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141. Under what conditions can children with autism spectrum disorder identify the meaning of novel words, in comparison to typically developing children? A meta analysis

subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies (...) by re-running the analyses using only data from studies using the Jablonski scale. ">Sensitivity Example: For meta-analyses using the mean difference or risk ration as effect measure and containing at least 20 studies, we will produce funnel plots and assess publication bias using Egger’s regression test. ">Publication bias

2021 PROSPERO

142. General medicine: Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions?

General medicine: Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions? Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions? | BMJ Evidence-Based Medicine Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu (...) Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions? Article Text EBM opinion and debate General medicine Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions? Tomás Ó Flatharta , Aidan Flynn , Eamon C

2019 Evidence-Based Medicine

143. High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants. Full Text available with Trip Pro

to November 2016), as well as conference proceedings, previous reviews, and trial registries.Randomised and quasi-randomised controlled trials that compared high-volume versus standard-volume enteral feeds for preterm or low birth weight infants.Two review authors assessed trial eligibility and risk of bias and independently extracted data. We analysed treatment effects in individual trials and reported the risk ratio and risk difference for dichotomous data, and the mean difference for continuous data (...) , with respective 95% confidence intervals. . We assessed the quality of evidence at the outcome level via the GRADE approach.We found one eligible trial that included 64 infants. This trial was not blinded. Analysis showed a higher rate of weight gain in the high-volume feeds group: mean difference 6.20 g/kg/d (95% confidence interval 2.71 to 9.69). There was no increase in the risk of feed intolerance or necrotising enterocolitis with high-volume feeds, but 95% confidence intervals around these estimates were

2017 Cochrane

144. A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial

]; mean between-group difference -0·07 kg per week, 95% CI -0·09 to -0·04). No between-group differences in perinatal complications were observed. Interpretation: Our evidence-based programme showed that health-care delivery systems could further adapt to meet the needs of their clinical settings to prevent excess GWG and improve healthy behaviours and markers of insulin resistance among women with overweight or obesity by using telehealth lifestyle interventions. Funding: US National Institutes (...) A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial A Telehealth Lifestyle Intervention to Reduce Excess Gestational Weight Gain in Pregnant Women With Overweight or Obesity (GLOW): A Randomised, Parallel-Group, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search

2020 EvidenceUpdates

145. Layperson-Led vs Professional-Led Behavioral Interventions for Weight Loss in Pediatric Obesity: A Systematic Review and Meta-analysis Full Text available with Trip Pro

outcomes and measures: The immediate and sustained changes in weight and body mass index (BMI) standardized mean difference (SMD) were primary outcomes planned before data collection began, whereas waist circumference and percent body fat were secondary outcomes. The hypothesis being tested was formulated before the data collection. Results: Of 25 586 citations retrieved, we included 78 RCTs (5780 participants), with a follow-up of 12 to 104 weeks. Compared with the control condition, random-effects (...) models revealed that professional-led weight loss interventions were associated with reductions in weight (mean difference [MD], -1.60 kg [95% CI, -2.30 to -0.99 kg]; 68 trials; P < .001) and BMI (SMD, -0.30 [95% CI, -0.39 to -0.20]; 59 trials; P < .001) that were not sustained long term (weight MD, -1.02 kg [95% CI, -2.20 to 0.34 kg]; 21 trials; P = .06; BMI SMD, -0.12 [95% CI, -0.46 to 0.21]; 20 trials; P < .001). There was no association between layperson-led interventions and weight loss

2020 EvidenceUpdates

146. Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial. (Abstract)

. Among infants in the liberal vs restrictive transfusion thresholds groups, respectively, incidence of any transfusion was 400/492 (81.3%) vs 315/521 (60.5%); median volume transfused was 40 mL (IQR, 16-73 mL) vs 19 mL (IQR, 0-46 mL); and weekly mean hematocrit was 3 percentage points higher with liberal thresholds. Among infants in the liberal vs restrictive thresholds groups, the primary outcome occurred in 200/450 (44.4%) vs 205/478 (42.9%), respectively, for a difference of 1.6% (95% CI, -4.8 (...) groups, necrotizing enterocolitis requiring surgical intervention occurred in 20/492 (4.1%) vs 28/518 (5.4%); bronchopulmonary dysplasia occurred in 130/458 (28.4%) vs 126/485 (26.0%); and treatment for retinopathy of prematurity was required in 41/472 (8.7%) vs 38/492 (7.7%). Growth at follow-up was also not significantly different between groups.Among infants with birth weights of less than 1000 g, a strategy of liberal blood transfusions compared with restrictive transfusions did not reduce

