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Wound Infection

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161. Assessment of the Improvement of Wound Healing Rate and Wound Bioburden With the Combination of Next Science Wound Gel and Wash

Keywords provided by Next Science TM: biofilm EPS matrix antimicrobial Additional relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries Anti-Bacterial Agents Anti-Infective Agents (...) Assessment of the Improvement of Wound Healing Rate and Wound Bioburden With the Combination of Next Science Wound Gel and Wash Assessment of the Improvement of Wound Healing Rate and Wound Bioburden With the Combination of Next Science Wound Gel and Wash - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

162. Standard wound management versus negative-pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb-a two-arm parallel group superiority randomised controlled trial: protocol for Wound Healing i (Full text)

Standard wound management versus negative-pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb-a two-arm parallel group superiority randomised controlled trial: protocol for Wound Healing i Patients with closed high-energy injuries associated with major trauma have surprisingly high rates of surgical site infection in incisions created during fracture fixation. One factor that may reduce the risk of surgical site infection (...) is the type of dressing applied over the closed surgical incision. In this multicentre randomised clinical trial, negative-pressure wound therapy will be compared with standard dressings with outcomes of deep infection, quality of life, pain and disability.Adult patients presenting to hospital within 72 hours of sustaining major trauma, requiring a surgical incision to treat a fractured lower limb, are eligible for inclusion. Randomisation, stratified by trial centre, open/closed fracture at presentation

2018 BMJ open PubMed

163. The Society for Vascular Surgery lower extremity threatened limb classification system based on Wound, Ischemia, and foot Infection (WIfI) correlates with risk of major amputation and time to wound healing (Full text)

The Society for Vascular Surgery lower extremity threatened limb classification system based on Wound, Ischemia, and foot Infection (WIfI) correlates with risk of major amputation and time to wound healing The purpose of this study was to evaluate whether the new Society for Vascular Surgery (SVS) Wound, Ischemia, and foot Infection (WIfI) classification system correlates with important clinical outcomes for limb salvage and wound healing.A total of 201 consecutive patients with threatened (...) limbs treated from 2010 to 2011 in an academic medical center were analyzed. These patients were stratified into clinical stages 1 to 4 on the basis of the SVS WIfI classification. The SVS objective performance goals of major amputation, 1-year amputation-free survival (AFS) rate, and wound healing time (WHT) according to WIfI clinical stages were compared.The mean age was 58 years (79% male, 93% with diabetes). Forty-two patients required major amputation (21%); 159 (78%) had limb salvage

2015 EvidenceUpdates PubMed

164. Randomized clinical trial of negative pressure wound therapy for high-risk groin wounds in lower extremity revascularization

Randomized clinical trial of negative pressure wound therapy for high-risk groin wounds in lower extremity revascularization The surgical site infection (SSI) rate in vascular surgery after groin incision for lower extremity revascularization can lead to significant morbidity and mortality. This trial was designed to study the effect of negative pressure wound therapy (NPWT) on SSI in closed groin wounds after lower extremity revascularization in patients at high risk for SSI.A single-center (...) , randomized, controlled trial was performed at an academic tertiary medical center. Patients with previous femoral artery surgical exposure, body mass index of >30 kg/m2 or the presence of ischemic tissue loss were classified as a high-risk patient for SSI. All wounds were closed primarily and patients were randomized to either NPWT or standard dressing. The primary outcome of the trial was postoperative 30-day SSI in the groin wound. The secondary outcomes included 90-day SSI, hospital duration of stay

2017 EvidenceUpdates

165. Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. (PubMed)

Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. Prolonged wound drainage after TKA is associated with increased risk of infection. To decrease wound drainage, tissue adhesive has been suggested as an adjunct to wound closure after TKA; however, no studies of which we are aware have investigated the effect of tissue adhesive in a modern fast-track TKA setting.The purpose (...) that may prove important such as patient preferences or longer term differences in wound healing or infection should be studied in the future.Level I, therapeutic study.

