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141. Metformin shows early promise for controlling clozapine-related weight gain

analysis. This analysis may be misleading as the non-random drop out of participants or cross over or people from control to treatment groups are not taken into account. Well-designed European trials would help to resolve and uncertainty in the research so far. What did it find? After a follow-up period of 12 weeks to six months: There was greater weight loss for people on metformin compared to placebo (mean difference ‑3.12kg, 95% confidence interval [CI] ‑4.88kg to ‑1.37kg). BMI was lower for people (...) ? After a follow-up period of 12 weeks to six months: There was greater weight loss for people on metformin compared to placebo (mean difference ‑3.12kg, 95% confidence interval [CI] ‑4.88kg to ‑1.37kg). BMI was lower for people on metformin than placebo (mean differences ‑1.18kg/m2, 95% CI ‑1.76kg/m2 to ‑0.61kg/m2). Waist circumference was smaller in people receiving metformin compared to placebo (mean difference ‑1.69cm, 95% CI ‑3.06cm to ‑0.32cm). Glucose and triglycerides were significantly lower

2019 NIHR Dissemination Centre

142. A football programme for overweight men achieves sustained weight loss

and behaviour change. NICE suggests that programmes are tailored to support the needs of different groups, such as men. Programmes are advised to set weight loss goals for the end of the programme and for one year. However, they should also stress the importance of maintaining new dietary habits and physical activity levels in the long term to prevent weight regain and discuss strategies to overcome any difficulties in maintaining new behaviours. What are the implications? This study supports the value (...) a difference in intake of fruit and vegetables or vigorous physical activity. The FFIT programme was estimated to cost on average £2,450 per participant including programme costs and self-reported use of healthcare resources. The programme was estimated to be cost-effective at £10,770 to £15,300 per quality-adjusted life year (QALY) gained at 3.5 years, and £1,790 to £2,200 per QALY over the course of the person’s lifetime. What does current guidance say on this issue? The NICE 2014 guideline on weight

2019 NIHR Dissemination Centre

143. Low fat or low carbohydrate diets seem just as effective for weight loss

% vs 23% for protein. Weight change at 12 months was -5.3 kg for the HLF diet vs -6.0 kg for the HLC diet (mean between-group difference, 0.7 kg [95% CI, -0.2 to 1.6 kg]). There was no significant diet-genotype pattern interaction (P = .20) or diet-insulin secretion (INS-30) interaction (P = .47) with 12-month weight loss. There were 18 adverse events or serious adverse events that were evenly distributed across the 2 diet groups. Conclusions and Relevance: In this 12-month weight loss diet study (...) Low fat or low carbohydrate diets seem just as effective for weight loss Low fat or low carbohydrate diets seem just as effective for weight loss Discover Portal Discover Portal Low fat or low carbohydrate diets seem just as effective for weight loss Published on 22 May 2018 doi: Overweight to obese adults who followed a low fat or low carbohydrate diet for 12 months both lost around 5 or 6kg in body weight. It made no difference whether they had a gene-type indicating that they break down fats

2019 NIHR Dissemination Centre

144. Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities. (PubMed)

or chemicals. The digestion processes were optimised, and the digestates were separated in fractions with four different molecular weight ranges by using a cross-flow membrane filtration technique. Total hydrolysates and fractions were tested in vitro for a wide range of biological activities. For the first time rice-derived peptides were assayed for anti-tyrosinase, anti-inflammatory, cytotoxicity and irritation capacities. Antioxidant and anti-hypertensive activities were also evaluated. Protamex (...) Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities. Recently, the isolation of new health-related bioactive molecules derived from agro-food industrial by-products by means of environment-friendly extraction processes has become of particular interest. In the present study, a protein by-product from the rice starch industry was hydrolysed with five commercial proteolytic enzymes, avoiding the use of solvents

