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Yellow Nail Syndrome

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1. Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome (PubMed)

Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome A differential diagnosis must be made between transient yellow discoloration of the nails and yellow nail syndrome. We highlight some practical aspects of yellow nail discoloration.

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2017 Orphanet journal of rare diseases

2. Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps. (PubMed)

Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps. Lymphatic dysfunction is hypothesized to be an underlying factor in the pathophysiology of yellow nail syndrome (YNS) (yellow nails, lymphedema, pleural effusions, and frequently chronic rhinosinusitis [CRS]). It is unclear why some YNS patients develop CRS. We quantified lymphatic and total vasculature of sinonasal mucosa in YNS patients and compared it to controls from CRS patients

2019 International forum of allergy & rhinology

3. Yellow Nail Syndrome With Dramatic Improvement of Nail Manifestations After Endoscopic Sinus Surgery (PubMed)

Yellow Nail Syndrome With Dramatic Improvement of Nail Manifestations After Endoscopic Sinus Surgery Yellow nail syndrome (YNS) is a rare disease of unknown cause characterized by the triad of yellow nails, respiratory manifestations, and lymphedema. Although several therapies for YNS have been reported, there is no common consensus in the treatment. In this case report, we present a case of 56-year-old woman with YNS, whose nail manifestation was dramatically improved after endoscopic sinus (...) surgery for the treatment of chronic rhinosinusitis.Endoscopic sinus surgery involving middle meatal antrostomy was performed for the case of YNS with chronic rhinosinusitis and bronchiectasis resistant to antibacterial drugs.A month after the surgery, the patient's nails eventually showed dramatic improvement.Otorhinolaryngologists should recognize that chronic rhinosinusitis can be a symptom of YNS, and that the aggressive treatment including surgical approach for chronic rhinosinusitis may

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2017 Clinical medicine insights. Ear, nose and throat

4. Hyperplasia of Lymphoid Follicles and Lymphangiectasia in the Parietal Pleura in Bucillamine-induced Yellow Nail Syndrome (PubMed)

Hyperplasia of Lymphoid Follicles and Lymphangiectasia in the Parietal Pleura in Bucillamine-induced Yellow Nail Syndrome Yellow nail syndrome (YNS) pleurisy is often difficult to control, and pathological examinations have rarely been reported. We herein report a case of bucillamine-induced YNS in which histopathology of the parietal pleura revealed hyperplasia of the lymphoid follicles and lymphangiectasia. Even after the discontinuation of bucillamine, the pleurisy and lymphedema showed

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2018 Internal Medicine

5. Yellow nail syndrome with chylothorax after coronary artery bypass grafting (PubMed)

Yellow nail syndrome with chylothorax after coronary artery bypass grafting Yellow nail syndrome is a rare condition considered secondary to functional anomalies of lymphatic drainage. Yellow nail syndrome is diagnosed through the triad of intrathoracic findings (30% being pleural effusions), nail discoloration, and lymphedema, with any two features sufficient for diagnosis. We report the second case of post-operative yellow nail syndrome.After coronary artery bypass grafting, our patient (...) presented with chylothorax on post-operative day 13 and yellow toenail discoloration on post-operative day 28, diagnosing yellow nail syndrome. Initial conservative management with pigtail catheter drainage and low-fat diet with medium-chain triglycerides reduced chylous drainage from 350 mL/day on post-operative day 14 to < 100 mL/day on post-operative day 17. However, by post-operative day 18, drainage returned to 350 mL/day that persisted despite attempts to readjust the catheter position

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2018 Journal of cardiothoracic surgery

6. Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease (PubMed)

Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease Yellow nail syndrome is a rare acquired condition of unknown aetiology associated with distinct nail discolouration/xanthonychia, pulmonary manifestations, and lymphoedema. Pleural plaques and diffuse pleural thickening are typically, although not exclusively, recognised as markers of prior commercial asbestos exposure. The presence of such biomarkers may assist an asbestos (...) personal injury evaluation. A postmortem examination performed on a 72-year-old man with known long-standing yellow nail syndrome identified pleural plaques and diffuse pleural thickening. An evaluation of the occupational history identified no known asbestos exposure. Electron microscopic mineral fibre analysis detected no asbestos fibres. To the best of our knowledge, this is the only case of yellow nail syndrome in which these benign pleural changes are reported ex asbestos. Alternate causes

