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Wound Infection

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1. In patients undergoing minor dermatological procedures, does the application of Savlon antiseptic cream post-operatively, as opposed to leaving the wound dry, increase the incidence of poor wound healing/delayed wound healing or infection (or poor outcome

In patients undergoing minor dermatological procedures, does the application of Savlon antiseptic cream post-operatively, as opposed to leaving the wound dry, increase the incidence of poor wound healing/delayed wound healing or infection (or poor outcome Getting Evidence into Clinical Practice: General Practice Nurse Evidence Based Practice (CAT Group) Date: July 2018 CAT Lead: Rachel Viggars, Gwenllian Wynne-Jones Date CAT completed: April 2018 Email:a.finney@keele.ac.uk Date CAT (...) to be reviewed: April 2021 Specific Question: In patients undergoing minor dermatological procedures, does the application of Savlon antiseptic cream post operatively as opposed to leaving the wound dry, increase the incidence of poor wound healing / delayed wound healing or infection (or poor outcomes in general). Clinical bottom line We have been unable to identify evidence for the benefits of the use of Savlon in minor wounds or post-operatively. However, we have also found no evidence to suggest

2018 Home Modification Information Clearinghouse

2. The V.A.C. Veraflo Therapy system for infected wounds

The V.A.C. Veraflo Therapy system for infected wounds The V The V .A. .A.C. V C. Ver eraflo Ther aflo Therap apy system for infected y system for infected wounds wounds Medtech innovation briefing Published: 2 September 2019 www.nice.org.uk/guidance/mib189 pathways Summary Summary The technology technology described in this briefing is the V.A.C. Veraflo Therapy system. It is used to promote healing in chronic and acutely infected wounds. The inno innovativ vative aspects e aspects (...) are that V.A.C. Veraflo Therapy system combines the use of negative pressure wound therapy (NPWT) and wound cleaning with topical solutions. Treatment is delivered in automated treatment cycles allowing wounds to be repetitively cleansed without the need for dressing removal. The intended place in ther place in therap apy y would be to replace normal NPWT in standard care in people with open infected wounds or chronic wounds that do not respond to standard care. The main points from the e main points from

2019 National Institute for Health and Clinical Excellence - Advice

3. Preventing and managing bacterial wound infections in prison

of wound infection, or throat infection, should seek medical attention immediately and be excluded from work until no longer Management and prevention of bacterial wound infections in prescribed places of detention 14 infectious. They should advise their general practitioner (GP) of occupational risk and appropriate swabs should be carried out to determine if GAS is the cause of the symptoms. Environmental cleaning Staff and other persons, particularly those with cleaning/washing duties, should (...) Preventing and managing bacterial wound infections in prison Management and prevention of bacterial wound infections in prescribed places of detention Guidelines for healthcare, custodial staff and responding health protection services Management and prevention of bacterial wound infections in prescribed places of detention 2 About Public Health England Public Health England exists to protect and improve the nation’s health and wellbeing, and reduce health inequalities. We do this through world

2019 Public Health England

4. Wound care for non-infected surgical wounds?

Wound care for non-infected surgical wounds? Q&A - Wound care for non-infected surgical wounds? - Trip Database NEW! or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button (...) . An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Asked 15 Nov 2019 · , Doctor/physician - secondary care, BE Wound care for non-infected surgical wounds? Original Q below - above is Google Translate! Wondzorg niet geïnfecteerde chirurgische wonden Wel of geen eindverband? 1 Please log in to post a reply Your response: Reply Notes about answers If you see something you feel is wrong, don’t criticise

2019 Trip Community Q&A

5. Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial. (Abstract)

Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial. Following surgery to treat major trauma-related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting.To assess outcomes in patients who have incisions resulting from surgery for lower limb (...) a specialized dressing used to create negative pressure over the wound, vs standard wound dressing not involving negative pressure (n = 763).The primary outcome measure was deep surgical site infection at 30 days diagnosed according to the criteria from the US Centers for Disease Control and Prevention. A preplanned secondary analysis of the primary outcome was performed at 90 days. The secondary outcomes were patient-reported disability (Disability Rating Index), health-related quality of life (EuroQol 5

2020 JAMA

6. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds (Abstract)

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds Previous studies show conflicting results in wound healing outcomes based on angiosome direct perfusion (DP), but few have adjusted for wound characteristics in their analyses. We have previously shown that the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification correlates (...) with wound healing in diabetic foot ulcers (DFUs) treated by a multidisciplinary team. The aim of this study was to compare WIfI classification vs DP and pedal arch patency as predictors of wound healing in patients presenting with DFU and peripheral arterial disease.We performed a retrospective review of a prospectively maintained database of all patients with peripheral arterial disease presenting to our multidisciplinary DFU clinic who underwent angiography. An angiosome was considered directly

