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Wound Infection

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101. Is sternal rewiring mandatory in surgical treatment of deep sternal wound infections? (PubMed)

Is sternal rewiring mandatory in surgical treatment of deep sternal wound infections? Deep sternal wound infections (DSWIs) are a rare but serious complication after median sternotomy, and treatment success depends mainly on surgical experience. We compared treatment outcomes after conventional sternal rewiring and reconstruction with no sternal rewiring in patients with a sternal wound infection.We retrospectively enrolled patients who developed a DSWI after an open-heart procedure with median (...) of sepsis before surgical treatment. Fifty-six patients underwent surgical reconstruction with conventional sternal rewiring (23 cases, 41%) or another interventions with no sternal refixation (33 cases, 59%). Eighty-one percent of sternal wound infections followed coronary bypass surgery (alone or combinated with another procedures), and 60% were diagnosed after hospital discharge. Staphylococcus aureus was cultured in 30% of all wounds and, 56.5% of cases reconstructed by sternal rewiring vs. 26.5

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2018 Journal of thoracic disease

102. Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling (PubMed)

Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote (...) secretory gel (PSG), which blocks the gut and facilitates the regurgitation of infective parasites. The interaction between the wound created by the sand fly bite and PSG is not known. Here we nanoinjected a sand fly egested dose of PSG into BALB/c mouse skin that lead to the differential expression of 7,907 transcripts. These transcripts were transiently up-regulated during the first 6 hours post-wound and enriched for pathways involved in inflammation, cell proliferation, fibrosis, epithelial cell

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2018 PLoS pathogens

103. Household light source for potent photo-dynamic antimicrobial effect and wound healing in an infective animal model (PubMed)

Household light source for potent photo-dynamic antimicrobial effect and wound healing in an infective animal model Photodynamic antimicrobial chemotherapy (PACT) is considered a promising alternative to conventional antibiotic approach. We have previously developed a novel PS containing five lysine amino acids, pentalysine-β-carbonylphthalocyanine Zinc (ZnPc(Lys)5), which in the presence of light, is highly toxic against a range of bacterial strains, including hospital isolated, drug resistant

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2018 Biomedical optics express

104. The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection (PubMed)

The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection Background: Incidence of infection following total elbow replacement (TER) is recognised to be higher compared to hip or knee arthroplasty. Extensive swelling following TER can complicate the wound healing which might lead to infection. Tranexamic Acid (TXA) is proven to reduce blood loss peri-operatively which might contribute to better healing outcomes. Our aim is to assess the effect of TXA (...) and the mean post-operative level was 122.70g/l. No patient in this series required blood transfusion. At two weeks and six weeks follow-up, all wound healed up with no signs of infection. Conclusion: TXA has been proven to be safe an effective way of reducing peri-operative bleeding. TXA maintains haemostasis after releasing the tourniquet and therefore reduces the swelling and wound complications post-operatively.

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2018 Journal of Bone and Joint Infection

105. Xiphoid-sparing midline sternotomy reduces wound infection risk after coronary bypass surgery (PubMed)

Xiphoid-sparing midline sternotomy reduces wound infection risk after coronary bypass surgery Because of its advantages, full midline sternotomy has remained the main approach for cardiac surgery. However, the development of post-sternotomy wound infections is its primary disadvantage. We evaluated the impact of xiphoid process (XIP)-sparing midline sternotomy regarding reducing the risk of deep sternal wound infections (DSWIs).Data from 446 patients who underwent coronary artery bypass (...) . The generalized linear model was used to compare xiphoid-sparing and conventional sternotomy regarding the development of sternal wound infections.The sternal infection rates were 0.8% and 4.5% in the xiphoid-sparing and standard sternotomy groups, respectively (P=0.014). After adjustment for the IPTW, the xiphoid-sparing group showed a decreased risk for DSWIs (odds ratio 0.171, 95% confidence interval, 0.036-0.806, P=0.026) compared to the traditional sternotomy group.XIP-sparing midline sternotomy may

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2018 Journal of thoracic disease

106. Negative-Pressure Wound Therapy in a Pseudomonas aeruginosa Infection Model (PubMed)

Negative-Pressure Wound Therapy in a Pseudomonas aeruginosa Infection Model Negative-pressure wound therapy (NPWT) is an effective strategy for the management of contaminated wounds, including those infected by Pseudomonas aeruginosa. We hypothesized that NPWT would reduce virulence factors as well as biofilm components and inhibit virulence-regulated gene expression in a model of P. aeruginosa wound infection.Wounds were created in anesthetized rabbits and P. aeruginosa was inoculated (...) A conjugated to Alexa Fluor® 647.NPWT was more effective than the control treatment in reducing virulence factors and bacteria counts in vivo. A biofilm component, eDNA, was less abundant in the NPWT group. The results of the RT-PCR indicated that the expression levels of P. aeruginosa virulence-regulated genes and quorum-sensing population density-dependent systems were significantly inhibited by NPWT treatment.NPWT reduced bacteria counts, virulence factors, and eDNA in a P. aeruginosa wound infection

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2018 BioMed research international

107. Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure.

Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure. Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03468621 Recruitment Status

2018 Clinical Trials

108. Early Detection of Surgical Wound Infections Using Sensor Technology

Early Detection of Surgical Wound Infections Using Sensor Technology Early Detection of Surgical Wound Infections Using Sensor Technology - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Detection (...) of Surgical Wound Infections Using Sensor Technology (SSI-Sensor) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03401658 Recruitment Status : Not yet recruiting First Posted : January 17, 2018 Last Update Posted : February 26

2018 Clinical Trials

109. Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children

Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03700814 Recruitment Status : Completed First

2018 Clinical Trials

110. Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds (PubMed)

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds Alarming data about increasing resistance to conventional antibiotics are reported, while at the same time the development of new antibiotics is stagnating. Skin and soft tissue infections (SSTIs) are mainly caused by the so called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) which (...) to be promising therapeutic options for the treatment of SSTIs and wounds as they show a broad spectrum of antimicrobial activity, low resistance rates and display pivotal immunomodulatory as well as wound healing promoting activities such as induction of cell migration and proliferation and angiogenesis. In this review, we evaluate the potential of AMPs for the treatment of bacterial SSTIs and wounds and provide an overview of the mechanisms of actions of AMPs that contribute to combat skin infections

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2018 Frontiers in pharmacology

111. Draft Genome Sequence of an NDM-1- and KPC-2-Coproducing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Isolated from Burn Wound Infections (PubMed)

Draft Genome Sequence of an NDM-1- and KPC-2-Coproducing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Isolated from Burn Wound Infections We report here the draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant Klebsiella pneumoniae strain, isolated from a 58-year-old male in the People's Republic of China with a burn injury.Copyright © 2018 Wei et al.

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2018 Genome Announcements

112. Liposome Entrapment of Bacteriophages Improves Wound Healing in a Diabetic Mouse MRSA Infection (PubMed)

Liposome Entrapment of Bacteriophages Improves Wound Healing in a Diabetic Mouse MRSA Infection Diabetic populations are more prone to developing wound infections which results in poor and delayed wound healing. Infection with drug resistant organisms further worsen the situation, driving searches for alternative treatment approaches such as phage therapy. Major drawback of phage therapy, however, is low phage persistence in situ, suggesting further refinement of the approach. In the present (...) work we address this issue by employing liposomes as delivery vehicles. A liposome entrapped phage cocktail was evaluated for its ability to resolve a Staphylococcus aureus-induced diabetic excission wound infection. Two characterized S. aureus specific lytic phages, MR-5 and MR-10 alone, in combination (cocktail), or entrapped in liposomes (versus as free phages) were assesed for their therapeutic efficacy in resolving diabetic wound infection. Mice treated with free phage cocktail showed

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2018 Frontiers in microbiology

113. Real-Life Evidence for Tedizolid Phosphate in the Treatment of Cellulitis and Wound Infections: A Case Series (PubMed)

Real-Life Evidence for Tedizolid Phosphate in the Treatment of Cellulitis and Wound Infections: A Case Series Tedizolid phosphate 200 mg, once daily for 6 days, has recently been approved for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in several countries; however, clinical experience in real-life settings is currently limited. Here, we report on the use of tedizolid with an extended treatment duration for complex and severe ABSSSIs in real-world (...) clinical settings.Two patients with cellulitis and two patients with surgical site infection (SSI), aged 26-60 years, were treated with tedizolid phosphate 200 mg, intravenous/oral (IV/PO) or IV only, once daily at four different institutions.Two morbidly obese patients had non-necrotizing, non-purulent severe cellulitis, which were complicated by sepsis or systemic inflammatory response syndrome plus myositis. One female patient failed on first-line empiric therapy with IV cefalotin, clindamycin

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2018 Infectious diseases and therapy

114. Construction and analysis of alginate-based honey hydrogel as an ointment to heal of rat burn wound related infections (PubMed)

Construction and analysis of alginate-based honey hydrogel as an ointment to heal of rat burn wound related infections Developing a strategy for making the alginate base hydrogel components against burned wound infections could be promising for healing the mentioned wounds followed by elimination of the biofilm forming bacteria colonization. Construction of an alginate based hydrogel and evaluating healing activities of the mentioned component as local ointment were the main objectives (...) in constructed alginate-based hydrogel alginate and honey because of C = O bond variations structurally confirmed proper construction of hydrogel. The hydrogel was the better healing activity in rats burned wound too. In conclusion the promising efficiency of alginate-based hydrogel in an elimination of bacterial infections was confirmed as the main aim of the current survey.