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2017 PLoS ONE

145. Preventing excess weight gain

of the guideline in 2011. Healthy weight 3.2 The majority of evidence in the reviews considered by the Committee tended to define a healthy weight as a BMI of 18.5 kg/m 2 to 24.9 kg/m 2 , in line with existing NICE guidelines (see NICE's guideline on obesity). However, the Committee recognised that, given that mean BMI is around 27 kg/m 2 for adults, the aim for many people may be to prevent further weight gain. The Committee also recognised that what is considered a 'healthy weight' may differ by ethnic group (...) a healthy weight or preventing excess weight gain and people who commission, design, implement or evaluate interventions that directly or indirectly help different population groups maintain a healthy weight or prevent excess weight gain. (For further details, see related NICE guidance). In addition, it may be of interest to members of the public. Note that the guideline recommendations are based on the best available evidence. Practical examples are based on wider population recommendations

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

146. Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. (PubMed)

), clinical response in global state (mean score/change in global state), weight gain, leaving the study early (acceptability of treatment), service utilisation outcomes (hospital days or admissions to hospital) and quality of life.We found some significant differences between clozapine combination strategies for global and mental state (clinically significant response and change), and there were data for leaving the study early and weight gain. We found no data for service utilisation and quality of life (...) -resistant schizophrenia (or related disorders) and comparing clozapine plus another antipsychotic drug with clozapine plus a different antipsychotic drug.We extracted data independently. For dichotomous data, we calculated risk ratios (RRs) and 95% confidence intervals (CI) on an intention-to-treat basis using a random-effects meta-analysis. For continuous data, we calculated mean differences (MD) and 95% CIs. We used GRADE to create 'Summary of findings' tables and assessed risk of bias for included

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2017 Cochrane

147. Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging (PubMed)

Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging [Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were (...) divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3±7.0 years, while it was 16.7±12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease

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2015 Journal of physical therapy science

148. The value of venous-to-arterial carbon dioxide difference to arteriovenous oxygen content difference ratio in prognosis of severe sepsis and septic shock: a systematic review and meta-analysis

is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e (...) studies using the Jablonski scale. ">Sensitivity Example: For meta-analyses using the mean difference or risk ration as effect measure and containing at least 20 studies, we will produce funnel plots and assess publication bias using Egger’s regression test. ">Publication bias

2019 PROSPERO

149. Effects of post exercise massage at different moments of application on different outcomes: a systematic review and meta-analysis

. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same (...) using the mean difference or risk ration as effect measure and containing at least 20 studies, we will produce funnel plots and assess publication bias using Egger’s regression test. ">Publication bias

2019 PROSPERO

150. Differences in views and attitudes among people of different ethnicities toward precision medicine research: a systematic review

is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same (fixed) across all studies. However (...) with data from the latest possible time point (in studies reporting an outcome at multiple time points). We will test the robustness of linear regression of time-to-treatment by performing stratified analysis (treatment pre-ischemia vs during vs post-ischemia). We will assess the effect of our decision to pool all reported scales for histological damage by re-running the analyses using only data from studies using the Jablonski scale. ">Sensitivity Example: For meta-analyses using the mean difference

2019 PROSPERO

151. Power Threat Meaning Framework: innovative and important? #PTMFramework

be amused by the idea that they were taking a radical behaviourist perspective! Hope the helps the confusion. Penny Priest replied: View In what way is it a different use of the word functional? And why would the PTMF authors not be amused by this? replied: View Thanks Penny. This is pretty fundamental. Functional analysis has a specific meaning, and typically is validated by extablishing experimental control. For FA 101 see this: By contrast, see how function is considered in psychoanalysis 101 here (...) Power Threat Meaning Framework: innovative and important? #PTMFramework Power Threat Meaning Framework: innovative & important? #PTMFramework Search National Elf Service Search National Elf Service » » » Power Threat Meaning Framework: innovative and important? #PTMFramework May 2 2018 Posted by >, The past 50 years has seen globalisation of psychiatric diagnostic (categorical) frameworks. Early versions were notoriously unreliable; when categories are unreliable they cannot be valid, meaning

