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Wound Infection

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101. Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy Full Text available with Trip Pro

Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion. The tissue specimens were harvested on days 0 (6 h after bacterial (...) inoculation), 2, 4, 6, and 8 at the center of wound beds. Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion. The agrA expression of S.aureus and the transcription and production of virulence factors including Eap, Spa and α-toxin were significantly different. The bacterial invasion depth was significantly less with effect of NPWT. The markedly different activation of quorum sensing systems that enable cell-to-cell

2017 Antonie van Leeuwenhoek

102. Treatment of Decubitis Ulcer Stage IV in the Patient with Polytrauma and Vertical Share Pelvic Fracture, Diagnosed Entherocollitis and Deep Wound Infection with Clostridium Difficile with Combined Negative Pressure Wound Therapy (NPWT) and Faecal Manageme Full Text available with Trip Pro

Treatment of Decubitis Ulcer Stage IV in the Patient with Polytrauma and Vertical Share Pelvic Fracture, Diagnosed Entherocollitis and Deep Wound Infection with Clostridium Difficile with Combined Negative Pressure Wound Therapy (NPWT) and Faecal Manageme The aim of this paper was to present a case with the successful treatment of decubitis ulcer stage IV in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection (...) on both gluteal regia Grade IV and deep muscular necrosis. Several times we perform a necrectomy of necrotic tissue but the wound become bigger and the infection have a progressive intention. In that time we used VAK system for 6 weeks combined with faecal management system and with local necrectomy and system application of Antibiotics and Flagyl for enterocollitis in doses prescripted from specialists from Infective clinic. This new device to manage faecal deep decubital infection and enterocollitis

2017 Open access Macedonian journal of medical sciences

103. Wound management with negative pressure wound therapy in postoperative infection after open reconstruction of chronic Achilles tendon rupture Full Text available with Trip Pro

Wound management with negative pressure wound therapy in postoperative infection after open reconstruction of chronic Achilles tendon rupture Deep infection after reconstruction of chronic Achilles tendon rupture is a major and intractable complication.We report a case of late deep infection following a surgery for chronic Achilles tendon rupture, and its simple and successful treatment with negative pressure wound therapy (NPWT). Six months following the reconstruction of chronic Achilles (...) tendon rupture, a deep infection developed and reconstructed part of the tendon ruptured again. After appropriate debridement.There is no definitive treatment strategy for postoperative infection following open Achilles tendon repair. NPWT was applied to the wound, to promote wound healing and healthy granulation. In our case, NPWT promoted the wound healing and the infected Achilles tendon with tendon loss formed a healthy bridge with granulation tissue spontaneously. The patient resumed her normal

2017 International journal of surgery case reports

104. Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy

Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03563625 Recruitment Status : Completed First Posted : June 20, 2018 Last

2017 Clinical Trials

105. A systematic review of randomized and non-randomized studies for a meta-analysis of incisional negative pressure wound therapy versus regular surgical dressings for the prevention of surgical site infection, wound dehiscence, skin necrosis, seroma, and he

A systematic review of randomized and non-randomized studies for a meta-analysis of incisional negative pressure wound therapy versus regular surgical dressings for the prevention of surgical site infection, wound dehiscence, skin necrosis, seroma, and he Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied

2019 PROSPERO

106. [Wound infections after surgery-effect of triclosan-coated sutures]

[Wound infections after surgery-effect of triclosan-coated sutures] Sårinfektioner efter kirurgi – effekt av triklosanbelagda suturer [Wound infections after surgery-effect of triclosan-coated sutures] Sårinfektioner efter kirurgi – effekt av triklosanbelagda suturer [Wound infections after surgery-effect of triclosan-coated sutures] Lennmarken C, Persson E Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Lennmarken C, Persson E. Sårinfektioner efter kirurgi – effekt av triklosanbelagda suturer. [Wound infections after surgery-effect of triclosan-coated sutures] Stockholm: The HTA Center of the Stockholm County Council/Gotland. 2014:11. 2014 Authors' conclusions The conclusion of the assessment is that triclosan coated sutures had in various operations a limited beneficial effect with significantly lower incidence of superficial

2014 Health Technology Assessment (HTA) Database.

107. Does this patient have an infection of a chronic wound?

Does this patient have an infection of a chronic wound? Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