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2018 Case reports in pulmonology

7. Effectiveness of clarithromycin in patients with yellow nail syndrome. (PubMed)

Effectiveness of clarithromycin in patients with yellow nail syndrome. Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it is suggested to be due to a congenital lymph abnormality. Since YNS is accompanied by chronic bronchial infection in more than half of patients, we hypothesized that treatment with clarithromycin (CAM) could be effective (...) , and 2 patients (40%) were male. Four patients had sinusitis, and 2 had rheumatoid arthritis. Regarding respiratory manifestations, 4 patients had sinobronchial syndrome and 2 had pleural effusion. Nail discoloration improved in every patient after CAM treatment. Four patients also experienced improvement in their respiratory manifestations.In patients with YNS, the anti-inflammatory activity of macrolides might improve their systemic inflammation. This improvement could help to reduce lymphedema

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2018 BMC pulmonary medicine

8. Yellow Nail Syndrome (PubMed)

Yellow Nail Syndrome 29271348 2018 12 11 2018 12 11 1866-0452 114 50 2017 Dec 15 Deutsches Arzteblatt international Dtsch Arztebl Int Yellow Nail Syndrome. 874 10.3238/arztebl.2017.0874b arztebl.2017.0874b Lübbert Christoph C Kunz Manfred M eng Case Reports Journal Article Germany Dtsch Arztebl Int 101475967 1866-0452 IM Aged Female Humans Lymphedema Yellow Nail Syndrome diagnosis 2017 12 23 6 0 2017 12 23 6 0 2018 12 12 6 0 ppublish 29271348 arztebl.2017.0874b 10.3238/arztebl.2017.0874b

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2017 Deutsches Ärzteblatt international

9. Yellow nail syndrome: a review (PubMed)

Yellow nail syndrome: a review Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic (...) impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clinical manifestations implicating lymphatic functions or cancer and, hence, is also considered a paraneoplastic syndrome. YNS management is symptomatic and not codified. YNS can resolve spontaneously. Oral vitamin E alone or even better when associated with triazole antifungals may achieve partial or total disappearance of nail discoloration. Pleural effusion can be treated

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2017 Orphanet journal of rare diseases

10. The Development of Yellow Nail Syndrome after the Implantation of a Permanent Cardiac Pacemaker (PubMed)

The Development of Yellow Nail Syndrome after the Implantation of a Permanent Cardiac Pacemaker Yellow nail syndrome (YNS) is characterized by yellowish nails, lymphedema, sinusitis, and pulmonary involvement and can be triggered by various underlying conditions, such as sinusitis or titanium exposure from an artificial joint or dental implant. Since YNS is potentially treatable, its timely diagnosis is important. The authors recently experienced a case of YNS in a patient who developed (...) sinusitis, yellowish nails, bilateral edema of the extremities, and subclinical rheumatoid arthritis after the implantation of a cardiac pacemaker made from titanium. This case may be the first report of YNS induced by a titanium cardiac pacemaker.