2019 Clinical Orthopaedics and Related Research

166. Wound healing in wild male baboons: Estimating healing time from wound size. (Full text)

Wound healing in wild male baboons: Estimating healing time from wound size. Wound healing in animals is important to minimize the fitness costs of infection. Logically, a longer healing time is associated with higher risk of infection and higher energy loss. In wild mammals, wounds caused by aggressive intraspecific interactions can potentially have lethal repercussions. Clarifying wounding rate and healing time is therefore important for measuring the severity of the attacks. In addition (...) , impact of secondary damage of wounds (e.g., accidental peeling off of scabs) on heeling time is unknown despite the risk of infection in wild mammals. In baboons, most male injuries have been reported to result from male to male fights. Here, we investigated the relationship between wound size and healing time in wild anubis baboons to clarify the healing cost of physical attacks including secondary damage of wounds. Observations were conducted daily between August 2016 and July 2017 in Kenya

2018 PLoS ONE PubMed

167. Microdeformational wound therapy: A novel option to salvage complex wounds associated with the Nuss procedure. (PubMed)

antibiotics following resolution of the acute process. MDWT is performed until the wounds are completely epithelialized with no clinical signs of drainage or infection. The average length of MDWT in our patients was 39 days. Following complete wound healing the patients are maintained on antibiotics until implant removal.The use of microdeformational wound therapy in complex wounds associated with the Nuss procedure is a safe and effective modality. The technique may reduce the likelihood of implant (...) Microdeformational wound therapy: A novel option to salvage complex wounds associated with the Nuss procedure. Complex wounds associated with the Nuss procedure are a resource intensive complication that may lead to significant morbidity with potential removal of the implanted device and abandonment of the repair. We report our management technique of this complication utilizing microdeformational wound therapy (MDWT) that is safe, is efficacious and allows for salvage of the repair.We defined

2019 Journal of Pediatric Surgery

168. Nonsterile Gloves for ED Wound Closure

at less cost. You decide to learn what the literature has to say about sterile gloves for ED laceration repair. PICO Question Population: Patients with acute, uncomplicated lacerations requiring closure in the ED Intervention: Use of clean, non-sterile gloves during laceration repair Comparison: Use of sterile gloves for laceration repair Outcome: Rate of wound infection after repair Search Strategy You search Pubmed for “sterile nonsterile gloves laceration repair” and get two results, one of which (...) -repair wound infections. Research indicates that >105 organisms per mL are required to cause wound infection ( , , ) in traumatic lacerations or post-op wounds. Although clean, non-sterile gloves carry a significantly higher bacterial load, the increased non-sterile glove bacterial load is not sufficient to cause infections ( ). However, open boxes of gloves are more likely to carry bacterial contaminants, particularly when the gloves are wet ( , ). Sterile gloves at Barnes Jewish Hospital cost

2017 Washington University Emergency Medicine Journal Club

169. Sternal cables are not superior to traditional sternal wiring for preventing deep sternal wound infection. (Full text)

Sternal cables are not superior to traditional sternal wiring for preventing deep sternal wound infection. Deep sternal wound infection is a devastating complication of cardiac surgery. In the current era of increasing patient comorbidity, newer techniques must be evaluated in attempts to reduce the rates of deep sternal wound infection.A randomized controlled trial comparing sternal closure with traditional sternal wires in figure-8 formation with the Pioneer cabling system® from Medigroup (...) after adult cardiac surgery was performed.A total of 273 patients were enrolled with 137 and 135 patients randomized to sternal wires and cables group, respectively. Baseline characteristics between the two groups were well balanced. Deep sternal wound infection occurred in 0.7% of patients in the wires group and 3.7% of patients in the cables group (absolute risk difference = -3.0%, 95% confidence interval: -7.7 to 0.9%; P = 0.12). Patients in the cables group were extubated slightly earlier than

2017 Interactive cardiovascular and thoracic surgery PubMed

170. Surgical site infection in cesarean sections with the use of a plastic sheath wound retractor compared to the traditional self-retaining metal retractor. (PubMed)

