. Prostate cancer, like other cancers, is an extremely complex process. No single factor (eg, diet) can (...) explain the various facets of this disease. Nevertheless, the use of diet and dietary supplements for reducing the risk of developing prostate cancer or for treating prostate cancer continues to engage the interest of patients and researchers. [ ] Before discussing or recommending a dietary or lifestyle pattern that may help prevent prostate cancer or inhibit its progression, it would seem prudent to touch on probability, which should inform discussions of the role of nutrition in the prevention

2014 eMedicine.com

197. Proliferating Pilar Tumor (Diagnosis)

to disclose. What would you like to print? What would you like to print? Sections Proliferating Pilar Tumor Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Proliferating Pilar Tumor) and Proliferating Pilar Tumor What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Most (...) Popular Articles According to Dermatologists Recommended 2002 1060682-overview Diseases & Conditions Diseases & Conditions 2002 1058907-overview Diseases & Conditions Diseases & Conditions 2002 1059260-overview Diseases & Conditions Diseases & Conditions 2002 1112963-overview Diseases & Conditions Diseases & Conditions Need a Curbside Consult? Share cases and questions with Physicians on Medscape consult.

2014 eMedicine.com

198. Oral Manifestations of Drug Reactions (Diagnosis)

reactions have a broad spectrum of clinical manifestations that can mimic those of other disease states, including both local and systemic conditions. [ , , , , , ] Fortunately, several patterns of disease have been identified, and these can help the clinician determine a possible cause-and-effect relationship with a particular medication or group of medications. The clinical patterns of adverse drug reactions of the oral cavity include xerostomia, swelling, nonspecific ulceration, vesiculobullous (...) can lead to decreased fluid intake and dehydration. A variety of lesions, including classic target or bull's eye lesions, can affect the skin. More severe forms of disease include EM major ( ) and toxic epidermal necrolysis (TEN, Lyell syndrome). In addition to the oral and skin lesions, conjunctivitis of the ocular mucosa and urethritis of the genital mucosa are typical findings in patients with EM major. Over three-quarters of EM major cases and virtually all cases of TEN represent adverse drug

2014 eMedicine.com

199. Keratosis Palmaris et Plantaris (Diagnosis)

mutations. Treatment includes emollients and keratolytics in mild cases and oral retinoids in more severe disease. Surgical excision of severely deformed nails offers a temporary solution, but nail dystrophy recurs. Injection of botulinum toxin has shown relief for hyperhidrosis and pain. Also see . Striate PPK with woolly hair and left-sided dilated cardiomyopathy (Carvajal-Huerta syndrome) This condition is inherited in an autosomal recessive pattern. Both this disease and Naxos disease are autosomal (...) filament network. Molecular biology findings include homozygous mutations of the gene encoding desmoplakin, which maps to 6p24 and is the most abundant protein of the desmosome. Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome [ ] A synonym is PPK with erythroderma and hyperimmunoglobulin E. This condition is inherited in an autosomal recessive manner. Clinical features include striate PPK at birth or during early infancy. Patients have erythroderma, ichthyosis, nail

2014 eMedicine.com

200. Onychomatricoma (Diagnosis)

keratoacanthoma in the hand. J Hand Surg [Am] . 1989 Jan. 14(1):139-42. . Bokszczanin A, Levinson AI. Coexistent yellow nail syndrome and selective antibody deficiency. Ann Allergy Asthma Immunol . 2003 Nov. 91(5):496-500. . Wynes J, Wanat KA, Huen A, Mlodzienski AJ, Rubin AI. Pigmented Onychomatricoma: A Rare Pigmented Nail Unit Tumor Presenting as Longitudinal Melanonychia That Has Potential for Misdiagnosis as Melanoma. J Foot Ankle Surg . 2015 Jul-Aug. 54 (4):723-5. . Spaccarelli N, Wanat KA, Miller CJ (...) Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Onychomatricoma) and Onychomatricoma What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Most Popular Articles According to Dermatologists Recommended 2002 1106626-overview Diseases & Conditions Diseases & Conditions 2002 909807-overview

2014 eMedicine.com

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