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2017 Internal Medicine

11. Bucillamine‐induced yellow nail syndrome (PubMed)

Bucillamine‐induced yellow nail syndrome 29264101 2019 01 18 2189-6577 18 6 2017 12 Journal of general and family medicine J Gen Fam Med Bucillamine-induced yellow nail syndrome. 479-480 10.1002/jgf2.124 Tanizaki Ryutaro R Department of Community Medicine NABARI Mie University Graduate School of Medicine Tsu-city Mie Japan. Department of General Medicine Nabari City Hospita lNabari-city Mie Japan. Hashimoto Shuji S Department of Community Medicine NABARI Mie University Graduate School (...) of Medicine Tsu-city Mie Japan. Department of General Medicine Nabari City Hospita lNabari-city Mie Japan. Takemura Yousuke Y Department of Family Medicine Mie University Graduate School of Medicine Tsu-city Mie Japan. eng Journal Article 2017 08 29 Japan J Gen Fam Med 101689875 2189-7948 arthritis bucillamine edema pleural effusion yellow nail 2017 06 14 2017 07 13 2017 12 22 6 0 2017 12 22 6 0 2017 12 22 6 1 epublish 29264101 10.1002/jgf2.124 JGF2124 PMC5729360 Clin Rheumatol. 2004 Aug;23(4):376-8

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2017 Journal of General and Family Medicine

12. Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome. (PubMed)

Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome. Yellow nail syndrome (YNS) is an uncommon disorder, the classic triad of which consists of yellow nails, lymphedema, and respiratory symptoms. Few pediatric cases have been reported. We report a 9-year-old girl with yellowish nail discoloration for 1 year accompanied by respiratory symptoms, including chronic cough, recurrent pneumonia, bronchiectasis, and chronic sinusitis. The patient was diagnosed with YNS. Knowing (...) that a relationship between YNS and titanium has been reported, we collected her nail clippings and detected titanium in them by energy dispersive radiograph fluorescence. This patient's titanium exposure may have come from her habit of swallowing children's toothpaste. With meticulous avoidance of swallowing toothpaste, she had amelioration of her yellow nail discoloration as well as diminution of her respiratory symptoms. We reevaluated her nail clippings for titanium 3 years later, and no titanium was detected

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2016 Pediatrics

13. Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs (PubMed)

Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs Yellow nail syndrome (YNS) is a rare entity characterized by a triad of nail changes, lymphoedema and lung involvement. We report a 57-year-old man with rheumatoid arthritis (RA) and YNS. We have reviewed the previous case reports of RA and YNS and discuss the pulmonary manifestations.

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2016 Oxford Medical Case Reports

14. Yellow Nail Syndrome

Yellow Nail Syndrome Yellow Nail Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Yellow Nail Syndrome Yellow Nail Syndrome (...) Aka: Yellow Nail Syndrome From Related Chapters II. Epidemiology Rare III. Pathophysiology Delayed Results in nails heaping-up and thickening May be associated with microvascular permeability Hypoalbuminemia IV. Signs Convex (heaped-up) nails with loss of lunula Nail with yellow hue V. Associated Conditions (e.g. ) Thiol Medications (e.g. gold thiomalate) VI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Yellow

2018 FP Notebook

15. Bronchiectasis in yellow nail syndrome. (PubMed)

Bronchiectasis in yellow nail syndrome. Yellow nail syndrome (YNS) is a rare and poorly described disease process. In this case-control study, clinical features and findings on HRCT were compared with idiopathic bronchiectasis (IBx).A review of all patients attending an adult bronchiectasis clinic between 2007 and 2013 identified 25 YNS patients. IBx patients were matched in a 2:1 ratio for age, duration of symptoms and gender.Median age of onset was 53 years. There were 12 male and 23 (...) Caucasian YNS patients. Respiratory manifestations included chronic productive cough (100%), chronic rhinosinusitis (88%), pleural effusions (20%) and lymphoedema (12%). Chest symptoms preceded yellow nails in the majority (68%). Abnormal nails persisted at follow-up in 23 of 25 patients but improved in 14. In both disorders, there was symmetrical, predominantly lower lobe bronchiectasis on HRCT. Extent (P = 0.04), severity (P = 0.03) and bronchial wall thickness (P = 0.05) scores were lower in YNS

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2016 Respirology

16. Titanium Pigment and Yellow Nail Syndrome (PubMed)

Titanium Pigment and Yellow Nail Syndrome 27386465 2016 07 07 2018 11 13 2296-9195 1 4 2016 May Skin appendage disorders Skin Appendage Disord Titanium Pigment and Yellow Nail Syndrome. 197 10.1159/000445722 Dos Santos Vitorino Modesto VM Department of Internal Medicine, Armed Forces Hospital and Catholic University of Brasília, Brasília, Brazil. eng Journal Article 2016 04 15 Switzerland Skin Appendage Disord 101670617 2296-9160 2016 02 29 2016 03 18 2016 7 8 6 0 2016 7 8 6 0 2016 7 8 6 1

