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121. Assessment of different folic acid supplementation doses for low-birth-weight infants (PubMed)

Assessment of different folic acid supplementation doses for low-birth-weight infants The adequacy of 50 mcg folic acid supplementation given to low-birth-weight babies was investigated. The folate levels of the mothers and infants, and breastmilk, and the optimum dose for folic acid supplementation were also investigated.After obtaining blood from 141 low-birth-weight infants on the 1st day of life for serum and red cell folate levels, the infants were randomly allocated into three groups (...) postnatally. The feeding modes of the infants, maternal folic acid intake, and details of neonate intensive care unit course were recorded.The mean birth weight and gestational age of the infants were found as 1788.2±478.4 g and 33.5±2.9 weeks, respectively. The mean serum and red cell folate levels on admission were found as 21.2±12.2 ng/mL and 922.7±460.7 ng/mL, respectively. The mean maternal serum and red cell folate levels and the mean breast milk folate levels were found as 12.3±7.5 ng/mL, 845.5

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2016 Turkish Archives of Pediatrics/Türk Pediatri Arşivi Controlled trial quality: uncertain

122. Safety and efficacy of packed red blood cell transfusions at different doses in very low birth weight infants. (PubMed)

Safety and efficacy of packed red blood cell transfusions at different doses in very low birth weight infants. This double-blinded, randomized, crossover study evaluated the safety and effectiveness of 20 mL/kg aliquots of packed red blood cell (PRBC) transfusions versus 15 mL/kg aliquot transfusions in very low birth weight (VLBW) infants with anemia. The study enrolled 22 hemodynamically stable VLBW infants requiring PRBC transfusions, with a mean gestational age of 25.7 ± 2.2 weeks and birth (...) weight of 804 ± 261 g. Each infant was randomized to receive one of two treatment sequences: 15 mL/kg followed by 20 mL/kg or 20 mL/kg followed by 15 mL/kg. The infants were monitored during and after transfusions, and the efficacy and safety of the treatments were evaluated. Infants had higher posttransfusion hemoglobin (13.2 g/dL vs 11.8 g/dL, P < 0.01) and hematocrit levels (38.6 g/dL vs 34.4 g/dL, P < 0.01) following 20 mL/kg PRBC transfusions when compared to 15 mL/kg transfusions. There were

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2016 Proceedings (Baylor University. Medical Center) Controlled trial quality: uncertain

123. Weight Loss Analysis According to Different Formulas after Sleeve Gastrectomy With or Without Antral Preservation: a Randomised Study. (PubMed)

Weight Loss Analysis According to Different Formulas after Sleeve Gastrectomy With or Without Antral Preservation: a Randomised Study. The measurement of weight loss after bariatric surgery is under constant review in order to obtain the ideal standard for reporting weight loss. Several formulas have been proposed for this purpose. Our goal is to analyse weight loss after sleeve gastrectomy, with or without antrum preservation through different measurement formulas.A prospective randomised (...) study of 60 patients (30 patients with initial section at 3 cm from pylorus and 30 patients at 8 cm from the pylorus). We calculate the following variables at 3, 6 and 12 months from surgery: BMI, excess weight loss (%EWL), percentage of excess of BMI loss (%PEBMIL), expected BMI, % PEBMIL corrected by EBMI and percentage of total weight loss (%TWL).Weight evolution is similar in both groups, reaching a mean BMI of 33.62 ± 4.35 and 34.48 ± 4.23 kg/m2 respectively 12 months after surgery, closer

2016 Obesity Surgery Controlled trial quality: uncertain

124. Outcomes Associated with Weight Gain During Pregnancy: A Rapid Review

guidelines. ? The mean GWG ranged between 10.6kg and 15.8kg across included studies. Outcome measures ? 11/12 studies reported postpartum weight retention (PPWR) as a continuous variable (body weight after pregnancy minus pre- pregnancy weight). ? 5/12 studies reported postpartum BMI and its categories as an outcome. ? 2/12 reported the odds of overweight and obesity. ? Outcomes of included studies were measured at different time points. Results of the Review Main results* Postpartum weight retention (...) (PPWR) - weighted mean difference (WMD) PPWR Overall (11 studies – 10 moderate, 1 low quality) ? Women with an inadequate GWG had a significantly lower postpartum weight (WMD -2.14kg; 95% CI –2.61to -1.66kg; I 2 =88% p=0.00) between 2 weeks and 21 years postpartum, compared with women who had an adequate GWG ? Women with an excessive GWG were significantly greater postpartum weight (WMD 3.15kg; 95% CI 2.47 to 3.82 kg; I 2 =95% p=0.00) between 2 week and 21 years postpartum, compared with women who

