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1. Procedural Pain During Lumbar Medial Branch Blocks With and Without Skin Wheal Anesthesia: A Prospective Comparative Observational Study. (PubMed)

Procedural Pain During Lumbar Medial Branch Blocks With and Without Skin Wheal Anesthesia: A Prospective Comparative Observational Study. To determine if skin wheals reduce procedural pain associated with lumbar medial branch blocks (MBBs) performed with 25-gauge needles.Prospective comparative observational study.Outpatient Physical Medicine & Rehabilitation and interventional pain practice within an academic tertiary care center.Ninety-nine consecutive patients who underwent lumbar MBBs (...) for facet pain were included. Patients who were obese or required larger-diameter needles were excluded.One to three facet joints were targeted per side, with some patients receiving bilateral procedures. All injections were performed with 25-gauge, 3.5-inch Quincke tip needles under fluoroscopic guidance. A total of 306 needle sticks were recorded. MBBs were performed without skin wheals or any other type of local anesthesia (35 patients, 108 needle sticks), with skin wheals (30 patients, 94 needle

2019 Pain Medicine

2. Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal. (PubMed)

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal. Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not.To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy (...) , and impact on the patient's quality of life (Dermatology Life Quality Index [DLQI]) were determined every 2 weeks.The study population comprised 150 patients (30 per group) and 30 controls. Twenty-four hours after administration of antihistamine, inhibition of the histamine wheal by >75% was significantly associated with better UAS and DLQI scores. The safety and efficacy of the 5 antihistamines were similar. After updosing, rates of disease control (DLQI score <5) increased from 58.7% to 76.7

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2016 Journal of investigational allergology & clinical immunology

3. Video-optical monitoring of wheal and flare reactions: Effects of topical Na-sucrose-sulphate. (PubMed)

Video-optical monitoring of wheal and flare reactions: Effects of topical Na-sucrose-sulphate. In order to monitor the dynamics of experimentally-induced cutaneous inflammation in humans, we developed an objective, computerized video-optical method for wheal and flare area determination.The method was used for evaluation of PAF-acether-induced experimental inflammations on the volar aspect of the forearms of human volunteers. The study design was double-blind, randomized, placebo-controlled (...) . Repeated measurements can be performed, e.g., with intervals of 1 min to reveal the time-course of the inflammatory reaction. In the present study, the effect of topical application of creams containing 3 different concentrations of the putative anti-inflammatory drug sodium sucrose-sulphate (SoS) on cutaneous inflammation was investigated.30 min after intracutaneous PAF-acether injection, a statistically significantly increased (p<0.05) wheal area was found in skin sites treated by either 1%, 3% and 9

2016 Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

4. An unexpected metastasis of breast cancer mimicking wheal rush (PubMed)

An unexpected metastasis of breast cancer mimicking wheal rush Breast cancer is the most common cancer among women and ranks second in cancer deaths worldwide. Breast cancer can metastasize to the skin but rarely, cutaneous metastases may be the first indication of the cancer. Skin metastases of breast cancer are usually found on the chest and close to the point of the mastectomy. We present the rare clinical entity of a breast cancer which was first diagnosed due to the skin metastasis away (...) from the breast tumor. This is a rare case because the skin lesions usually appear simultaneously or secondary. Also, while the existing metastasis; the only symptom was the wheal rash.

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2016 Il Giornale di chirurgia

5. Pain on administration of non-alkalinised lidocaine for carpal tunnel decompression: A comparison between the Gale and the "advancing wheal" techniques. (PubMed)

Pain on administration of non-alkalinised lidocaine for carpal tunnel decompression: A comparison between the Gale and the "advancing wheal" techniques. This study compares two methods of administration of non-alkalinised lidocaine for carpal tunnel decompression in volunteers as well as in patients undergoing carpal tunnel release: The Gale subcutaneous injection technique and another subcutaneous injection technique known as the "advancing wheal" technique. The comparison was done in nine (...) male volunteers and in 20 patients. In the volunteer part of the study, both hands were injected and, hence, each volunteer acted as his own control. In the clinical part of the study, the 20 patients were randomised, with 10 patients receiving the Gale technique and the other 10 receiving the wheal technique.In volunteers, the advancing wheal technique was associated with less pain; but with a longer duration of injection and a higher number of needle pricks when compared with the Gale technique

