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1. In patients requiring wound cleansing or wound irrigation in general practice settings is sterile saline superior to tap water in reducing or preventing would infection and promoting healing?

In patients requiring wound cleansing or wound irrigation in general practice settings is sterile saline superior to tap water in reducing or preventing would infection and promoting healing? Getting Evidence into Clinical Practice: General Practice Nurse Evidence Based Practice (CAT Group) Date: March 2016 CAT Lead: Andrew Finney and Vicky Shone Date CAT completed: March 2016 Email:a.finney@keele.ac.uk Date CAT to be reviewed: March 2018 Specific Question: In patients requiring wound cleansing (...) , namely that practitioners should take into account: • the quality of water (tap water within the UK is of sufficient quality) • the nature of wounds (use saline solution when bone/ tendon can be observed within the wound) • the patient’s general condition, including the presence of comorbidities that compromise immune function (use saline solution in immunocompromised patients) Why is this important? The most important step in the cleansing and irrigation of wounds is to remove loose tissue

2016 Home Modification Information Clearinghouse

2. Effect of two post-surgical cleansing protocols on early periodontal wound healing and cytokine levels following osseous resective surgery: A randomized controlled study. (Abstract)

Effect of two post-surgical cleansing protocols on early periodontal wound healing and cytokine levels following osseous resective surgery: A randomized controlled study. The aim of this RCT study was to compare early wound healing and gingival crevicular fluid cytokine levels of patients treated with two different post-surgical cleansing protocols.A total of 30 chronic periodontitis patients scheduled for osseous resective surgery with fibre retention technique were randomly assigned to follow (...) one of two post-surgical protocols. Patients assigned to the test protocol (n = 15) were instructed to brush the surgical area with a sonic toothbrush starting the day after surgery in addition to 0.12% chlorhexidine (CHX) rinsing, while patients following the control protocol (n = 15) rinsed only with 0.12% CHX solution and resumed mechanical cleansing with a manual toothbrush on day 14 after surgery. Interleukin (IL)-1β and IL-8 levels were assessed before and 14 days post-operatively

2019 International journal of dental hygiene Controlled trial quality: uncertain

3. Is Water Effective for Wound Cleansing?

Is Water Effective for Wound Cleansing? SystematicReviewSnapshot TAKE-HOME MESSAGE The practice of cleansing wounds with water is as effective as using isotonic saline solution. METHODS DATA SOURCES This study was the fourth update of a systematic review on wound cleansing. In this update, the au- thors searched the Cochrane Wounds Group Specialized Regis- ter (searched November 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library 2011, Issue 4), Ovid MEDLINE (...) (2010 to Octo- ber, week 4, 2011; In-Process and Other Non-Indexed Citations, November 2011), Ovid EMBASE (2010 to 2011 week 44), and El- ton B. Stephens Company (EBSCO) CINAHL (2010 to No- vember 2011). The authors re- viewed the reference lists of rele- vant reviews and trials to identify additional studies. STUDY SELECTION Randomized and quasi-random- ized studies comparing wound cleansing with water to other so- lutions (sterile normal saline solu- tion, cooled boiled water) or no cleansing were

2012 Annals of Emergency Medicine Systematic Review Snapshots

4. Pressurised irrigation versus swabbing for wound cleansing: a multicentre, prospective, randomised controlled trial. (Abstract)

Pressurised irrigation versus swabbing for wound cleansing: a multicentre, prospective, randomised controlled trial. 25647827 2015 09 28 2016 10 20 1024-2708 20 Suppl 7 2014 Dec Hong Kong medical journal = Xianggang yi xue za zhi Hong Kong Med J Pressurised irrigation versus swabbing for wound cleansing: a multicentre, prospective, randomised controlled trial. 42-6 Mak S S S SS Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong. Lee M Y MY Central Nursing Department, North (...) Study Randomized Controlled Trial Research Support, Non-U.S. Gov't China Hong Kong Med J 9512509 1024-2708 IM Adult Aged Cost-Benefit Analysis Female Follow-Up Studies Humans Male Middle Aged Pain epidemiology etiology Patient Satisfaction Prospective Studies Therapeutic Irrigation economics methods Time Factors Wound Healing physiology Wounds and Injuries therapy 2015 2 4 6 0 2015 2 4 6 0 2015 9 29 6 0 ppublish 25647827