2018 Peel Health Library

125. The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea Guideline

events/h). The decrease in AHI correlated with the amount of weight lost. Improvements in some measures of quality oflife,aswellasdecreasesinbloodpressure and serum lipid concentrations, were also AMERICAN THORACIC SOCIETY DOCUMENTS American Thoracic Society Documents e77 Table 3. Studies of Weight-Loss Medications Medication No. of Studies Reviewed/No. of Subjects Follow-up (Range) Effect on Weight [Mean (95% CI) Difference in kg, or as Speci?ed] No. of Studies with OSA as Outcome/No. of Subjects (...) maybedifferentbasedonethnicand/orracial differences de?ning the risks for weight- related disorders in different populations. Methods This clinical practice guideline was developed in accordance with ATS policies and procedures. Panel Composition Theprojectwasproposedbythechairandco- chair through the ATS Sleep and Respiratory NeurobiologyAssemblyandwasapprovedby theATSBoardofDirectors.Potentialpanelists were identi?ed by the chair and co-chair on the basis of their expertise in sleep-disordered breathing, weight management

2018 American Thoracic Society

126. Healthy Weight Interventions for the Interpregnancy Period: A Rapid Review

difference -2.30?kg, 95% CI -3.22 to -1.39). (6) Diet and physical activity together were significantly more effective for weight loss (mean difference -3.24 kg, 95% CI -4.59 to -1.90) compared with physical activity alone (mean difference -1.63 kg, 95% CI -2.16 to -1.10). (6) There is limited evidence that dietary intervention alone (aiming for 35% energy deficit) starting at 12 weeks postpartum may help women in all BMI categories start to lose more weight after childbirth compared to usual care. (9 (...) ) resulted in significantly greater weight loss (mean difference - 4.61 kg, 95% CI -7.08 to -2.15) than those without (mean difference -1.34 kg, 95% CI - 1.66 to -1.02). (6) There was a significant correlation between a higher number of self- monitoring records returned and greater weight loss. (9) Homework completion or telephone contact with research staff was not significantly correlated with weight loss. (9) Women who are supervised by a trained diet and exercise specialist may be more successful

2018 Peel Health Library

127. Weight Loss to Prevent Obesity-Related Morbidity and Mortality in Adults: Behavioral Interventions

(−12.3 lb) among control groups. At 12 to 18 months, intervention participants were more likely to lose 5% of their initial weight compared with control participants (risk ratio, 1.94 [95% CI, 1.70 to 2.22]; 38 trials [n = 12,231]; I 2 = 67.2%; number needed to treat = 8). Participants in weight loss maintenance interventions had less weight gain compared with participants in control groups (pooled mean difference in weight change, −1.59 kg [−3.5 lb] [95% CI, −2.38 to −0.79]; 8 studies [n = 1408]; I (...) difference in weight change, −1.0 kg [−2.2 lb] to −5.8 kg [−12.8 lb]). , Participants also experienced a greater decrease in waist circumference and a greater likelihood of losing 5% of their initial weight compared with placebo groups. Three pharmacotherapy-based weight loss maintenance trials showed that participants receiving the intervention had better weight loss maintenance compared with placebo groups over 12 to 36 months (mean difference, −0.6 to −3.5 kg). Potential Harms of Behavioral Counseling