2018 EvidenceUpdates

7. Absorbable sutures containing triclosan decrease wound infection rates in children

Absorbable sutures containing triclosan decrease wound infection rates in children Las suturas absorbibles que contienen triclosán disminuyen las tasas de infección de la herida quirúrgica en los niños - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de (...) | Artículos Valorados Críticamente Renko M, Paalanne N, Tapiainen T, Hinkkainen M, Pokka T, Kinnula S, et al . Triclosan-containing sutures versus ordinary sutures for reducing surgical site infections in children: a double-blind, randomized controlled trial. Revisores: Ruiz-Canela Cáceres J 1 , García Vera C 2 . 1 CS Virgen de África. Sevilla. España. 2 CS José Ramón Muñoz Fernández. Zaragoza. España. Correspondencia: Juan Ruiz-Canela Cáceres. Correo electrónico: Fecha de recepción: 11/05/2017 Fecha de

2017 Evidencias en Pediatría

8. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers (Abstract)

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound (...) healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting.All patients presenting to our multidisciplinary DFU clinic from June 2012 to July 2017 were enrolled in a prospective database. A Cox proportional hazards model accounting for patients' sociodemographics, comorbidities, medication profiles, and wound characteristics was used to assess the association between WIfI classification and likelihood of wound healing at 1 year.There were 310 DFU

2018 EvidenceUpdates

9. Is it the technique or wound protection that is key to reducing wound infections in Roux-en-Y gastric bypass procedures? (Abstract)

Is it the technique or wound protection that is key to reducing wound infections in Roux-en-Y gastric bypass procedures? An unusually high surgical site infection (SSI) rate after Roux-en-Y gastric bypass (RYGB) was noted on routine outcomes review. Surgeon A, who had a rate of 8.9%, utilized the transoral technique (passage down esophagus into gastric pouch) for anvil insertion for the circular-stapled gastrojejunostomy. By comparison, SSI rate was 0% for Surgeon B, who inserted anvil (...) transabdominally (direct passage into stomach via gastrotomy) and used wound protection (wound protector and plastic drape over stapler). We sought to determine if it was the technique for anvil insertion (transoral or transabdominal) or use of wound protection that could help reduce SSIs.In mid-2017, Surgeon A added wound protection (wound protector and plastic drape over stapler) to the transoral technique to minimize oral flora wound contamination. Surgeon B made no changes. In this study, wound-related

2020 Surgical endoscopy

10. Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial (Abstract)

Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial Postoperative infection after hand-assisted laparoscopic donor nephrectomy (HALDN) confers significant morbidity to a healthy patient group. Current UK guidelines cite a lack of evidence for routine antibiotic prophylaxis. This trial assessed if a single preoperative antibiotic dose could reduce post HALDN infections.Eligible donors were randomly and blindly (...) allocated to preoperative single-dose intravenous co-amoxiclav or saline. The primary composite endpoint was clinical evidence of any postoperative infection at 30 days, including surgical site infection (SSI), urinary tract infection (UTI), and lower respiratory tract infection (LRTI).In all, 293 participants underwent HALDN (148 antibiotic arm and 145 placebo arm). Among them, 99% (291/293) completed follow-up. The total infection rate was 40.7% (59/145) in the placebo group and 23% (34 of 148

2020 EvidenceUpdates

12. NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing wounds

. Standard care is cleaning and dressing it. The best dressing to use depends on things like wound size and depth, and amount of exudate. More complicated wounds, for example surgical site infections, diabetic foot problems, venous leg ulcers and pressure ulcers, can result in chronic non-healing wounds and need more advanced care. Care of these types of wounds aims to promote healing and minimise the risk of further complications. For diabetic foot or venous leg ulcer, healthcare professionals record (...) the depth and position of the ulcer and offload or treat it with compression therapy to promote healing. If a non- healing wound is thought to be infected, healthcare professionals take a microbiological sample NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing wounds (MIB208) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 10and prescribe an antibiotic to treat

2020 National Institute for Health and Clinical Excellence - Advice

13. In patients requiring wound cleansing or wound irrigation in general practice settings is sterile saline superior to tap water in reducing or preventing would infection and promoting healing?

In patients requiring wound cleansing or wound irrigation in general practice settings is sterile saline superior to tap water in reducing or preventing would infection and promoting healing? Getting Evidence into Clinical Practice: General Practice Nurse Evidence Based Practice (CAT Group) Date: March 2016 CAT Lead: Andrew Finney and Vicky Shone Date CAT completed: March 2016 Email:a.finney@keele.ac.uk Date CAT to be reviewed: March 2018 Specific Question: In patients requiring wound cleansing (...) or wound irrigation in general practice settings is sterile saline superior to tap water in reducing or preventing would infection and promoting healing? Clinical bottom line Results showed that there was no increase in infection rates or reduction in wound healing in patients who had wounds cleaned with tap water. In three trials in adult patients, the infection rate was reduced with tap water. The authors concluded that tap water was no less effective than sterile saline but with certain conditions

2016 Home Modification Information Clearinghouse

14. Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound Full Text available with Trip Pro

Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound Cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. We have identified a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. Using this peptide as inspiration, we designed a synthetic peptide called DRGN-1. We evaluated the antimicrobial and anti-biofilm activity of both peptides against Pseudomonas (...) aeruginosa and Staphylococcus aureus. DRGN-1, more than VK25, exhibited potent antimicrobial and anti-biofilm activity, and permeabilized bacterial membranes. Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds. In a scratch wound closure assay used to elucidate the wound healing mechanism, the peptide promoted the migration of HEKa keratinocyte cells, which was inhibited by mitomycin C

