How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

28,211 results for

Wound Infection

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Efficacy of a Disposable Negative Wound Pressure Device in Reducing the Incidence of Wound Infection After HPB Surgery

Universitaria Integrata Verona: negative pressure wound therapy wound infection pancreaticoduodenectomy total pancreatectomy surgical palliation of pancreatic cancer Additional relevant MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Surgical Wound Infection Wound Infection Postoperative Complications Pathologic Processes (...) Efficacy of a Disposable Negative Wound Pressure Device in Reducing the Incidence of Wound Infection After HPB Surgery Efficacy of a Disposable Negative Wound Pressure Device in Reducing the Incidence of Wound Infection After HPB Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2018 Clinical Trials

42. Effect of Negative Pressure Wound Therapy With Instillation on Bioburden in Chronically Infected Wounds. (Abstract)

Effect of Negative Pressure Wound Therapy With Instillation on Bioburden in Chronically Infected Wounds. Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction (...) nonplanktonic bioburden of chronically, critically colonized wounds.Therefore, based on this and previously published work, this therapy provides both planktonic and nonplanktonic bioburden reduction as well as NPWT benefits and may be a tool for the preparation of infected wound beds prior to definitive closure.

2018 Wounds : a compendium of clinical research and practice Controlled trial quality: uncertain

43. Surgical Site Infection after Primary Closure of High-Risk Surgical Wounds in Emergency General Surgery Laparotomies and Closed Negative-Pressure Wound Therapy. (Abstract)

Surgical Site Infection after Primary Closure of High-Risk Surgical Wounds in Emergency General Surgery Laparotomies and Closed Negative-Pressure Wound Therapy. We hypothesized that the universal adoption of closed wounds with negative pressure wound therapy (NPWT) in emergency general surgery patients would result in low superficial surgical infection (SSI) rates.We performed a retrospective observational study using primary wound closure with external NPWT, from May 2017 to May 2018. Patients (...) with active soft tissue infection of the abdominal wall were excluded. Data were analyzed by Fisher's exact tests and Wilcoxon-Mann-Whitney tests, with significance is set at a value of p < 0.05.Eighty-five patients (53% female) with a median age of 65 years (range 19 to 98 years) underwent laparotomies. Four patients were excluded for active soft tissue infection. Wounds were classified as dirty (n = 18), contaminated (n = 52), and clean contaminated (n = 11). Median BMI was 27 kg/m2 (interquartile range

2018 Journal of the American College of Surgeons

44. Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection Full Text available with Trip Pro

Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection The study aimed to investigate whether mixing two different propolis samples can potentiate their biological activity. This hypothesis was tested by studying the effect of mixed propolis on microbial growth and wound healing and compared with the effect of each propolis individually.The effect of mixing two different propolis extracts (...) (A and B) collected from different locations in Iraq on Escherichia coli, Staphylococcus aureus, and Candida albicans was studied by minimum inhibitory concentration assessment and compared with the effect of each propolis. Wound healing effect of the mixed propolis was studied. Twenty-four rabbits were used for the experiment, and they were assigned to four groups. Wounds were created on the dorsum of each rabbit and treated by topical application of 1 mL of either mixed propolis, propolis

2018 Veterinary world

45. Negative pressure wound therapy for wounds healing by secondary intention

AEs: Reintervention 24 4.6.3.3 AEs: Bleeding 24 4.6.3.4 AEs: Infection 24 4.6.3.5 Total rate of SAEs 25 4.6.3.6 Separately identified SAEs 25 4.6.3.7 Conclusion on benefit regarding adverse events: Wound complications and treatment complications (AEs) 25 4.6.4 Results on amputation 25 4.6.5 Results on pain 26 4.6.5.1 Pain – continuous 26 4.6.5.2 Pain – dichotomous 26 4.6.5.3 Pain – dressing change 26 Extract of final report N17-01A Version 1.1 Negative pressure wound therapy – wounds healing (...) ]), ? Burns (n = 2, of which 1 study in small children) (TOPSKIN, Shen 2013 [187]), ? Groin wounds due to infections (n = 1) (Acosta 2013 [121]) ? And various wounds resulting from an underlying disease and/or of traumatic/iatrogenic aetiology (n = 10) (Braakenburg 2006 [134], CE/044/PIC [136], De Laat 2011 [145], Hu 2009 [159], Mody 2008 [174], Moisidis 2004, Mouës 2004 [177], Mohsin 2017 [175], Perez 2010 [182], SWHSI [192]). 4.3 Studies without reported results / calculation of data gap Using