2018 U.S. Preventive Services Task Force

128. Naltrexone / bupropion (Mysimba) - for the management of weight in adult patients

week 56 of the trial. The mean difference in percentage change of weight loss from baseline as compared with placebo was -3.7% (for the naltrexone 16mg + bupropion 360mg dose) and -4.8% for the naltrexone 32 mg + bupropion 360 mg dose. A significantly greater proportion of patients in the naltrexone/bupropion groups achieved a decrease in bodyweight of = 5% as compared with placebo (48% [32mg/360mg] and 39% [16mg/360mg] versus 16%; p<0.0001 for both comparisons. The COR-II study was a phase III (...) receiving naltrexone/bupropion (n=123) or to escalate to naltrexone 48mg + bupropion 360 mg daily (n=128). The co-primary endpoints were percentage of change in total body weight and proportion of patients with = 5% decrease in total body weight at week 28. The proportion of patients with = 5% decrease in body weight from baseline was significantly greater in the naltrexone/bupropion group at 55.6% versus 17.5%;p<0.001 and the mean difference between the treatment groups was -4.6%;p<0.001. 4 The COR

2018 Pediatric Endocrine Society

129. Cycled light in the intensive care unit for preterm and low birth weight infants. (PubMed)

of blinding and small sample sizes.Six studies enrolling 424 infants compared CL versus ND. No study reported on weight at three or six months. One study (n = 40) found no statistically significant difference in weight at four months between CL and ND groups. In another study (n = 62), the ratio of day-night activity before discharge favoured the CL group (mean difference (MD) 0.18, 95% confidence interval (CI) 0.17 to 0.19), indicating 18% more activity during the day than during the night in the CL (...) group compared with the ND group. Two studies (n = 189) reported on retinopathy of prematurity (stage ≥ 3) and reported no statistically significant differences between CL and ND groups (typical risk ratio (RR) 0.53, 95% CI 0.25 to 1.11, I(2) = 0%; typical risk difference (RD) -0.09, 95% CI -0.19 to 0.01, I(2) = 0%). Two studies (n = 77) reported length of hospital stay (days) and noted a significant reduction in length of stay between CL and ND groups favouring the CL group (weighted mean

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2016 Cochrane

130. Progestin-only contraceptives: effects on weight. (PubMed)

were lack of randomizations (NRS) and high loss to follow-up or early discontinuation.These 22 studies showed limited evidence of change in weight or body composition with use of POCs. Mean weight gain at 6 or 12 months was less than 2 kg (4.4 lb) for most studies. Those with multiyear data showed mean weight change was approximately twice as much at two to four years than at one year, but generally the study groups did not differ significantly. Appropriate counseling about typical weight gain may (...) between progestin-only contraceptive use and changes in body weight.Until 4 August 2016, we searched MEDLINE, CENTRAL, POPLINE, LILACS, ClinicalTrials.gov, and ICTRP. For the initial review, we contacted investigators to identify other trials.We considered comparative studies that examined a POC versus another contraceptive method or no contraceptive. The primary outcome was mean change in body weight or mean change in body composition. We also considered the dichotomous outcome of loss or gain

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2016 Cochrane

131. Long-term effects of weight-reducing diets in people with hypertension. (PubMed)

: systolic blood pressure: mean difference (MD) -4.5 mm Hg (95% CI -7.2 to -1.8 mm Hg) (3 of 8 studies included in analysis), and diastolic blood pressure: MD -3.2 mm Hg (95% CI -4.8 to -1.5 mm Hg) (3 of  8  studies included in analysis). There was moderate-quality evidence for weight reduction in dietary weight loss groups as compared to controls: MD -4.0 kg (95% CI -4.8 to -3.2) (5 of 8 studies included in analysis). Two studies used withdrawal of antihypertensive medication as their primary outcome (...) Long-term effects of weight-reducing diets in people with hypertension. All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension.Primary objectivesTo assess the long-term effects of weight-reducing diets in people with hypertension on all-cause mortality, cardiovascular morbidity, and adverse events

2016 Cochrane

132. Long-term effects of weight-reducing drugs in people with hypertension. (PubMed)

effectively than in participants in the usual-care/placebo groups. Orlistat reduced systolic blood pressure as compared to placebo by -2.5 mm Hg (mean difference (MD); 95% confidence interval (CI): -4.0 to -0.9 mm Hg) and diastolic blood pressure by -1.9 mm Hg (MD; 95% CI: -3.0 to -0.9 mm Hg). Sibutramine increased diastolic blood pressure compared to placebo by +3.2 mm Hg (MD; 95% CI: +1.4 to +4.9 mm Hg). The one trial that investigated phentermine/topiramate suggested it lowered blood pressure.In people (...) Long-term effects of weight-reducing drugs in people with hypertension. All major guidelines on antihypertensive therapy recommend weight loss; anti-obesity drugs may be able to help in this respect.To assess the long-term effects of pharmacologically induced reduction in body weight in adults with essential hypertension on all-cause mortality, cardiovascular morbidity, and adverse events (including total serious adverse events, withdrawal due to adverse events, and total non-serious adverse