2016 Journal of plastic surgery and hand surgery

6. Idiopathic histaminergic angioedema without wheals: a case series of 31 patients (PubMed)

Idiopathic histaminergic angioedema without wheals: a case series of 31 patients Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-AAE patients. From 2014 to 2015, 534 patients were seen at our national reference centre (...) for angioedema and/or urticaria. Among them, we identified 31 patients with idiopathic histaminergic acquired angioedema without wheals (IH-AAE). Thirty-one patients (15 men and 16 women) with a mean age of 50 years met the criteria for IH-AAE. The average delay in diagnosis was 6·3 years. A history of allergy was found in 12 patients (38·7%), nine suffering from allergic rhinitis. The mean duration of attacks was 28·1 h. The AE attack was located in the upper respiratory tract in 54·8% of cases (17 patients

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2016 Clinical and experimental immunology

7. Wheal

Wheal Wheal Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Wheal Wheal Aka: Wheal II. Description Flat topped palpable lesions (...) of variable size Dermal collections of edema fluid III. Precautions: Wheal persists beyond 72 hours Consider l and biopsy IV. Examples Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Wheal." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Welts (C0221232) Definition (SCTSPA) Pápula o placa cutáneas eritematosas, que generalmente representan un edema

2018 FP Notebook

8. Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. (PubMed)

Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies.To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort.We used

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2016 Asthma & Immunology

9. Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity. (PubMed)

Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity. Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat.Intracutaneous skin tests with autologous sweat were performed on 50 AD patients and 24 control (...) subjects. In skin biopsies, tryptase and PAR-2 were enzyme and immunohistochemically stained. The associations between skin test reactivity and sweat histamine concentration, tryptase or chymase activity levels, tryptase or PAR-2 expression and AD clinical severity or IgE levels were investigated.The wheal reactions in the intracutaneous tests with autologous sweat were positive, weakly positive and negative in 38, 34 and 28% of the AD patients, respectively, and in 4, 46 and 50% of the healthy

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2016 International Archives of Allergy and Immunology

10. A Female with Hereditary Angioedema Developing Wheals: A Case Report. (PubMed)

A Female with Hereditary Angioedema Developing Wheals: A Case Report. 27350434 2017 02 28 2017 05 05 1651-2057 97 2 2017 02 08 Acta dermato-venereologica Acta Derm. Venereol. A Female with Hereditary Angioedema Developing Wheals: A Case Report. 285-286 10.2340/00015555-2490 van Kester Marloes S MS Department of Dermatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Bergman Wilma W Lavrijsen Adriana P M AP eng Case Reports Journal Article Sweden Acta Derm Venereol

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2016 Acta Dermato-Venereologica

11. The Lancet Weight Determines Wheal Diameter in Response to Skin Prick Testing with Histamine (PubMed)

The Lancet Weight Determines Wheal Diameter in Response to Skin Prick Testing with Histamine Skin prick test (SPT) is a common test for diagnosing immunoglobulin E-mediated allergies. In clinical routine, technicalities, human errors or patient-related biases, occasionally results in suboptimal diagnosis of sensitization.Although not previously assessed qualitatively, lancet weight is hypothesized to be important when performing SPT to minimize the frequency of false positives, false negatives (...) , and unwanted discomfort.Accurate weight-controlled SPT was performed on the volar forearms and backs of 20 healthy subjects. Four predetermined lancet weights were applied (25 g, 85 g, 135 g and 265 g) using two positive control histamine solutions (1 mg/mL and 10 mg/mL) and one negative control (saline). A total of 400 SPTs were conducted. The outcome parameters were: wheal size, neurogenic inflammation (measured by superficial blood perfusion), frequency of bleeding, and the lancet provoked pain

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2016 PloS one

12. Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. (PubMed)

Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. To compare the peripheral antihistaminic activity of bilastine, rupatadine and desloratadine in inhibiting the histamine-induced wheal and flare (W&F) response.Twenty-four healthy volunteers aged 18-40 years participated in this crossover, randomized, double-blind, placebo-controlled clinical study. Subjects received single doses (...) &F areas after each active treatment compared with corresponding basal values.Bilastine induced the greatest inhibition in wheal area and was significantly superior to desloratadine and rupatadine from 1 to 12 hours (both p < .001). Rupatadine and desloratadine were better than placebo without differences between them. Maximum wheal inhibition occurred at 6 hours (bilastine 83%, desloratadine 38%, rupatadine 37%). Onset of action was 1 hour for bilastine and 4 hours for desloratadine

2016 Current medical research and opinion

13. Generalized, well-dispersed rash · wheal development after tactile irritation · normal vital signs · Dx? (PubMed)

Generalized, well-dispersed rash · wheal development after tactile irritation · normal vital signs · Dx? 26551471 2016 02 17 2015 11 10 1533-7294 64 10 2015 Oct The Journal of family practice J Fam Pract Generalized, well-dispersed rash · wheal development after tactile irritation · normal vital signs · Dx? 645-7 Kelly Joseph V M JV CityMD Urgent Care, New York, NY, USA. Email: jvmkmd@gmail.com. eng Case Reports Journal Article United States J Fam Pract 7502590 0094-3509 0 Glucocorticoids 0