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2018 International journal of burns and trauma

115. Human amniotic membrane dressing for the treatment of an infected wound due to an entero-cutaneous fistula: Case report (PubMed)

Human amniotic membrane dressing for the treatment of an infected wound due to an entero-cutaneous fistula: Case report Infected wounds are difficult to treat and there are no standardized protocols.We report a case of infected postoperative wound and entero-cutaneous fistula in a 83 years-old woman. An innovative treatment protocol for Human amniotic membrane (HAM)-assisted dressing of infected wound as the Idea Stage following the IDEAL recommendations is presented. The development of amnion (...) preparation and the involved treatment steps are described. No adverse events and no graft rejection have been detected.Favorable results confirm the technical simplicity, safety and efficacy of this procedure. HAM has been shown to promote wound healing and to have antibacterial characteristics, which was supported by the presented case.We are able to report a successful treatment of an infected wound caused by entero-cutaneous fistula with HAM dressing. Following the IDEAL recommendations, consecutive

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2018 International journal of surgery case reports

116. In Vitro Antibacterial Activity of Selected Medicinal Plants in the Traditional Treatment of Skin and Wound Infections in Eastern Ethiopia (PubMed)

In Vitro Antibacterial Activity of Selected Medicinal Plants in the Traditional Treatment of Skin and Wound Infections in Eastern Ethiopia External infections involving the skin and wound are the most frequent complications affecting humans and animals. Medicinal plants play great roles in the treatment of skin and wound infections. This study was aimed to evaluate the in vitro antibacterial activity of crude methanolic extracts of nine medicinal plants.Agar well diffusion and broth dilution (...) of seven plants in treating skin and wound infections related to bacteria.

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2018 BioMed research international

117. Current perspectives on diagnosis and management of sternal wound infections (PubMed)

Current perspectives on diagnosis and management of sternal wound infections Deep sternal wound infection (DSWI), also known as mediastinitis, is a serious and potentially fatal condition. The diagnosis and treatment of DSWI are challenging. In this current narrative review, the epidemiology, risk factors, diagnosis, and surgical and antimicrobial management of DSWI are discussed. Ideally, the management of DSWI requires early and sufficient surgical debridement and appropriate antibiotic

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2018 Infection and drug resistance

118. MicroRNA therapy for infected wounds (PubMed)

MicroRNA therapy for infected wounds 30224382 2019 02 22 2019 02 22 1757-4684 10 10 2018 10 EMBO molecular medicine EMBO Mol Med MicroRNA therapy for infected wounds. e9574 10.15252/emmm.201809574 Hiebert Paul P 0000-0001-8179-4217 Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute for Technology (ETH) Zurich, Zurich, Switzerland. Werner Sabine S 0000-0001-7397-8710 Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute (...) for Technology (ETH) Zurich, Zurich, Switzerland. eng Journal Article Comment England EMBO Mol Med 101487380 1757-4676 0 MIRN223 microRNA, human 0 MicroRNAs IM EMBO Mol Med. 2018 Oct;10(10):null 30171089 Humans MicroRNAs Neutrophils Staphylococcal Infections Staphylococcus aureus Wound Infection 2018 9 19 6 0 2019 2 23 6 0 2018 9 19 6 0 ppublish 30224382 emmm.201809574 10.15252/emmm.201809574 PMC6180288 EMBO Mol Med. 2018 Oct;10(10):null 30171089 J Invest Dermatol. 2017 Apr;137(4):931-940 27894934 Trends

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2018 EMBO molecular medicine

119. A rare skin condition masquerading as a serious wound infection (PubMed)

A rare skin condition masquerading as a serious wound infection Pyoderma gangrenosum is a rare, serious and commonly missed condition that can effect post-operative surgical patients. The condition is commonly misdiagnosed as a wound infection, with subsequent inappropriate antibiotic therapy and wound debridement. We present the case of a 46-year-old patient who suffered this delayed diagnosis and multiple unnecessary interventions. We present this in an effort to raise awareness of the rare

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2018 Journal of surgical case reports

120. Chitosan-polyvinyl alcohol nanoscale liquid film-forming system facilitates MRSA-infected wound healing by enhancing antibacterial and antibiofilm properties (PubMed)

Chitosan-polyvinyl alcohol nanoscale liquid film-forming system facilitates MRSA-infected wound healing by enhancing antibacterial and antibiofilm properties Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most predominant and fatal pathogens at wound infection sites. MRSA is difficult to treat because of its antibiotic resistance and ability to form biofilms at the wound site.In this study, a novel nanoscale liquid film-forming system (LFFS) loaded with benzalkonium bromide (...) conductivity and in K+ and Mg2+ concentrations due to changes in the MRSA cell membrane permeability.The novel LFFS is promising as an effective system for disinfectant delivery and for application in the treatment of MRSA wound infections.

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2018 International journal of nanomedicine

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