2016 Cochrane

133. Validation of clinic weights from electronic health records against standardized weight measurements in weight loss trials. (PubMed)

and researcher-measured weights in BE WELL and another trial, E-LITE, were analyzed using growth curve modeling.Among BE WELL (n = 330) and E-LITE (n = 241) participants, 96% and 90% had clinic weights (mean [SD] of 5.8 [6.1] and 3.7 [3.9] records) over 12 and 15 months of follow-up, respectively. The concordance correlation coefficient was 0.99, and limits of agreement plots showed no pattern between or within treatment groups, suggesting overall good agreement between researcher-measured and nearest (...) -in-time clinic weights up to 3 months. The 95% confidence intervals for predicted percent differences fell within ±3% for clinic weights within 3 months of the researcher-measured weights. Furthermore, the growth curve slopes for clinic and researcher-measured weights by treatment group did not differ significantly, suggesting similar inferences about treatment effects over time, in both trials.Compared with researcher-measured weights, close-in-time clinic weights showed high agreement and inference

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2017 Obesity

134. Weight loss and frequency of body‐weight self‐monitoring in an online commercial weight management program with and without a cellular‐connected ‘smart’ scale: a randomized pilot study (PubMed)

significant weight loss, mean ± standard error weight loss did not differ between WWO-E and WWO at 3 months (5.1 ± 0.6 kg vs. 4.0 ± 0.7 kg, respectively; p = 0.257) or 6 months (5.3 ± 0.6 kg vs. 3.9 ± 0.7 kg, respectively; p = 0.116). However, a greater proportion of WWO-E lost ≥5% of initial body weight at 3 months (52.2% vs. 28.3%; p = 0.033), but not 6 months (43.5% vs. 30.4%; p = 0.280), compared with WWO. Mean ± standard deviation days with self-monitored weight was higher in WWO-E (80.5 ± 5.6; 44.7 (...) % of days) than WWO (12.0 ± 1.0; 6.7% of days; p < 0.001) across the 6-month study period.This is the first study to show that provision of a 'smart' scale with weekly tailored feedback substantially increased the frequency of self-weighing and the proportion of participants achieving an initial clinically significant ≥5% weight loss (52% vs. 28%) in an online commercial weight management program. Both WWO and WWO-E produced significant weight loss over 6 months. While mean weight losses were slightly

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2017 Obesity science & practice Controlled trial quality: uncertain

135. The Impact of Differences between Patient and General Population EQ-5D-3L Values on the Mean Tariff Scores of Different Patient Groups. (PubMed)

differences between these methods have an effect on the mean EQ-5D-3L tariff scores of different patient groups.The European tariff based on GHS valuations was compared with a German EHS tariff. Comparison was made in the context of EQ-5D-3L health states describing a number of diagnosed chronic diseases (stroke, diabetes, myocardial infarction, and cancer) taken from the Cooperative Health Research in the Augsburg Region population surveys. Comparison was made of both the difference in weighting (...) The Impact of Differences between Patient and General Population EQ-5D-3L Values on the Mean Tariff Scores of Different Patient Groups. Health states can be valued by those who currently experience a health state (experienced health states [EHS]) or by the general public, who value a set of given health states (GHS) described to them. There has been debate over which method is more appropriate when making resource allocation decisions.This article informs this debate by assessing whether