2015 Hong Kong medical journal = Xianggang yi xue za zhi Controlled trial quality: predicted high

5. Vaginal cleansing before caesarean delivery reduces risk of infections

infection. The vagina was cleansed with a topical antiseptic solution, usually povidone-iodine 10%, using a sponge, wipe or douche, for at least 30 seconds just before surgery. Women in the control group received a placebo or no cleansing. Other outcomes included wound infection and fever above 38 ° C. All trials used prophylactic antibiotics because this is standard care. Participants with known allergies were excluded. Nine of the sixteen trials took place in low or middle-income countries, and seven (...) in preventing postoperative womb infections. What did this study do? This systematic review identified 16 randomised controlled trials involving 4,837 women undergoing a caesarean delivery. Trials compared rates of postoperative womb infection. The vagina was cleansed with a topical antiseptic solution, usually povidone-iodine 10%, using a sponge, wipe or douche, for at least 30 seconds just before surgery. Women in the control group received a placebo or no cleansing. Other outcomes included wound

2019 NIHR Dissemination Centre

6. Wound Cleansing

Wound Cleansing Wound Cleansing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Wound Cleansing Wound Cleansing Aka: Wound Cleansing (...) , Decubitus Ulcer Cleansing From Related Chapters II. Goal Obtain clean decubitus wound without III. Protocol: Clean wound at each dressing change Use for cleansing most ulcers Use minimal mechanical force Gently cleanse with 20 to 50 cc Irrigation pressure Enough to enhance wound cleaning but avoid Keep pressure in range 4-15 psi Use gentle pressure via syringe Catheter-tip syringe Luer-lock syringe with butterfly with needle off Syringe with 19 gauge needle Whirlpool bath indications Ulcer with thick

2018 FP Notebook

7. Vaginal cleansing prior to caesarian section: To do or not to do?: A randomized trial. Full Text available with Trip Pro

Vaginal cleansing prior to caesarian section: To do or not to do?: A randomized trial. To evaluate the efficacy of preoperative vaginal cleansing using povidone-iodine solution 10% on rates of post cesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection).This prospective randomized trial was conducted among 226 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization method. The study group had (...) preoperative vaginal cleansing using povidone-iodine solution 10% for about 1 min, while the control group did not. All cases received the prophylactic antibiotics and the usual abdominal scrub. Adverse post CS infectious morbidities such as endometritis, febrile morbidity and wound infection were observed at the time of hospital discharge and weekly for 6 weeks postpartum.Both groups were matched regarding the baseline patients' characteristics. Overall, post-CS infectious morbidity was significantly

2019 Journal of gynecology obstetrics and human reproduction Controlled trial quality: uncertain

8. Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. Full Text available with Trip Pro

Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. Research into surfactant solutions for the debridement of chronic wounds suggests that surfactants may support wound bed preparation (WBP) in chronic wounds, however their efficacy has not been evaluated in randomised controlled trials (RCTs). Our aim was to assess the clinical efficacy of a propylbetaine-polihexanide (PP) solution versus normal saline (NS) solution in WBP (...) , assessing inflammatory signs and wound size reduction in patients with pressure ulcers (PUs) or vascular leg ulcers.In a single-blinded randomised controlled trial (RCT) patients were randomly allocated to two groups and treated with either propylbetaine-polihexanide (PP) solution (Prontosan) or NS. Wounds were assessed using the Bates-Jensen wound assessment tool (BWAT). Assessments took place at inclusion (T0), day 7 (T1), day 14 (T2), day 21 (T3), and day 28 (T4). Outcomes were analysed using a two

2016 Journal of wound care Controlled trial quality: uncertain

9. Chronic wounds: advanced wound dressings and antimicrobial dressings

Chronic wounds: advanced wound dressings and antimicrobial dressings Chronic wounds: advanced wound dressings and Chronic wounds: advanced wound dressings and antimicrobial dressings antimicrobial dressings Evidence summary Published: 30 March 2016 nice.org.uk/guidance/esmpb2 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries of product characteristics (SPCs), British national formulary (BNF (...) ) or the MHRA or NICE websites for up-to-date information. Overall summary This evidence summary discusses the best available evidence for advanced wound dressings and antimicrobial dressings for managing common chronic wounds (diabetic foot ulcers, pressure ulcers, venous leg ulcers and infected wounds). It includes evidence and recommendations from national guidance (if available) and the most up-to-date systematic reviews and meta-analyses (search date July 2015). Dressings should provide the optimal

2016 National Institute for Health and Clinical Excellence - Advice

10. The V.A.C. Veraflo Therapy system for infected wounds

are that V.A.C. Veraflo Therapy system combines the use of negative pressure wound therapy (NPWT) and wound cleaning with topical solutions. Treatment is delivered in automated treatment cycles allowing wounds to be repetitively cleansed without the need for dressing removal. The intended place in ther place in therap apy y would be to replace normal NPWT in standard care in people with open infected wounds or chronic wounds that do not respond to standard care. The main points from the e main points from (...) offset these costs with potential savings related to decreases in dressing changes and nursing time, number of sharp debridements and shorter hospital stays. The technology The technology The V.A.C. Veraflo Therapy system (KCI a subsidiary of Acelity LP Inc) combines negative pressure wound therapy (NPWT) and wound instillation with topical solutions for wound healing. The therapy system delivers automated cycles of wound cleansing, removal of infectious material and exudate and NPWT depending