2020 JAMA

147. COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis Full Text available with Trip Pro

, Google Scholar, Preprints, bioRxiv, and medRxiv. We used the odds ratio (OR) and mean difference (MD) as measure of analysis. Summary estimates were calculated using random effects models. 38 studies were included; data from 279 women were analyzed; 60 patients were diagnosed with COVID-19. The meta-analysis showed no significant association between COVID-19 and preterm delivery (OR = 2.25; 95%CI: 0.96, 5.31; p = 0.06; I² = 0%). No significant relationship was found between birth weight and COVID-19 (...) COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

148. Weight Loss in Underserved Patients - A Cluster-Randomized Trial. (Abstract)

, 83.4% completed the 24-month trial. The percent weight loss at 24 months was significantly greater in the intensive-lifestyle group (change in body weight, -4.99%; 95% confidence interval [CI], -6.02 to -3.96) than in the usual-care group (-0.48%; 95% CI, -1.57 to 0.61), with a mean between-group difference of -4.51 percentage points (95% CI, -5.93 to -3.10) (P<0.001). There were no significant between-group differences in serious adverse events.A high-intensity, lifestyle-based treatment program (...) Weight Loss in Underserved Patients - A Cluster-Randomized Trial. Evidence of the effectiveness of treatment for obesity delivered in primary care settings in underserved populations is lacking.We conducted a cluster-randomized trial to test the effectiveness of a high-intensity, lifestyle-based program for obesity treatment delivered in primary care clinics in which a high percentage of the patients were from low-income populations. We randomly assigned 18 clinics to provide patients

2020 NEJM

149. Cycled Phototherapy Dose-Finding Study for Extremely Low-Birth-Weight Infants: A Randomized Clinical Trial Full Text available with Trip Pro

minutes per hour against TSB level. The comparator arm was usual care (continuous PT). Main outcomes and measures: Mean peak TSB level and total PT hours through day 14 in all 6 centers and predischarge brainstem auditory-evoked response wave V latency in 1 center. Mortality and major morbidities were secondary outcomes despite limited power. Results: Consent was requested for 452 eligible infants and obtained for 305 (all enrolled) (mean [SD] birth weight, 749 [152] g; gestational age, 25.7 [1.9 (...) TSB levels were 7.1 vs 6.4 mg/dL (adjusted difference, 0.7; 95% CI, 0.4-1.1 mg/dL) and mean total PT hours were 34 vs 72 (adjusted difference, -39; 95% CI, -45 to -32). Wave V latency adjusted for postmenstrual age was similar in 37 infants receiving 15 min/h or more of PT and 33 infants receiving continuous PT: 7.42 vs 7.32 milliseconds (difference, 0.10; 95% CI, -0.11 to 0.30 millisecond). The relative risk for death was 0.79 (95% CI, 0.40-1.54), with a risk difference of -4.5% (95% CI, -10.9

2020 EvidenceUpdates

150. Effect of Telehealth Extended Care for Maintenance of Weight Loss in Rural US Communities: A Randomized Clinical Trial Full Text available with Trip Pro

% body weight reduction at follow-up. Results: Among 445 participants (mean [SD] age, 55.4 [10.2] years; 368 [82.7%] women; 329 [73.9%] white), 149 participants (33.5%) were randomized to individual telephone counseling, 143 participants (32.1%) were randomized to group telephone counseling, and 153 participants (34.4%) were randomized to the email education control. Mean (SD) baseline weight was 99.9 (14.6) kg, and mean (SD) weight loss after the initial intervention was 8.3 (4.9) kg. Mean weight (...) Effect of Telehealth Extended Care for Maintenance of Weight Loss in Rural US Communities: A Randomized Clinical Trial Effect of Telehealth Extended Care for Maintenance of Weight Loss in Rural US Communities: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library

2020 EvidenceUpdates

151. Progestin-only contraceptives: effects on weight. Full Text available with Trip Pro

were lack of randomizations (NRS) and high loss to follow-up or early discontinuation.These 22 studies showed limited evidence of change in weight or body composition with use of POCs. Mean weight gain at 6 or 12 months was less than 2 kg (4.4 lb) for most studies. Those with multiyear data showed mean weight change was approximately twice as much at two to four years than at one year, but generally the study groups did not differ significantly. Appropriate counseling about typical weight gain may (...) between progestin-only contraceptive use and changes in body weight.Until 4 August 2016, we searched MEDLINE, CENTRAL, POPLINE, LILACS, ClinicalTrials.gov, and ICTRP. For the initial review, we contacted investigators to identify other trials.We considered comparative studies that examined a POC versus another contraceptive method or no contraceptive. The primary outcome was mean change in body weight or mean change in body composition. We also considered the dichotomous outcome of loss or gain