2015 Journal of Family Practice

14. Presentation, diagnosis and treatment of angioedema without wheals: a retrospective analysis of a cohort of 1058 patients. (PubMed)

Presentation, diagnosis and treatment of angioedema without wheals: a retrospective analysis of a cohort of 1058 patients. The first classification of angioedema without wheals was recently reported and comprises different forms of the disease distinguished by aetiology, mediator of oedema and inheritance.In total, 1725 consecutive patients with angioedema without wheals were examined at our centre between 1993 and 2012. We excluded from the analysis 667 patients because of incomplete data

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2015 Journal of internal medicine

15. Wheels within wheals: The burden of urticaria and angioedema (PubMed)

Wheels within wheals: The burden of urticaria and angioedema 25715237 2015 12 17 2018 11 13 1539-6304 36 2 2015 Mar-Apr Allergy and asthma proceedings Allergy Asthma Proc Wheels within wheals: the burden of urticaria and angioedema. 89-91 10.2500/aap.2015.36.3841 Bellanti Joseph A JA Settipane Russell A RA eng Editorial United States Allergy Asthma Proc 9603640 1088-5412 IM Angioedema diagnosis therapy Desensitization, Immunologic Home Infusion Therapy Humans Life Style Patient Satisfaction

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2015 Allergy and Asthma Proceedings

16. Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines. (PubMed)

Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines. Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests. This study assessed the effect of long-lasting treatment with montelukast alone or in combination with antihistamines on wheal and flare in skin pricks tests (...) were performed in all participants.Both levocetirizine and desloratadine in monotherapy, or in combination with montelukast, were effective in reducing wheal and flare in SPT. Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A. Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms

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2014 Inflammation research : official journal of the European Histamine Research Society ... [et al.]

17. OBSERVATIONS ON THE FORMATION OF WHEALS: IV. The Influence of Calcium Concentrations on Histamine Wheals (PubMed)

OBSERVATIONS ON THE FORMATION OF WHEALS: IV. The Influence of Calcium Concentrations on Histamine Wheals 16694028 2006 05 31 2008 11 20 0021-9738 11 1 1932 Jan The Journal of clinical investigation J. Clin. Invest. OBSERVATIONS ON THE FORMATION OF WHEALS: IV. The Influence of Calcium Concentrations on Histamine Wheals. 195-203 Weaver W K WK Department of Medicine, Washington University Medical School, and the Barnard Free Skin and Cancer Hospital, St. Louis. Alexander H L HL McConnell F S FS

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1932 Journal of Clinical Investigation

18. OBSERVATIONS ON THE FORMATION OF WHEALS: V. The Effects of Variation of the CO2 Combining Power of the Blood on Histamine Wheals (PubMed)

OBSERVATIONS ON THE FORMATION OF WHEALS: V. The Effects of Variation of the CO2 Combining Power of the Blood on Histamine Wheals 16694029 2006 05 31 2018 11 13 0021-9738 11 1 1932 Jan The Journal of clinical investigation J. Clin. Invest. OBSERVATIONS ON THE FORMATION OF WHEALS: V. The Effects of Variation of the CO(2) Combining Power of the Blood on Histamine Wheals. 205-9 McConnell F S FS Department of Medicine, Washington University Medical School and the Barnard Free Skin and Cancer

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1932 Journal of Clinical Investigation

19. Comparison of effects of 5 and 10 mg oral desloratadine and levocetirizine on histamine-induced wheal and flare response in healthy volunteers. (PubMed)

Comparison of effects of 5 and 10 mg oral desloratadine and levocetirizine on histamine-induced wheal and flare response in healthy volunteers. Levocetirizine and desloratadine are mostly used as H1-antihistamines in the treatment of allergic disease in 5 and 10 mg doses.In this study, the efficacy of single oral dosages of 5 and 10 mg desloratadine and levocetirizine were compared by using histamine-induced wheal and flare reactions.Eighty healthy volunteers were randomized for four double (...) -blinded treatment with desloratadine 5 and 10 mg and levocetirizine 5 and 10 mg. Wheal and flare responses were produced by histamine. Measurements were performed just before the ingestion of antihistamines (baseline) and afterward at 30, 60, 240 min and 24 h. The values obtained for each antihistamine were compared with baseline values.It was found that except the flare reactions at 30th min, levocetirizine 5 and 10 mg suppressed histamine-induced wheal and flare reactions more than desloratadine 5

2013 Journal of Dermatological Treatment

20. A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults

A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01981499 Recruitment Status

2013 Clinical Trials

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