2019 National Institute for Health and Clinical Excellence - Advice

11. Evidence appraisal of Takalkar YP, Namdeo Garale M, Somasundaram S, Venkataramani K, Gothwal KN, Pandrowala SA. Comparison of efficacy of chlorhexidine alcohol scrub and povidone iodine scrub in hand cleansing in elective clean surgery.: Int Surg J. 2016; (Abstract)

Evidence appraisal of Takalkar YP, Namdeo Garale M, Somasundaram S, Venkataramani K, Gothwal KN, Pandrowala SA. Comparison of efficacy of chlorhexidine alcohol scrub and povidone iodine scrub in hand cleansing in elective clean surgery.: Int Surg J. 2016; 28241956 2019 01 24 2019 01 24 1878-0369 105 3 2017 03 AORN journal AORN J Evidence appraisal of Takalkar YP, Namdeo Garale M, Somasundaram S, Venkataramani K, Gothwal KN, Pandrowala SA. Comparison of efficacy of chlorhexidine alcohol scrub (...) and povidone iodine scrub in hand cleansing in elective clean surgery.: Int Surg J. 2016;3(4):1937-1941. 332-337 S0001-2092(17)30033-9 10.1016/j.aorn.2017.01.009 Allen George G eng Comparative Study Journal Article Randomized Controlled Trial United States AORN J 0372403 0001-2092 0 Anti-Infective Agents, Local 85H0HZU99M Povidone-Iodine R4KO0DY52L Chlorhexidine IM N Adolescent Adult Aged Anti-Infective Agents, Local Checklist Child Chlorhexidine administration & dosage Double-Blind Method Elective

2019 AORN journal Controlled trial quality: uncertain

12. Chlorhexidine Vaginal Cleansing Versus Iodine Prior to C-section and the Rate of Postoperative Infection

frequent complications of post cesarean infections. Endometritis accounts for 6-27% followed by clinically significant fever, which was reported about 5-24%,while the incidence of wound infection is about 2-9%.Previous studies evaluated whether vaginal cleansing can reduce the incidence of postoperative infectious morbidity. In most of the studies, povidone iodine was used as intervention. Objectives: The aim of this study is to test the hypothesis that preoperative vaginal cleansing with chlorhexidine (...) would be superior to iodine for the prevention of maternal infectious morbidities including endometritis, fever and wound complications. Methods: This prospective randomized single blinded controlled trial will be conducted at Makassed General Hospital between February 2018 and January 2019. Total of 300 patients, 150 in each group, will be enrolled. Group 1 patients will receive chlorhexidine vaginal cleansing while group 2 patients will receive iodine prior to C-section. Adverse post infectious

2018 Clinical Trials

13. Negative pressure wound therapy with instillation

Chronic wounds account for an estimated $25 billion dollars in healthcare expenditures per year. Treatment of wounds depends upon the wound type and severity; however, it typically includes debridement (surgical, mechanical, enzymatic, or biological), cleansing, and frequent changes of moist dressings. Description of Technology: Negative pressure wound therapy (NPWT) involves the application of subatmospheric pressure to the surface of a chronic or acute wound. NPWT is thought to promote wound healing (...) Negative pressure wound therapy with instillation Negative pressure wound therapy with instillation Negative pressure wound therapy with instillation HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Negative pressure wound therapy with instillation. Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2016 Authors' objectives

2017 Health Technology Assessment (HTA) Database.

14. Efficacy of debridement and wound cleansing with 2% hydrogen peroxide on graft take in the chronic-colonized burn wounds; a randomized controlled clinical trial. (Abstract)

Efficacy of debridement and wound cleansing with 2% hydrogen peroxide on graft take in the chronic-colonized burn wounds; a randomized controlled clinical trial. Severe burns are associated with dramatic outcomes which are potentially detrimental. Nowadays the standard treatment for deep partial thickness and full-thickness burn is early excision and grafting, which is not always feasible this leads to chronicity and microbial colonization of burn wounds. Interesting properties of hydrogen (...) peroxide 2% soaked gauze convinced us to use it in management of chronic burn wounds.From January 2009 to September 2011, in a prospective clinical trial, 49 patients (98 limbs) with chronic-colonized burn wounds in both limbs were included in this study. Tissue cultures were taken from all the wounds. For the right, after debridement of granulation tissue and washing with hydrogen peroxide 2% soaked gauze for 5min followed by normal saline irrigation, grafting was done; debridement and skin grafting