2018 The Mental Elf

152. Weight management: lifestyle services for overweight or obese adults

be in place to allow people to be referred to, or receive support from (or across) the different service tiers of an obesity pathway, as necessary. This includes referrals to and from lifestyle weight management programmes. All the options in the local obesity pathway should be made clear to both professionals and the public. Identify local services, facilities or groups that could be included in the local obesity pathway, meet the needs of different groups and address the wider determinants of health (...) find a waist circumference measurement helpful for self-monitoring, it does not help to assess people with a BMI greater than 35 kg/m 2 .) Recommendation 3 Raise awareness of local weight management issues among commissioners Local authorities and Public Health England should ensure all those commissioning lifestyle weight management services are aware of: the number of adults who are overweight or obese locally, including any variations in rates between different groups the effect of the local

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

153. Associations of Parental General Monitoring with Adolescent Weight-Related Behaviors and Weight Status. (PubMed)

Associations of Parental General Monitoring with Adolescent Weight-Related Behaviors and Weight Status. This study examined how parental general monitoring (PGM), which refers to parental awareness of adolescents' activities in various domains, is associated with adolescents' weight status and related behaviors and whether these relationships differ among racial/ethnic groups.Data are from 4,088 Black, Latino, and White youth assessed in seventh grade (mean age = 13.06). BMI percentile based (...) on measured height and weight indicated weight status. PGM was assessed by adolescent report of parents' awareness of money spending, friends, and whereabouts. Adolescents reported both healthy and unhealthy dietary intake (DI), physical activity, and screen time over the past 7 days. Total sample and multigroup structural models were estimated.PGM was associated with lower weight status for the total sample, as well as being positively associated with healthy DI and physical activity and inversely

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2018 Obesity

154. Computed diffusion weighted imaging (cDWI) and voxelwise-computed diffusion weighted imaging (vcDWI) for oncologic liver imaging: A pilot study (PubMed)

with b = 100,600,800,1000 and 1500s/mm2. cDWI (cb1000/cb1500) and vcDWI were computed based on following combinations: i) b = 100/600 s/mm2, ii) b = 100/800 s/mm2, iii) b = 100/1000s/mm2, iv) b = 100/600/1000s/mm2 v) all measured b-values. Mean signal intensity (SI) and standard deviation (SD) in the liver, spleen, kidney, bone marrow and in liver lesions were acquired. The coefficient of variation (CV = SD/SI), the differences of SI between measured and calculated high b-value images and the lesion (...) Computed diffusion weighted imaging (cDWI) and voxelwise-computed diffusion weighted imaging (vcDWI) for oncologic liver imaging: A pilot study Aim of the study was to evaluate the influence of the selection of measured b-values on the precision of cDWI in the upper abdomen as well as on the lesion contrast of PET-positive liver metastases in cDWI and vcDWI.We performed a retrospective analysis of 10 patients (4 m, 63.5 ± 12.9 y/o) with PET-positive liver metastases examined in 3 T-PET/MRI

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2018 European Journal of Radiology Open

155. Value of Diffusion-Weighted Imaging Combined with Susceptibility-Weighted Imaging in Differentiating Benign from Malignant Parotid Gland Lesions (PubMed)

patients (26 benign cases and 10 malignant cases) were confirmed by surgical pathology. The apparent diffusion coefficient (ADC), normalized ADC (ADCNormalized), intratumoral susceptibility signals (ITSS), and morphological characteristics were analyzed with SPSS 19.0 software. RESULTS The mean ADC values of parotid gland lesions was not different between malignant and benign lesions (P=0.07), while the differences between ADCNormalized (P=0.026) and ITSS grading (P=0.014) were statistically (...) Value of Diffusion-Weighted Imaging Combined with Susceptibility-Weighted Imaging in Differentiating Benign from Malignant Parotid Gland Lesions BACKGROUND The aim of this study was to investigate the diagnostic value of diffusion-weighted imaging (DWI) in combination with susceptibility-weighted imaging (SWI) for differentiating benign parotid gland lesions from malignant ones. MATERIAL AND METHODS This retrospective study was approved by the Ethics Committee of our hospital. A total of 36