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

46. Negative pressure wound therapy for wounds healing by primary intention

of greater benefit of NPWT in comparison with standard wound therapy in wounds healing by primary intention. The analyses additionally revealed an indication of greater benefit of NPWT in terms of avoiding wound infection in wounds healing by primary intention. For the remaining outcomes (particularly mortality, total rate of complications, pain, length of hospital stay, and health-related quality of life), there were no hints of benefit or harm of NPWT. Extract of final report N17-01B Version 1.0 (...) of assessment-relevant outcomes 15 4.5 Assessment of the risk of bias at study level and at outcome level 17 4.6 Results on patient-relevant outcomes 18 4.6.1 Results on mortality 18 4.6.2 Results on wound closure 19 4.6.2.1 Wound healing and time to wound healing 19 4.6.2.2 Conclusion on benefit regarding wound closure 19 4.6.3 Results on adverse events: Wound complications and treatment complications (AEs) 19 4.6.3.1 AEs: Re-intervention 19 4.6.3.2 AEs: Bleeding 20 4.6.3.3 AEs: Infection 20 4.6.3.4 Total

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

47. Differentiation between infected and non-infected wounds using an electronic nose. (Abstract)

a promising diagnostic tool for wound infection given the diagnostic properties presented in this pilot study. A larger study is needed to confirm our results.Copyright © 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. (...) Differentiation between infected and non-infected wounds using an electronic nose. The aim of this study was to explore whether an electronic nose, Aetholab, is able to discriminate between infected versus non-infected wounds, based on headspace analyses from wound swabs.A total of 77 patients participated in this pilot study. Each wound was assessed for infection based on clinical judgment. Additionally, two wound swabs were taken, one for microbiological culture and one for measurement

2019 Clinical Microbiology and Infection

48. Can a smartphone-delivered tool facilitate the assessment of surgical site infection and result in earlier treatment? Tracking wound infection with smartphone technology (TWIST): protocol for a randomised controlled trial in emergency surgery patients. Full Text available with Trip Pro

Can a smartphone-delivered tool facilitate the assessment of surgical site infection and result in earlier treatment? Tracking wound infection with smartphone technology (TWIST): protocol for a randomised controlled trial in emergency surgery patients. National data suggest that surgical site infection (SSI) complicates 2%-10% of general surgery cases, although the patient-reported incidence is much higher. SSIs cause significant patient morbidity and represent a significant burden on acute (...) healthcare services, in a cohort predominantly suitable for outpatient management. Over three-quarters of UK adults now own smartphones, which could be harnessed to improve access to care. We aim to investigate if a smartphone-delivered wound assessment tool results in earlier treatment.This is a randomised controlled trial aiming to recruit 500 patients across National Health Service (NHS) hospitals. All emergency abdominal surgery patients over the age of 16 who own smartphones will be considered

2019 BMJ open

49. Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation With Subsequent Postclosure Deep Wound Infection (Bioburden Study). (Abstract)

Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation With Subsequent Postclosure Deep Wound Infection (Bioburden Study). Infection remains the most common and significant complication after high-energy fractures. The Bioburden Study is a multicenter, prospective, observational cohort study of wound bacterial bioburden and antibiotic care in severe open lower extremity fractures. The aims of this study are to (1) characterize (...) the contemporary extremity wound "bioburden" at the time of definitive wound closure; (2) determine the concordance between polymerase chain reaction results and hospital microbiology; (3) determine, among those who develop deep infections, the concordance between the pathogens at wound closure and at deep infection; and (4) compare the probability of deep infection between those who did and did not receive an appropriate course of antibiotics based on bioburden at the time of wound closure. To address

2017 Journal of Orthopaedic Trauma

50. Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa. Full Text available with Trip Pro

Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa. Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) are important human pathogens that are associated with a range of infection types, including wound and disseminated infections. Treatment has been complicated by rising rates of antimicrobial resistance. Immunoprophylactic strategies are not constrained by antimicrobial resistance (...) mechanisms. Vaccines against these organisms would be important public health tools, yet they are not available. KP surface O polysaccharides (OPS) are protective antigens in animal models of infection. Similarly, PA flagellin (Fla), the major subunit of the flagellar filament, is required for virulence and is a target of protective antibodies in animal models. We report herein the development of a combined KP and PA glycoconjugate vaccine comprised of the four most common KP OPS types associated