2013 Burns : journal of the International Society for Burn Injuries Controlled trial quality: uncertain

15. Water for wound cleansing.

Water for wound cleansing. Water for wound cleansing. – Less Is More Search for: Simpler & Better Medicine Menu / Summary: Wound cleansing with tap water may be more effective than wound cleansing with sterile saline in reducing the infection rate in adults with acute wounds, however there is not clear evidence that cleansing wounds increases healing or reduces infection. Strength of Recommendation = B Advertisements Like this: Like Loading... Categories: Tags: Post navigation Simpler, Better

2015 Less Is More Blog

16. The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns

was CE marked in 1997. The Versajet II system was CE marked in 2011 and was launched in 2012. Intended use Intended use The Versajet II hydrosurgery system is intended for wound debridement (acute and chronic wounds and burns), soft tissue debridement and cleansing of the surgical site if clinicians judge that sharp debridement and pulsed lavage irrigation is needed. It can be used in adults and children, for indications including pressure, diabetic and foot ulcers, burns and wounds that need plastic (...) The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns The V The Versajet ersajet II h II hy ydrosurgery system for surgical drosurgery system for surgical debridement of acute and chronic wounds and debridement of acute and chronic wounds and burns burns Medtech innovation briefing Published: 4 February 2014 nice.org.uk/guidance/mib1 pathways Summary Summary Effectiv Effectiveness eness Six randomised controlled trials and 3 non- randomised

2014 National Institute for Health and Clinical Excellence - Advice

17. Pressurised irrigation versus swabbing method in cleansing wounds healed by secondary intention: A randomised controlled trial with cost-effectiveness analysis. (Abstract)

Pressurised irrigation versus swabbing method in cleansing wounds healed by secondary intention: A randomised controlled trial with cost-effectiveness analysis. Wound cleansing should create an optimal healing environment by removing excess debris, exudates, foreign and necrotic material which are commonly present in the wounds that heal by secondary intention. At present, there is no research evidence for whether pressurised irrigation has better wound healing outcomes compared (...) with conventional swabbing practice in cleansing wound.This study investigated the differences between pressurised irrigation and swabbing method in cleansing wounds that healed by secondary intention in relation to wound healing outcomes and cost-effectiveness.Multicentre, prospective, randomised controlled trial.The study took place in four General Outpatient Clinics in Hong Kong.Two hundred and fifty six patients with wounds healing by secondary intention were randomly assigned by having a staff independent

2014 International journal of nursing studies Controlled trial quality: predicted high

18. Evaluating Bactisure Wound Lavage in Orthopedic Wounds

Official Title: Evaluating Bactisure Wound Lavage in Cleansing Orthopedic Surgical Wounds Actual Study Start Date : July 1, 2017 Actual Primary Completion Date : December 22, 2018 Estimated Study Completion Date : February 28, 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Device: Bactisure Level 1 Panel is a quantitative real-time PCR test to detect 12 microbial organisms that may be present in patient specimen (bacteria (...) Evaluating Bactisure Wound Lavage in Orthopedic Wounds Evaluating Bactisure Wound Lavage in Orthopedic Wounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluating Bactisure Wound Lavage in Orthopedic

2017 Clinical Trials

19. Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing?

Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing? Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01885273 Recruitment Status : Completed First Posted : June 24, 2013 Last Update Posted : June 24, 2013 Sponsor: Prince of Wales Hospital, Shatin, Hong Kong

2013 Clinical Trials

20. Wound cleansing for pressure ulcers. (Abstract)

Wound cleansing for pressure ulcers. Pressure ulcers (also called pressure sores, bed sores and decubitus ulcers) are areas of tissue damage that occur in the elderly, malnourished or acutely ill, who cannot reposition themselves. Pressure ulcers impose a significant financial burden on health care systems and negatively affect quality of life. Wound cleansing is considered an important component of pressure ulcer care.This systematic review seeks to answer the following question: what (...) is the effect of wound cleansing solutions and wound cleansing techniques on the rate of healing of pressure ulcers?For this third update, we searched the Cochrane Wounds Group Specialised Register (searched 3 January 2013); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 12); Ovid MEDLINE (2010 to November Week 3 2012); Ovid MEDLINE (In-Process & Other Non-Indexed Citations December 31, 2012); Ovid EMBASE (2010 to 2012 Week 52); and EBSCO CINAHL (2010 to 21

2013 Cochrane database of systematic reviews (Online)

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