Surgical site infection in cesarean sections with the use of a plastic sheath wound retractor compared to the traditional self-retaining metal retractor. A cesarean section rate of up to 19.4% is reported worldwide. Surgical site infection occurs with rates of up to 13.5%. Plastic-sheath wound retractors show reduced rates of surgical site infections in abdominal surgery. There is limited evidence in women having cesarean sections. This study evaluates the use of the Alexis(®) O C-Section (...) with wound healing. From October 2013 to December 2015 at the Charité University Hospital, Berlin. 98 patients to the Alexis(®) O C-Section Retractor group and 100 to the traditional Collins self-retaining metal retractor group.A statistically significant reduction in the rate of surgical site infections, when the Alexis(®) O C-Section Retractor was used for wound retraction compared to the traditional Collins metal self-retaining wound retractor, 1% vs. 8% (RR 7.84, 95% CI (2.45-70.71) p=0.035).The use

2017 European journal of obstetrics, gynecology, and reproductive biology

171. A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study): Erratum. (PubMed)

A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study): Erratum. 28876278 2017 11 15 1531-2291 31 9 2017 09 Journal of orthopaedic trauma J Orthop Trauma A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study): Erratum. e308 10.1097/01.bot.0000524641.86554.01 eng Journal

2017 Journal of Orthopaedic Trauma

172. Wound infection following stoma reversal: a prospective comparative study between primary closure and partial closure with intervening silver dressings. (PubMed)

Wound infection following stoma reversal: a prospective comparative study between primary closure and partial closure with intervening silver dressings. 26728021 2017 04 03 2017 04 03 1432-1262 31 7 2016 Jul International journal of colorectal disease Int J Colorectal Dis Wound infection following stoma reversal: a prospective comparative study between primary closure and partial closure with intervening silver dressings. 1381-2 10.1007/s00384-015-2487-0 Zubaidah N H NH Department of Surgery (...) , Malaysia. Gee T T Department of Surgery, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia. eng Comparative Study Letter Randomized Controlled Trial 2016 01 04 Germany Int J Colorectal Dis 8607899 0179-1958 3M4G523W1G Silver IM Bandages Female Humans Male Middle Aged Prospective Studies Silver pharmacology Surgical Stomas adverse effects Surgical Wound Infection etiology Wound Closure Techniques Wound Healing drug effects 2015 12 21 2016 1 6 6 0 2016 1 6 6

2017 International journal of colorectal disease

173. Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections

Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03021668 Recruitment Status : Completed First Posted : January 16, 2017 Results First Posted

2017 Clinical Trials

174. The Use of Klorsept Solution for Debriding Infected Wounds: is it Effective and Safe? Prospective Observational Study

The Use of Klorsept Solution for Debriding Infected Wounds: is it Effective and Safe? Prospective Observational Study The Use of Klorsept Solution for Debriding Infected Wounds: is it Effective and Safe? Prospective Observational Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. The Use of Klorsept Solution for Debriding Infected Wounds: is it Effective and Safe? Prospective Observational Study (Klorsept) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03049670 Recruitment Status : Unknown Verified

2017 Clinical Trials

175. Regional and Seasonal Variations in the Incidence and Causative Organisms for Post-traumatic Wound Infections and Osteomyelitis After Open Fractures

Regional and Seasonal Variations in the Incidence and Causative Organisms for Post-traumatic Wound Infections and Osteomyelitis After Open Fractures Regional and Seasonal Variations in the Incidence and Causative Organisms for Post-traumatic Wound Infections and Osteomyelitis After Open Fractures - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Regional and Seasonal Variations in the Incidence and Causative Organisms for Post-traumatic Wound Infections and Osteomyelitis After Open Fractures The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2017 Clinical Trials

176. Enterococcus faecalis modulates immune activation and slows healing during wound infection. (Full text)

Enterococcus faecalis modulates immune activation and slows healing during wound infection. Enterococcus faecalis is one of the most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynamics of E faecalis and show that infected wounds result in 2 different states depending on the initial inoculum. Low-dose inocula were associated with short-term, low (...) -titer colonization whereas high-dose inocula were associated with acute bacterial replication and long-term persistence. High-dose infection and persistence were also associated with immune cell infiltration, despite suppression of some inflammatory cytokines and delayed wound healing. During high-dose infection, the multiple peptide resistance factor, which is involved in resisting immune clearance, contributes to E faecalis fitness. These results comprehensively describe a mouse model