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2014 Value in Health

136. Success of a weight loss plan for overweight dogs: The results of an international weight loss study. (PubMed)

descriptions.At baseline, median (range) age was 74 (12 to 193) months and median body condition score was 8 (range 7-9). 896 of the 926 dogs (97%) lost weight, with mean weight loss being 11.4 ±5.84%. Sexually intact dogs lost more weight than neutered dogs (P = 0.001), whilst female dogs lost more weight than male dogs (P = 0.007), with the difference being more pronounced in North and South American dogs (median [Q1, Q3]: female: 11.5% [8.5%, 14.5%]; male: 9.1% [6.3%, 12.1%], P = 0.053) compared with those (...) Success of a weight loss plan for overweight dogs: The results of an international weight loss study. Obesity is a global concern in dogs with an increasing prevalence, and effective weight loss solutions are required that work in different geographical regions. The main objective was to conduct an international, multi-centre, weight loss trial to determine the efficacy of a dietary weight loss intervention in obese pet dogs.A 3-month prospective observational cohort study of weight loss in 926

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2017 PLoS ONE

137. The association between baseline persistent pain and weight change in patients attending a specialist weight management service. (PubMed)

The association between baseline persistent pain and weight change in patients attending a specialist weight management service. To quantify the influence of baseline pain levels on weight change at one-year follow-up in patients attending a National Health Service specialist weight management programme.We compared one-year follow-up weight (body mass) change between patient sub-groups of none-to-mild, moderate, and severe pain at baseline. A mean sub-group difference in weight change of ≥5kg (...) = 0.03) lower than the moderate pain group.Patients with severe pain upon entry to a specialist weight management service in England achieve a smaller mean weight loss at one-year follow-up than those with none-to-moderate pain. The magnitude of the difference in mean weight loss was clinically relevant, highlighting the importance of addressing severe persistent pain in obese patients undertaking weight management programmes.

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2017 PLoS ONE

138. Group-based diet and exercise programmes can lead to weight loss

trials (RCTs) of group‐based diet and/or physical activity interventions for overweight/obese adults (BMI ≥ 25). Intervention characteristics were synthesised narratively. Mean differences (MD) in weight loss were calculated using a random‐effects meta‐analysis, and sub‐group analyses were conducted to identify moderators of effectiveness. Results Forty‐seven RCTs reporting 60 evaluations of group‐based interventions were included. MD in weight loss between intervention and control groups was −3.49 (...) limitations mean that it is difficult to determine exactly what works and how. The group approach seems generally effective, more so for men than women, and is more effective in those programmes that target weight loss rather than maintenance. Share your views on the research. Why was this study needed? Obesity is a major public health concern across the UK and internationally. In 2016, 26% of men and 27% of women in England were obese, and a further 40% of men and 30% of women were overweight. People who

2019 NIHR Dissemination Centre

139. A school-based lifestyle intervention didn’t help children avoid unhealthy weight gain

with parental support. Final phase four in the autumn reinforced the messages learnt. The delivery format varied from assemblies to activity workshops and drama groups. Sessions were provided by HeLP coordinators with assistance from teachers and other personnel (e.g. actors and sportspersons). A total of 1,324 children participated, and 94% had a follow-up for two years. What did it find? HeLP had no effect on the main outcome of body mass index (BMI) at 24 months (mean difference [MD] between groups -0.02 (...) . There was no difference on weekends. Analysis of the child-completed My Lifestyle Questionnaire indicated that improved knowledge, confidence and motivation, and family approval might have been behind these dietary changes. The intervention was estimated to cost £214 per child. This was mainly attributed to costs of the various personnel, their training and travel. With no weight-related effects, nor reduction in obesity-related illness (such as diabetes or cardiovascular disease), it seemed clear the programme would

2019 NIHR Dissemination Centre

140. 52-week programme leads to more weight loss than 12-week

of approaches that people can take to reduce their weight. The first challenge is losing weight, but people can find it difficult to keep off the weight that they have lost. NICE recommends that GPs refer obese people (and overweight if there is capacity) to lifestyle weight management programmes that last for at least three months. To date, studies have compared different programmes but not directly looked at whether longer programmes may offer better results. This trial investigated whether referring (...) in all groups had regained some weight, but weight loss since the start of the trial was still significantly different between groups: 52-weeks ‑4.29kg; 12-weeks ‑3.00kg; and brief intervention ‑2.30kg. Participants receiving either the 12- or 52-week programme were more likely to have lost 5% of their body weight by one year (42% and 57%, respectively) compared to the brief intervention (25%). By two years fewer people had maintained 5% loss, but both programmes were still more effective than

2019 NIHR Dissemination Centre

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