108. Surgical site infections: prevention and treatment

include the risks of surgical site infections, what is being done to reduce them and how they are managed. For more guidance on providing information to adults and discussing their preferences with them, see the NICE guideline on patient experience in adult NHS services. [2008] [2008] 1.1.2 Offer patients and carers information and advice on how to care for their wound after discharge. [2008] [2008] 1.1.3 Offer patients and carers information and advice about how to recognise a surgical site infection (...) surgery on a dirty or infected wound. [2008] [2008] 1.2.18 Inform patients before the operation, whenever possible, if they will need antibiotic prophylaxis, and afterwards if they have been given antibiotics during their operation. [2008] [2008] 1.3 Intraoperative phase Hand decontamination Hand decontamination 1.3.1 The operating team should wash their hands prior to the first operation on the list using an aqueous antiseptic surgical solution, with a single-use brush or pick for the nails

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

109. Closed-incision negative pressure therapy to reduce groin wound infections in vascular surgery: a randomised controlled trial. (Abstract)

Closed-incision negative pressure therapy to reduce groin wound infections in vascular surgery: a randomised controlled trial. Groin wound infections pose a major problem in vascular surgery. Closed-incision negative pressure therapy (ciNPT) was especially designed for the management of incisions at risk of surgical site infections. The aim of this study was to investigate whether ciNPT is able to reduce the incidence of wound infections after vascular surgery. Data on 132 consecutive patients (...) , scheduled for vascular surgery with a longitudinal femoral cutdown, were collected prospectively. All patients were randomised either to the ciNPT group (n = 64) or the control group (n = 68) with conventional dressing. In the ciNPT group, the foam dressing was applied intraoperatively and removed after 5 days. The control group received an absorbent dressing. All wounds were evaluated after 5 and 42 days. Infections were graded according the Szilagyi classification (I-III°). There were no significant

2018 International wound journal Controlled trial quality: uncertain

110. [Pain Management, Local Infection, Satisfaction, Adverse Effects and Residual Pain after Major Open Abdominal Surgery: Epidural versus Continuous Wound Infusion (PAMA Trial)]. Full Text available with Trip Pro

[Pain Management, Local Infection, Satisfaction, Adverse Effects and Residual Pain after Major Open Abdominal Surgery: Epidural versus Continuous Wound Infusion (PAMA Trial)]. The Management of postoperative pain after abdominal surgery is a major challenge to the anesthesiologist. The optimization of postoperative analgesia improves prognosis contributing also to patient satisfaction and reducing morbidity and mortality. The aim of this randomized control study is to perform the comparative (...) analysis in terms of effectiveness of an unconventional and still poorly technique implemented, continuous wound infusion, and the currently most applied and gold standard technique, epidural analgesia, in the postoperative period after abdominal surgery.Fifty patients, previously subjected to abdominal surgery by median laparotomy with xifo-pubic incision were randomized to receive postoperative analgesia via epidural (n = 25) or via continuous wound infusion (n = 25) during 48 hours. The primary

2018 Acta medica portuguesa Controlled trial quality: uncertain

111. Empirical measurement of pressure in NPWT for infected wounds: how long can it really stay under pressure? (Abstract)

Empirical measurement of pressure in NPWT for infected wounds: how long can it really stay under pressure? Surgical site infections represent one of the most common surgical complications. Negative pressure wound therapy is considered an effective wound management system, based on the principle that a negative pressure inside the wound can suction fluids and approximate wound edges. With the negative pressure wound therapy systems commercially available it is assumed that the pressure inside (...) the wound is stable at the set values. We conducted a prospective experimental study to investigate this. The negative pressure level achieved inside the dressing was investigated at a standard distance from the pad of suction and at specific times in patients with surgical site infections. Pressure measurements were performed in 28 dressings in 14 patients admitted to the Emergency Surgery Department between April 2016 and June 2017. In general, the machine was set at a pressure of -100 mmHg. Negative

2018 Wound Repair and Regeneration

112. Psychrobacter sanguinis Wound Infection Associated with Marine Environment Exposure, Washington, USA. Full Text available with Trip Pro

Psychrobacter sanguinis Wound Infection Associated with Marine Environment Exposure, Washington, USA. We report a 26-year-old man with Psychrobacter sanguinis cellulitis of a wound sustained during ocean fishing in Washington, USA, in 2017. Psychrobacter spp. are opportunistic pathogens found in a wide range of environments. Clinicians should be aware of Psychrobacter spp. and perform 16S rRNA sequencing if this pathogen is suspected.

2018 Emerging Infectious Diseases

113. Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections. Full Text available with Trip Pro

Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections. This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with surgical site infection at 30 days. Furthermore, a duration of surgery of >346 min and a total cefazolin closure (...) concentration of <104 mg/liter were significant thresholds for an increased risk of infection. This study provides new data that informs dosing strategies for effective antimicrobial prophylaxis (AP) in patients undergoing cardiac surgery with cardiopulmonary bypass.Copyright © 2018 American Society for Microbiology.