2017 Journal of Infectious Diseases PubMed

177. Volatile organic compound detection as a potential means of diagnosing cutaneous wound infections. (Full text)

Volatile organic compound detection as a potential means of diagnosing cutaneous wound infections. Chronic cutaneous wound infections and surgical site infections (SSIs) present a huge burden on the healthcare system and can lead to increased morbidity and mortality. Current diagnostic methods of identifying and confirming infection involve culture-based and molecular methods. Both techniques are time-consuming and delays commonly lead to untargeted empirical treatment. An ideal diagnostic (...) method would be noninvasive and highly sensitive and detect pathogenic organisms with a high degree of accuracy to allow targeted treatment. Volatile organic compounds (VOCs) are a diverse group of carbon-based molecules produced and released by humans and microorganisms. VOC detection has the potential in aiding cutaneous wound infection diagnostics using noninvasive and time-efficient methods. This review provides a comprehensive update on VOCs produced and emitted by bacteria commonly associated

2017 Wound Repair and Regeneration PubMed

178. Routine Use of Topical Bacitracin to Prevent Sternal Wound Infections After Cardiac Surgery. (PubMed)

Routine Use of Topical Bacitracin to Prevent Sternal Wound Infections After Cardiac Surgery. The development of sternal wound infections remains a serious complication after cardiac surgery. A number of studies have assessed the use of topical antibiotics placed on the sternal edges. We evaluated the routine use of bacitracin ointment applied over the sternotomy skin incision as a prophylactic measure against sternal wound infections.A retrospective review of all coronary artery bypass graft (...) and valve surgery cases performed at a single institution between 2006 and 2015 was performed (n = 1,495). Appropriate preoperative intravenous antibiotics were administered for all patients. Bacitracin topical antibiotic ointment was routinely applied to the sternal surgical incision after skin closure for all patients during this period. The incidence of sternal wound infection was assessed.During this 9-year experience, no episodes of deep sternal wound infections were observed, compared

2017 Annals of Thoracic Surgery

179. A systematic review of clinical effectiveness of wound edge protector devices in reducing surgical site infections in patients undergoing abdominal surgery. (PubMed)

A systematic review of clinical effectiveness of wound edge protector devices in reducing surgical site infections in patients undergoing abdominal surgery. This article highlights the clinical effectiveness of wound edge protector devices (WEPD) in preventing the post-operative surgical site infections (SSI) in patients undergoing abdominal surgery. Using the principles of meta-analysis and systematic review as recommended by the Cochrane Collaboration, the data from selected randomized (...) , controlled trials (RCTs) were analysed to generate summated outcome and presented in the form of odds ratio (OR). Eighteen RCTs on 3808 reported the effectiveness of WEPD in patients undergoing abdominal surgery. The use of WEPD was associated with the reduced incidence of overall SSI (OR 0.59; 95% CI 0.43-0.81; z = 3.30; p < 0.001) and superficial SSI (OR 0.42; 95% CI 0.18-0.95; z = 2.09; p < 0.04). In addition, WEPD also successfully reduced the risk of SSI in clean-contaminated wounds (OR 0.67; 95% CI

2017 Updates in surgery

180. Predictive ability of the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system after first-time lower extremity revascularizations. (Full text)

Predictive ability of the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system after first-time lower extremity revascularizations. The Society for Vascular Surgery (SVS) Wound, Ischemia and foot Infection (WIfI) classification system was proposed to predict 1-year amputation risk and potential benefit from revascularization. Our goal was to evaluate the predictive ability of this scale in a real-world selection of patients undergoing a first-time lower (...) extremity revascularization for chronic limb-threatening ischemia (CLTI).From 2005 to 2014, 1336 limbs underwent a first-time lower extremity revascularization for CLTI, of which 992 had sufficient data to classify all three WIfI components (wound, ischemia, and foot infection). Limbs were stratified into the SVS WIfI clinical stages (from 1 to 4) for 1-year amputation risk estimation, a novel WIfI composite score from 0 to 9 (that weighs all WIfI variables equally), and a novel WIfI mean score from 0

2017 Journal of Vascular Surgery PubMed

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