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2018 Medical science monitor : international medical journal of experimental and clinical research

156. Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults With Overweight/Obesity

Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults With Overweight/Obesity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical (...) for the weight-reduced population we will enroll. While the DPP Post-CORE program includes 15 sessions delivered over 15-months, we will deliver sessions #1-12 and 15 over a 12-week period. Content for sessions 13 and 14 from the DPP Post-CORE curriculum focus specifically on Type 2 Diabetes Mellitus and Heart Disease. The informational handouts will be provided to participants, but not specifically covered in weekly meetings. Groups will differ only in specific caloric prescriptions (described in the Arms

2018 Clinical Trials

157. Effects of the Additional Weight on the Reaching Behavior of Pre Term Infants With Low Birth Weight

remove one or more studies before adding more. Effects of the Additional Weight on the Reaching Behavior of Pre Term Infants With Low Birth Weight The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03405181 Recruitment Status : Completed First Posted : January 19, 2018 Last Update Posted : February 25 (...) program of eight sessions (2x/week; 4 weeks). The AWIG and LWIG will receive the training with an additional weight (characterized by a bracelet with a weight of 20% of the mass of the upper limbs)and the AWPG and LWPG will receive the same training, however, without the additional weight (only the bracelets).. All infants will be assessed in three different moments: 1) Pre-intervention: baseline, before the start of the intervention program; 2) Post-intervention: evaluation performed after the end

2018 Clinical Trials

158. How do orthopaedic surgeons and rehabilitation professionals interpret and assess ‘toe touch’ weight bearing and ‘partial’ weight bearing status in the rehabilitation setting? (PubMed)

in their interpretation of TTWB and PWB, however there was a wide range of responses. There was a significant difference between the predicted %TBW and the actual values demonstrated by the 'educated patient' (mean difference 4.8 (TTWB) and 22.9 (PWB)).Healthcare professionals vary greatly in their interpretation of the terms TTWB and PWB. Therefore, for a consistency in rehabilitation delivery the terms should not be used in isolation without a further descriptor. Static measures of weight application are lower than (...) physiotherapists) at Defence Medical Rehabilitation Centre Headley Court were also recruited. Both groups provided their interpretation of TTWB and PWB as a percentage of total body weight (%TBW). Each rehabilitation professional, then applied what they interpreted to be TTWB and PWB using a Lasar Posture weighing device. The predicted values were compared with the actual values demonstrated.There was no significant difference between orthopaedic surgeons and rehabilitation professionals

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2018 BMJ Open Sport — Exercise Medicine

159. Comparison of a Weight Bearing and a Non-weight Bearing Protocol on Osteoporotic Women With Chronic Low Back Pain

studies (100). Please remove one or more studies before adding more. Comparison of a Weight Bearing and a Non-weight Bearing Protocol on Osteoporotic Women With Chronic Low Back Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov (...) , each participant will be assigned to one of two groups - weight bearing group or non-weight bearing group. After recruiting at least 3 participants in each group, a different investigator will begin a specific exercise protocol for each of the groups for four weeks - twice a week, 45 minutes each time, a total of 8 sessions. After each participant finishes all 8 sessions, she will be tested for the second time by the first investigator, the same tests as the first time. A third identical test

2018 Clinical Trials

160. Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions? (PubMed)

-weight changes.In this study we examined whether body-fat distribution at baseline was associated with long-term and short-term weight changes.We included 3 observational studies (ntotal = 7271) with mean follow-up times of 5-9 y and two 8-10-wk weight loss intervention studies (ntotal = 1091). We examined the association between baseline waist circumference and weight changes in a substitution regression model, where body weight, height, and fat-free mass were fixed so that a difference in waist (...) Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions? Body fat distribution is a marker of metabolic health independent of body size. Visceral fat accumulation has been suggested to result from a decreased expandability of the subcutaneous fat depots. Furthermore, the visceral fat may be easier to mobilize than the peripheral fat. We examined whether differences in abdominal obesity at baseline influenced prospective body

2018 American Journal of Clinical Nutrition

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