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2016 Skin appendage disorders

17. Characteristics of patients with yellow nail syndrome and pleural effusion. (PubMed)

Characteristics of patients with yellow nail syndrome and pleural effusion. Yellow nail syndrome (YNS) can be associated with a pleural effusion (PE) but the characteristics of these patients are not well defined. We performed a systematic review across four electronic databases for studies reporting clinical findings, PE characteristics, and most effective treatment of YNS. Case descriptions and retrospective studies were included, unrestricted by year of publication. We reviewed 112 studies (...) (150 patients), spanning a period of nearly 50 years. The male/female ratio was 1.2/1. The median age was 60 years (range: 0-88). Seventy-eight percent were between 41-80 years old. All cases had lymphoedema and 85.6% had yellow nails. PEs were bilateral in 68.3%. The appearance of the fluid was serous in 75.3%, milky in 22.3% and purulent in 3.5%. The PE was an exudate in 94.7% with lymphocytic predominance in 96% with a low count of nucleated cells. In 61 of 66 (92.4%) of patients, pleural fluid

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2014 Respirology

18. Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer (PubMed)

Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer 22605706 2013 02 12 2018 11 13 1757-790X 2012 2012 Mar 20 BMJ case reports BMJ Case Rep Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. 10.1136/bcr.11.2011.5183 bcr1120115183 Taki Hirofumi H First Department of Internal Medicine, University of Toyama, Toyama, Toyama, Japan. htaki-tym@umin.ac.jp Tobe Kazuyuki K eng Case Reports (...) Journal Article 2012 03 20 England BMJ Case Rep 101526291 1757-790X 0 Sulfhydryl Compounds IM Arthritis, Rheumatoid complications Bronchiectasis diagnosis Diagnosis, Differential Humans Lymphedema diagnosis Stomach Neoplasms complications diagnosis surgery Sulfhydryl Compounds adverse effects Yellow Nail Syndrome complications diagnosis 2012 5 19 6 0 2012 5 19 6 0 2013 2 13 6 0 epublish 22605706 bcr.11.2011.5183 10.1136/bcr.11.2011.5183 PMC3316821 Thorax. 1966 May;21(3):247-53 5914998 Chest. 1972 May

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2012 BMJ case reports

19. Yellow Nail Syndrome

Yellow Nail Syndrome Yellow Nail Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Yellow Nail Syndrome Yellow Nail Syndrome (...) Aka: Yellow Nail Syndrome From Related Chapters II. Epidemiology Rare III. Pathophysiology Delayed Results in nails heaping-up and thickening May be associated with microvascular permeability Hypoalbuminemia IV. Signs Convex (heaped-up) nails with loss of lunula Nail with yellow hue V. Associated Conditions (e.g. ) Thiol Medications (e.g. gold thiomalate) VI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Yellow

2015 FP Notebook

20. Yellow-nail syndrome: report of three cases. (PubMed)

Yellow-nail syndrome: report of three cases. The yellow nail syndrome, a combination of yellow discolouration of and dystrophic changes in the nails, pleural effusions and lymphedema, is thought to be relatively rare; to date 44 cases have been reported. Of a further three patients with this syndrome, one had all three features, one had the yellow nails alone and the other had pleural effusions and lymphedema without classic nail changes. Each had recurrent lower respiratory tract infections (...) ; and of all 47, chronic pulmonary infections occurred in approximately one quarter and were frequently associated with chronic sinus infections. The underlying abnormality is presumed to be a congenital defect of the lymphatics, but so far this has not been demonstrated to be the cause of the nail changes, the pathogenesis of which remains obscure.

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1976 Canadian Medical Association Journal

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