2018 PLoS ONE

51. Far-UVC light prevents MRSA infection of superficial wounds in vivo. Full Text available with Trip Pro

skin damage measured in terms of epidermal thickness and DNA photodamage.In the circumstance of superficial incisions infected with bacteria alighting onto the wound, 222-nm light showed the same bactericidal properties of 254-nm light but without the associated skin damage.Being safe for patient and hospital staff, our results suggested that far-UVC light (222 nm) might be a convenient approach to prevent transmission of drug-resistant infectious agents in the clinical setting. (...) Far-UVC light prevents MRSA infection of superficial wounds in vivo. Prevention of superficial surgical wound infections from drug-resistant bacteria such as methicillin resistant Staphylococcus aureus (MRSA) currently present major health care challenges. The majority of surgical site infections (SSI) are believed to be caused by airborne transmission of bacteria alighting onto the wound during surgical procedures. We have previously shown that far-ultraviolet C light in the wavelength range

2018 PLoS ONE

52. Effectiveness and postoperative wound infection of preperitoneal pelvic packing in patients with hemodynamic instability caused by pelvic fracture. Full Text available with Trip Pro

Effectiveness and postoperative wound infection of preperitoneal pelvic packing in patients with hemodynamic instability caused by pelvic fracture. Despite the use of a multidisciplinary treatment approach, the mortality rate of hemodynamic instability due to severe pelvic fracture remains 40-60%. Several recent studies have shown that preperitoneal pelvic packing (PPP) was useful for achieving hemostasis in these patients in the acute phase. However, few studies have examined postoperative (...) complications. The purpose of the present study was to evaluate clinical outcomes and wound infections of PPP in these patients.We retrospectively reviewed the medical charts of 62 patients with hemorrhagic shock due to pelvic fracture between March 2011 and May 2017. Excluding four patients (two with other major hemorrhage sites and two who experienced cardiac arrest in the emergency room), the patients were divided into PPP (n = 30) and non-PPP (n = 28) groups according to PPP application. Clinical

2018 PLoS ONE

53. Anatomic study of the vascular perfusion of the sternum and its clinical relevance in deep sternal wound infection Full Text available with Trip Pro

Anatomic study of the vascular perfusion of the sternum and its clinical relevance in deep sternal wound infection Introduction: Deep sternal wound infections (DSWI) are a rare but devastating complication after median sternotomy. Minor perfusion in bone and soft tissue, especially after recruiting the internal mammary artery for bypass supports the development of wound infection and nonunion of the sternal bone. The aim of the study was the macroscopic and radiological presentation

2017 GMS Interdisciplinary plastic and reconstructive surgery DGPW

54. Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. Full Text available with Trip Pro

Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. Sexual violence is associated with increased risk of HIV acquisition/transmission in women. Forced sex can result in physical trauma to the reproductive tract as well as severe psychological distress. However, immuno-biological mechanisms linking sexual violence and HIV susceptibility are incompletely understood. Using the Women's Interagency (...) -infected and uninfected women. Our data indicates a complex relationship between chronic sexual abuse exposure, depressive symptoms, and FRT immune mediators that are also affected by HIV status. Association of chronic sexual abuse with increase in inflammation-associated cytokine/chemokine expression, along with impaired wound-healing associated growth-factors can create a microenvironment that can facilitate HIV infection. Evaluation of longitudinal changes in exposures and biomarkers are needed

2018 PLoS ONE

55. Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing. Full Text available with Trip Pro

Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing. There are very few articles in the literature describing continuous models of bacterial infections that mimic disease pathogenesis in humans and animals without using separate cohorts of animals at each stage of disease. In this work, we developed bioluminescent mouse models of partial-thickness scald wound infection and sepsis that mimic disease pathogenesis in humans and animals (...) using a recombinant luciferase-expressing Staphylococcus aureus strain (Xen29). Two days post-scald wound infection, mice were treated twice daily with a 2% topical mupirocin ointment for 7 days. For sepsis experiments, mice were treated intraperitoneally with 6 mg/kg daptomycin 2 h and 6 h post-infection and time to moribund monitored for 72 h. Consistent bacterial burden data were obtained from individual mice by regular photon intensity quantification on a Xenogen IVIS Lumina XRMS Series III

2018 PLoS ONE

56. Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds. (Abstract)

Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds. Methicillin-resistant Staphylococcus aureus (MRSA) infection after surgery is usually rare, but incidence can be up to 33% in certain types of surgery. Postoperative MRSA infection can occur as surgical site infections (SSI), chest infections, or bloodstream infections (bacteraemia). The incidence of MRSA SSIs varies from 1% to 33% depending upon the type of surgery (...) performed and the carrier status of the individuals concerned. The optimal antibiotic regimen for the treatment of MRSA in surgical wounds is not known.To compare the benefits and harms of various antibiotic treatments in people with established surgical site infections (SSIs) caused by MRSA .In February 2013 we searched the following databases: The Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL); Database of Abstracts of Reviews of Effects (DARE

2013 Cochrane

57. Leg ulcer infection: antimicrobial prescribing

in adults with infected leg ulcer, see the rationales. Leg ulcer infection: antimicrobial prescribing (NG152) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 10 of 28T erms used in the guideline T erms used in the guideline Leg ulcer Leg ulcer A leg ulcer is a long-lasting (chronic) open wound that takes more than 4 to 6 weeks to heal. Leg ulcers usually develop on the lower leg, between the shin and the ankle (...) . Although microbiological sampling is not required at initial presentation, the committee agreed that it is appropriate to consider this if symptoms or signs of the infection are worsening or have not improved as expected. This will guide future antibiotic choice if the person has a resistant infection. The committee agreed that before microbiological sampling the wound should be cleaned to remove surface contaminants, slough or necrotic tissue, in line with Public Health England's guidance on venous

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

58. Red-blue light irradiation in the prevention of surgical wound infection after mandibular distraction using internal distractors in hemifacial microsomia: A randomized trial. (Abstract)

Red-blue light irradiation in the prevention of surgical wound infection after mandibular distraction using internal distractors in hemifacial microsomia: A randomized trial. Postoperative infection is a complication of mandibular distraction osteogenesis (DO) in patients with hemifacial microsomia (HFM). The risk of surgical wound infection in DO is reported to be high due to the long duration of the distraction process. Treatment during the perioperative period is critical in combating (...) infection.This study aimed to evaluate the effectiveness of red-blue irradiation in the prevention of surgical wound infection after mandibular distraction.In our single-centered, randomized clinical study, 118 patients diagnosed with HFM who had undergone DO between April 2016 and April 2018 were included. The patients were randomly divided into two groups: the experimental group received red-blue irradiation treatment and the control group received white-light irradiation.None of the infections occurring

2019 Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery Controlled trial quality: uncertain

59. Intrawound vancomycin powder increases post-operative wound complications and does not decrease periprosthetic joint infection in primary total and unicompartmental knee arthroplasties. (Abstract)

Intrawound vancomycin powder increases post-operative wound complications and does not decrease periprosthetic joint infection in primary total and unicompartmental knee arthroplasties. A frequent reason for revision surgery after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) is periprosthetic joint infection (PJI). The efficacy of intrawound VP in preventing PJI after primary TKA or UKA is rarely reported. The purpose of this study was to investigate the efficacy (...) and side effects of local high-dose VP application to the joint to prevent PJI in TKA and UKA.From 2010 to 2017, 166 consecutive patients that underwent primary TKA or UKA were enrolled. Seventy-five patients (92 knees) did not receive VP (control group), while 90 patients (110 knees, VP group) received VP (intrawound, 1 g) before capsule closure during TKA and UKA. Aseptic wound complications, such as skin erosion, wound dehiscence, and prolonged wound healing, were evaluated within 3 months post

2019 Knee Surgery, Sports Traumatology, Arthroscopy

60. Surgical wound infection following open humeral fracture caused by Mycobacterium houstonense: a case report. Full Text available with Trip Pro

Surgical wound infection following open humeral fracture caused by Mycobacterium houstonense: a case report. Historically Mycobacterium houstonense belongs to the unnamed third biovariant complex of the Mycobacterium fortuitum group, which are sorbitol positive. To date, there have been few reports of human infection induced by M. houstonense worldwide.We describe the case of a 68-year-old man with surgical wound infection, following an open humeral fracture, caused by M. houstonense (...) and Escherichia coli. An implant bone plate had been embedded for internal fixation during surgery on the humeral fracture previously. A week later E. coli was isolated from the skin wound secretions. Cefoperazone-sulbactam was used for treatment for two weeks but the infection was not controlled, with a subsequent risk of deep wound infection. External fixation of the fracture was then performed instead of internal fixation. Ten days later, M. houstonense was isolated from new wound secretions. M

2019 BMC Infectious Diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>