2016 Cochrane

152. Weight management: lifestyle services for overweight or obese adults

be in place to allow people to be referred to, or receive support from (or across) the different service tiers of an obesity pathway, as necessary. This includes referrals to and from lifestyle weight management programmes. All the options in the local obesity pathway should be made clear to both professionals and the public. Identify local services, facilities or groups that could be included in the local obesity pathway, meet the needs of different groups and address the wider determinants of health (...) find a waist circumference measurement helpful for self-monitoring, it does not help to assess people with a BMI greater than 35 kg/m 2 .) Recommendation 3 Raise awareness of local weight management issues among commissioners Local authorities and Public Health England should ensure all those commissioning lifestyle weight management services are aware of: the number of adults who are overweight or obese locally, including any variations in rates between different groups the effect of the local

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

153. Association of Sex or Race With the Effect of Weight Loss on Physical Function: A Secondary Analysis of 8 Randomized Clinical Trials Full Text available with Trip Pro

] years; 920 [69.9%] female; 275 [20.9%] Black) with overweight or obesity (mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 33.9 [4.4]) were included at baseline. Six-month weight change achieved among those randomized to CR was -7.7% (95% CI, -8.3% to -7.2%), with no difference noted by sex; however, White individuals lost more weight than Black individuals assigned to CR (-9.0% [95% CI, -9.6% to -8.4%] vs -6.0% [95% CI, -6.9% to 5.2%]; P < .001 (...) and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina. PMID: 32821924 PMCID: DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Importance: Consideration of differential treatment effects among subgroups in clinical trial research is a topic of increasing interest. This is an especially salient issue for weight loss trials. Objective: To determine whether stratification by sex and race is associated with meaningful differences in physical

2020 EvidenceUpdates

154. Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial Full Text available with Trip Pro

and measures: The primary outcome was weight loss. Secondary outcomes from the in-person cohort included changes in weight, fat mass, lean mass, fasting insulin, fasting glucose, hemoglobin A1c levels, estimated energy intake, total energy expenditure, and resting energy expenditure. Results: Overall, 116 participants (mean [SD] age, 46.5 [10.5] years; 70 [60.3%] men) were included in the study. There was a significant decrease in weight in the TRE (-0.94 kg; 95% CI, -1.68 to -0.20; P = .01 (...) ), but no significant change in the CMT group (-0.68 kg; 95% CI, -1.41 to 0.05, P = .07) or between groups (-0.26 kg; 95% CI, -1.30 to 0.78; P = .63). In the in-person cohort (n = 25 TRE, n = 25 CMT), there was a significant within-group decrease in weight in the TRE group (-1.70 kg; 95% CI, -2.56 to -0.83; P < .001). There was also a significant difference in appendicular lean mass index between groups (-0.16 kg/m2; 95% CI, -0.27 to -0.05; P = .005). There were no significant changes in any of the other secondary

2020 EvidenceUpdates

155. The impact of pharmacological and lifestyle interventions on body weight in people with type 1 diabetes: A systematic review and meta-analysis Full Text available with Trip Pro

receptor agonist liraglutide 0.6 mg (mean difference [MD]: -2.22 kg [95% CI: -2.55 to -1.90]), 1.2 mg (MD: -3.74 kg [95% CI: -4.16 to -3.33]) and 1.8 mg (MD: -4.85 kg [95% CI: -5.29 to -4.41]), and the SGLT-2 inhibitors empagliflozin 2.5 mg (MD: -1.47 kg [95% CI: -2.23 to -0.71]), 10 mg (MD: -2.77 kg [95% CI: -3.24 to -2.31]) and 25 mg (MD: -3.06 kg [95% CI: -3.57 to -2.55]) and sotagliflozin 200 mg (MD: -2.40 kg [95% CI: -2.87 to -1.94]) and 400 mg (MD: -3.23 [95% CI: -3.73 to -2.72]) were associated (...) The impact of pharmacological and lifestyle interventions on body weight in people with type 1 diabetes: A systematic review and meta-analysis The impact of pharmacological and lifestyle interventions on body weight in people with type 1 diabetes: A systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable

2020 EvidenceUpdates

156. Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes Full Text available with Trip Pro

to weeks 24 and 76 in HbA1c, body weight (BW) and systolic blood pressure (SBP) by respective baseline categories (HbA1c 90 kg, SBP 140 mmHg). Analyses were also conducted with a model using continuous covariates of cardio-metabolic factors. Results: In total, 637 patients (56.7% males; mean [SD] age 55.7 [9.9] years, HbA1c 7.9% [0.9%], BW 81.2 [18.8] kg, SBP 129.4 [14.6] mmHg) received one or more dose of either empagliflozin 10 mg (n = 217) or 25 mg (n = 213), or placebo (n = 207). At both time (...) Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced

2020 EvidenceUpdates

157. Weight-adapted ultra-low-dose pancreatic perfusion CT: radiation dose, image quality, and perfusion parameters. (Abstract)

Weight-adapted ultra-low-dose pancreatic perfusion CT: radiation dose, image quality, and perfusion parameters. We evaluate the reliability and feasibility of weight-adapted ultra-low-dose pancreatic perfusion CT.A total of 100 (47 men, 53 women) patients were enrolled prospectively and were assigned to five groups (A, B, C, D, and E) with different combination of tube voltage and tube current according to their body weight. Radiation dose parameters including volume CT dose index (CTDI (...)  kg. The mean subjective image quality score was above 4.45 on a 5-point scale with good agreement between two radiologists. Groups A-D had equivalent performance on objective image quality (P > 0.05), while Group E performed even better (P < 0.05). No significant differences emerged in comparison with perfusion parameters (BF, BV, PMB) of normal pancreas parenchyma between the five groups.Weight-adapted ultra-low-dose pancreatic perfusion CT can effectively reduce radiation dose without prejudice

2019 Abdominal radiology (New York) Controlled trial quality: uncertain

158. Among extremely low birth weight infants, exclusive maternal feeding decreases necrotizing enterocolitis risk, mortality and health costs

words: ; Reception date: 18/01/2017 Acceptance date: 23/01/2017 Publication date: 25/01/2017 Structured Abstract Objective: To estimate the costs and decrease in mortality that could be achieved at Neonatal Intensive Care Units (NICUs) if the intake of at least 90% of extremely low birth weight (ELBW) infants was at least 98% human milk. Study design: economic study by means of Markov Chain Monte Carlo (MCMC) simulation modelling. Setting: hospital-based study. Study population: simulated population (...) Among extremely low birth weight infants, exclusive maternal feeding decreases necrotizing enterocolitis risk, mortality and health costs Among extremely low birth weight infants, exclusive maternal feeding decreases necrotizing enterocolitis risk, mortality and health costs - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library

2017 Evidencias en Pediatría

159. Changes in weight and body composition among students after entering the university: a systematic review Full Text available with Trip Pro

academic year. Deliens et al., 2013 BELGIUM Variables at beginning and end of semester: Weight (kg) = 63.1 and 64.1*; BMI (kg/m 2 ) = 21.8 and 22.1*; body fat (%) = 21.7 and 22.5*; body fat (kg) = 13.7 and 14.5*; lean mass (kg) = 49.4 and 49.6 * significant difference. First semester at university is critical period for weight gain and body fat. Hootman et al., 2017 USA Gains in first year: Weight (kg) = 2.1; body fat (%) = 1.6; mean change in weight (kg) = +2.3 ♂ and +2.0 ♀; mean gain in fat (...) studied for a number of years. In a literature review, Crombie et al.5 concluded that the mean increase in weight in the first year is lower than that suggested by the term “freshman 15” and is actually between 4.4 to 6.6 pounds (two to three kg). Excess weight and weight gain are related to an increased risk of the development of chronic non-communicable diseases . However, limiting the investigation of changes in body weight or the body mass index (BMI) may be insufficient for a reliable analysis

2019 Revista chilena de nutrición

160. Systematic review of interventions in the childcare setting with direct parental involvement: effectiveness on child weight status and energy balance-related behaviours Full Text available with Trip Pro

. With regard to the intervention group, 61.1% found some favourable results on weight status, 73.3% on physical activity, 88.9% on sedentary behaviour, and all on nutrition-related behaviour. There were studies that also showed unfavourable results. Only a small number of studies was able to show significant differences between the intervention and control group (22.2% weight status, 60.0% physical activity, 66.6% sedentary behaviour, 76.9% nutrition behaviour). Effect sizes, if available, were (...) that overweight-related lifestyle behaviours track from childhood into adulthood, just like weight status [ ]. Therefore, early childhood provides a window of opportunity for the prevention of overweight and obesity [ ]. EBRBs are influenced by multiple factors, such as the child’s environment [ ]. From a socio-ecological perspective, different types of environments and different settings can influence behaviour [ , , ]. Environments can be categorized into sociocultural (attitudes, beliefs and values related

2019 International Journal of Behavioral Nutrition and Physical Activity

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