2017 NPJ biofilms and microbiomes

15. Culture results from wound biopsy versus wound swab: does it matter for the assessment of wound infection? (Abstract)

Culture results from wound biopsy versus wound swab: does it matter for the assessment of wound infection? The aim of this study was to determine whether assessment of wound infection differs when culture results from wound biopsy versus wound swab are available in clinical practice.For 180 eligible patients, a swab and biopsy were taken from one wound during a regular appointment at a wound care facility in eastern Netherlands. Culture results from both methods were supplemented with clinical (...) information and provided to a panel of six experts who independently assessed each wound as infect or not, separately for swab and biopsy. Assessments for biopsy and swab were compared for the complete expert panel, and for individual experts.The complete expert panel provided the same wound assessment based on (clinical information and) culture results from wound biopsy and wound swab in 158 of 180 wounds (87.8%, kappa 0.67). For individual experts, agreement between biopsy and swab varied between 77

2018 Clinical Microbiology and Infection

16. Comparing negative pressure wound therapy with instillation (NPWT-I) with other types of wound care for the treatment of infected and contaminated wounds.

Comparing negative pressure wound therapy with instillation (NPWT-I) with other types of wound care for the treatment of infected and contaminated wounds. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

17. Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of <i>Rhus coriaria</i> on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues. Full Text available with Trip Pro

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues. Impaired wound healing was mainly associated with severe microbial infections which significantly affect diagnostic and therapeutic strategies. Thus, in this study, the potential wound healing activity, anti-inflammatory, and antimicrobial activity of an aqueous extract of Rhus coriaria extract (AERc (...) , the AERc-treated animals at doses of 5 mg.mL-1 and 10 mg.mL-1 exhibited a significant reduction in the wound area, increased deposition of collagen, HPX, and reduction in MMP-8, and MPO enzyme activity when compared with controls. Scar formation and epithelization were completed in 10 days compared to controls. In addition, in wounds infected separately with Staph. aureus or P. aeruginosa, the AERc extract significantly improved wound contraction, deposition of collagen, and HPx and reduced MMP-8

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

18. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing but not major amputation in patients with diabetic foot ulcers treated in a multidisciplinary setting Full Text available with Trip Pro

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing but not major amputation in patients with diabetic foot ulcers treated in a multidisciplinary setting The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) threatened limb classification has been shown to correlate well with risk of major amputation and time to wound healing in heterogeneous diabetic and nondiabetic populations. Major amputation (...) continues to plague the most severe stage 4 WIfI patients, with 1-year amputation rates of 20% to 64%. Our aim was to determine the association between WIfI stage and wound healing and major amputation among patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting.All patients presenting to our multidisciplinary DFU clinic from July 2012 to December 2015 were enrolled in a prospective database. Wound healing and major amputation were compared for patients stratified by WIfI

2017 EvidenceUpdates

19. Randomized clinical study to compare negative pressure wound therapy with simultaneous saline irrigation and traditional negative pressure wound therapy for complex foot infections. Full Text available with Trip Pro

Randomized clinical study to compare negative pressure wound therapy with simultaneous saline irrigation and traditional negative pressure wound therapy for complex foot infections. The aim of this study was to compare the efficacy of different negative pressure wound therapy (NPWT) devices and NPWT with and without simultaneous irrigation in patients admitted to hospital with moderate and severe foot infections. Ninety patients were randomized in a 12-week prospective, randomized (...) noninferiority trial to compare wound healing in patients with moderate and severe infected foot wounds treated with NPWT after surgery. Inclusion criteria included ABI > 0.5 or toe pressures >30 PVR/mmHg, >18 years of age and exclusion included active Charcot arthropathy, collagen vascular disease, HIV, and hypercoagulable state. We compared two different traditional devices, NPWT-K (KCI, VAC Ulta) and NPWT-C (Cardinal, PRO), and NPWT-I with saline irrigation (Cardinal, PRO). All patients had therapy

2019 Wound Repair and Regeneration Controlled trial quality: predicted high

20. Use of Closed Incisional Negative Pressure Wound Therapy After Revision Total Hip and Knee Arthroplasty in Patients at High Risk for Infection: A Prospective, Randomized Clinical Trial Full Text available with Trip Pro

Use of Closed Incisional Negative Pressure Wound Therapy After Revision Total Hip and Knee Arthroplasty in Patients at High Risk for Infection: A Prospective, Randomized Clinical Trial Continuous wound drainage after arthroplasty can lead to the development of a periprosthetic joint infection. Closed incisional negative pressure wound therapy (ciNPWT) has been reported to help alleviate drainage and other wound complications. The purpose of this prospective randomized controlled trial (...) joint infection and inflammatory arthritis, the ciNPWT cohort had a significantly decreased wound complication rate (odds ratio 0.28, 95% confidence interval 0.11-0.68).ciNPWT may decrease the rate of postoperative wound complications in patients who are at an increased risk of such wound issues after revision arthroplasty.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

2019 EvidenceUpdates

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