2018 Antimicrobial Agents and Chemotherapy

114. Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure.

researchers. Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Veikko Nikulainen, Turku University Hospital: woundclosure technique surgical site infection intrademal transdermal suture Additional relevant MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Wounds and Injuries Wound Infection Surgical Wound Surgical Wound Infection Postoperative Complications Pathologic Processes (...) Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure. Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2018 Clinical Trials

115. Normal Saline Versus Betadine Use to Reduce the Incidence of Wound Infection in Cesarean Section

Numbers: assistant professor2 First Posted: October 31, 2018 Last Update Posted: October 31, 2018 Last Verified: October 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by hadeer meshal, Kasr El Aini Hospital: saline, betadine, cesarean scar infection Additional relevant MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Wound Infection Povidone-Iodine Anti-Infective Agents (...) Normal Saline Versus Betadine Use to Reduce the Incidence of Wound Infection in Cesarean Section Normal Saline Versus Betadine Use to Reduce the Incidence of Wound Infection in Cesarean Section - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

116. Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds

Infection Communicable Diseases Wounds and Injuries Skin Diseases, Bacterial Bacterial Infections Skin Diseases, Infectious Skin Diseases Anti-Bacterial Agents Cefazolin Antibiotics, Antitubercular Anti-Infective Agents Antitubercular Agents (...) Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2018 Clinical Trials

117. Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial. (Abstract)

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial. Wound infections are the main cause of sepsis in patients with burns and increase burn-related morbidity and mortality. Bacteriophages, natural bacterial viruses, are being considered as an alternative therapy to treat infections caused by multidrug-resistant bacteria. We aimed to compare the efficacy (...) and tolerability of a cocktail of lytic anti-Pseudomonas aeruginosa bacteriophages with standard of care for patients with burns.In this randomised phase 1/2 trial, patients with a confirmed burn wound infection were recruited from nine burn centres in hospitals in France and Belgium. Patients were eligible if they were aged 18 years or older and had a burn wound clinically infected with P aeruginosa. Eligible participants were randomly assigned (1:1) by use of an interactive web response system to a cocktail

2018 Lancet infectious diseases Controlled trial quality: predicted high

118. Deep sternal wound infection after bilateral internal thoracic artery grafting: Insights from a Japanese national database. Full Text available with Trip Pro

Deep sternal wound infection after bilateral internal thoracic artery grafting: Insights from a Japanese national database. Despite its survival benefits, bilateral internal thoracic artery (BITA) grafting is not commonly utilized due to concerns over deep sternal wound infection (DSWI). The present study investigated the early outcome of BITA grafting and analyzed the risk of DSWI using a Japanese national database (the Japan Adult Cardiovascular Surgery Database).Data from 560 hospitals were (...) used. Between April 2012 and December 2015, BITA was harvested in 14,249 patients, corresponding to 32.6% of isolated coronary artery bypass cases. DSWI was defined as a wound infection requiring surgical intervention and/or the administration of antibiotics. Multiple logistic regression analysis was employed to model the risk of DSWI.The mean age was 67.1 years. The prevalence of diabetes, renal failure, hemodialysis, and liver dysfunction was 51.8%, 21.2%, 7.8%, and 1.2%, respectively

2018 Journal of Thoracic and Cardiovascular Surgery

119. Treatment of Infected Wounds in the Age of Antimicrobial Resistance: Contemporary Alternative Therapeutic Options. (Abstract)

Treatment of Infected Wounds in the Age of Antimicrobial Resistance: Contemporary Alternative Therapeutic Options. As antibiotic resistance increases and antimicrobial options diminish, there is a pressing need to identify and develop new and/or alternative (non-antimicrobial-based) wound therapies. The authors describe the implications of antibiotic resistance on their current wound treatment paradigms and review the most promising non-antibiotic-based antimicrobial agents currently

2018 Plastic and reconstructive surgery

120. Infection and wound breakdown in spontaneous second-degree perineal tears: An exploratory mixed methods study. Full Text available with Trip Pro

Infection and wound breakdown in spontaneous second-degree perineal tears: An exploratory mixed methods study. Perineal trauma affects large numbers of women who have a vaginal birth. This study explores the incidence, etiology and women's experiences of wound infection/breakdown associated with spontaneous second degree tears.This was an exploratory mixed methods study set in an urban tertiary National Health Service hospital in 2014-2015. The study included a prospective observational study (...) of second-degree tears using electronic patient records. Infection was defined using criteria adapted from Public Health England's Surgical Site Infection Surveillance Service. We also did a case-control study of maternity records to explore factors associated with perineal infection/wound breakdown, and semi-structured interviews with a purposeful sample of women who experienced wound infection/breakdown.Of 2892 vaginal births during the study period, 76.8% sustained perineal trauma, with second-degree

2018 Birth

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